ELLEN LADENHEIM

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi Gastrointestinal regulatory peptides and central nervous system mechanisms of weight control
    Ellen E Ladenheim
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Curr Opin Endocrinol Diabetes Obes 19:13-8. 2012
  2. ncbi Gastrin-releasing peptide messenger ribonucleic acid expression in the hypothalamic paraventricular nucleus is altered by melanocortin receptor stimulation and food deprivation
    Ellen E Ladenheim
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Endocrinology 150:672-8. 2009
  3. ncbi Factors contributing to obesity in bombesin receptor subtype-3-deficient mice
    Ellen E Ladenheim
    Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, Maryland 21205, USA
    Endocrinology 149:971-8. 2008
  4. ncbi Capsaicin treatment differentially affects feeding suppression by bombesin-like peptides
    Ellen E Ladenheim
    Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, MD 21205, USA
    Physiol Behav 91:36-41. 2007
  5. ncbi Leptin enhances feeding suppression and neural activation produced by systemically administered bombesin
    Ellen E Ladenheim
    Dept of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Ross 618, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Am J Physiol Regul Integr Comp Physiol 289:R473-R477. 2005
  6. ncbi Disruptions in feeding and body weight control in gastrin-releasing peptide receptor deficient mice
    E E Ladenheim
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Endocrinol 174:273-81. 2002
  7. ncbi Running wheel activity prevents hyperphagia and obesity in Otsuka long-evans Tokushima Fatty rats: role of hypothalamic signaling
    Sheng Bi
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 618, Baltimore, Maryland 21205, USA
    Endocrinology 146:1676-85. 2005
  8. ncbi Adiposity signaling and meal size control
    Timothy H Moran
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Physiol Behav 103:21-4. 2011
  9. ncbi Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake
    Su Gao
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:17358-63. 2007
  10. ncbi Leptin modulation of peripheral controls of meal size
    Timothy H Moran
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Ross 618, 720 Rutland Ave, Baltimore, MD 21205, United States
    Physiol Behav 89:511-6. 2006

Research Grants

  1. NEURAL AND GI SUBSTRATES IN BOMBESIN SATIETY
    ELLEN LADENHEIM; Fiscal Year: 2001
  2. NEURAL AND GI SUBSTRATES IN BOMBESIN SATIETY
    ELLEN LADENHEIM; Fiscal Year: 2006

