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Species | Oliver LaeyendeckerSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Pregnancy does not affect HIV incidence test results obtained using the BED capture enzyme immunoassay or an antibody avidity assayOliver Laeyendecker
Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
PLoS ONE 5:e13259. 2010..Accurate incidence estimates are needed for surveillance of the HIV epidemic. HIV surveillance occurs at maternal-child health clinics, but it is not known if pregnancy affects HIV incidence testing...- HIV incidence determination in the United States: a multiassay approachOliver Laeyendecker
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
J Infect Dis 207:232-9. 2013..Accurate testing algorithms are needed for estimating human immunodeficiency virus (HIV) incidence from cross-sectional surveys... - Factors associated with incorrect identification of recent HIV infection using the BED capture immunoassayOliver Laeyendecker
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 21205, USA
AIDS Res Hum Retroviruses 28:816-22. 2012..Some men were persistently misclassified as recently infected up to 8 years after HIV seroconversion... - Specificity of four laboratory approaches for cross-sectional HIV incidence determination: analysis of samples from adults with known nonrecent HIV infection from five African countriesOliver Laeyendecker
Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
AIDS Res Hum Retroviruses 28:1177-83. 2012..Studies are underway to compare the sensitivity of these methods for detection of recent HIV infection... - The effect of viral suppression on cross-sectional incidence testing in the johns hopkins hospital emergency departmentOliver Laeyendecker
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, MD, USA
J Acquir Immune Defic Syndr 48:211-5. 2008..To determine the effect of viral suppression on cross-sectional incidence testing... - The effect of sample handling on cross sectional HIV incidence testing resultsOliver Laeyendecker
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, Maryland, United States of America
PLoS ONE 6:e25899. 2011..To determine if mishandling prior to testing would make a sample from a chronically infected subject appear recently infected when tested by cross-sectional HIV incidence assays... - Factors associated with the prevalence and incidence of herpes simplex virus type 2 infection among men in Rakai, UgandaAaron A R Tobian
Department of Pathology, Johns Hopkins University School of Medicine, Maryland, USA
J Infect Dis 199:945-9. 2009..70 [95% CI, 0.55-0.91]), and was not significantly affected by enrollment HIV status. Education on modifiable behavioral changes may reduce the acquisition of HSV-2. (ClinicalTrials.gov identifiers: NCT00425984 and NCT00124878 .)... - Male circumcision decreases acquisition and increases clearance of high-risk human papillomavirus in HIV-negative men: a randomized trial in Rakai, UgandaRonald H Gray
Department of Population, Family, and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
J Infect Dis 201:1455-62. 2010..HR-HPV clearance was determined in men with prior genotype-specific HR-HPV infections. Rate ratios (RRs) and 95% confidence intervals (CIs) of HR-HPV acquisition were estimated by Poisson multiple regression... - Efficiency of CCR5 coreceptor utilization by the HIV quasispecies increases over time, but is not associated with disease progressionAndrew D Redd
Laboratory of Immunoregulation, NIAID, NIH, Bethesda, Maryland, USA
AIDS Res Hum Retroviruses 28:289-94. 2012..These data demonstrate that the R5-UE of the viral quasispecies early in HIV infection is not associated with disease progression, and that R5-UE levels increase in HIV-infected individuals over time... - Effect of hormonal contraceptive use on HIV progression in female HIV seroconverters in Rakai, UgandaChelsea B Polis
Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
AIDS 24:1937-44. 2010..To assess the association between hormonal contraceptive use and HIV progression... - Effects of genital ulcer disease and herpes simplex virus type 2 on the efficacy of male circumcision for HIV prevention: Analyses from the Rakai trialsRonald H Gray
Johns Hopkins University, Baltimore, Maryland, United States of America
PLoS Med 6:e1000187. 2009..We assessed the role of GUD and HSV-2 in the protection against HIV afforded by MC... - Male circumcision for the prevention of HSV-2 and HPV infections and syphilisAaron A R Tobian
Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
