Bryan Lau

Summary

Affiliation: Johns Hopkins Bloomberg School of Public Health
Country: USA

Publications

  1. pmc Parametric mixture models to evaluate and summarize hazard ratios in the presence of competing risks with time-dependent hazards and delayed entry
    Bryan Lau
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Stat Med 30:654-65. 2011
  2. pmc Identifying individuals with virologic failure after initiating effective antiretroviral therapy: The surprising value of mean corpuscular hemoglobin in a cross-sectional study
    Bryan Lau
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N, Wolfe Street, Baltimore, Maryland 21205, USA
    AIDS Res Ther 7:25. 2010
  3. ncbi request reprint Use of total lymphocyte count and hemoglobin concentration for monitoring progression of HIV infection
    Bryan Lau
    Department of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Acquir Immune Defic Syndr 39:620-5. 2005
  4. pmc Alcohol consumption and CD4 T-cell count response among persons initiating antiretroviral therapy
    Stefan Kowalski
    Department of Biomedical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21287, USA
    J Acquir Immune Defic Syndr 61:455-61. 2012
  5. pmc Competing risk regression models for epidemiologic data
    Bryan Lau
    Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    Am J Epidemiol 170:244-56. 2009
  6. pmc Evaluation of human immunodeficiency virus biomarkers: inferences from interval and clinical cohort studies
    Bryan Lau
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Epidemiology 20:664-72. 2009
  7. pmc Changes in sexual and drug-related risk behavior following antiretroviral therapy initiation among HIV-infected injection drug users
    Tsung Chieh Fu
    Department of Epidemiology, University of Washington School of Public Health, Seattle, USA
    AIDS 26:2383-91. 2012
  8. ncbi request reprint C-reactive protein is a marker for human immunodeficiency virus disease progression
    Bryan Lau
    Department of Medicine, The Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Arch Intern Med 166:64-70. 2006
  9. ncbi request reprint Rapid declines in total lymphocyte counts and hemoglobin concentration prior to AIDS among HIV-1-infected men
    Bryan Lau
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    AIDS 17:2035-44. 2003
  10. pmc Evaluating competing adverse and beneficial outcomes using a mixture model
    Bryan Lau
    Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Stat Med 27:4313-27. 2008

