SE-JINS LEE

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi Role of satellite cells versus myofibers in muscle hypertrophy induced by inhibition of the myostatin/activin signaling pathway
    Se Jin Lee
    Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 109:E2353-60. 2012
  2. ncbi Redundancy of myostatin and growth/differentiation factor 11 function
    Alexandra C McPherron
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    BMC Dev Biol 9:24. 2009
  3. ncbi Treating cancer cachexia to treat cancer
    Se Jin Lee
    Johns Hopkins University School of Medicine, Department of Molecular Biology and Genetics, 725 N, Wolfe St, PCTB 803, Baltimore, Maryland 21205, USA
    Skelet Muscle 1:2. 2011
  4. ncbi Regulation of muscle mass by follistatin and activins
    Se Jin Lee
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Endocrinol 24:1998-2008. 2010
  5. ncbi Genetic analysis of the role of proteolysis in the activation of latent myostatin
    Se Jin Lee
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    PLoS ONE 3:e1628. 2008
  6. ncbi Sprinting without myostatin: a genetic determinant of athletic prowess
    Se Jin Lee
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, PCTB 803, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Trends Genet 23:475-7. 2007
  7. ncbi Quadrupling muscle mass in mice by targeting TGF-beta signaling pathways
    Se Jin Lee
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 2:e789. 2007
  8. ncbi Regulation of muscle growth by multiple ligands signaling through activin type II receptors
    Se Jin Lee
    Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 102:18117-22. 2005
  9. ncbi Regulation of muscle mass by myostatin
    Se Jin Lee
    Johns Hopkins University School of Medicine, Department of Molecular Biology and Genetics, Baltimore, MD 21205, USA
    Annu Rev Cell Dev Biol 20:61-86. 2004
  10. ncbi Regulation of myostatin activity and muscle growth
    S J Lee
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 98:9306-11. 2001

Research Grants

  1. ROLE OF MYOSTATIN IN CACHEXIA
    Se Jin Lee; Fiscal Year: 2005
  2. Characterization of myostatin and GDF-11
    Se Jin Lee; Fiscal Year: 2006
  3. Characterization of myostatin and GDF-11
    Se Jin Lee; Fiscal Year: 2007
  4. Characterization of myostatin and GDF-11
    Se Jin Lee; Fiscal Year: 2010
  5. Characterization of myostatin and GDF-11
    Se Jin Lee; Fiscal Year: 2003
  6. GDF-8 (MYOSTATIN) AND GDF-11
    Se Jin Lee; Fiscal Year: 2002
  7. Mechanisms underlying myostatin regulation and activity
    Se Jin Lee; Fiscal Year: 2010

