Josh Lauring

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity
    Josh Lauring
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Department of Chemical and Biomolecular Engineering, Baltimore, MD 21231, USA
    Blood 111:856-64. 2008
  2. pmc Knock in of the AKT1 E17K mutation in human breast epithelial cells does not recapitulate oncogenic PIK3CA mutations
    J Lauring
    Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Oncogene 29:2337-45. 2010
  3. pmc Knockin of mutant PIK3CA activates multiple oncogenic pathways
    John P Gustin
    The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 106:2835-40. 2009
  4. pmc The growth response to androgen receptor signaling in ERα-negative human breast cells is dependent on p21 and mediated by MAPK activation
    Joseph P Garay
    The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Breast Cancer Res 14:R27. 2012
  5. pmc Single copies of mutant KRAS and mutant PIK3CA cooperate in immortalized human epithelial cells to induce tumor formation
    Grace M Wang
    The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of, The Johns Hopkins University, Baltimore, Maryland 21287, USA
    Cancer Res 73:3248-61. 2013
  6. pmc Tamoxifen-stimulated growth of breast cancer due to p21 loss
    Abde M Abukhdeir
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 105:288-93. 2008
  7. ncbi request reprint A PCR-based high-throughput screen with multiround sample pooling: application to somatic cell gene targeting
    Hiroyuki Konishi
    Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, 1650 Orleans Street, Baltimore, Maryland 21231, USA
    Nat Protoc 2:2865-74. 2007
  8. ncbi request reprint Knock-in of mutant K-ras in nontumorigenic human epithelial cells as a new model for studying K-ras mediated transformation
    Hiroyuki Konishi
    The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cancer Res 67:8460-7. 2007
  9. pmc Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells
    Hiroyuki Konishi
    The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 108:17773-8. 2011
  10. pmc Functional analysis of non-hotspot AKT1 mutants found in human breast cancers identifies novel driver mutations: implications for personalized medicine
    Kyung H Yi
    The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Oncotarget 4:29-34. 2013

Collaborators

Detail Information

Publications13

  1. pmc The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity
    Josh Lauring
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Department of Chemical and Biomolecular Engineering, Baltimore, MD 21231, USA
    Blood 111:856-64. 2008
    ..These results provide the first direct evidence that MMSET plays a significant role in t(4;14) MM and suggest that therapies targeting this gene could impact this particular subset of poor-prognosis patients...
  2. pmc Knock in of the AKT1 E17K mutation in human breast epithelial cells does not recapitulate oncogenic PIK3CA mutations
    J Lauring
    Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Oncogene 29:2337-45. 2010
    ....
  3. pmc Knockin of mutant PIK3CA activates multiple oncogenic pathways
    John P Gustin
    The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 106:2835-40. 2009
    ..Our findings suggest GSK3beta is an important effector of mutant PIK3CA, and that lithium, an FDA-approved therapy for bipolar disorders, has selective antineoplastic properties against cancers that harbor these mutations...
  4. pmc The growth response to androgen receptor signaling in ERα-negative human breast cells is dependent on p21 and mediated by MAPK activation
    Joseph P Garay
    The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Breast Cancer Res 14:R27. 2012
    ..In addition, many breast cancers co-express other steroid hormone receptors that can affect AR signaling, further obfuscating the effects of androgens on breast cancer cells...
  5. pmc Single copies of mutant KRAS and mutant PIK3CA cooperate in immortalized human epithelial cells to induce tumor formation
    Grace M Wang
    The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of, The Johns Hopkins University, Baltimore, Maryland 21287, USA
    Cancer Res 73:3248-61. 2013
    ..In addition, Pdk1 activation of the downstream effector p90RSK is also increased by the combined presence of mutant KRAS and PIK3CA. These results provide new insights into mutant KRAS function and its role in carcinogenesis...
  6. pmc Tamoxifen-stimulated growth of breast cancer due to p21 loss
    Abde M Abukhdeir
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 105:288-93. 2008
    ..These data reveal a previously uncharacterized molecular mechanism of tamoxifen resistance and have potential clinical implications for the management of tamoxifen-resistant breast cancers...
  7. ncbi request reprint A PCR-based high-throughput screen with multiround sample pooling: application to somatic cell gene targeting
    Hiroyuki Konishi
    Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, 1650 Orleans Street, Baltimore, Maryland 21231, USA
    Nat Protoc 2:2865-74. 2007
    ..Single-cell cloning is subsequently performed to isolate gene-targeted clones. The entire protocol can be completed in 4-8 weeks depending on the proliferative capacity of the cell line...
  8. ncbi request reprint Knock-in of mutant K-ras in nontumorigenic human epithelial cells as a new model for studying K-ras mediated transformation
    Hiroyuki Konishi
    The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cancer Res 67:8460-7. 2007
    ..Thus, this system serves as a new model for elucidating the oncogenic contribution of mutant K-ras as expressed in a large fraction of human cancer cells...
  9. pmc Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells
    Hiroyuki Konishi
    The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 108:17773-8. 2011
    ..Thus, BRCA1 haploinsufficiency may accelerate hereditary breast carcinogenesis by facilitating additional genetic alterations...
  10. pmc Functional analysis of non-hotspot AKT1 mutants found in human breast cancers identifies novel driver mutations: implications for personalized medicine
    Kyung H Yi
    The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Oncotarget 4:29-34. 2013
    ..The other three mutants were inactive in all assays. These findings validate novel driver mutations in AKT1, and extend the number and type of mutations that activate the PI3-kinase pathway in human breast cancers...
  11. pmc PIK3CA and AKT1 mutations have distinct effects on sensitivity to targeted pathway inhibitors in an isogenic luminal breast cancer model system
    Julia A Beaver
    Authors Affiliation The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland
    Clin Cancer Res 19:5413-22. 2013
    ..Pathway mutations have been proposed as predictive biomarkers for efficacy of PI3K-targeted therapies. However, the precise contribution of distinct PI3K pathway mutations to drug sensitivity is unknown...
  12. ncbi request reprint The phosphoinositide-3-kinase-Akt-mTOR pathway as a therapeutic target in breast cancer
    Josh Lauring
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21287, USA
    J Natl Compr Canc Netw 11:670-8. 2013
    ..This article reviews the role of the PI3-kinase-Akt-mTOR pathway in breast cancer biology and the clinical trial evidence available to date...
  13. pmc BEAMing sheds light on drug resistance
    Josh Lauring
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA
    Clin Cancer Res 17:7508-10. 2011
    ....