R J Kurman

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi request reprint Precursors of endometrial and ovarian carcinoma
    Robert J Kurman
    Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine and Hospital, Baltimore, MD, USA
    Virchows Arch 456:1-12. 2010
  2. pmc Pathogenesis of ovarian cancer: lessons from morphology and molecular biology and their clinical implications
    Robert J Kurman
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Int J Gynecol Pathol 27:151-60. 2008
  3. pmc Papillary tubal hyperplasia: the putative precursor of ovarian atypical proliferative (borderline) serous tumors, noninvasive implants, and endosalpingiosis
    Robert J Kurman
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA
    Am J Surg Pathol 35:1605-14. 2011
  4. ncbi request reprint Serous borderline tumours of the ovary
    R J Kurman
    Department of Pathology, Washington Hospital Center, Washington, DC, USA
    Histopathology 47:310-5. 2005
  5. pmc The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory
    Robert J Kurman
    Departments of Pathology, Gynecology and Obstetrics and Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Surg Pathol 34:433-43. 2010
  6. ncbi request reprint Demonstration of human papillomavirus (HPV) genomic amplification and viral-like particles from CaSki cell line in SCID mice
    T C Wu
    Department of Pathology, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    J Virol Methods 65:287-98. 1997
  7. ncbi request reprint Pseudomyxoma peritonei: new concepts in diagnosis, origin, nomenclature, and relationship to mucinous borderline (low malignant potential) tumors of the ovary
    B M Ronnett
    Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA
    Anat Pathol 2:197-226. 1997
  8. ncbi request reprint The development of high-grade serous carcinoma from atypical proliferative (borderline) serous tumors and low-grade micropapillary serous carcinoma: a morphologic and molecular genetic analysis
    Reiko Dehari
    Department of Pathology, Gynecology and Obstetrics, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Am J Surg Pathol 31:1007-12. 2007
  9. pmc Defining the cut point between low-grade and high-grade ovarian serous carcinomas: a clinicopathologic and molecular genetic analysis
    Ayse Ayhan
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Am J Surg Pathol 33:1220-4. 2009
  10. doi request reprint HSD3B1 as a novel trophoblast-associated marker that assists in the differential diagnosis of trophoblastic tumors and tumorlike lesions
    Tsui Lien Mao
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Am J Surg Pathol 32:236-42. 2008

Research Grants

  1. Pathogenesis of Ovarian Serous Borderline Tumors
    Robert Kurman; Fiscal Year: 2007
  2. Pathogenesis of Ovarian Serous Borderline Tumors
    Robert J Kurman; Fiscal Year: 2010
  3. Pathogenesis of Ovarian Serous Borderline Tumors
    Robert Kurman; Fiscal Year: 2009

Detail Information

Publications91

  1. doi request reprint Precursors of endometrial and ovarian carcinoma
    Robert J Kurman
    Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine and Hospital, Baltimore, MD, USA
    Virchows Arch 456:1-12. 2010
    ..Furthermore, similarities and differences of the precursor lesions of specific tumors of these two genital tract organs are also addressed with a brief discussion of the clinical implications of their diagnosis...
  2. pmc Pathogenesis of ovarian cancer: lessons from morphology and molecular biology and their clinical implications
    Robert J Kurman
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Int J Gynecol Pathol 27:151-60. 2008
    ..The model does not replace the histopathologic classification but, by drawing attention to the molecular genetic events that play a role in tumor progression, sheds light on new approaches to early detection and treatment...
  3. pmc Papillary tubal hyperplasia: the putative precursor of ovarian atypical proliferative (borderline) serous tumors, noninvasive implants, and endosalpingiosis
    Robert J Kurman
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA
    Am J Surg Pathol 35:1605-14. 2011
    ..If this hypothesis is confirmed, it can be concluded that low-grade and high-grade ovarian tumors develop from tubal epithelium and involve the ovary secondarily...
  4. ncbi request reprint Serous borderline tumours of the ovary
    R J Kurman
    Department of Pathology, Washington Hospital Center, Washington, DC, USA
    Histopathology 47:310-5. 2005
    ..The significance of a micropapillary pattern is discussed, and issues related to extra-ovarian implants...
  5. pmc The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory
    Robert J Kurman
    Departments of Pathology, Gynecology and Obstetrics and Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Surg Pathol 34:433-43. 2010
    ..Appreciation of these new concepts will allow for a more rationale approach to screening, treatment, and prevention that potentially can have a significant impact on reducing the mortality of this devastating disease...
  6. ncbi request reprint Demonstration of human papillomavirus (HPV) genomic amplification and viral-like particles from CaSki cell line in SCID mice
    T C Wu
    Department of Pathology, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    J Virol Methods 65:287-98. 1997
    ..This experimental model provides a potential system for studying the molecular pathogenesis of HPV infections...