Collaborators

Detail Information

Publications28

  1. pmc Parametric mixture models to evaluate and summarize hazard ratios in the presence of competing risks with time-dependent hazards and delayed entry
    Bryan Lau
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Stat Med 30:654-65. 2011
    ..An application to the Women's Interagency HIV Study is provided to investigate injection drug use and the time to either the initiation of effective antiretroviral therapy, or clinical disease progression as a competing event...
  2. pmc Identifying individuals with virologic failure after initiating effective antiretroviral therapy: The surprising value of mean corpuscular hemoglobin in a cross-sectional study
    Bryan Lau
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N, Wolfe Street, Baltimore, Maryland 21205, USA
    AIDS Res Ther 7:25. 2010
    ..We assessed whether routinely collected clinical markers could improve prediction of concurrent HIV RNA levels...
  3. ncbi request reprint Use of total lymphocyte count and hemoglobin concentration for monitoring progression of HIV infection
    Bryan Lau
    Department of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Acquir Immune Defic Syndr 39:620-5. 2005
    ..Prior research has demonstrated rapid declines in total lymphocyte count (TLC) and hemoglobin levels before AIDS, but the prognostic accuracy of these declines has not been examined prospectively...
  4. pmc Alcohol consumption and CD4 T-cell count response among persons initiating antiretroviral therapy
    Stefan Kowalski
    Department of Biomedical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21287, USA
    J Acquir Immune Defic Syndr 61:455-61. 2012
    ..We evaluated the longitudinal association of alcohol use with immunologic response to combination antiretroviral therapy (ART) among HIV-infected individuals...
  5. pmc Competing risk regression models for epidemiologic data
    Bryan Lau
    Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    Am J Epidemiol 170:244-56. 2009
    ..71, 95% confidence interval: 1.37, 2.13 and (sd)RH = 2.01, 95% confidence interval: 1.62, 2.51). Methods for competing risks should be used by epidemiologists, with the choice of method guided by the scientific question...
  6. pmc Evaluation of human immunodeficiency virus biomarkers: inferences from interval and clinical cohort studies
    Bryan Lau
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Epidemiology 20:664-72. 2009
    ..No studies have evaluated the impact of the frequency of marker measurements for either their predictive value of mortality or how they may influence inference of the effect of therapy initiation in analyses from observational data...
  7. pmc Changes in sexual and drug-related risk behavior following antiretroviral therapy initiation among HIV-infected injection drug users
    Tsung Chieh Fu
    Department of Epidemiology, University of Washington School of Public Health, Seattle, USA
    AIDS 26:2383-91. 2012
    ..To evaluate whether HAART is associated with subsequent sexual and drug-related risk behavior compensation among injection drug users (IDUs)...
  8. ncbi request reprint C-reactive protein is a marker for human immunodeficiency virus disease progression
    Bryan Lau
    Department of Medicine, The Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Arch Intern Med 166:64-70. 2006
    ..Limited data on acute-phase C-reactive protein (CRP) levels in human immunodeficiency virus (HIV) infection exist...
  9. ncbi request reprint Rapid declines in total lymphocyte counts and hemoglobin concentration prior to AIDS among HIV-1-infected men
    Bryan Lau
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    AIDS 17:2035-44. 2003
    ..To describe temporal patterns in total lymphocyte count (TLC) and hemoglobin (Hgb) concentration during HIV infection and relate these patterns to changes in other markers and to clinical disease...
  10. pmc Evaluating competing adverse and beneficial outcomes using a mixture model
    Bryan Lau
    Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Stat Med 27:4313-27. 2008
    ....
  11. pmc Alcohol consumption among HIV-infected women: impact on time to antiretroviral therapy and survival
    Robyn C Neblett
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Womens Health (Larchmt) 20:279-86. 2011
    ..We sought to determine factors associated with alcohol use among HIV-infected women engaged in clinical care and if baseline alcohol use was associated with time to combination antiretroviral therapy (cART) and death in this population...
  12. pmc Trends and disparities in antiretroviral therapy initiation and virologic suppression among newly treatment-eligible HIV-infected individuals in North America, 2001-2009
    David B Hanna
    Johns Hopkins University, Baltimore, Maryland, USA
    Clin Infect Dis 56:1174-82. 2013
    ..We sought to examine trends in treatment initiation and resulting human immunodeficiency virus (HIV) virologic suppression in North America between 2001 and 2009, and demographic and geographic disparities in these outcomes...
  13. pmc Virologic and immunologic response to HAART, by age and regimen class
    Keri N Althoff
    Johns Hopkins University, Baltimore, Maryland 21287, USA
    AIDS 24:2469-79. 2010
    ..To determine the impact of age and initial HAART regimen class on virologic and immunologic response within 24 months after initiation...
  14. pmc HIV infection, immune suppression, and uncontrolled viremia are associated with increased multimorbidity among aging injection drug users
    Megan L Salter