Detail Information

Publications16

  1. ncbi Gastrointestinal regulatory peptides and central nervous system mechanisms of weight control
    Ellen E Ladenheim
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Curr Opin Endocrinol Diabetes Obes 19:13-8. 2012
    ..This review focuses on recent advances in understanding the multiple roles of gastrointestinal peptides in the control of food intake and body weight with specific emphasis on ghrelin, amylin and glucagon-like peptide 1...
  2. ncbi Gastrin-releasing peptide messenger ribonucleic acid expression in the hypothalamic paraventricular nucleus is altered by melanocortin receptor stimulation and food deprivation
    Ellen E Ladenheim
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Endocrinology 150:672-8. 2009
    ....
  3. ncbi Factors contributing to obesity in bombesin receptor subtype-3-deficient mice
    Ellen E Ladenheim
    Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, Maryland 21205, USA
    Endocrinology 149:971-8. 2008
    ..However, our finding that pair-feeding did not completely normalize fat distribution and plasma leptin levels suggests there is also a metabolic dysregulation that may contribute to, or sustain, their obese phenotype...
  4. ncbi Capsaicin treatment differentially affects feeding suppression by bombesin-like peptides
    Ellen E Ladenheim
    Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, MD 21205, USA
    Physiol Behav 91:36-41. 2007
    ..These results suggest that different neural substrates underlie the anorexic effects of peripherally administered BN-like peptides...
  5. ncbi Leptin enhances feeding suppression and neural activation produced by systemically administered bombesin
    Ellen E Ladenheim
    Dept of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Ross 618, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Am J Physiol Regul Integr Comp Physiol 289:R473-R477. 2005
    ..These data provide further support for the hypothesis that the effect of leptin on food intake may be mediated, in part, by modulating meal-related satiety signals...
  6. ncbi Disruptions in feeding and body weight control in gastrin-releasing peptide receptor deficient mice
    E E Ladenheim
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Endocrinol 174:273-81. 2002
    ..These data suggest that the GRP-R mediates the feeding effects of BN-like peptides and participates in the termination of meals in mice...
  7. ncbi Running wheel activity prevents hyperphagia and obesity in Otsuka long-evans Tokushima Fatty rats: role of hypothalamic signaling
    Sheng Bi
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 618, Baltimore, Maryland 21205, USA
    Endocrinology 146:1676-85. 2005
    ....
  8. ncbi Adiposity signaling and meal size control
    Timothy H Moran
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Physiol Behav 103:21-4. 2011
    ..The original work by Woods and colleagues provided the necessary experimental paradigms for these advances...
  9. ncbi Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake
    Su Gao
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:17358-63. 2007
    ..Together, these findings highlight site-specific impacts of hypothalamic ACC activation in leptin's anorectic signaling cascade...
  10. ncbi Leptin modulation of peripheral controls of meal size
    Timothy H Moran
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Ross 618, 720 Rutland Ave, Baltimore, MD 21205, United States
    Physiol Behav 89:511-6. 2006
    ....
  11. ncbi Peptide YY(3-36) inhibits gastric emptying and produces acute reductions in food intake in rhesus monkeys
    Timothy H Moran
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Ross 618, 720 Rutland Ave, Baltimore, MD 21205, USA
    Am J Physiol Regul Integr Comp Physiol 288:R384-8. 2005
    ..Together, these data suggest that PYY(3-36) has the ability to reduce food intake in acute test situations in nonhuman primates. Whether this is a physiological action of the endogenous peptide remains to be determined...
  12. ncbi Responsivity to NPY and melanocortins in obese OLETF rats lacking CCK-A receptors
    Timothy H Moran
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Physiol Behav 75:397-402. 2002
    ....
  13. ncbi Transferrin fusion technology: a novel approach to prolonging biological half-life of insulinotropic peptides
    Byung Joon Kim
    National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Pharmacol Exp Ther 334:682-92. 2010
    ..EX-4-Tf proved to be as effective as EX-4 but had longer lived effects on blood glucose and food intake. This novel transferrin fusion technology could improve the pharmacology of various peptides...
  14. ncbi Peptide YY(3-36) and food intake: a peptide waiting for a paradigm?
    Ellen E Ladenheim
    Am J Physiol Regul Integr Comp Physiol 293:R37-8. 2007
  15. ncbi Context-dependent transduction of within-meal afferent signaling
    Timothy H Moran
    Am J Physiol Regul Integr Comp Physiol 286:R816-7. 2004
  16. ncbi Fourth ventricular CART reduces food and water intake and produces a conditioned taste aversion in rats
    Susan Aja
    Behav Neurosci 116:918-21. 2002
    ..These data demonstrate that 4V CART's actions in ingestive behavior are not specific to nutrients and suggest that aspects of 4V CART's actions in reducing intake may be secondary to the production of an aversive state...

Research Grants13

  1. NEURAL AND GI SUBSTRATES IN BOMBESIN SATIETY
    ELLEN LADENHEIM; Fiscal Year: 2001
    ..Together, the results of these experiments will significantly enhance our understanding of the actions of brain/gut peptides in food intake and body weight regulation. ..
  2. NEURAL AND GI SUBSTRATES IN BOMBESIN SATIETY
    ELLEN LADENHEIM; Fiscal Year: 2006
    ..Such an understanding will significantly enhance our understanding of the mechanisms underlying overall energy regulation and may lead to novel treatments for obesity or eating disorders ..