Oliver Laeyendecker

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Pregnancy does not affect HIV incidence test results obtained using the BED capture enzyme immunoassay or an antibody avidity assay
    Oliver Laeyendecker
    Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 5:e13259. 2010
  2. pmc Performance of a limiting-antigen avidity enzyme immunoassay for cross-sectional estimation of HIV incidence in the United States
    Jacob Konikoff
    Department of Biostatistics, School of Public Health, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 8:e82772. 2013
  3. pmc High prevalence of CXCR4 usage among treatment-naive CRF01_AE and CRF51_01B-infected HIV-1 subjects in Singapore
    Kah Ying Ng
    Institute of Infectious Disease and Epidemiology, Communicable Disease Centre, Tan Tock Seng Hospital, Singapore 308433, Singapore
    BMC Infect Dis 13:90. 2013
  4. pmc HIV incidence determination in the United States: a multiassay approach
    Oliver Laeyendecker
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Infect Dis 207:232-9. 2013
  5. pmc Factors associated with incorrect identification of recent HIV infection using the BED capture immunoassay
    Oliver Laeyendecker
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 21205, USA
    AIDS Res Hum Retroviruses 28:816-22. 2012
  6. pmc Specificity of four laboratory approaches for cross-sectional HIV incidence determination: analysis of samples from adults with known nonrecent HIV infection from five African countries
    Oliver Laeyendecker
    Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    AIDS Res Hum Retroviruses 28:1177-83. 2012
  7. pmc The effect of sample handling on cross sectional HIV incidence testing results
    Oliver Laeyendecker
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, Maryland, United States of America
    PLoS ONE 6:e25899. 2011
  8. pmc The effect of viral suppression on cross-sectional incidence testing in the johns hopkins hospital emergency department
    Oliver Laeyendecker
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, MD, USA
    J Acquir Immune Defic Syndr 48:211-5. 2008
  9. pmc Factors associated with the prevalence and incidence of herpes simplex virus type 2 infection among men in Rakai, Uganda
    Aaron A R Tobian
    Department of Pathology, Johns Hopkins University School of Medicine, Maryland, USA
    J Infect Dis 199:945-9. 2009
  10. pmc HIV diversity as a biomarker for HIV incidence estimation: including a high-resolution melting diversity assay in a multiassay algorithm
    Matthew M Cousins
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Clin Microbiol 52:115-21. 2014

Detail Information

Publications62

  1. pmc Pregnancy does not affect HIV incidence test results obtained using the BED capture enzyme immunoassay or an antibody avidity assay
    Oliver Laeyendecker
    Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 5:e13259. 2010
    ..Accurate incidence estimates are needed for surveillance of the HIV epidemic. HIV surveillance occurs at maternal-child health clinics, but it is not known if pregnancy affects HIV incidence testing...
  2. pmc Performance of a limiting-antigen avidity enzyme immunoassay for cross-sectional estimation of HIV incidence in the United States
    Jacob Konikoff
    Department of Biostatistics, School of Public Health, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 8:e82772. 2013
    ..We evaluated the performance of the LAg-Avidity assay alone and in multi-assay algorithms (MAAs) that included other biomarkers...
  3. pmc High prevalence of CXCR4 usage among treatment-naive CRF01_AE and CRF51_01B-infected HIV-1 subjects in Singapore
    Kah Ying Ng
    Institute of Infectious Disease and Epidemiology, Communicable Disease Centre, Tan Tock Seng Hospital, Singapore 308433, Singapore
    BMC Infect Dis 13:90. 2013
    ..We examined the correlation between HIV-1 subtype and co-receptor usage among treatment-naïve HIV-1 subjects in Singapore. Additionally, we investigated whether the subtype co-receptor association was influenced by stage of infection...
  4. pmc HIV incidence determination in the United States: a multiassay approach
    Oliver Laeyendecker
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Infect Dis 207:232-9. 2013
    ..Accurate testing algorithms are needed for estimating human immunodeficiency virus (HIV) incidence from cross-sectional surveys...
