Noah Lechtzin

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc A randomized trial of nature scenery and sounds versus urban scenery and sounds to reduce pain in adults undergoing bone marrow aspirate and biopsy
    Noah Lechtzin
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Altern Complement Med 16:965-72. 2010
  2. pmc Rationale and design of a randomized trial of home electronic symptom and lung function monitoring to detect cystic fibrosis pulmonary exacerbations: the early intervention in cystic fibrosis exacerbation (eICE) trial
    N Lechtzin
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore MD, United States Electronic address
    Contemp Clin Trials 36:460-9. 2013
  3. doi request reprint Validation of the Cough Quality-of-Life Questionnaire in patients with idiopathic pulmonary fibrosis
    Noah Lechtzin
    Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Chest 143:1745-9. 2013
  4. ncbi request reprint Supramaximal inflation improves lung compliance in subjects with amyotrophic lateral sclerosis
    Noah Lechtzin
    Department of Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Chest 129:1322-9. 2006
  5. ncbi request reprint How beneficial is noninvasive ventilation in patients with amyotrophic lateral sclerosis?
    Noah Lechtzin
    Johns Hopkins University, and Johns Hopkins ALS Clinic, Baltimore, MD 21205, USA
    Nat Clin Pract Neurol 2:356-7. 2006
  6. ncbi request reprint Measures of dyspnea in patients with amyotrophic lateral sclerosis
    Noah Lechtzin
    Department of Medicine, Division of Pulmonary and Critical Care, Johns Hopkins University School of Medicine, 1830 E Monument Street, 5th Floor, Baltimore, Maryland 21205, USA
    Muscle Nerve 35:98-102. 2007
  7. ncbi request reprint Outcomes of adults with cystic fibrosis infected with antibiotic-resistant Pseudomonas aeruginosa
    Noah Lechtzin
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Respiration 73:27-33. 2006
  8. ncbi request reprint Use of noninvasive ventilation in patients with amyotrophic lateral sclerosis
    Noah Lechtzin
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, 1830 E Monument Street, Fifth Floor, Baltimore, MD 21205, USA
    Amyotroph Lateral Scler Other Motor Neuron Disord 5:9-15. 2004
  9. doi request reprint Pain is a common problem affecting clinical outcomes in adults with cystic fibrosis
    MARGARET HAYES
    Department of Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Chest 140:1598-603. 2011
  10. pmc Primary cytomegalovirus phosphoprotein 65-specific CD8+ T-cell responses and T-bet levels predict immune control during early chronic infection in lung transplant recipients
    Matthew R Pipeling
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
    J Infect Dis 204:1663-71. 2011

Research Grants

  1. Improving Respiratory Outcomes in ALS
    Noah Lechtzin; Fiscal Year: 2006

Detail Information

Publications42

  1. pmc A randomized trial of nature scenery and sounds versus urban scenery and sounds to reduce pain in adults undergoing bone marrow aspirate and biopsy
    Noah Lechtzin
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Altern Complement Med 16:965-72. 2010
    ..Bone marrow aspiration and biopsy (BMAB) is painful when performed with only local anesthetic. Our objective was to determine whether viewing nature scenes and listening to nature sounds can reduce pain during BMAB...
  2. pmc Rationale and design of a randomized trial of home electronic symptom and lung function monitoring to detect cystic fibrosis pulmonary exacerbations: the early intervention in cystic fibrosis exacerbation (eICE) trial
    N Lechtzin
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore MD, United States Electronic address
    Contemp Clin Trials 36:460-9. 2013
    ..Pulmonary exacerbations lead to impaired lung function, worse quality of life, and shorter survival. We hypothesized that aggressive early treatment of acute pulmonary exacerbation may improve clinical outcomes...
  3. doi request reprint Validation of the Cough Quality-of-Life Questionnaire in patients with idiopathic pulmonary fibrosis
    Noah Lechtzin
    Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Chest 143:1745-9. 2013
    ..This study aimed to assess the reliability and validity of the CQLQ in individuals with IPF...