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Clin Infect Dis 53:1256-64. 2011
    ....
  15. pmc Identification of nevirapine-resistant HIV-1 in the latent reservoir after single-dose nevirapine to prevent mother-to-child transmission of HIV-1
    Megan Wind-Rotolo
    Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    J Infect Dis 199:1301-9. 2009
    ..Although resistant viruses fade to undetectable levels in plasma, they may persist as stably integrated proviruses within the latent reservoir in resting CD4(+) T cells, potentially complicating future treatment...
  16. ncbi request reprint Interval and clinical cohort studies: epidemiological issues
    Bryan Lau
    Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21218, USA
    AIDS Res Hum Retroviruses 23:769-76. 2007
    ..The interval and clinical cohort designs are distinguished and the advantages and disadvantages inherent in each design are discussed...
  17. pmc Hazardous alcohol use: a risk factor for non-adherence and lack of suppression in HIV infection
    Geetanjali Chander
    Department of Medicine, Johns Hopkins University School of Medicine, 1830 E Monument Street, Baltimore, MD 21287, USA
    J Acquir Immune Defic Syndr 43:411-7. 2006
    ..We examined the independent effect of alcohol and combined effects of drug and alcohol use on antiretroviral (ART) utilization, adherence, and viral suppression in an urban cohort of HIV-infected individuals...
  18. ncbi request reprint Risk of non-AIDS-related mortality may exceed risk of AIDS-related mortality among individuals enrolling into care with CD4+ counts greater than 200 cells/mm3
    Bryan Lau
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Acquir Immune Defic Syndr 44:179-87. 2007
    ..To quantify cause-specific mortality risk attributable to non-AIDS-related and AIDS-related causes before and after the advent of highly active antiretroviral therapy (HAART)...
  19. ncbi request reprint Methods for the analysis of continuous biomarker assay data with increased sensitivity
    Bryan Lau
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Epidemiology 15:724-32. 2004
    ....
  20. pmc Missing data on the estimation of the prevalence of accumulated human immunodeficiency virus drug resistance in patients treated with antiretroviral drugs in north america
    Alison G Abraham
    Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Suite E7640, Baltimore, MD 21205, USA
    Am J Epidemiol 174:727-35. 2011
    ....
  21. pmc Copy-years viremia as a measure of cumulative human immunodeficiency virus viral burden
    Stephen R Cole
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Am J Epidemiol 171:198-205. 2010
    ..Copy-years viremia, a novel measure of cumulative viral burden, may provide prognostic information beyond traditional single measures of viremia...
  22. pmc Clinic-based treatment of opioid-dependent HIV-infected patients versus referral to an opioid treatment program: A randomized trial
    Gregory M Lucas
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ann Intern Med 152:704-11. 2010
    ..Opioid dependence is common in HIV clinics. Buprenorphine-naloxone (BUP) is an effective treatment of opioid dependence that may be used in routine medical settings...
  23. pmc Exceeding the limits of liver histology markers
    Shruti H Mehta
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 1830 E Monument St, Room 455 ID, Baltimore, MD 21287, USA
    J Hepatol 50:36-41. 2009
    ..We characterized the magnitude of the impact of error in the "gold standard" on the observed diagnostic accuracy of surrogate markers...
  24. pmc Insurance status, not race, is associated with mortality after an acute cardiovascular event in Maryland
    Derek K Ng
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Room E7133, Baltimore, MD 21025, USA
    J Gen Intern Med 27:1368-76. 2012
    ..It is unclear how lack of health insurance or otherwise being underinsured contributes to observed racial disparities in health outcomes related to cardiovascular disease...
  25. pmc Risk factors for chronic kidney disease in a large cohort of HIV-1 infected individuals initiating antiretroviral therapy in routine care
    Robert C Kalayjian
    Metro Health Medical Center, Cleveland, Ohio, USA
    AIDS 26:1907-15. 2012
    ....
  26. pmc Importance of age of onset in pancreatic cancer kindreds
    Kieran A Brune
    Department of Pathology, Sol Goldman Pancreatic Cancer Research Center at Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    J Natl Cancer Inst 102:119-26. 2010
    ..Young-onset cancer is a hallmark of many familial cancer syndromes, yet the implications of young-onset disease in predicting risk of pancreatic cancer among familial pancreatic cancer (FPC) kindred members remain unclear...
  27. pmc Chronic kidney disease incidence, and progression to end-stage renal disease, in HIV-infected individuals: a tale of two races
    Gregory M Lucas
    Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicines, Baltimore, Maryland, USA
    J Infect Dis 197:1548-57. 2008
    ..Little is known about the racial differences in the incidence and progression of HIV-related chronic kidney disease (CKD) that underlie African American-white disparities in HIV-related end-stage renal disease (ESRD)...
  28. ncbi request reprint Rapid declines in total lymphocyte count and hemoglobin in HIV infection begin at CD4 lymphocyte counts that justify antiretroviral therapy
    Stephen J Gange
    Department of Epidemiology and Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
    AIDS 17:119-21. 2003