N Engl J Med 360:1298-309. 2009..We assessed the efficacy of male circumcision for the prevention of herpes simplex virus type 2 (HSV-2) and human papillomavirus (HPV) infections and syphilis in HIV-negative adolescent boys and men... - C-reactive protein levels increase during HIV-1 disease progression in Rakai, Uganda, despite the absence of microbial translocationAndrew D Redd
Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
J Acquir Immune Defic Syndr 54:556-9. 2010..However, the role of general immune activation in HIV disease progression in this population was not fully examined... - Geographic HIV type 1 subtype distribution in Rakai district, UgandaAleisha N Collinson-Streng
Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, MD 21205, USA
AIDS Res Hum Retroviruses 25:1045-8. 2009..001) and more subtype D in southern clusters compared with northern clusters (78% vs. 65%, p < 0.008). These data illustrate the geographic complexity of subtype variation, which has important implications for HIV-1 vaccine design... - Use of a multifaceted approach to analyze HIV incidence in a cohort study of women in the United States: HIV Prevention Trials Network 064 StudySusan H Eshleman
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Infect Dis 207:223-31. 2013..We used a multifaceted approach to estimate HIV incidence in the HIV Prevention Trials Network (HPTN) 064 study... - Antiretroviral drug susceptibility among HIV-infected adults failing antiretroviral therapy in Rakai, UgandaSteven J Reynolds
Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
AIDS Res Hum Retroviruses 28:1739-44. 2012..PI resistance was not detected in individuals failing second-line ART. Surveillance for transmitted and acquired drug resistance remains a priority for scale-up of ART... - Changes in the distribution of HIV type 1 subtypes D and A in Rakai District, Uganda between 1994 and 2002Samantha A Conroy
Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, Maryland, USA
AIDS Res Hum Retroviruses 26:1087-91. 2010..Over this 8-year period, the overall viral population in this region evolved toward the less virulent HIV-1A strain, most likely as a consequence of the faster disease progression and lower transmissibility of HIV-1D... - Previously transmitted HIV-1 strains are preferentially selected during subsequent sexual transmissionsAndrew D Redd
Laboratory of Immunoregulation, Division of Intramural Research DIR, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD, USA
J Infect Dis 206:1433-42. 2012..A genetic bottleneck is known to exist for human immunodeficiency virus (HIV) at the point of sexual transmission. However, the nature of this bottleneck and its effect on viral diversity over time is unclear... - Circumcision in HIV-infected men and its effect on HIV transmission to female partners in Rakai, Uganda: a randomised controlled trialMaria J Wawer
Department of Population, Family and Reproductive Health, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
Lancet 374:229-37. 2009..We assessed whether circumcision in HIV-infected men would reduce transmission of the virus to female sexual partners... - Comparison of three commercial immunoassays for detection of herpes simplex virus type 2 antibodies in commercial sex workers in Yunnan Province, ChinaThoai D Ngo
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Clin Vaccine Immunol 15:1301-3. 2008..8%, 94.2%, and 60.1%, respectively. The Focus assay performed optimally at an index of 1.5 (95.2% sensitivity and 93.4% specificity), and the Kalon assay performed optimally at an index of 1.2 (93.3% sensitivity and 95.2% specificity)... - Antiretroviral drug susceptibility among drug-naive adults with recent HIV infection in Rakai, UgandaSusan H Eshleman
Department of Pathology, Johns Hopkins University School of Medicine, 646 Ross Bldg, 720 Rutland Ave, Baltimore, MD 21205, USA
AIDS 23:845-52. 2009..To analyze antiretroviral drug susceptibility in HIV from recently infected adults in Rakai, Uganda, prior to the availability of antiretroviral drug treatment... - Effect of sexually transmitted disease (STD) coinfections on performance of three commercially available immunosorbent assays used for detection of herpes simplex virus type 2-specific antibody in men attending Baltimore, Maryland, STD clinicsJean Summerton
Division of Infectious Diseases, The Johns Hopkins University, 1721 E Madison St, Ross Research Bldg 1159, Baltimore, MD 21205 2196, USA
Clin Vaccine Immunol 14:1545-9. 2007..The recommended index cutoff value of 1.1 for the Focus and Kalon assays was found to be optimal for this population... - Hepatitis B virus and sexual behavior in Rakai, UgandaLara Stabinski
Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