  7. ncbi request reprint Pseudomyxoma peritonei: new concepts in diagnosis, origin, nomenclature, and relationship to mucinous borderline (low malignant potential) tumors of the ovary
    B M Ronnett
    Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA
    Anat Pathol 2:197-226. 1997
    ..Tumors exhibiting the features currently interpreted as borderline should be included in the benign group and designated atypical proliferative mucinous tumors...
  8. ncbi request reprint The development of high-grade serous carcinoma from atypical proliferative (borderline) serous tumors and low-grade micropapillary serous carcinoma: a morphologic and molecular genetic analysis
    Reiko Dehari
    Department of Pathology, Gynecology and Obstetrics, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Am J Surg Pathol 31:1007-12. 2007
    ..The above results suggest that the majority of high-grade and low-grade carcinomas develop independently but in rare cases, a high-grade serous carcinoma may arise from an atypical proliferative serous (borderline) tumor...
  9. pmc Defining the cut point between low-grade and high-grade ovarian serous carcinomas: a clinicopathologic and molecular genetic analysis
    Ayse Ayhan
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Am J Surg Pathol 33:1220-4. 2009
    ....
  10. doi request reprint HSD3B1 as a novel trophoblast-associated marker that assists in the differential diagnosis of trophoblastic tumors and tumorlike lesions
    Tsui Lien Mao
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Am J Surg Pathol 32:236-42. 2008
    ..In conclusion, as compared with other trophoblastic markers, HSD3B1 is highly specific and sensitive, being expressed in all types of trophoblastic lesions but not in a variety of nontrophoblastic tumors of the uterus, lung, and breast...
  11. ncbi request reprint Molecular genetic analysis of ovarian serous cystadenomas
    Eric J Cheng
    Department of Pathology, The Johns Hopkins University, Baltimore, MD 21231, USA
    Lab Invest 84:778-84. 2004
    ..Accordingly, it appears that serous cystadenomas develop as a hyperplastic expansion from epithelial inclusions with a clonal/neoplastic transformation occurring in a subset of them...
  12. ncbi request reprint Diagnostic criteria and behavior of ovarian seromucinous (endocervical-type mucinous and mixed cell-type) tumors: atypical proliferative (borderline) tumors, intraepithelial, microinvasive, and invasive carcinomas
    Heidi W Shappell
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN, USA
    Am J Surg Pathol 26:1529-41. 2002
    ..We therefore recommend the term "seromucinous" for these tumors, which acknowledges both their serous and mucinous features...
  13. ncbi request reprint Expression of Mel-CAM in implantation site intermediate trophoblastic cell line, IST-1, limits its migration on uterine smooth muscle cells
    I Shih
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Cell Sci 111:2655-64. 1998
    ..These observations are consistent with an important role for Mel-CAM in limiting trophoblastic migration within the myometrium in the implantation site...
  14. ncbi request reprint HLA-G is a potential tumor marker in malignant ascites
    Gad Singer
    Department of Pathology, Johns Hopkins University Medical Institutions, Baltimore Maryland 21231, USA
    Clin Cancer Res 9:4460-4. 2003
    ..HLA-G is a potential tumor-associated marker and that one of its isoforms, HLA-G5, produces a secretory protein. This study is to assess the clinical utility of secreted HLA-G levels in differential diagnosis of malignant ascites...
  15. ncbi request reprint Characterization of active mitogen-activated protein kinase in ovarian serous carcinomas
    Chih Yi Hsu
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Clin Cancer Res 10:6432-6. 2004
    ..This study evaluates the expression of active MAPK in ovarian serous carcinomas, with response to treatment and survival...
  16. ncbi request reprint Immunohistochemistry of choriocarcinoma: an aid in differential diagnosis and in elucidating pathogenesis
    Tsui Lien Mao
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Am J Surg Pathol 31:1726-32. 2007
    ....
  17. ncbi request reprint Synchronous and metachronous endocervical and ovarian neoplasms: evidence supporting interpretation of the ovarian neoplasms as metastatic endocervical adenocarcinomas simulating primary ovarian surface epithelial neoplasms
    Esther Elishaev
    Department of Pathology, Johns Hopkins University School of Medicine and Hospital, Baltimore, MD 21231, USA
    Am J Surg Pathol 29:281-94. 2005
    ..The presence of HPV DNA in these ovarian tumors confirms that they are metastatic endocervical adenocarcinomas...
  18. ncbi request reprint Histologic alterations in endometrial hyperplasia and well-differentiated carcinoma treated with progestins
    Darren T Wheeler
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Am J Surg Pathol 31:988-98. 2007
    ..These findings indicate that progestin therapy should be continued for no less than 6 months to accurately assess treatment response. A modified classification for progestin-treated lesions of the endometrium is proposed...
