P W Ladenson

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Recombinant thyrotropin for detection of recurrent thyroid cancer
    Paul W Ladenson
    Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, 1830 E Monument Street, Suite 333, Baltimore, Maryland 21287, USA
    Trans Am Clin Climatol Assoc 113:21-30. 2002
  2. ncbi request reprint Psychological wellbeing in patients
    Paul W Ladenson
    Division of Endocrinology and Metabolism, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Clin Endocrinol (Oxf) 57:575-6. 2002
  3. doi request reprint Cost-effectiveness of a novel molecular test for cytologically indeterminate thyroid nodules
    Henry Li
    Division of Health Sciences Informatics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Clin Endocrinol Metab 96:E1719-26. 2011
  4. doi request reprint Effects of the thyromimetic agent diiodothyropropionic acid on body weight, body mass index, and serum lipoproteins: a pilot prospective, randomized, controlled study
    P W Ladenson
    Department of Endocrinology and Metabolism, John Hopkins University, 1830 East Monument Street, Suite 333, Baltimore, Maryland 21287 0003, USA
    J Clin Endocrinol Metab 95:1349-54. 2010
  5. ncbi request reprint Strategies for thyrotropin use to monitor patients with treated thyroid carcinoma
    P W Ladenson
    Division of Endocrinology and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Thyroid 9:429-33. 1999
  6. pmc Lung dosimetry for radioiodine treatment planning in the case of diffuse lung metastases
    Hong Song
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, School of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA
    J Nucl Med 47:1985-94. 2006
  7. ncbi request reprint BRAF T1796A transversion mutation in various thyroid neoplasms
    M Xing
    Division of Endocrinology and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Clin Endocrinol Metab 89:1365-8. 2004
  8. pmc Lung toxicity in radioiodine therapy of thyroid carcinoma: development of a dose-rate method and dosimetric implications of the 80-mCi rule
    George Sgouros
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, School of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA
    J Nucl Med 47:1977-84. 2006
  9. ncbi request reprint BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer
    Mingzhao Xing
    Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 333, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 90:6373-9. 2005
  10. ncbi request reprint Smoke exposure is associated with a lower prevalence of serum thyroid autoantibodies and thyrotropin concentration elevation and a higher prevalence of mild thyrotropin concentration suppression in the third National Health and Nutrition Examination Surve
    Ruth M Belin
    Division of Endocrinology and Metabolism, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 89:6077-86. 2004

Detail Information

Publications46

  1. pmc Recombinant thyrotropin for detection of recurrent thyroid cancer
    Paul W Ladenson
    Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, 1830 E Monument Street, Suite 333, Baltimore, Maryland 21287, USA
    Trans Am Clin Climatol Assoc 113:21-30. 2002
    ..Temporary thyroid hormone withdrawal has previously been used, but causes hypothyroidism and, rarely, tumor progression...
  2. ncbi request reprint Psychological wellbeing in patients
    Paul W Ladenson
    Division of Endocrinology and Metabolism, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Clin Endocrinol (Oxf) 57:575-6. 2002
  3. doi request reprint Cost-effectiveness of a novel molecular test for cytologically indeterminate thyroid nodules
    Henry Li
    Division of Health Sciences Informatics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Clin Endocrinol Metab 96:E1719-26. 2011
    ..A new approach for preoperative molecular classification of cytologically indeterminate thyroid nodules has a reported sensitivity of 91% and specificity of 75%; however, its cost-effectiveness has yet to be assessed...
  4. doi request reprint Effects of the thyromimetic agent diiodothyropropionic acid on body weight, body mass index, and serum lipoproteins: a pilot prospective, randomized, controlled study
    P W Ladenson
    Department of Endocrinology and Metabolism, John Hopkins University, 1830 East Monument Street, Suite 333, Baltimore, Maryland 21287 0003, USA
    J Clin Endocrinol Metab 95:1349-54. 2010
    ..However, DITPA's adverse effects at doses used resulted in a high dropout rate and potentially dangerous skeletal actions were observed...