  5. pmc Factors associated with incorrect identification of recent HIV infection using the BED capture immunoassay
    Oliver Laeyendecker
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 21205, USA
    AIDS Res Hum Retroviruses 28:816-22. 2012
    ..Some men were persistently misclassified as recently infected up to 8 years after HIV seroconversion...
  6. pmc Specificity of four laboratory approaches for cross-sectional HIV incidence determination: analysis of samples from adults with known nonrecent HIV infection from five African countries
    Oliver Laeyendecker
    Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    AIDS Res Hum Retroviruses 28:1177-83. 2012
    ..Studies are underway to compare the sensitivity of these methods for detection of recent HIV infection...
  7. pmc The effect of sample handling on cross sectional HIV incidence testing results
    Oliver Laeyendecker
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, Maryland, United States of America
    PLoS ONE 6:e25899. 2011
    ..To determine if mishandling prior to testing would make a sample from a chronically infected subject appear recently infected when tested by cross-sectional HIV incidence assays...
  8. pmc The effect of viral suppression on cross-sectional incidence testing in the johns hopkins hospital emergency department
    Oliver Laeyendecker
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, MD, USA
    J Acquir Immune Defic Syndr 48:211-5. 2008
    ..To determine the effect of viral suppression on cross-sectional incidence testing...
  9. pmc Factors associated with the prevalence and incidence of herpes simplex virus type 2 infection among men in Rakai, Uganda
    Aaron A R Tobian
    Department of Pathology, Johns Hopkins University School of Medicine, Maryland, USA
    J Infect Dis 199:945-9. 2009
    ..70 [95% CI, 0.55-0.91]), and was not significantly affected by enrollment HIV status. Education on modifiable behavioral changes may reduce the acquisition of HSV-2. (ClinicalTrials.gov identifiers: NCT00425984 and NCT00124878 .)...
  10. pmc HIV diversity as a biomarker for HIV incidence estimation: including a high-resolution melting diversity assay in a multiassay algorithm
    Matthew M Cousins
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Clin Microbiol 52:115-21. 2014
    ..MAAs that include the HRM diversity assay can provide accurate HIV incidence estimates using stored blood plasma or serum samples without a requirement for CD4 cell count data. ..
  11. pmc Male circumcision decreases acquisition and increases clearance of high-risk human papillomavirus in HIV-negative men: a randomized trial in Rakai, Uganda
    Ronald H Gray
    Department of Population, Family, and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Infect Dis 201:1455-62. 2010
    ..HR-HPV clearance was determined in men with prior genotype-specific HR-HPV infections. Rate ratios (RRs) and 95% confidence intervals (CIs) of HR-HPV acquisition were estimated by Poisson multiple regression...
  12. pmc Differential specificity of HIV incidence assays in HIV subtypes A and D-infected individuals from Rakai, Uganda
    Caroline E Mullis
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    AIDS Res Hum Retroviruses 29:1146-50. 2013
    ..The association of misclassification of the BED-CEIA with the avidity assay in subtype D-infected individuals limits the utility of using these assays in combination within this population...
  13. pmc Efficiency of CCR5 coreceptor utilization by the HIV quasispecies increases over time, but is not associated with disease progression
    Andrew D Redd
    Laboratory of Immunoregulation, NIAID, NIH, Bethesda, Maryland, USA
    AIDS Res Hum Retroviruses 28:289-94. 2012
    ..These data demonstrate that the R5-UE of the viral quasispecies early in HIV infection is not associated with disease progression, and that R5-UE levels increase in HIV-infected individuals over time...
  14. pmc Effects of genital ulcer disease and herpes simplex virus type 2 on the efficacy of male circumcision for HIV prevention: Analyses from the Rakai trials
    Ronald H Gray
    Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS Med 6:e1000187. 2009
    ..We assessed the role of GUD and HSV-2 in the protection against HIV afforded by MC...