  19. ncbi request reprint Assessment of TP53 mutation using purified tissue samples of ovarian serous carcinomas reveals a higher mutation rate than previously reported and does not correlate with drug resistance
    R Salani
    The Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Int J Gynecol Cancer 18:487-91. 2008
    ..3%, which is much higher than previously reported. Furthermore, we found that TP53 is not directly involved in the development of drug resistance in high-grade ovarian serous carcinomas...
  20. ncbi request reprint Mutations of BRAF and KRAS precede the development of ovarian serous borderline tumors
    Chung Liang Ho
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Cancer Res 64:6915-8. 2004
    ..Our findings provide cogent evidence that mutations of BRAF and KRAS occur in the epithelium of cystadenomas adjacent to SBTs and strongly suggest that they are very early events in tumorigenesis, preceding the development of SBT...
  21. ncbi request reprint Pseudoinfiltrative tubal metaplasia of the endocervix: a potential form of in utero diethylstilbestrol exposure-related adenosis simulating minimal deviation adenocarcinoma
    Russell Vang
    Division of Gynecologic Pathology, Department of Pathology, The Johns Hopkins University School of Medicine and Hospital, Baltimore, Maryland 21231, USA
    Int J Gynecol Pathol 24:391-8. 2005
    ..The clinicopathologic findings suggest the lesions are benign, and the association with in utero DES exposure raises the possibility that these could be a form of DES-related adenosis...
  22. ncbi request reprint Clinical significance of Her-2/neu overexpression in uterine serous carcinoma
    Teresa P Diaz-Montes
    The Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, The Johns Hopkins Medical Institutions, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Gynecol Oncol 100:139-44. 2006
    ..To evaluate the clinico-pathologic characteristics and survival outcome associated with overexpression of Her-2/neu in patients with uterine serous carcinoma (USC)...
  23. ncbi request reprint HLA-G immunoreactivity is specific for intermediate trophoblast in gestational trophoblastic disease and can serve as a useful marker in differential diagnosis
    Gad Singer
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Am J Surg Pathol 26:914-20. 2002
    ..In conclusion, HLA-G immunoreactivity appears to be specific for IT in gestational trophoblastic disease and can serve as a useful marker in the differential diagnosis of these lesions...
  24. ncbi request reprint Molecular pathogenesis of ovarian borderline tumors: new insights and old challenges
    Ie Ming Shih
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Clin Cancer Res 11:7273-9. 2005
    ..This review summarizes recent molecular studies of ovarian borderline tumors with special emphasis on the role of SBT in tumor progression and its relationship to ovarian serous carcinoma...
  25. ncbi request reprint Nuclear size distinguishes low- from high-grade ovarian serous carcinoma and predicts outcome
    Chih Yi Hsu
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Hum Pathol 36:1049-54. 2005
    ..In addition, MNA is an independent prognostic factor for high-grade serous carcinoma...
  26. ncbi request reprint Cyclin E and p16 immunoreactivity in epithelioid trophoblastic tumor--an aid in differential diagnosis
    Tsui Lien Mao
    Departments of Pathology and Gynecology and Obstetrics, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Am J Surg Pathol 30:1105-10. 2006
    ..The majority of other types of trophoblastic lesions showed diffuse and intense nuclear immunoreactivity for cyclin E whereas none were positive for p16...
  27. ncbi request reprint Noninvasive and invasive micropapillary (low-grade) serous carcinoma of the ovary: a clinicopathologic analysis of 135 cases
    Ann E Smith Sehdev
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Am J Surg Pathol 27:725-36. 2003
    ..The findings provide further support for the hypothesis that there are distinct pathways of carcinogenesis for low-grade and high-grade serous carcinoma of the ovary...
  28. ncbi request reprint p63 expression is useful in the distinction of epithelioid trophoblastic and placental site trophoblastic tumors by profiling trophoblastic subpopulations
    I Ming Shih
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Am J Surg Pathol 28:1177-83. 2004
    ..Recognizing these distinctive expression patterns helps to further elucidate the biology of trophoblast and can also provide a useful tool for the differential diagnosis of trophoblastic lesions...
  29. ncbi request reprint The Role of E-cadherin in the Motility and Invasion of Implantation Site Intermediate Trophoblast
    Ie Ming Shih
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA
    Placenta 23:706-15. 2002
    ....
  30. ncbi request reprint The relationship of glands to thick-wall blood vessels as a marker of invasion in endocervical adenocarcinoma
    Darren T Wheeler
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Int J Gynecol Pathol 24:125-30. 2005
    ..This feature, in combination with certain glandular growth patterns and cytologic atypia, can be highly suggestive, if not diagnostic, of invasive carcinoma...