  5. ncbi request reprint Strategies for thyrotropin use to monitor patients with treated thyroid carcinoma
    P W Ladenson
    Division of Endocrinology and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Thyroid 9:429-33. 1999
    ..Physicians should consider patients' pretest probability of disease in deciding whether and how often to perform rTSH-stimulated testing after primary treatment for thyroid carcinoma...
  6. pmc Lung dosimetry for radioiodine treatment planning in the case of diffuse lung metastases
    Hong Song
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, School of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA
    J Nucl Med 47:1985-94. 2006
    ..In this work we demonstrated the use of MCNP, a Monte Carlo electron and photon transport code, in a 3-dimensional (3D) imaging-based absorbed dose calculation for tumor and normal lungs...
  7. ncbi request reprint BRAF T1796A transversion mutation in various thyroid neoplasms
    M Xing
    Division of Endocrinology and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Clin Endocrinol Metab 89:1365-8. 2004
    ....
  8. pmc Lung toxicity in radioiodine therapy of thyroid carcinoma: development of a dose-rate method and dosimetric implications of the 80-mCi rule
    George Sgouros
    Division of Nuclear Medicine, Russell H Morgan Department of Radiology and Radiological Science, School of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA
    J Nucl Med 47:1977-84. 2006
    ..This is particularly important, for example, in pediatric patients exhibiting diffuse lung metastases. The approach also highlights the impact of altered radioiodine kinetics as seen with recombinant human thyroid-stimulating hormone...
  9. ncbi request reprint BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer
    Mingzhao Xing
    Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 333, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 90:6373-9. 2005
    ..Use of BRAF mutation in papillary thyroid cancer (PTC) has the potential to improve risk stratification of this cancer...
  10. ncbi request reprint Smoke exposure is associated with a lower prevalence of serum thyroid autoantibodies and thyrotropin concentration elevation and a higher prevalence of mild thyrotropin concentration suppression in the third National Health and Nutrition Examination Surve
    Ruth M Belin
    Division of Endocrinology and Metabolism, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 89:6077-86. 2004
    ..Understanding the underlying mechanism could help identify potential pathways for the prevention of autoimmune thyroid disease...
  11. ncbi request reprint Prevalence of postpartum thyroid dysfunction: a quantitative review
    Wanda K Nicholson
    Department of Gynecology and Obstetrics, The Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    Thyroid 16:573-82. 2006
    ..7 times more likely to occur in women with TPOAbs. The high prevalence may warrant routine screening TPOAbs, but the benefits, cost, and risks related to subsequent therapy must be weighed...
  12. ncbi request reprint Detection of BRAF mutation on fine needle aspiration biopsy specimens: a new diagnostic tool for papillary thyroid cancer
    Mingzhao Xing
    Division of Endocrinology and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 89:2867-72. 2004
    ..Thus, we have demonstrated the usefulness of BRAF mutation detection on FNAB specimens that can help diagnose and identify those PTC patients who may need more aggressive surgical treatment and vigilant clinical monitoring...
  13. ncbi request reprint A comparison of short-term changes in health-related quality of life in thyroid carcinoma patients undergoing diagnostic evaluation with recombinant human thyrotropin compared with thyroid hormone withdrawal
    Pamela R Schroeder
    Johns Hopkins Medical Institutions, Division of Endocrinology and Metabolism, 1830 East Monument Street, Suite 333, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 91:878-84. 2006
    ..Levothyroxine (L-T4) withdrawal for thyroglobulin measurement and whole body scanning increases these tests' sensitivities but causes hypothyroidism. Recombinant human TSH (rhTSH) enables testing without L-T4 withdrawal...
  14. ncbi request reprint BRAF mutation in papillary thyroid carcinoma
    Yoram Cohen
    Division of Head and Neck Cancer Research, Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2196, USA
    J Natl Cancer Inst 95:625-7. 2003
    ..Our data suggest that activating BRAF mutations may be an important event in the development of papillary thyroid cancer...