  4. ncbi request reprint Supramaximal inflation improves lung compliance in subjects with amyotrophic lateral sclerosis
    Noah Lechtzin
    Department of Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Chest 129:1322-9. 2006
    ..Noninvasive positive-pressure ventilation (NPPV) prolongs survival in ALS patients but may also have additional beneficial effects...
  5. ncbi request reprint How beneficial is noninvasive ventilation in patients with amyotrophic lateral sclerosis?
    Noah Lechtzin
    Johns Hopkins University, and Johns Hopkins ALS Clinic, Baltimore, MD 21205, USA
    Nat Clin Pract Neurol 2:356-7. 2006
  6. ncbi request reprint Measures of dyspnea in patients with amyotrophic lateral sclerosis
    Noah Lechtzin
    Department of Medicine, Division of Pulmonary and Critical Care, Johns Hopkins University School of Medicine, 1830 E Monument Street, 5th Floor, Baltimore, Maryland 21205, USA
    Muscle Nerve 35:98-102. 2007
    ..The BDI and TDI thus appear to be useful measures in ALS and may have both clinical and research applications...
  7. ncbi request reprint Outcomes of adults with cystic fibrosis infected with antibiotic-resistant Pseudomonas aeruginosa
    Noah Lechtzin
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Respiration 73:27-33. 2006
    ....
  8. ncbi request reprint Use of noninvasive ventilation in patients with amyotrophic lateral sclerosis
    Noah Lechtzin
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, 1830 E Monument Street, Fifth Floor, Baltimore, MD 21205, USA
    Amyotroph Lateral Scler Other Motor Neuron Disord 5:9-15. 2004
    ..The extent of NIPPV use in ALS patients and the factors associated with its use have not been studied...
  9. doi request reprint Pain is a common problem affecting clinical outcomes in adults with cystic fibrosis
    MARGARET HAYES
    Department of Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Chest 140:1598-603. 2011
    ..We hypothesized that pain is common, is associated with psychologic distress, and adversely affects clinical outcomes...
  10. pmc Primary cytomegalovirus phosphoprotein 65-specific CD8+ T-cell responses and T-bet levels predict immune control during early chronic infection in lung transplant recipients
    Matthew R Pipeling
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
    J Infect Dis 204:1663-71. 2011
    ..However, the correlates of immune control during chronic CMV infection remain incompletely understood...
  11. pmc Differential CMV-specific CD8+ effector T cell responses in the lung allograft predominate over the blood during human primary infection
    Matthew R Pipeling
    Division of Pulmonary and Critical Care Medicine, Department of Pathology and Medical Microbiology, Johns Hopkins University, School of Medicine, Baltimore, MD 21224, USA
    J Immunol 181:546-56. 2008
    ..Moreover, we show intercompartmental phenotypic differences in CMV-specific memory responses during the transition to chronic infection...
  12. ncbi request reprint Amyotrophic lateral sclerosis: evaluation and treatment of respiratory impairment
    Noah Lechtzin
    Department of Medicine, Division of Pulmonary and Critical Care, Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Amyotroph Lateral Scler Other Motor Neuron Disord 3:5-13. 2002
    ..Tracheostomy with long-term mechanical ventilation is not frequently used but can be an important component of care for ALS. This review describes an approach to respiratory evaluation and care of patients with ALS...
  13. ncbi request reprint The relationship between age and process of care and patient tolerance of bronchoscopy
    Boyd T Hehn
    Division of Pulmonary and Critical Care Medicine, Allergy, Immunology, and Sleep Medicine, Henry Ford Hospital, Detroit, Michigan, USA
    J Am Geriatr Soc 51:917-22. 2003
    ..To determine whether patient age is associated with differences in flexible bronchoscopy technique and tolerance...
  14. pmc Increased right ventricular Septomarginal trabeculation mass is a novel marker for pulmonary hypertension: comparison with ventricular mass index and right ventricular mass
    Jens Vogel-Claussen
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Invest Radiol 46:567-75. 2011
    ....