  31. ncbi request reprint Endocervical adenocarcinomas with ovarian metastases: analysis of 29 cases with emphasis on minimally invasive cervical tumors and the ability of the metastases to simulate primary ovarian neoplasms
    Brigitte M Ronnett
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Am J Surg Pathol 32:1835-53. 2008
    ....
  32. ncbi request reprint Micropapillary serous carcinoma of the ovary has distinct patterns of chromosomal imbalances by comparative genomic hybridization compared with atypical proliferative serous tumors and serous carcinomas
    Annette Staebler
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Hum Pathol 33:47-59. 2002
    ..Other cases of MPSC with independent genetic alterations may represent another subset of tumors that are a distinct entity from APST and SC...
  33. ncbi request reprint Molecular basis of gestational trophoblastic diseases
    Ie Ming Shih
    Department of Pathology, Johns Hopkins Medical Institution, Baltimore, Maryland 21287 6917, USA
    Curr Mol Med 2:1-12. 2002
    ..This review will focus on these advances with special emphasis on the pathogenesis of each specific form of GTD. In addition, the morphology and clinical behavior of each of these entities will be briefly discussed...
  34. pmc Ovarian low-grade and high-grade serous carcinoma: pathogenesis, clinicopathologic and molecular biologic features, and diagnostic problems
    Russell Vang
    Department of Pathology Division of Gynecologic Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Adv Anat Pathol 16:267-82. 2009
    ..This review provides an update on the pathogenesis and clinicopathologic features of these 2 types of serous carcinomas and addresses some of the diagnostic problems that are encountered in routine practice...
  35. pmc Low-grade serous carcinoma of the ovary displaying a macropapillary pattern of invasion
    Anna Yemelyanova
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Am J Surg Pathol 32:1800-6. 2008
    ..The recognition of this pattern is important, especially in cases when a tumor is composed entirely of macropapillae...
  36. doi request reprint Subdividing ovarian and peritoneal serous carcinoma into moderately differentiated and poorly differentiated does not have biologic validity based on molecular genetic and in vitro drug resistance data
    Russell Vang
    Department of Pathology, Division of Gynecologic Pathology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21231, USA
    Am J Surg Pathol 32:1667-74. 2008
    ..Accordingly, they can be simply classified as high-grade serous carcinoma...
  37. pmc Early detection and treatment of ovarian cancer: shifting from early stage to minimal volume of disease based on a new model of carcinogenesis
    Robert J Kurman
    Department of Pathology, Bloomberg School of Public Health, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Am J Obstet Gynecol 198:351-6. 2008
    ..A more rational approach to early detection of ovarian cancer should focus on low volume rather than low stage of disease...
  38. pmc Distinct DNA methylation profiles in ovarian serous neoplasms and their implications in ovarian carcinogenesis
    Ie Ming Shih
    Division of Gynecologic Pathology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Am J Obstet Gynecol 203:584.e1-22. 2010
    ..The purpose of this study was to analyze DNA methylation profiles among different types of ovarian serous neoplasm, which is a task that has not been performed...
  39. ncbi request reprint Refined diagnostic criteria for implants associated with ovarian atypical proliferative serous tumors (borderline) and micropapillary serous carcinomas
    K A Bell
    Department of Pathology, Division of Gynecologic Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21231, USA
    Am J Surg Pathol 25:419-32. 2001
    ..Accordingly, we propose that these extraovarian lesions be designated "well-differentiated serous carcinoma."..
  40. ncbi request reprint Generation of type-specific probes for the detection of single-copy human papillomavirus by a novel in situ hybridization method
    C C Huang
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Mod Pathol 11:971-7. 1998
    ..We concluded that our new method was highly sensitive and could be applied to formalin-fixed, paraffin-embedded clinical material for the detection of HPV...
  41. pmc A serologically identified tumor antigen encoded by a homeobox gene promotes growth of ovarian epithelial cells
    H Naora
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2196, USA
    Proc Natl Acad Sci U S A 98:4060-5. 2001
    ..These results reveal HOXB7 as a tumor antigen whose up-regulated expression could play a significant role in promoting growth and development of ovarian carcinomas...
  42. ncbi request reprint Expression of extracellular matrix proteins in ovarian serous tumors
    Ritu Salani
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Int J Gynecol Pathol 26:141-6. 2007
    ..007). In summary, ovarian carcinomas exhibit up-regulated expression of several extracellular matrix proteins, and syndecan 1 represents a novel tumor-associated marker in ovarian serous carcinomas...
  43. doi request reprint Are all pelvic (nonuterine) serous carcinomas of tubal origin?
    Christopher G Przybycin
    Departments of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Am J Surg Pathol 34:1407-16. 2010
    ....