  15. pmc Effect of hormonal contraceptive use on HIV progression in female HIV seroconverters in Rakai, Uganda
    Chelsea B Polis
    Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    AIDS 24:1937-44. 2010
    ..To assess the association between hormonal contraceptive use and HIV progression...
  16. pmc Male circumcision for the prevention of HSV-2 and HPV infections and syphilis
    Aaron A R Tobian
    Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    N Engl J Med 360:1298-309. 2009
    ..We assessed the efficacy of male circumcision for the prevention of herpes simplex virus type 2 (HSV-2) and human papillomavirus (HPV) infections and syphilis in HIV-negative adolescent boys and men...
  17. pmc Estimation of HIV incidence in a large, community-based, randomized clinical trial: NIMH project accept (HIV Prevention Trials Network 043)
    Oliver Laeyendecker
    Laboratory of Immunoregulation, NIAID, NIH, Baltimore, Maryland, United States of America
    PLoS ONE 8:e68349. 2013
    ..The study intervention included enhanced community-based voluntary counseling and testing. The primary endpoint was HIV incidence, assessed in a single, cross-sectional, post-intervention survey of >50,000 participants...
  18. pmc Antibody maturation and viral diversification in HIV-infected women
    Maria M James
    Department of Pathology, Johns Hopkins Univ School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 8:e57350. 2013
    ..Antibody maturation and viral diversification were examined in these women...
  19. pmc C-reactive protein levels increase during HIV-1 disease progression in Rakai, Uganda, despite the absence of microbial translocation
    Andrew D Redd
    Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Acquir Immune Defic Syndr 54:556-9. 2010
    ..However, the role of general immune activation in HIV disease progression in this population was not fully examined...
  20. pmc Geographic HIV type 1 subtype distribution in Rakai district, Uganda
    Aleisha N Collinson-Streng
    Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, MD 21205, USA
    AIDS Res Hum Retroviruses 25:1045-8. 2009
    ..001) and more subtype D in southern clusters compared with northern clusters (78% vs. 65%, p < 0.008). These data illustrate the geographic complexity of subtype variation, which has important implications for HIV-1 vaccine design...
  21. pmc Use of a multifaceted approach to analyze HIV incidence in a cohort study of women in the United States: HIV Prevention Trials Network 064 Study
    Susan H Eshleman
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Infect Dis 207:223-31. 2013
    ..We used a multifaceted approach to estimate HIV incidence in the HIV Prevention Trials Network (HPTN) 064 study...
  22. pmc Antiretroviral drug susceptibility among HIV-infected adults failing antiretroviral therapy in Rakai, Uganda
    Steven J Reynolds
    Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    AIDS Res Hum Retroviruses 28:1739-44. 2012
    ..PI resistance was not detected in individuals failing second-line ART. Surveillance for transmitted and acquired drug resistance remains a priority for scale-up of ART...
  23. pmc Changes in the distribution of HIV type 1 subtypes D and A in Rakai District, Uganda between 1994 and 2002
    Samantha A Conroy
    Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, Maryland, USA
    AIDS Res Hum Retroviruses 26:1087-91. 2010
    ..Over this 8-year period, the overall viral population in this region evolved toward the less virulent HIV-1A strain, most likely as a consequence of the faster disease progression and lower transmissibility of HIV-1D...
  24. pmc Previously transmitted HIV-1 strains are preferentially selected during subsequent sexual transmissions
    Andrew D Redd
    Laboratory of Immunoregulation, Division of Intramural Research DIR, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD, USA
    J Infect Dis 206:1433-42. 2012
    ..A genetic bottleneck is known to exist for human immunodeficiency virus (HIV) at the point of sexual transmission. However, the nature of this bottleneck and its effect on viral diversity over time is unclear...