  15. pmc Pulmonary arterial hypertension: MR imaging-derived first-pass bolus kinetic parameters are biomarkers for pulmonary hemodynamics, cardiac function, and ventricular remodeling
    Jan Skrok
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Nelson Basement MRI 110, 600 N Wolfe St, Baltimore, MD 21287, USA
    Radiology 263:678-87. 2012
    ....
  16. doi request reprint Tricuspid annular plane systolic excursion is a robust outcome measure in systemic sclerosis-associated pulmonary arterial hypertension
    Stephen C Mathai
    Divisions of Pulmonary and Critical Care Medicine, Cardiology, and Rheumatology, Department of Medicine, Johns Hopkins, University School of Medicine, Baltimore, Maryland, USA
    J Rheumatol 38:2410-8. 2011
    ..But its role in systemic sclerosis (SSc)-associated PAH has not been established. Our objective was to validate the TAPSE in the assessment of RV function and prediction of survival in SSc-PAH...
  17. ncbi request reprint Distraction therapy with nature sights and sounds reduces pain during flexible bronchoscopy: a complementary approach to routine analgesia
    Gregory B Diette
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Chest 123:941-8. 2003
    ..To determine whether distraction therapy with nature sights and sounds during flexible bronchoscopy (FB) reduces pain and anxiety...
  18. ncbi request reprint Early use of non-invasive ventilation prolongs survival in subjects with ALS
    Noah Lechtzin
    Johns Hopkins University School of Medicine, MD 21205, USA
    Amyotroph Lateral Scler 8:185-8. 2007
    ..Until more definitive data are available from randomized trials, our findings suggest that clinicians either encourage earlier use of NPPV or use more sensitive tests for respiratory muscle impairment than upright FVC...
  19. doi request reprint Appropriate goal level for 25-hydroxyvitamin D in cystic fibrosis
    Natalie E West
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Chest 140:469-74. 2011
    ..We sought to determine the appropriate goal 25OHD level in patients with CF by identifying the level below which the risk of PTH > 50 pg/mL begins to increase...
  20. ncbi request reprint Association between respiratory tract methicillin-resistant Staphylococcus aureus and survival in cystic fibrosis
    Elliott C Dasenbrook
    Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, Ohio 44106 5067, USA
    JAMA 303:2386-92. 2010
    ..Because the time between infection with bacteria in CF and death can be decades, observational studies with long periods of follow-up are well suited to address the current gap in knowledge...
  21. ncbi request reprint Pulmonary predictors of survival in amyotrophic lateral sclerosis: use in clinical trial design
    Eric P Schmidt
    Department of Medicine, 1830 East Monument Street, Room 525, Baltimore, MD 21287, USA
    Muscle Nerve 33:127-32. 2006
    ..These tests are well suited to predict survival for trial enrollment and patient counseling. Supine FVC's simplicity of use and availability to ALS investigators makes it a particularly attractive predictor of one-year survival in ALS...
  22. doi request reprint Thalidomide for the treatment of cough in idiopathic pulmonary fibrosis: a randomized trial
    Maureen R Horton
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Intern Med 157:398-406. 2012
    ..Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disorder of unknown cause with no effective treatment. Cough affects up to 80% of patients with IPF, is frequently disabling, and lacks effective therapy...
  23. pmc Regional and global biventricular function in pulmonary arterial hypertension: a cardiac MR imaging study
    Monda L Shehata
    Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe St, Nelson Basement MRI 110, Baltimore, MD 21287, USA
    Radiology 266:114-22. 2013
    ....
  24. pmc Respiratory symptoms and disease characteristics as predictors of pulmonary function abnormalities in patients with rheumatoid arthritis: an observational cohort study
    Dimitrios A Pappas
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, 1830 E, Monument Street, 5th Floor, Baltimore, MD 21202, USA
    Arthritis Res Ther 12:R104. 2010
    ....