  44. doi request reprint Increased natural killer cells and decreased regulatory T cells are seen in complex atypical endometrial hyperplasia and well-differentiated carcinoma treated with progestins
    Agnieszka K Witkiewicz
    Department of Pathology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Hum Pathol 41:26-32. 2010
    ..These results suggest that progestin treatment affects subpopulations of lymphocytes in the endometrium and may induce immune suppression of complex atypical hyperplasia and well-differentiated endometrial carcinoma...
  45. pmc Trophoblastic neoplasms express fatty acid synthase, which may be a therapeutic target via its inhibitor C93
    Stefanie M Ueda
    Kelly Gynecologic Oncology Service, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Am J Pathol 175:2618-24. 2009
    ..FASN inhibitors such as C93 warrant further investigation as targeted therapeutic agents for metastatic and chemoresistant gestational trophoblastic neoplasia...
  46. ncbi request reprint Detection and quantitation of human papillomavirus DNA in the plasma of patients with cervical carcinoma
    Seung Myung Dong
    Department of Otolaryngology Head and Neck Surgery, Head and Neck Cancer Research Division, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 11:3-6. 2002
    ..It remains to be demonstrated whether quantitative PCR analysis of HPV DNA in plasma may have utility in patients at high risk of recurrent disease...
  47. ncbi request reprint Cervical adenoid basal tumors comprised of adenoid basal epithelioma associated with various types of invasive carcinoma: clinicopathologic features, human papillomavirus DNA detection, and P16 expression
    Anil V Parwani
    Department of Pathology, The Johns Hopkins University School of Medicine and Hospital, Baltimore, MD 21231, USA
    Hum Pathol 36:82-90. 2005
    ..The invasive component is usually evident in the excisional biopsy specimen, allowing for recognition of a tumor that needs further management...
  48. ncbi request reprint Patterns of p53 mutations separate ovarian serous borderline tumors and low- and high-grade carcinomas and provide support for a new model of ovarian carcinogenesis: a mutational analysis with immunohistochemical correlation
    Gad Singer
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Am J Surg Pathol 29:218-24. 2005
    ....
  49. ncbi request reprint Primary and metastatic mucinous adenocarcinomas in the ovaries: incidence in routine practice with a new approach to improve intraoperative diagnosis
    Jeffrey D Seidman
    Department of Pathology, Washington Hospital Center, Washington, DC 20010, USA
    Am J Surg Pathol 27:985-93. 2003
    ..After careful exclusion of noninvasive, microinvasive, and metastatic tumors, pure mucinous adenocarcinoma primary in the ovary appears to be substantially less common than previously reported...
  50. pmc Molecular genetic analysis of placental site trophoblastic tumors and epithelioid trophoblastic tumors confirms their trophoblastic origin
    Robert J Oldt
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Am J Pathol 161:1033-7. 2002
    ..This study provides the first molecular evidence that placental site trophoblastic tumors and epithelioid trophoblastic tumors are of fetal (trophoblastic) origin...
  51. ncbi request reprint Salpingitis, salpingoliths, and serous tumors of the ovaries: is there a connection?
    Jeffrey D Seidman
    Department of Pathology, Washington Hospital Center, Washington, DC 20010, USA
    Int J Gynecol Pathol 21:101-7. 2002
    ..In addition, the high frequency of salpingitis in women with endometriosis may be related to the mechanism of endometriosis-associated infertility...
  52. ncbi request reprint Cytokeratins 7 and 20, Dpc4, and MUC5AC in the distinction of metastatic mucinous carcinomas in the ovary from primary ovarian mucinous tumors: Dpc4 assists in identifying metastatic pancreatic carcinomas
    Hongxiu Ji
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore 21231, USA
    Int J Gynecol Pathol 21:391-400. 2002
    ..Loss of Dpc4 expression is useful for distinguishing metastatic pancreatic carcinomas in the ovary from both primary ovarian mucinous tumors and metastatic mucinous carcinomas derived from other sites...
  53. ncbi request reprint Antigen-specific cancer immunotherapy using a GM-CSF secreting allogeneic tumor cell-based vaccine
    E Y Chang
    Department of Pathology, School of Medicine, The Johns Hopkins University, Baltimore, Maryland, USA
    Int J Cancer 86:725-30. 2000
    ....
  54. ncbi request reprint Patients with pseudomyxoma peritonei associated with disseminated peritoneal adenomucinosis have a significantly more favorable prognosis than patients with peritoneal mucinous carcinomatosis
    B M Ronnett
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21231, USA
    Cancer 92:85-91. 2001
    ..A recent study reported a pathologic classification that separated patients into prognostically distinct groups, but the follow-up was relatively short...