  25. pmc Comparison of three commercial immunoassays for detection of herpes simplex virus type 2 antibodies in commercial sex workers in Yunnan Province, China
    Thoai D Ngo
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Clin Vaccine Immunol 15:1301-3. 2008
    ..8%, 94.2%, and 60.1%, respectively. The Focus assay performed optimally at an index of 1.5 (95.2% sensitivity and 93.4% specificity), and the Kalon assay performed optimally at an index of 1.2 (93.3% sensitivity and 95.2% specificity)...
  26. pmc Circumcision in HIV-infected men and its effect on HIV transmission to female partners in Rakai, Uganda: a randomised controlled trial
    Maria J Wawer
    Department of Population, Family and Reproductive Health, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Lancet 374:229-37. 2009
    ..We assessed whether circumcision in HIV-infected men would reduce transmission of the virus to female sexual partners...
  27. pmc Antiretroviral drug susceptibility among drug-naive adults with recent HIV infection in Rakai, Uganda
    Susan H Eshleman
    Department of Pathology, Johns Hopkins University School of Medicine, 646 Ross Bldg, 720 Rutland Ave, Baltimore, MD 21205, USA
    AIDS 23:845-52. 2009
    ..To analyze antiretroviral drug susceptibility in HIV from recently infected adults in Rakai, Uganda, prior to the availability of antiretroviral drug treatment...
  28. pmc Effect of natural and ARV-induced viral suppression and viral breakthrough on anti-HIV antibody proportion and avidity in patients with HIV-1 subtype B infection
    Sarah K Wendel
    Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, Maryland, USA
    PLoS ONE 8:e55525. 2013
    ..Viral suppression and viral breakthrough impact the humoral immune response to HIV infection. We evaluated the impact of viral suppression and viral breakthrough on results obtained with two cross-sectional HIV incidence assays...
  29. pmc Hepatitis B virus and sexual behavior in Rakai, Uganda
    Lara Stabinski
    Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Med Virol 83:796-800. 2011
    ..Therefore vaccination against HBV, particularly susceptible adults with HIV or at risk of HIV/STDs should be a priority...
  30. pmc Effect of sexually transmitted disease (STD) coinfections on performance of three commercially available immunosorbent assays used for detection of herpes simplex virus type 2-specific antibody in men attending Baltimore, Maryland, STD clinics
    Jean Summerton
    Division of Infectious Diseases, The Johns Hopkins University, 1721 E Madison St, Ross Research Bldg 1159, Baltimore, MD 21205 2196, USA
    Clin Vaccine Immunol 14:1545-9. 2007
    ..The recommended index cutoff value of 1.1 for the Focus and Kalon assays was found to be optimal for this population...
  31. pmc The rates of HIV superinfection and primary HIV incidence in a general population in Rakai, Uganda
    Andrew D Redd
    Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, MD 21205, USA
    J Infect Dis 206:267-74. 2012
    ..Human immunodeficiency virus (HIV) superinfection has been documented in high-risk individuals; however, the rate of superinfection among HIV-infected individuals within a general population remains unknown...
  32. pmc Identification of new CRF51_01B in Singapore using full genome analysis of three HIV type 1 isolates
    Oon Tek Ng
    Johns Hopkins School of Medicine, Johns Hopkins Medical Institution, Baltimore, MD, USA
    AIDS Res Hum Retroviruses 28:527-30. 2012
    ..As the three patients were not epidemiologically linked, this recombinant form has been designated CRF51_01B. Identification of the novel recombinant forms indicates ongoing active HIV-1 transmission in Singapore...
  33. pmc Frequency of long-term nonprogressors in HIV-1 seroconverters From Rakai Uganda
    Oliver Laeyendecker
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Acquir Immune Defic Syndr 52:316-9. 2009
    ..Studies on long-term nonprogressors (LTNP) have been conducted in the USA and Europe. This study examined the frequency of LTNPs and HIV controllers among 637 HIV-1 seroconverters in rural Uganda...