  15. doi request reprint Clinical review: Prevalence and incidence of endocrine and metabolic disorders in the United States: a comprehensive review
    Sherita H Golden
    Johns Hopkins University School of Medicine, Division of Endocrinology and Metabolism, 2024 East Monument Street, Suite 2 600, Baltimore, Maryland 21205, USA
    J Clin Endocrinol Metab 94:1853-78. 2009
    ..There has not been a comprehensive compilation of data regarding the epidemiology of all endocrine and metabolic disorders in the United States...
  16. ncbi request reprint Practical application of recombinant thyrotropin testing in clinical practice
    P W Ladenson
    Division of Endocrinology and Metabolism, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-0003, USA
    Endocr Pract 7:195-201. 2001
    ..CONCLUSION: Radioiodine scanning and serum thyroglobulin measurement after intramuscular injection of rTSH are valuable new monitoring options in patients with treated thyroid cancer, avoiding the adverse effects of hypothyroidism...
  17. pmc Three-dimensional radiobiologic dosimetry: application of radiobiologic modeling to patient-specific 3-dimensional imaging-based internal dosimetry
    Andrew R Prideaux
    Russell H Morgan Department of Radiology and Radiological Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21231, USA
    J Nucl Med 48:1008-16. 2007
    ..The methodology is illustrated using data from a thyroid cancer patient treated with radioiodine...
  18. pmc 124I PET-based 3D-RD dosimetry for a pediatric thyroid cancer patient: real-time treatment planning and methodologic comparison
    Robert F Hobbs
    Department of Radiology, Johns Hopkins University, Baltimore, Maryland 21231, USA
    J Nucl Med 50:1844-7. 2009
    ..A retrospective analysis of the conventional methodologies with appropriate corrections yielded absorbed dose estimates consistent with 3D-RD...
  19. ncbi request reprint The role of positron emission tomography/computed tomography in the management of recurrent papillary thyroid carcinoma
    Zayna Nahas
    Department of Radiology, Johns Hopkins School of Medicine, Baltimore, Maryland 21287 0910, USA
    Laryngoscope 115:237-43. 2005
    ..The aim of the study was to evaluate the role of combined positron emission tomography/computed tomography (PET/CT) fusion imaging in the detection and management of recurrent papillary thyroid cancer...
  20. ncbi request reprint Dysprealbuminemic hyperthyroxinemia in a patient with hyperthyroid graves disease
    Scott J Cameron
    Clinical Chemistry Division, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21287 0003, USA
    Clin Chem 51:1065-9. 2005
    ..These findings indicate that hypothyroidism can be masked by coexisting euthyroid dysprealbuminemic hyperthyroxinemia...
  21. ncbi request reprint Early occurrence of RASSF1A hypermethylation and its mutual exclusion with BRAF mutation in thyroid tumorigenesis
    Mingzhao Xing
    Division of Endocrinology and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 64:1664-8. 2004
    ....
  22. ncbi request reprint Hypothyroidism
    Caroline G P Roberts
    Division of Endocrinology and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Lancet 363:793-803. 2004
    ..We summarise present understanding of the history, epidemiology, pathophysiology, and clinical diagnosis and management of hypothyroidism...
  23. ncbi request reprint Optimal laboratory testing for diagnosis and monitoring of thyroid nodules, goiter, and thyroid cancer
    P W Ladenson
    Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD 21287 4904, USA
    Clin Chem 42:183-7. 1996
    ..Periodic serum Tg measurements and 131I scans are complementary monitoring techniques. Serum calcitonin measurement and screening for ret protooncogene mutations are both valuable for identifying individuals with MTC...
  24. pmc The impact of age and gender on papillary thyroid cancer survival
    J Jonklaas
    Division of Endocrinology and Metabolism, Georgetown University Medical Center, Washington, DC 20007, USA
    J Clin Endocrinol Metab 97:E878-87. 2012
    ..Thyroid cancer predominately affects women, carries a worse prognosis in older age, and may have higher mortality in men. Superimposed on these observations is the fact that most women have attained menopause by age 55 yr...