  55. ncbi request reprint A new Mel-CAM (CD146)-specific monoclonal antibody, MN-4, on paraffin-embedded tissue
    I M Shih
    Department of Pathology, The Johns Hopkins Medical Institution, Baltimore, Maryland, USA
    Mod Pathol 11:1098-106. 1998
    ..This antibody is useful in retrospective studies of Mel-CAM expression in archival tissue sections and might provide a diagnostic and prognostic marker for human neoplasms...
  56. ncbi request reprint The distribution of low and high-risk HPV types in vulvar and vaginal intraepithelial neoplasia (VIN and VaIN)
    Monica Srodon
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Am J Surg Pathol 30:1513-8. 2006
    ..Finally, comparison of the distribution of HPV in the vagina and vulva suggests that VaIN is more closely related to cervical intraepithelial neoplasia than to VIN...
  57. ncbi request reprint Amplicon profiles in ovarian serous carcinomas
    Kentaro Nakayama
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Int J Cancer 120:2613-7. 2007
    ..Taken together, our results provide the first comprehensive analysis of DNA copy number changes in highly pure ovarian serous carcinoma. These findings may have important biological and clinical implications...
  58. ncbi request reprint Lack of expression of c-kit protein (CD117) in mesenchymal tumors of the uterus and ovary
    Walter M Klein
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Int J Gynecol Pathol 22:181-4. 2003
    ..Therefore, it is unlikely that patients with these tumors will benefit from treatment with the currently available tyrosine kinase inhibitors...
  59. ncbi request reprint Pathology of borderline (low malignant potential) ovarian tumours
    Jeffrey D Seidman
    Department of Pathology, Washington Hospital Center, Washington, DC 20010, USA
    Best Pract Res Clin Obstet Gynaecol 16:499-512. 2002
    ..The remaining mucinous borderline tumours are always confined to the ovaries and have a benign behaviour. Since borderline tumours can now be classified into benign and malignant types, the category has no further utility...
  60. ncbi request reprint CD10 imunostaining does not distinguish endometrial carcinoma invading myometrium from carcinoma involving adenomyosis
    Monica Srodon
    Department of Pathology, John Hopkins Medical Institutions, Baltimore, Maryland 21231 2410, USA
    Am J Surg Pathol 27:786-9. 2003
    ....
  61. ncbi request reprint Mutational analysis of K-ras segregates ovarian serous carcinomas into two types: invasive MPSC (low-grade tumor) and conventional serous carcinoma (high-grade tumor)
    Gad Singer
    Department of Pathology, The Johns Hopkins University School of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Int J Gynecol Pathol 22:37-41. 2003
    ..The results indicate that CSCs with micropapillary features are not derived from invasive MPSCs. The molecular findings also support the view that ovarian serous carcinomas should be graded as low- and high-grade tumors...
  62. pmc A BTB/POZ protein, NAC-1, is related to tumor recurrence and is essential for tumor growth and survival
    Kentaro Nakayama
    Department of Pathology, Johns Hopkins Medical Institutions, 1550 Orleans Street, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 103:18739-44. 2006
    ....
  63. ncbi request reprint Intrauterine progesterone treatment of early endometrial cancer
    Fredrick J Montz
    Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins Hospital and Medical Institutions, Baltimore, MD 21287, USA
    Am J Obstet Gynecol 186:651-7. 2002
    ....
  64. ncbi request reprint Inactivation of the mitogen-activated protein kinase pathway as a potential target-based therapy in ovarian serous tumors with KRAS or BRAF mutations
    Gudrun Pohl
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Cancer Res 65:1994-2000. 2005
    ....
  65. ncbi request reprint Serous borderline (low malignant potential, atypical proliferative) ovarian tumors: workshop perspectives
    Debra A Bell
    Department of Pathology, Massachusetts General Hospital, Boston 02114 2696, USA
    Hum Pathol 35:934-48. 2004
    ....
  66. pmc Ovarian tumorigenesis: a proposed model based on morphological and molecular genetic analysis
    Ie Ming Shih
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Pathol 164:1511-8. 2004
    ..This model of carcinogenesis reconciles the relationship of borderline tumors to invasive carcinoma and provides a morphological and molecular framework for studies aimed at elucidating the pathogenesis of ovarian cancer...
  67. ncbi request reprint Interobserver and intraobserver variability of a two-tier system for grading ovarian serous carcinoma
    Anais Malpica
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Surg Pathol 31:1168-74. 2007
    ....
  68. ncbi request reprint Shortened telomeres in serous tubal intraepithelial carcinoma: an early event in ovarian high-grade serous carcinogenesis
    Elisabetta Kuhn
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Am J Surg Pathol 34:829-36. 2010
    ....