  34. pmc Decreased kidney function in a community-based cohort of HIV-Infected and HIV-negative individuals in Rakai, Uganda
    Gregory M Lucas
    Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    J Acquir Immune Defic Syndr 55:491-4. 2010
    ..However little is known about natural history HIV-related kidney disease or about background rates of reduced GFR in HIV-negative individuals in this region...
  35. pmc Identification of HIV superinfection in seroconcordant couples in Rakai, Uganda, by use of next-generation deep sequencing
    Andrew D Redd
    Johns Hopkins University School of Medicine, Rangos Building, Room 530, 855 N Wolfe St, Baltimore, MD 21205, USA
    J Clin Microbiol 49:2859-67. 2011
    ..Our results indicate that NGS can be used for detection of HIV superinfection within large cohorts, which could assist in determining the incidence and the epidemiologic, virologic, and immunological correlates of this phenomenon...
  36. pmc A comparison of two measures of HIV diversity in multi-assay algorithms for HIV incidence estimation
    Matthew M Cousins
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 9:e101043. 2014
    ..Multi-assay algorithms (MAAs) can be used to estimate HIV incidence in cross-sectional surveys. We compared the performance of two MAAs that use HIV diversity as one of four biomarkers for analysis of HIV incidence...
  37. pmc Immune responses in Ugandan women infected with subtypes A and D HIV using the BED capture immunoassay and an antibody avidity assay
    Andrew F Longosz
    Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, Baltimore, MD Clinical Sciences, Family Health International 360, Durham, NC Case Western Reserve University, Cleveland, OH and Johns Hopkins University School of Medicine, Baltimore, MD
    J Acquir Immune Defic Syndr 65:390-6. 2014
    ..It is unclear whether this reflects a poor initial response to infection or a waning antibody response later in infection...
  38. pmc Impact of HIV subtype on performance of the limiting antigen-avidity enzyme immunoassay, the bio-rad avidity assay, and the BED capture immunoassay in Rakai, Uganda
    Andrew F Longosz
    1 Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, Baltimore, Maryland
    AIDS Res Hum Retroviruses 30:339-44. 2014
    ..Sex and age were not significantly associated with misclassification by any assay. The LAg-Avidity EIA with a cutoff <1.0 OD-n had the lowest frequency of misclassification in this Ugandan population...
  39. pmc Use of commercial enzyme immunoassays to detect antibodies to the herpes simplex virus type 2 glycoprotein G in a low-risk population in Hanoi, Vietnam
    Thoai D Ngo
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Clin Vaccine Immunol 15:382-4. 2008
    ..01). Screening by Focus and then retesting with Kalon/Biokit of positive samples can reduce falsely positive results significantly (P < 0.01)...
  40. pmc Molecular epidemiology of HIV type 1 in Singapore and identification of novel CRF01_AE/B recombinant forms
    Oon Tek Ng
    Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    AIDS Res Hum Retroviruses 27:1135-7. 2011
    ..However, 85% of subjects infected with the novel recombinant forms self-identified as men who have sex with men or bisexuals compared with only 41% of individuals infected with CRF01_AE and 62% infected with subtype B (p = 0.001)...
  41. pmc High prevalence of liver fibrosis associated with HIV infection: a study in rural Rakai, Uganda
    Lara Stabinski
    Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Antivir Ther 16:405-11. 2011
    ..Liver disease is a leading cause of mortality among HIV-infected persons in the United States and Europe. However, data regarding the effects of HIV and antiretroviral therapy (ART) on liver disease in Africa are sparse...
  42. pmc Incorrect identification of recent HIV infection in adults in the United States using a limiting-antigen avidity assay
    Andrew F Longosz
    aLaboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH bDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health cDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland dDepartment of Epidemiology, School of Public Health, University of California at Los Angeles, Los Angeles, California eDepartment of Medicine fDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    AIDS 28:1227-32. 2014
    ..To evaluate factors associated with misclassification by the limiting-antigen avidity (LAg-avidity) assay among individuals with long-standing HIV infection...