J Med Virol 83:796-800. 2011..Therefore vaccination against HBV, particularly susceptible adults with HIV or at risk of HIV/STDs should be a priority... - The rates of HIV superinfection and primary HIV incidence in a general population in Rakai, UgandaAndrew D Redd
Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, MD 21205, USA
J Infect Dis 206:267-74. 2012..Human immunodeficiency virus (HIV) superinfection has been documented in high-risk individuals; however, the rate of superinfection among HIV-infected individuals within a general population remains unknown... - Identification of new CRF51_01B in Singapore using full genome analysis of three HIV type 1 isolatesOon Tek Ng
Johns Hopkins School of Medicine, Johns Hopkins Medical Institution, Baltimore, MD, USA
AIDS Res Hum Retroviruses 28:527-30. 2012..As the three patients were not epidemiologically linked, this recombinant form has been designated CRF51_01B. Identification of the novel recombinant forms indicates ongoing active HIV-1 transmission in Singapore... - Decreased kidney function in a community-based cohort of HIV-Infected and HIV-negative individuals in Rakai, UgandaGregory M Lucas
Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
J Acquir Immune Defic Syndr 55:491-4. 2010..However little is known about natural history HIV-related kidney disease or about background rates of reduced GFR in HIV-negative individuals in this region... - Frequency of long-term nonprogressors in HIV-1 seroconverters From Rakai UgandaOliver Laeyendecker
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
J Acquir Immune Defic Syndr 52:316-9. 2009..Studies on long-term nonprogressors (LTNP) have been conducted in the USA and Europe. This study examined the frequency of LTNPs and HIV controllers among 637 HIV-1 seroconverters in rural Uganda... - Identification of HIV superinfection in seroconcordant couples in Rakai, Uganda, by use of next-generation deep sequencingAndrew D Redd
Johns Hopkins University School of Medicine, Rangos Building, Room 530, 855 N Wolfe St, Baltimore, MD 21205, USA
J Clin Microbiol 49:2859-67. 2011..Our results indicate that NGS can be used for detection of HIV superinfection within large cohorts, which could assist in determining the incidence and the epidemiologic, virologic, and immunological correlates of this phenomenon... - Antibody maturation and viral diversification in HIV-infected womenMaria M James
Department of Pathology, Johns Hopkins Univ School of Medicine, Baltimore, Maryland, United States of America
PLoS ONE 8:e57350. 2013..Antibody maturation and viral diversification were examined in these women... - Molecular epidemiology of HIV type 1 in Singapore and identification of novel CRF01_AE/B recombinant formsOon Tek Ng
Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
AIDS Res Hum Retroviruses 27:1135-7. 2011..However, 85% of subjects infected with the novel recombinant forms self-identified as men who have sex with men or bisexuals compared with only 41% of individuals infected with CRF01_AE and 62% infected with subtype B (p = 0.001)... - High prevalence of liver fibrosis associated with HIV infection: a study in rural Rakai, UgandaLara Stabinski
Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Antivir Ther 16:405-11. 2011..Liver disease is a leading cause of mortality among HIV-infected persons in the United States and Europe. However, data regarding the effects of HIV and antiretroviral therapy (ART) on liver disease in Africa are sparse... - Use of commercial enzyme immunoassays to detect antibodies to the herpes simplex virus type 2 glycoprotein G in a low-risk population in Hanoi, VietnamThoai D Ngo
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Clin Vaccine Immunol 15:382-4. 2008..01). Screening by Focus and then retesting with Kalon/Biokit of positive samples can reduce falsely positive results significantly (P < 0.01)... - Identification of nevirapine-resistant HIV-1 in the latent reservoir after single-dose nevirapine to prevent mother-to-child transmission of HIV-1Megan Wind-Rotolo
Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
J Infect Dis 199:1301-9. 2009..Although resistant viruses fade to undetectable levels in plasma, they may persist as stably integrated proviruses within the latent reservoir in resting CD4(+) T cells, potentially complicating future treatment... - Association of recent HIV infection and in-utero HIV-1 transmissionTaha E Taha
Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
AIDS 25:1357-64. 2011..We used this MAA to evaluate the association between recent maternal HIV infection and in-utero transmission of HIV... - HIV surveillance in a large, community-based study: results from the pilot study of Project Accept (HIV Prevention Trials Network 043)Estelle Piwowar-Manning