  69. ncbi request reprint Pathology of ovarian carcinoma
    Jeffrey D Seidman
    Department of Pathology, Washington Hospital Center, 110 Irving Street, Northwest, Washington, DC 20010, USA
    Hematol Oncol Clin North Am 17:909-25, vii. 2003
    ..Micropapillary serous carcinomas (a less common variant, also called serous borderline tumor with a micropapillary pattern) and tumors with invasive implants behave similar to low-grade invasive carcinomas...
  70. pmc Serous tubal intraepithelial carcinoma upregulates markers associated with high-grade serous carcinomas including Rsf-1 (HBXAP), cyclin E and fatty acid synthase
    Ann Smith Sehdev
    Department of Pathology, Legacy Health Systems, Portland, OR, USA
    Mod Pathol 23:844-55. 2010
    ..In contrast, mucin-4 immunoreactivity either did not change or was reduced in most STICs. These results suggest that overexpression of Rsf-1, cyclin E and FASN occurs early in tumor progression...
  71. pmc Diverse tumorigenic pathways in ovarian serous carcinoma
    Gad Singer
    Department of Pathology, The Johns HopkinsUniversity School of Medicine, Baltimore, Maryland, USA
    Am J Pathol 160:1223-8. 2002
    ..The other pathway is characterized by rapid progression from the ovarian surface epithelium or inclusion cysts to a conventional (high-grade) serous carcinoma...
  72. ncbi request reprint Detection of Chlamydia trachomatis DNA in archival paraffinized specimens from chronic salpingitis cases using the polymerase chain reaction
    E L Hinton
    Greater Baltimore Medical Center, Maryland, USA
    Fertil Steril 74:152-7. 2000
    ..To identify Chlamydia trachomatis by the polymerase chain reaction (PCR) in fallopian tube tissues with chronic salpingitis...
  73. ncbi request reprint The pathology of intermediate trophoblastic tumors and tumor-like lesions
    I M Shih
    Division of Gynecologic Pathology, Department of Pathology and Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Int J Gynecol Pathol 20:31-47. 2001
    ..Correct diagnosis is important because each of these lesions may require different therapeutic approaches...
  74. ncbi request reprint Decreased progesterone receptor expression in the intermediate trophoblastic cells of spontaneous abortions
    Timothy N Hickman
    Department of Gynecology and Obstetrics, Division of Reproductive Endocrinology and Infertility, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Fertil Steril 77:1001-5. 2002
    ..To determine whether there are differences in the expression of progesterone receptor (PR) in intermediate trophoblastic cells of pregnancies ending in either spontaneous abortion (SAB) or elective abortion...
  75. ncbi request reprint Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma
    Gad Singer
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    J Natl Cancer Inst 95:484-6. 2003
    ..The apparent restriction of these BRAF and KRAS mutations to low-grade serous ovarian carcinoma and its precursors suggests that low-grade and high-grade ovarian serous carcinomas develop through independent pathways...
  76. ncbi request reprint Expression of Rsf-1, a chromatin-remodeling gene, in ovarian and breast carcinoma
    Tsui Lien Mao
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Hum Pathol 37:1169-75. 2006
    ..Because Rsf-1 overexpression occurs in only a small number of breast carcinomas, it is unlikely that Rsf-1 is a critical gene in the development of breast carcinoma...
  77. ncbi request reprint Detection of allelic imbalance in ascitic supernatant by digital single nucleotide polymorphism analysis
    Hsueh Wei Chang
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Clin Cancer Res 8:2580-5. 2002
    ..In this study we determined the presence of allelic imbalance (AI) in tumor-released DNA in ascitic supernatant by directly counting the alleles using a newly developed technology, digital single nucleotide polymorphism (SNP) analysis...
  78. ncbi request reprint HLA-G expression in effusions is a possible marker of tumor susceptibility to chemotherapy in ovarian carcinoma
    Ben Davidson
    Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Montebello N 0310 Oslo, Norway
    Gynecol Oncol 96:42-7. 2005
    ..The objective of this study was to evaluate the expression and clinical role of HLA-G in effusions and corresponding solid tumors from patients diagnosed with advanced-stage ovarian carcinoma...
  79. ncbi request reprint Obesity as a potential risk factor for adenocarcinomas and squamous cell carcinomas of the uterine cervix
    James V Lacey
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20852, USA
    Cancer 98:814-21. 2003
    ..The authors evaluated whether obesity, which can influence hormone levels, was associated with adenocarcinoma and squamous cell carcinoma...
  80. ncbi request reprint The histologic type and stage distribution of ovarian carcinomas of surface epithelial origin
    Jeffrey D Seidman
    Department of Pathology, Washington Hospital Center, Washington, DC 20010, USA
    Int J Gynecol Pathol 23:41-4. 2004
    ....