  43. pmc HIV subtype is not associated with dementia among individuals with moderate and advanced immunosuppression in Kampala, Uganda
    Ned Sacktor
    Department of Neurology, Johns Hopkins Bayview Medical Center, 301 Building, Suite 2100, 4940 Eastern Ave, Baltimore, MD, 21224, USA
    Metab Brain Dis 29:261-8. 2014
    ..There was no association between HIV subtype and dementia among HIV+ individuals with moderate and advanced immunosuppression. Future studies should be performed to confirm these results...
  44. pmc Development of methods for cross-sectional HIV incidence estimation in a large, community randomized trial
    Oliver Laeyendecker
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 8:e78818. 2013
    ..The primary endpoint of the trial was based on a single, cross-sectional, post-intervention HIV incidence assessment...
  45. pmc Failure to Identify HIV-Infected Individuals in a Clinical Trial Using a Single HIV Rapid Test for Screening
    Estelle Piwowar-Manning
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland
    HIV Clin Trials 15:62-8. 2014
    ..Conclusions: In clinical trials, HIV infections can be missed for a variety of reasons. Using more than one assay to screen for HIV infection may reduce the number of missed infections. ..
  46. pmc Identification of nevirapine-resistant HIV-1 in the latent reservoir after single-dose nevirapine to prevent mother-to-child transmission of HIV-1
    Megan Wind-Rotolo
    Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    J Infect Dis 199:1301-9. 2009
    ..Although resistant viruses fade to undetectable levels in plasma, they may persist as stably integrated proviruses within the latent reservoir in resting CD4(+) T cells, potentially complicating future treatment...
  47. pmc Association of recent HIV infection and in-utero HIV-1 transmission
    Taha E Taha
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    AIDS 25:1357-64. 2011
    ..We used this MAA to evaluate the association between recent maternal HIV infection and in-utero transmission of HIV...
  48. pmc HIV surveillance in a large, community-based study: results from the pilot study of Project Accept (HIV Prevention Trials Network 043)
    Estelle Piwowar-Manning
    Dept of Pathology, Johns Hopkins Univ, School of Medicine, Baltimore, MD, USA
    BMC Infect Dis 11:251. 2011
    ..We evaluated the accuracy of in-country HIV rapid testing and determined HIV prevalence in the Project Accept pilot study...
  49. pmc Genital herpes evaluation by quantitative TaqMan PCR: correlating single detection and quantity of HSV-2 DNA in cervicovaginal lavage fluids with cross-sectional and longitudinal clinical data
    Bulbulgul Aumakhan
    Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Virol J 7:328. 2010
    ....
  50. pmc HIV subtype D is associated with dementia, compared with subtype A, in immunosuppressed individuals at risk of cognitive impairment in Kampala, Uganda
    Ned Sacktor
    Departments of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Clin Infect Dis 49:780-6. 2009
    ..The objective of this study was to examine the relationship between HIV subtype and the severity of HIV-associated cognitive impairment among individuals initiating antiretroviral therapy in Uganda...
  51. pmc The role of viral introductions in sustaining community-based HIV epidemics in rural Uganda: evidence from spatial clustering, phylogenetics, and egocentric transmission models
    Mary K Grabowski
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS Med 11:e1001610. 2014
    ....
  52. pmc Use of a high resolution melting (HRM) assay to compare gag, pol, and env diversity in adults with different stages of HIV infection
    Matthew M Cousins
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 6:e27211. 2011
    ..This assay provides a single numeric HRM score that reflects the level of genetic diversity of HIV in a sample from an infected individual...
  53. pmc Detection of individuals with acute HIV-1 infection using the ARCHITECT HIV Ag/Ab Combo assay
    Susan H Eshleman
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Acquir Immune Defic Syndr 52:121-4. 2009
    ..We evaluated use of the ARCHITECT HIV Ag/Ab Combo assay (HIV Combo; Abbott Diagnostics; available for sale outside the United States only) for detection of acute HIV infection...