  25. ncbi request reprint Detection of serum deoxyribonucleic acid methylation markers: a novel diagnostic tool for thyroid cancer
    Shuiying Hu
    Division of Endocrinology and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 91:98-104. 2006
    ..Serum DNA methylation markers may potentially be useful in diagnosing thyroid cancer and monitoring its recurrence...
  26. doi request reprint Use of the thyroid hormone analogue eprotirome in statin-treated dyslipidemia
    Paul W Ladenson
    Division of Endocrinology and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, USA
    N Engl J Med 362:906-16. 2010
    ..Consequently, thyromimetic drugs hold promise as lipid-lowering agents if adverse effects can be avoided...
  27. ncbi request reprint A genome-wide scan for autoimmune thyroiditis in the Old Order Amish: replication of genetic linkage on chromosome 5q11.2-q14.3
    Elsie M Allen
    Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Clin Endocrinol Metab 88:1292-6. 2003
    ..01) to autoimmune thyroiditis and/or AITD-hypothyroidism was also detected in five other regions. We conclude that a gene on chromosome 5q11.2-q14.3 is likely to contribute to susceptibility to AITD in the Amish...
  28. pmc Toll-like receptor-MyD88 and Fc receptor pathways of mast cells mediate the thyroid dysfunctions observed during nonthyroidal illness
    Roberto Rocchi
    Department of Pathology and Division of Endocrinology and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:6019-24. 2007
    ..The study demonstrates a link between Toll-like and Fc receptor signaling and thyroid gland function, uncovering a role of mast cells in murine NTI...
  29. ncbi request reprint Development and use of evidence-based clinical practice guidelines for thyroid disease
    Ruth M Belin
    Division of Endocrinology and Metabolism, Department of Medicine, Johns Hopkins Medical Institutions, 1830 East Monument Street, Suite 333, Baltimore, MD 21287, USA
    Endocrinol Metab Clin North Am 31:795-817. 2002
    ....
  30. ncbi request reprint Hypermethylation of the Pendred syndrome gene SLC26A4 is an early event in thyroid tumorigenesis
    Mingzhao Xing
    Division of Endocrinology and Metabolism, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 63:2312-5. 2003
    ..SLC26A4 gene methylation in benign adenomas and the relatively well-differentiated WRO cell line suggest that this alteration is an early event in thyroid tumorigenesis...
  31. ncbi request reprint Uncommon mutation, but common amplifications, of the PIK3CA gene in thyroid tumors
    Guojun Wu
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 333, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 90:4688-93. 2005
    ..As in many other human cancers, overactivation of the phosphotidylinositol 3-kinase (PI3K)/Akt signaling pathway occurs frequently in thyroid cancer, but the mechanism is not completely clear...
  32. ncbi request reprint Methylation of the thyroid-stimulating hormone receptor gene in epithelial thyroid tumors: a marker of malignancy and a cause of gene silencing
    Mingzhao Xing
    Division of Endocrinology and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 63:2316-21. 2003
    ..We propose that methylation of TSHR may provide a novel diagnostic marker of malignancy and a basis for potential use of demethylating agents in conjunction with TSH-promoted radioiodine therapy for epithelial thyroid cancers...
  33. ncbi request reprint Iodine biokinetics and dosimetry in radioiodine therapy of thyroid cancer: procedures and results of a prospective international controlled study of ablation after rhTSH or hormone withdrawal
    Heribert Hänscheid
    Klinik und Poliklinik fur Nuklearmedizin, Universitat Wurzburg, D 97080 Wurzburg, Germany
    J Nucl Med 47:648-54. 2006
    ..7 GBq (131)I in differentiated thyroid cancer after stimulation with recombinant human TSH (rhTSH) or by thyroid hormone withdrawal (THW) are presented...
  34. pmc Thyroid status, cardiovascular risk, and mortality in older adults
    Anne R Cappola
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    JAMA 295:1033-41. 2006
    ..Previous studies have suggested that subclinical abnormalities in thyroid-stimulating hormone levels are associated with detrimental effects on the cardiovascular system...