  25. ncbi request reprint Spirometry in the supine position improves the detection of diaphragmatic weakness in patients with amyotrophic lateral sclerosis
    Noah Lechtzin
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Chest 121:436-42. 2002
    ..To determine which respiratory function tests best predicted diaphragmatic strength in patients with amyotrophic lateral sclerosis...
  26. doi request reprint Comparison of 21-gauge and 22-gauge aspiration needle in endobronchial ultrasound-guided transbronchial needle aspiration: results of the American College of Chest Physicians Quality Improvement Registry, Education, and Evaluation Registry
    Lonny B Yarmus
    Johns Hopkins University, Baltimore, MD 21205, USA
    Chest 143:1036-43. 2013
    ..To our knowledge, this is the largest study undertaken to date to determine whether the 21G needle adds diagnostic benefit...
  27. ncbi request reprint Respiratory effects of amyotrophic lateral sclerosis: problems and solutions
    Noah Lechtzin
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore MD 21205, USA
    Respir Care 51:871-81; discussion 881-4. 2006
    ..This review discusses the respiratory evaluation and treatment of patients with ALS, about which a great deal is known. It also includes material on related problems, such as speech and swallowing difficulties and end-of-life care...
  28. doi request reprint Persistent methicillin-resistant Staphylococcus aureus and rate of FEV1 decline in cystic fibrosis
    Elliott C Dasenbrook
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, 1830 E Monument Street, 5th Floor, Baltimore, MD 21205, USA
    Am J Respir Crit Care Med 178:814-21. 2008
    ..The prevalence in cystic fibrosis (CF) of respiratory cultures with methicillin-resistant Staphylococcus aureus (MRSA) has dramatically increased over the last 10 years, but the effect of MRSA on FEV(1) decline in CF is unknown...
  29. ncbi request reprint Patient satisfaction with bronchoscopy
    Noah Lechtzin
    Division of Pulmonary and Critical Care Medicine, School of Medicine, Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 166:1326-31. 2002
    ..Sicker patients may be at a risk of dissatisfaction with FB. Process of care measures that could improve satisfaction with FB include providing better information to patients and optimizing the experience of bronchoscope insertion...
  30. ncbi request reprint Accurate ALSFRS-R scores can be generated from retrospective review of clinic notes
    Noah Lechtzin
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Amyotroph Lateral Scler 10:244-7. 2009
    ..This study indicates that ALSFRS-R scores can be accurately reproduced from information in clinic notes and should be considered as a marker of disease severity for use in retrospective studies...
  31. doi request reprint Systemic sclerosis-related pulmonary hypertension associated with interstitial lung disease: impact of pulmonary arterial hypertension therapies
    Jerome Le Pavec
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Arthritis Rheum 63:2456-64. 2011
    ..This study was undertaken to evaluate our experience with PH-ILD with regard to the efficacy and safety of PAH therapies in this patient cohort...
  32. ncbi request reprint Current treatment of adult Duchenne muscular dystrophy
    Kathryn R Wagner
    Department of Neurology, The Johns Hopkins School of Medicine, Meyer 5 119, 600 N Wolfe St, Baltimore, MD 21287, USA
    Biochim Biophys Acta 1772:229-37. 2007
    ..Current and future therapies directed at prolonging the lifespan of those with DMD will result in further increases in this adult population with special needs and concerns. These needs are best addressed in a multidisciplinary clinic...
  33. pmc Right and left ventricular myocardial perfusion reserves correlate with right ventricular function and pulmonary hemodynamics in patients with pulmonary arterial hypertension
    Jens Vogel-Claussen
    Department of Radiology, Johns Hopkins University School of Medicine, Nelson Basement MRI 143, 600 N Wolfe St, Baltimore, MD 21287, USA
    Radiology 258:119-27. 2011
    ....
