Chulan Kwon

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Direct contact with endoderm-like cells efficiently induces cardiac progenitors from mouse and human pluripotent stem cells
    Hideki Uosaki
    Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    PLoS ONE 7:e46413. 2012
  2. pmc Notch post-translationally regulates β-catenin protein in stem and progenitor cells
    Chulan Kwon
    Gladstone Institute of Cardiovascular Disease and Department of Pediatrics, University of California, San Francisco, 1650 Owens Street, San Francisco, California 94158, USA
    Nat Cell Biol 13:1244-51. 2011
  3. pmc A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate
    Chulan Kwon
    Gladstone Institute of Cardiovascular Disease and Departments of Pediatrics and Biochemistry and Biophysics, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA
    Nat Cell Biol 11:951-7. 2009
  4. pmc Fibronectin mediates mesendodermal cell fate decisions
    Paul Cheng
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Development 140:2587-96. 2013
  5. pmc A genome-wide screen reveals a role for microRNA-1 in modulating cardiac cell polarity
    Isabelle N King
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Dev Cell 20:497-510. 2011
  6. pmc Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors
    Chulan Kwon
    Gladstone Institute of Cardiovascular Disease and Department of Pediatrics, University of California, 1650 Owens Street, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 104:10894-9. 2007
  7. pmc MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling
    Chulan Kwon
    Gladstone Institute of Cardiovascular Disease and Department of Pediatrics, University of California, 1650 Owens Street, San Francisco, CA 94158
    Proc Natl Acad Sci U S A 102:18986-91. 2005
  8. pmc Non-canonical Notch signaling: emerging role and mechanism
    Peter Andersen
    Division of Cardiology, Department of Medicine, Johns Hopkins University, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Trends Cell Biol 22:257-65. 2012
  9. pmc Wnt/beta-catenin signaling acts at multiple developmental stages to promote mammalian cardiogenesis
    Chulan Kwon
    Gladstone Institute of Cardiovascular Disease, San Francisco, San Francisco, California 94158, USA
    Cell Cycle 7:3815-8. 2008
  10. pmc Mutations in Alström protein impair terminal differentiation of cardiomyocytes
    Lincoln T Shenje
    1 Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA 2
    Nat Commun 5:3416. 2014

Collaborators

Detail Information

Publications10

  1. pmc Direct contact with endoderm-like cells efficiently induces cardiac progenitors from mouse and human pluripotent stem cells
    Hideki Uosaki
    Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    PLoS ONE 7:e46413. 2012
    ..However, available methods to induce CPCs are not efficient or require high-cost cytokines with extensive optimization due to cell line variations...
  2. pmc Notch post-translationally regulates β-catenin protein in stem and progenitor cells
    Chulan Kwon
    Gladstone Institute of Cardiovascular Disease and Department of Pediatrics, University of California, San Francisco, 1650 Owens Street, San Francisco, California 94158, USA
    Nat Cell Biol 13:1244-51. 2011
    ..It did, however, require the endocytic adaptor protein Numb and lysosomal activity. This study reveals a previously unrecognized function of Notch in negatively titrating active β-catenin protein levels in stem and progenitor cells...
  3. pmc A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate
    Chulan Kwon
    Gladstone Institute of Cardiovascular Disease and Departments of Pediatrics and Biochemistry and Biophysics, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA
    Nat Cell Biol 11:951-7. 2009
    ..These findings reveal a regulatory network controlling CPC expansion and cell fate that involves unanticipated functions of beta-catenin, Notch1 and Isl1 that may be leveraged for regenerative approaches involving CPCs...
  4. pmc Fibronectin mediates mesendodermal cell fate decisions
    Paul Cheng
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Development 140:2587-96. 2013
    ....
  5. pmc A genome-wide screen reveals a role for microRNA-1 in modulating cardiac cell polarity
    Isabelle N King
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Dev Cell 20:497-510. 2011
    ..These findings illustrate the power of Drosophila-based screens to find points of intersection between miRNAs and conserved pathways in mammals...
  6. pmc Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors
    Chulan Kwon
    Gladstone Institute of Cardiovascular Disease and Department of Pediatrics, University of California, 1650 Owens Street, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 104:10894-9. 2007
    ..Together, these data provide in vivo and in vitro evidence that canonical Wnt signaling promotes the expansion of cardiac progenitors and differentiation of cardiomyocytes...
  7. pmc MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling
    Chulan Kwon
    Gladstone Institute of Cardiovascular Disease and Department of Pediatrics, University of California, 1650 Owens Street, San Francisco, CA 94158
    Proc Natl Acad Sci U S A 102:18986-91. 2005
    ..These findings demonstrate that dmiR-1 may "fine-tune" critical steps involved in differentiation of cardiac and somatic muscle progenitors and targets a pathway required for progenitor cell specification and asymmetric cell division...
  8. pmc Non-canonical Notch signaling: emerging role and mechanism
    Peter Andersen
    Division of Cardiology, Department of Medicine, Johns Hopkins University, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Trends Cell Biol 22:257-65. 2012
    ..The non-canonical Notch pathway appears to be highly conserved from flies to mammals. Here, we discuss the emerging conserved mechanism and role of ligand/transcription-independent Notch signaling in cell and developmental biology...
  9. pmc Wnt/beta-catenin signaling acts at multiple developmental stages to promote mammalian cardiogenesis
    Chulan Kwon
    Gladstone Institute of Cardiovascular Disease, San Francisco, San Francisco, California 94158, USA
    Cell Cycle 7:3815-8. 2008
    ..Here we discuss the required roles of Wnt/beta-catenin signaling at the different stages of heart development...
  10. pmc Mutations in Alström protein impair terminal differentiation of cardiomyocytes
    Lincoln T Shenje
    1 Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA 2
    Nat Commun 5:3416. 2014
    ..Homozygous Alms1-mutant mice have increased cardiomyocyte proliferation at 2 weeks postnatal compared with wild-type littermates. We conclude that deficiency of Alström protein impairs postnatal cardiomyocyte cell cycle arrest. ..