Dept of Pathology, Johns Hopkins Univ, School of Medicine, Baltimore, MD, USA
BMC Infect Dis 11:251. 2011..We evaluated the accuracy of in-country HIV rapid testing and determined HIV prevalence in the Project Accept pilot study... - Genital herpes evaluation by quantitative TaqMan PCR: correlating single detection and quantity of HSV-2 DNA in cervicovaginal lavage fluids with cross-sectional and longitudinal clinical dataBulbulgul Aumakhan
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Virol J 7:328. 2010.... - HIV subtype D is associated with dementia, compared with subtype A, in immunosuppressed individuals at risk of cognitive impairment in Kampala, UgandaNed Sacktor
Departments of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Clin Infect Dis 49:780-6. 2009..The objective of this study was to examine the relationship between HIV subtype and the severity of HIV-associated cognitive impairment among individuals initiating antiretroviral therapy in Uganda... - Effect of natural and ARV-induced viral suppression and viral breakthrough on anti-HIV antibody proportion and avidity in patients with HIV-1 subtype B infectionSarah K Wendel
Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, Maryland, USA
PLoS ONE 8:e55525. 2013..Viral suppression and viral breakthrough impact the humoral immune response to HIV infection. We evaluated the impact of viral suppression and viral breakthrough on results obtained with two cross-sectional HIV incidence assays... - Use of a high resolution melting (HRM) assay to compare gag, pol, and env diversity in adults with different stages of HIV infectionMatthew M Cousins
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
PLoS ONE 6:e27211. 2011..This assay provides a single numeric HRM score that reflects the level of genetic diversity of HIV in a sample from an infected individual... 
Male circumcision for HIV prevention in men in Rakai, Uganda: a randomised trialRonald H Gray
Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21215, USA
Lancet 369:657-66. 2007..Ecological and observational studies suggest that male circumcision reduces the risk of HIV acquisition in men. Our aim was to investigate the effect of male circumcision on HIV incidence in men...- Detection of individuals with acute HIV-1 infection using the ARCHITECT HIV Ag/Ab Combo assaySusan H Eshleman
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Acquir Immune Defic Syndr 52:121-4. 2009..We evaluated use of the ARCHITECT HIV Ag/Ab Combo assay (HIV Combo; Abbott Diagnostics; available for sale outside the United States only) for detection of acute HIV infection... - Microbial translocation, the innate cytokine response, and HIV-1 disease progression in AfricaAndrew D Redd
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 106:6718-23. 2009..These data suggest that microbial translocation and its subsequent inflammatory immune response do not have a causal relationship with HIV-1 disease progression in Africa... - Molecular epidemiology of HIV-1 subtypes in southern ChinaOliver Laeyendecker
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
J Acquir Immune Defic Syndr 38:356-62. 2005.... - Performance of a commercial, type-specific enzyme-linked immunosorbent assay for detection of herpes simplex virus type 2-specific antibodies in UgandansOliver Laeyendecker
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
J Clin Microbiol 42:1794-6. 2004..A higher index cutoff value was required for optimal sensitivity and specificity, and overall performance of the assay was not affected by HIV status... - Rates of HIV-1 transmission per coital act, by stage of HIV-1 infection, in Rakai, UgandaMaria J Wawer
Heilbrun Department of Population and Family Health, Columbia University Mailman School of Public Health, New York, New York 10032, USA
J Infect Dis 191:1403-9. 2005..We estimated rates of human immunodeficiency virus (HIV)-1 transmission per coital act in HIV-discordant couples by stage of infection in the index partner... 
Effect of human immunodeficiency virus Type 1 (HIV-1) subtype on disease progression in persons from Rakai, Uganda, with incident HIV-1 infectionNoah Kiwanuka
Uganda Virus Research Institute, Entebbe, Uganda
J Infect Dis 197:707-13. 2008..Human immunodeficiency virus type 1 (HIV-1) subtypes differ in biological characteristics that may affect pathogenicity...- Treatment interruptions predict resistance in HIV-positive individuals purchasing fixed-dose combination antiretroviral therapy in Kampala, UgandaJessica H Oyugi
Infectious Diseases Institute, Kampala, Uganda
AIDS 21:965-71. 2007..To evaluate adherence, treatment interruptions, and outcomes in patients purchasing antiretroviral fixed-dose combination (FDC) therapy...