  34. ncbi request reprint Incidence and risk factors for multiple antibiotic-resistant Pseudomonas aeruginosa in cystic fibrosis
    Christian A Merlo
    The Johns Hopkins University School of Medicine, 1830 E Monument St Fifth Floor, Baltimore, MD 21205, USA
    Chest 132:562-8. 2007
    ..The main objective of the study was to estimate the incidence and identify risk factors for the acquisition of MARPA among individuals with CF...
  35. pmc Hemodynamic predictors of survival in scleroderma-related pulmonary arterial hypertension
    Aránzazu Campo
    MD, Division of Pulmonary and Critical Care Medicine, 1830 E Monument St, Fifth Floor, Baltimore, MD 21205, USA
    Am J Respir Crit Care Med 182:252-60. 2010
    ..Pulmonary arterial hypertension (PAH) related to systemic sclerosis (SSc) has a poorer prognosis compared with other forms of PAH for reasons that remain unexplained...
  36. ncbi request reprint In-hospital mortality following acute exacerbations of chronic obstructive pulmonary disease
    Susheel P Patil
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, 1830 E Monument Street, Suite 7110 A, Baltimore, MD 21205, USA
    Arch Intern Med 163:1180-6. 2003
    ..Our objective was to obtain a generalizable estimate of in-hospital mortality from acute exacerbation of COPD in the United States and to identify predictors of in-hospital mortality using administrative data...
  37. doi request reprint Optimizing endobronchial ultrasound for molecular analysis. How many passes are needed?
    Lonny Yarmus
    1 Section of Interventional Pulmonology, Division of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, Maryland
    Ann Am Thorac Soc 10:636-43. 2013
    ....
  38. pmc Failure of high-dose ergocalciferol to correct vitamin D deficiency in adults with cystic fibrosis
    Michael P Boyle
    Johns Hopkins Adult CF Program, 1830 East Monument Street, 5th Floor, Baltimore, MD 21205, USA
    Am J Respir Crit Care Med 172:212-7. 2005
    ..Treatment guidelines for vitamin D monitoring and supplementation in cystic fibrosis (CF) have recently been developed and published by a consensus committee, but have not been prospectively tested...
  39. doi request reprint Statin therapy is associated with decreased pulmonary vascular pressures in severe COPD
    Robert M Reed
    University of Maryland School of Medicine, Division of Pulmonary and Critical Care Medicine, Baltimore, Maryland 21201, USA
    COPD 8:96-102. 2011
    ..We examined the association between statin use and pulmonary hemodynamics in a well-characterized cohort of patients undergoing evaluation for lung transplantation...
  40. doi request reprint Elevated HDL cholesterol levels are associated with osteoporosis in lung transplant candidates with chronic obstructive pulmonary disease
    Robert M Reed
    Johns Hopkins University School of Medicine, Division of Pulmonary and Critical Care Medicine, USA
    Respir Med 104:1943-50. 2010
    ..Increased high density lipoprotein cholesterol (HDLc) has been observed in COPD and linked with osteoporosis in the general population. This association has not been previously examined in COPD...
  41. doi request reprint Training perspective: the impact of starting an endobronchial ultrasound program at a major academic center on fellows training of transbronchial needle aspiration
    David J Feller-Kopman
    Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Ann Am Thorac Soc 10:127-30. 2013
    ..As interventional pulmonology fellowships and the overall use of EBUS become more prevalent, institutions will need to consider how to train their fellows in lymph node sampling...
  42. ncbi request reprint Persistent cytomegalovirus-specific memory responses in the lung allograft and blood following primary infection in lung transplant recipients
    Oksana A Shlobin
    Department of Pulmonary and Critical Care Medicine, Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Immunol 176:2625-34. 2006
    ..02) compared with those who failed to develop CMV immunity. Together, our data reveal immunologic heterogeneity in D(+)R(-) LTRs, with the development and persistence of primary CMV responses that may provide clinical benefit...

Research Grants1

  1. Improving Respiratory Outcomes in ALS
    Noah Lechtzin; Fiscal Year: 2006
    The Principal Investigator, Dr. Noah Lechtzin, is a promising young investigator who has made a substantial commitment to an academic career in clinical research...