  81. pmc Amplification of a chromatin remodeling gene, Rsf-1/HBXAP, in ovarian carcinoma
    Ie Ming Shih
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 102:14004-9. 2005
    ..Furthermore, Rsf-1 gene knockdown inhibited cell growth in OVCAR3 cells, which harbor Rsf-1 amplification. Taken together, these findings indicate an important role of Rsf-1 amplification in ovarian cancer...
  82. ncbi request reprint Lipomatous variant of angiomyofibroblastoma: report of two cases and review of the literature
    Dengfeng Cao
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Int J Gynecol Pathol 24:196-200. 2005
    ....
  83. ncbi request reprint Neonatal estrogenic exposure suppresses PTEN-related endometrial carcinogenesis in recombinant mice
    Monjura Begum
    Department of Reproductive Medicine and Surgery, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Honjo, Kumamoto City, Kumamoto, Japan
    Lab Invest 86:286-96. 2006
    ..These findings provide new insight into the interaction between endometrial epithelium and stroma in endometrial carcinogenesis in vivo...
  84. ncbi request reprint Homozygous deletion of MKK4 in ovarian serous carcinoma
    Kentaro Nakayama
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Cancer Biol Ther 5:630-4. 2006
    ..These findings suggest that homozygous deletion or reduced expression of MKK4 may contribute to the development of ovarian serous carcinoma...
  85. ncbi request reprint Pathological characteristics of cervical adenocarcinoma in a multi-center US-based study
    Sophia S Wang
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Bethesda, MD 20852 7234, USA
    Gynecol Oncol 103:541-6. 2006
    ..We report a detailed pathology review of cervical adenocarcinoma subtypes, comparing growth patterns and appearance of non-neoplastic epithelium to inform possible clues for disease progression and early detection...
  86. ncbi request reprint Sequence mutations and amplification of PIK3CA and AKT2 genes in purified ovarian serous neoplasms
    Kentaro Nakayama
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Cancer Biol Ther 5:779-85. 2006
    ....
  87. ncbi request reprint Treatment of micropapillary serous ovarian carcinoma (the aggressive variant of serous borderline tumors)
    Jeffrey D Seidman
    Cancer 95:675-6. 2002
  88. ncbi request reprint Notch3 gene amplification in ovarian cancer
    Joon T Park
    Department of Gynecology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Cancer Res 66:6312-8. 2006
    ..These results indicate that Notch3 is required for proliferation and survival of Notch3-amplified tumors and inactivation of Notch3 can be a potential therapeutic approach for ovarian carcinomas...
  89. ncbi request reprint p16INK4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia
    RĂ¼diger Klaes
    Division of Molecular Pathology, Department of Pathology, University of Heidelberg, Germany
    Am J Surg Pathol 26:1389-99. 2002
    ..Thus, p16 immunohistochemistry can reduce false-negative and false-positive biopsy interpretation and thereby significantly improve cervical (pre)-cancer diagnosis...
  90. ncbi request reprint Calretinin, a more sensitive but less specific marker than alpha-inhibin for ovarian sex cord-stromal neoplasms: an immunohistochemical study of 215 cases
    Saeid Movahedi-Lankarani
    Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland 21231, USA
    Am J Surg Pathol 26:1477-83. 2002
    ..The high frequency of calretinin in fibrous neoplasms suggests that a subgroup of these neoplasms may be derived from specialized gonadal stromal cells, perhaps thecal cells...
  91. ncbi request reprint Assessment of plasma DNA levels, allelic imbalance, and CA 125 as diagnostic tests for cancer
    Hsueh Wei Chang
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    J Natl Cancer Inst 94:1697-703. 2002
    ..AI can be detected in genomic tumor DNA released into the blood after necrosis or apoptosis. We evaluated plasma DNA concentration, allelic status in plasma DNA, and serum CA 125 level as screening tests for ovarian and other cancers...

Research Grants4

  1. Pathogenesis of Ovarian Serous Borderline Tumors
    Robert Kurman; Fiscal Year: 2007
    ..This will refine diagnostic and prognostic markers of advanced stage tumors. These results will be expected to have a significant impact on the clinical management of patients with this disease. ..
  2. Pathogenesis of Ovarian Serous Borderline Tumors
    Robert J Kurman; Fiscal Year: 2010
    ..This will refine diagnostic and prognostic markers of advanced stage tumors. These results will be expected to have a significant impact on the clinical management of patients with this disease. ..
  3. Pathogenesis of Ovarian Serous Borderline Tumors
    Robert Kurman; Fiscal Year: 2009
    ..This will refine diagnostic and prognostic markers of advanced stage tumors. These results will be expected to have a significant impact on the clinical management of patients with this disease. ..