  35. ncbi request reprint The role of PET in follow-up of patients treated for differentiated epithelial thyroid cancers
    Sophie Leboulleux
    Department of Nuclear Medicine and Endocrine Tumors at the Institut Gustave Roussy, Villejuif, France
    Nat Clin Pract Endocrinol Metab 3:112-21. 2007
    ..In patients with metastatic disease, PET can help to identify patients needing closer follow-up...
  36. ncbi request reprint Outcomes of patients with differentiated thyroid carcinoma following initial therapy
    Jacqueline Jonklaas
    Georgetown University Medical Center, Washington, DC 20007, USA
    Thyroid 16:1229-42. 2006
    ..We were unable to show any impact, positive or negative, of specific therapies in stage I patients...
  37. ncbi request reprint Letter re: uncommon mutation but common amplifications of the PIK3CA gene in thyroid tumors
    Dingxie Liu
    J Clin Endocrinol Metab 90:5509. 2005
  38. ncbi request reprint Management of the nontoxic multinodular goiter: a North American survey
    Steen J Bonnema
    Department of Endocrinology, Odense University Hospital, DK 5000 Odense C, Denmark
    J Clin Endocrinol Metab 87:112-7. 2002
    ..There is, however, still a wide variation in the perceived optimal management of this condition among members of both organizations...
  39. ncbi request reprint Well-differentiated epithelial thyroid cancer management in the Asia Pacific region: a report and clinical practice guideline
    Felix Sundram
    Nuclear Medicine Department, Singapore General Hospital, Singapore
    Thyroid 16:461-9. 2006
    ..Thyroid cancer is among the 10 most common malignancies in populations in the Asia Pacific region, where access to various relevant health care resources varies widely...
  40. pmc Subclinical thyroid dysfunction, cardiac function, and the risk of heart failure. The Cardiovascular Health study
    Nicolas Rodondi
    Department of Ambulatory Care and Community Medicine, University of Lausanne, Lausanne, Switzerland
    J Am Coll Cardiol 52:1152-9. 2008
    ..The goal of this study was to determine whether subclinical thyroid dysfunction was associated with incident heart failure (HF) and echocardiogram abnormalities...
  41. ncbi request reprint Cardiovascular consequences of subclinical thyroid dysfunction: more smoke but no fire
    Paul W Ladenson
    Ann Intern Med 148:880-1. 2008
  42. pmc Imaging of musculoskeletal bacterial infections by [124I]FIAU-PET/CT
    Luis A Diaz
    The Howard Hughes Medical Institute, The Ludwig Center for Cancer Genetics and Therapeutics at Johns Hopkins, Baltimore, Maryland, United States of America
    PLoS ONE 2:e1007. 2007
    ..The substrate specificity difference has been exploited to develop a new imaging technique that can detect the presence of viable bacteria...
  43. ncbi request reprint Subacute thyroiditis causing thyroid storm
    Steven I Sherman
    Thyroid 17:283. 2007
  44. pmc Theophylline increases the uptake of radioiodine by mouse thyroid
    Jong Min Lee
    Department of Internal Medicine, The Catholic University of Korea, Medical College, Seoul, Korea
    J Korean Med Sci 19:704-9. 2004
    ..The in vitro effects of theophylline on both radioiodine uptake and cAMP production in a dose-dependent manner are consistent with an action mediated by phosphodiesterase inhibition...
  45. ncbi request reprint Independent clonal origins of distinct tumor foci in multifocal papillary thyroid carcinoma
    Trisha M Shattuck
    Center for Molecular Medicine and Division of Endocrinology and Metabolism, University of Connecticut School of Medicine, Farmington, CT 06030 3101, USA
    N Engl J Med 352:2406-12. 2005
    ..Papillary thyroid carcinoma is frequently multifocal. We investigated whether noncontiguous tumor foci arise from intraglandular metastases from a single primary tumor or originate as unrelated clones derived from independent precursors...
  46. ncbi request reprint Hypothyroidism and atherosclerosis
    Anne R Cappola
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    J Clin Endocrinol Metab 88:2438-44. 2003