  54. pmc Microbial translocation, the innate cytokine response, and HIV-1 disease progression in Africa
    Andrew D Redd
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:6718-23. 2009
    ..These data suggest that microbial translocation and its subsequent inflammatory immune response do not have a causal relationship with HIV-1 disease progression in Africa...
  55. ncbi request reprint Male circumcision for HIV prevention in men in Rakai, Uganda: a randomised trial
    Ronald H Gray
    Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21215, USA
    Lancet 369:657-66. 2007
    ..Ecological and observational studies suggest that male circumcision reduces the risk of HIV acquisition in men. Our aim was to investigate the effect of male circumcision on HIV incidence in men...
  56. pmc Prevalence and factors associated with herpes simplex virus type 2 infection in patients attending a Baltimore city emergency department
    Eshan U Patel
    Division of Intramural Research, NIAID, NIH, Baltimore, Maryland, United States of America
    PLoS ONE 9:e102422. 2014
    ..We evaluate the seroprevalence and factors associated with HSV-2 infection among patients attending the Johns Hopkins Hospital Adult Emergency Department (JHH ED)...
  57. pmc Impaired natural killer cell responses are associated with loss of the highly activated NKG2A(+)CD57(+)CD56(dim) subset in HIV-1 subtype D infection in Uganda
    Prossy Naluyima
    aMakerere University Walter Reed Project, Kampala, Uganda bCenter for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden cUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring dHenry M Jackson Foundation for the Advancement of Military Medicine eLaboratory of Immunoregulation, Division of Intramural Research, NIAID, NIH, Bethesda fSchool of Medicine, Johns Hopkins University, Baltimore, Maryland, USA gSchool of Public Health, Makerere University College of Health Sciences, Kampala hRakai Health Sciences Program, Uganda Virus Research Institute, Entebbe iFaculty of Medicine, Makerere University College of Health Sciences, Kampala, Uganda jBloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    AIDS 28:1273-8. 2014
    ..Here, we studied NK cell activation and function in Ugandans with chronic untreated HIV-1 subtype D infection in comparison to uninfected community matched controls...
  58. ncbi request reprint Molecular epidemiology of HIV-1 subtypes in southern China
    Oliver Laeyendecker
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Acquir Immune Defic Syndr 38:356-62. 2005
    ....
  59. pmc Performance of a commercial, type-specific enzyme-linked immunosorbent assay for detection of herpes simplex virus type 2-specific antibodies in Ugandans
    Oliver Laeyendecker
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Clin Microbiol 42:1794-6. 2004
    ..A higher index cutoff value was required for optimal sensitivity and specificity, and overall performance of the assay was not affected by HIV status...
  60. ncbi request reprint Rates of HIV-1 transmission per coital act, by stage of HIV-1 infection, in Rakai, Uganda
    Maria J Wawer
    Heilbrun Department of Population and Family Health, Columbia University Mailman School of Public Health, New York, New York 10032, USA
    J Infect Dis 191:1403-9. 2005
    ..We estimated rates of human immunodeficiency virus (HIV)-1 transmission per coital act in HIV-discordant couples by stage of infection in the index partner...
  61. ncbi request reprint Treatment interruptions predict resistance in HIV-positive individuals purchasing fixed-dose combination antiretroviral therapy in Kampala, Uganda
    Jessica H Oyugi
    Infectious Diseases Institute, Kampala, Uganda
    AIDS 21:965-71. 2007
    ..To evaluate adherence, treatment interruptions, and outcomes in patients purchasing antiretroviral fixed-dose combination (FDC) therapy...
  62. doi request reprint Effect of human immunodeficiency virus Type 1 (HIV-1) subtype on disease progression in persons from Rakai, Uganda, with incident HIV-1 infection
    Noah Kiwanuka
    Uganda Virus Research Institute, Entebbe, Uganda
    J Infect Dis 197:707-13. 2008
    ..Human immunodeficiency virus type 1 (HIV-1) subtypes differ in biological characteristics that may affect pathogenicity...