Collaborators

Detail Information

Publications18

  1. ncbi Role of satellite cells versus myofibers in muscle hypertrophy induced by inhibition of the myostatin/activin signaling pathway
    Se Jin Lee
    Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 109:E2353-60. 2012
    ....
  2. ncbi Redundancy of myostatin and growth/differentiation factor 11 function
    Alexandra C McPherron
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    BMC Dev Biol 9:24. 2009
    ..In order to investigate the possible functional redundancy of myostatin and Gdf11, we analyzed the effect of eliminating the functions of both of these signaling molecules...
  3. ncbi Treating cancer cachexia to treat cancer
    Se Jin Lee
    Johns Hopkins University School of Medicine, Department of Molecular Biology and Genetics, 725 N, Wolfe St, PCTB 803, Baltimore, Maryland 21205, USA
    Skelet Muscle 1:2. 2011
    ....
  4. ncbi Regulation of muscle mass by follistatin and activins
    Se Jin Lee
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Endocrinol 24:1998-2008. 2010
    ....
  5. ncbi Genetic analysis of the role of proteolysis in the activation of latent myostatin
    Se Jin Lee
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    PLoS ONE 3:e1628. 2008
    ....
  6. ncbi Sprinting without myostatin: a genetic determinant of athletic prowess
    Se Jin Lee
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, PCTB 803, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Trends Genet 23:475-7. 2007
    ..Furthermore, they show that loss of even one functional MSTN allele seems to confer a competitive advantage to racing whippets, providing the first definitive evidence that loss of myostatin function can enhance athletic performance...
  7. ncbi Quadrupling muscle mass in mice by targeting TGF-beta signaling pathways
    Se Jin Lee
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 2:e789. 2007
    ....
  8. ncbi Regulation of muscle growth by multiple ligands signaling through activin type II receptors
    Se Jin Lee
    Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 102:18117-22. 2005
    ..Finally, we provide genetic evidence that these ligands signal through both activin type II receptors, ACVR2 and ACVR2B, to regulate muscle growth in vivo...
  9. ncbi Regulation of muscle mass by myostatin
    Se Jin Lee
    Johns Hopkins University School of Medicine, Department of Molecular Biology and Genetics, Baltimore, MD 21205, USA
    Annu Rev Cell Dev Biol 20:61-86. 2004
    ..Skeletal muscle appears to be the first example of a tissue whose size is controlled by this type of regulatory mechanism, and myostatin appears to be the first example of the long-sought chalone...
  10. ncbi Regulation of myostatin activity and muscle growth
    S J Lee
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 98:9306-11. 2001
    ..Our findings suggest that the propeptide, follistatin, or other molecules that block signaling through this pathway may be useful agents for enhancing muscle growth for both human therapeutic and agricultural applications...
  11. ncbi Myostatin and the control of skeletal muscle mass
    S J Lee
    Department of Molecular Biology and Genetics Johns Hopkins University School of Medicine 725 North Wolfe Street, Baltimore, Maryland, 21205, USA
    Curr Opin Genet Dev 9:604-7. 1999
    ....
  12. ncbi Double muscling in cattle due to mutations in the myostatin gene
    A C McPherron
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 94:12457-61. 1997
    ....
  13. ncbi Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member
    A C McPherron
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 387:83-90. 1997
    ..These results suggest that GDF-8 functions specifically as a negative regulator of skeletal muscle growth...
  14. ncbi Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11
    A C McPherron
    Department of Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Genet 22:260-4. 1999
    ..Our findings suggest that Gdf11 is a secreted signal that acts globally to specify positional identity along the anterior/posterior axis...
  15. ncbi Growth/differentiation factor-10: a new member of the transforming growth factor-beta superfamily related to bone morphogenetic protein-3
    N S Cunningham
    Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Growth Factors 12:99-109. 1995
    ..Gdf10 was mapped to the proximal region of mouse chromosome 14 close to a region known to contain a spontaneous recessive mutation that is associated with a craniofacial defect...
  16. ncbi Characterization of growth-differentiation factor 15, a transforming growth factor beta superfamily member induced following liver injury
    E C Hsiao
    Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Cell Biol 20:3742-51. 2000
    ..Our findings suggest either that Gdf15 does not have a regulatory role in liver injury and regeneration or that Gdf15 function within the liver is redundant with that of other signaling molecules...
  17. ncbi Characterization of GDF-10 expression patterns and null mice
    R Zhao
    Department of Molecular Biology and Genetics, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland, 21205, USA
    Dev Biol 212:68-79. 1999
    ..These findings suggest either that GDF-10 plays no regulatory role in these tissues or that its function is redundant with that of other growth factor-like molecules...
  18. ncbi GDF-3 and GDF-9: two new members of the transforming growth factor-beta superfamily containing a novel pattern of cysteines
    A C McPherron
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    J Biol Chem 268:3444-9. 1993
    ..These findings raise new possibilities regarding subunit interactions among members of this superfamily...

Research Grants23

  1. ROLE OF MYOSTATIN IN CACHEXIA
    Se Jin Lee; Fiscal Year: 2005
    ..abstract_text> ..
  2. Characterization of myostatin and GDF-11
    Se Jin Lee; Fiscal Year: 2006
    ..abstract_text> ..
  3. Characterization of myostatin and GDF-11
    Se Jin Lee; Fiscal Year: 2007
    ..abstract_text> ..
  4. Characterization of myostatin and GDF-11
    Se Jin Lee; Fiscal Year: 2010
    ....
  5. Characterization of myostatin and GDF-11
    Se Jin Lee; Fiscal Year: 2003
    ..abstract_text> ..
  6. GDF-8 (MYOSTATIN) AND GDF-11
    Se Jin Lee; Fiscal Year: 2002
    ..The final aim is to clone the genes for the GDF-8 and GDF-11 receptors. ..
  7. Mechanisms underlying myostatin regulation and activity
    Se Jin Lee; Fiscal Year: 2010
    ....