Chulan Kwon

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Notch post-translationally regulates β-catenin protein in stem and progenitor cells
    Chulan Kwon
    Gladstone Institute of Cardiovascular Disease and Department of Pediatrics, University of California, San Francisco, 1650 Owens Street, San Francisco, California 94158, USA
    Nat Cell Biol 13:1244-51. 2011
  2. pmc A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate
    Chulan Kwon
    Gladstone Institute of Cardiovascular Disease and Departments of Pediatrics and Biochemistry and Biophysics, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA
    Nat Cell Biol 11:951-7. 2009
  3. pmc A genome-wide screen reveals a role for microRNA-1 in modulating cardiac cell polarity
    Isabelle N King
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Dev Cell 20:497-510. 2011
  4. pmc Fibronectin mediates mesendodermal cell fate decisions
    Paul Cheng
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Development 140:2587-96. 2013
  5. pmc Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors
    Chulan Kwon
    Gladstone Institute of Cardiovascular Disease and Department of Pediatrics, University of California, 1650 Owens Street, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 104:10894-9. 2007
  6. pmc MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling
    Chulan Kwon
    Gladstone Institute of Cardiovascular Disease and Department of Pediatrics, University of California, 1650 Owens Street, San Francisco, CA 94158
    Proc Natl Acad Sci U S A 102:18986-91. 2005
  7. pmc Wnt/beta-catenin signaling acts at multiple developmental stages to promote mammalian cardiogenesis
    Chulan Kwon
    Gladstone Institute of Cardiovascular Disease, San Francisco, San Francisco, California 94158, USA
    Cell Cycle 7:3815-8. 2008

Collaborators

Detail Information

Publications7

  1. pmc Notch post-translationally regulates β-catenin protein in stem and progenitor cells
    Chulan Kwon
    Gladstone Institute of Cardiovascular Disease and Department of Pediatrics, University of California, San Francisco, 1650 Owens Street, San Francisco, California 94158, USA
    Nat Cell Biol 13:1244-51. 2011
    ..It did, however, require the endocytic adaptor protein Numb and lysosomal activity. This study reveals a previously unrecognized function of Notch in negatively titrating active β-catenin protein levels in stem and progenitor cells...
  2. pmc A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate
    Chulan Kwon
    Gladstone Institute of Cardiovascular Disease and Departments of Pediatrics and Biochemistry and Biophysics, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA
    Nat Cell Biol 11:951-7. 2009
    ..These findings reveal a regulatory network controlling CPC expansion and cell fate that involves unanticipated functions of beta-catenin, Notch1 and Isl1 that may be leveraged for regenerative approaches involving CPCs...
  3. pmc A genome-wide screen reveals a role for microRNA-1 in modulating cardiac cell polarity
    Isabelle N King
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Dev Cell 20:497-510. 2011
    ..These findings illustrate the power of Drosophila-based screens to find points of intersection between miRNAs and conserved pathways in mammals...
  4. pmc Fibronectin mediates mesendodermal cell fate decisions
    Paul Cheng
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Development 140:2587-96. 2013
    ....
  5. pmc Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors
    Chulan Kwon
    Gladstone Institute of Cardiovascular Disease and Department of Pediatrics, University of California, 1650 Owens Street, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 104:10894-9. 2007
    ..Together, these data provide in vivo and in vitro evidence that canonical Wnt signaling promotes the expansion of cardiac progenitors and differentiation of cardiomyocytes...
  6. pmc MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling
    Chulan Kwon
    Gladstone Institute of Cardiovascular Disease and Department of Pediatrics, University of California, 1650 Owens Street, San Francisco, CA 94158
    Proc Natl Acad Sci U S A 102:18986-91. 2005
    ..These findings demonstrate that dmiR-1 may "fine-tune" critical steps involved in differentiation of cardiac and somatic muscle progenitors and targets a pathway required for progenitor cell specification and asymmetric cell division...
  7. pmc Wnt/beta-catenin signaling acts at multiple developmental stages to promote mammalian cardiogenesis
    Chulan Kwon
    Gladstone Institute of Cardiovascular Disease, San Francisco, San Francisco, California 94158, USA
    Cell Cycle 7:3815-8. 2008
    ..Here we discuss the required roles of Wnt/beta-catenin signaling at the different stages of heart development...