Prakash Kulkarni

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Cancer: tilting at windmills?
    Prakash Kulkarni
    Department of Urology, The Johns Hopkins University School of Medicine, 600 N Wolfe St, 105B Marburg, 21287, Baltimore, MD, USA
    Mol Cancer 12:108. 2013
  2. pmc Cancer/testis antigens and urological malignancies
    Prakash Kulkarni
    James Buchanan Brady Urological Institute, 600 North Wolfe Street, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Nat Rev Urol 9:386-96. 2012
  3. pmc Protein folding and the order/disorder paradox
    Prakash Kulkarni
    Department of Urology, James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Cell Biochem 112:1949-52. 2011
  4. doi request reprint Stress-response protein RBM3 attenuates the stem-like properties of prostate cancer cells by interfering with CD44 variant splicing
    Yu Zeng
    The James Buchanan Brady Urological Institute, Baltimore, Maryland, USA
    Cancer Res 73:4123-33. 2013
  5. pmc Cancer/Testis Antigens as potential predictors of biochemical recurrence of prostate cancer following radical prostatectomy
    Takumi Shiraishi
    James Buchanan Brady Urological Institute, Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Transl Med 9:153. 2011
  6. pmc Cancer/testis antigens: novel tools for discerning aggressive and non-aggressive prostate cancer
    Takumi Shiraishi
    Department of Urology, James Buchanan Brady Urological Institute, Baltimore, MD 21287, USA
    Asian J Androl 14:400-4. 2012
  7. pmc Cyr61 is regulated by cAMP-dependent protein kinase with serum levels correlating with prostate cancer aggressiveness
    Naoki Terada
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Prostate 72:966-76. 2012
  8. pmc A majority of the cancer/testis antigens are intrinsically disordered proteins
    Krithika Rajagopalan
    Department of Urology, James Buchanan Brady Urological Institute, Baltimore, MD 21287, USA
    J Cell Biochem 112:3256-67. 2011
  9. pmc The cancer/testis antigen prostate-associated gene 4 (PAGE4) is a highly intrinsically disordered protein
    Yu Zeng
    Department of Urology, James Buchanan Brady Urological Institute and the George O Brien Urology Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Biol Chem 286:13985-94. 2011
  10. pmc Derepression of Cancer/testis antigens in cancer is associated with distinct patterns of DNA hypomethylation
    Robert Kim
    James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    BMC Cancer 13:144. 2013

Collaborators

  • Jun Luo
  • Robert Kim
  • Ellen Shapiro
  • Rahul V Kulkarni
  • Bo Yin
  • Dong Gao
  • Sridhar Hannenhalli
  • Fan Yang
  • Takumi Shiraishi
  • Robert H Getzenberg
  • Yu Zeng
  • Naoki Terada
  • Steven M Mooney
  • Krithika Rajagopalan
  • Takahito Suyama
  • Fozia Ahmed
  • Youqiang Li
  • Robert L Vessella
  • Nehal Parekh
  • KEITH R WENINGER
  • Shweta Rao
  • Ruoyi Qiu
  • Elizabeth Sacho
  • Hongying Huang
  • Dana Wodzenski
  • Chuize Kong
  • Donald J Vander Griend
  • David B Yeater
  • Leslie A Mangold
  • Alan W Partin
  • Christhunesa S Christudass
  • Brenten H Williams
  • Bruce Trock
  • John Orban
  • Yanan He
  • Wayne Yu

Detail Information

Publications15

  1. pmc Cancer: tilting at windmills?
    Prakash Kulkarni
    Department of Urology, The Johns Hopkins University School of Medicine, 600 N Wolfe St, 105B Marburg, 21287, Baltimore, MD, USA
    Mol Cancer 12:108. 2013
    ..We highlight the potential role of intrinsically disordered proteins (IDPs) and submit that targeting IDPs can lead to new insights and treatment protocols for cancer. ..
  2. pmc Cancer/testis antigens and urological malignancies
    Prakash Kulkarni
    James Buchanan Brady Urological Institute, 600 North Wolfe Street, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Nat Rev Urol 9:386-96. 2012
    ..Increasing evidence supports the utilization of these promising tools for urological indications...
  3. pmc Protein folding and the order/disorder paradox
    Prakash Kulkarni
    Department of Urology, James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Cell Biochem 112:1949-52. 2011
    ....
  4. doi request reprint Stress-response protein RBM3 attenuates the stem-like properties of prostate cancer cells by interfering with CD44 variant splicing
    Yu Zeng
    The James Buchanan Brady Urological Institute, Baltimore, Maryland, USA
    Cancer Res 73:4123-33. 2013
    ..Our work uncovers a hitherto unappreciated role of RBM3 in linking stress-regulated RNA splicing to tumorigenesis, with potential prognostic and therapeutic implications in prostate cancer...
  5. pmc Cancer/Testis Antigens as potential predictors of biochemical recurrence of prostate cancer following radical prostatectomy
    Takumi Shiraishi
    James Buchanan Brady Urological Institute, Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Transl Med 9:153. 2011
    ..The aim of this study was to identify promising CTAs that are associated with prostate cancer (PCa) recurrence following radical prostatectomy (RP)...
  6. pmc Cancer/testis antigens: novel tools for discerning aggressive and non-aggressive prostate cancer
    Takumi Shiraishi
    Department of Urology, James Buchanan Brady Urological Institute, Baltimore, MD 21287, USA
    Asian J Androl 14:400-4. 2012
    ..Here, we review recent developments that demonstrate the potential of the CTAs as biomarkers to discern the aggressive phenotype of prostate cancer...
  7. pmc Cyr61 is regulated by cAMP-dependent protein kinase with serum levels correlating with prostate cancer aggressiveness
    Naoki Terada
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Prostate 72:966-76. 2012
    ..Furthermore, we also explore the potential mechanism underlying the changes in Cyr61 expression during PCa progression...
  8. pmc A majority of the cancer/testis antigens are intrinsically disordered proteins
    Krithika Rajagopalan
    Department of Urology, James Buchanan Brady Urological Institute, Baltimore, MD 21287, USA
    J Cell Biochem 112:3256-67. 2011
    ..Identifying the CTAs that occupy hub positions in protein regulatory networks would allow a better understanding of their functions as well as the development of novel therapeutics to treat cancer...
  9. pmc The cancer/testis antigen prostate-associated gene 4 (PAGE4) is a highly intrinsically disordered protein
    Yu Zeng
    Department of Urology, James Buchanan Brady Urological Institute and the George O Brien Urology Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Biol Chem 286:13985-94. 2011
    ..Furthermore, overexpressing PAGE4 protected cells from stress-induced death. To our knowledge, PAGE4 is the first example of a CTA that is an IDP with an anti-apoptotic function...
  10. pmc Derepression of Cancer/testis antigens in cancer is associated with distinct patterns of DNA hypomethylation
    Robert Kim
    James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    BMC Cancer 13:144. 2013
    ..Regardless however, the mechanism(s) underlying their selective derepression and stage-specific expression in cancer remain poorly understood, although promoter DNA demethylation is believed to be the major driver...
  11. doi request reprint Creatine kinase brain overexpression protects colorectal cells from various metabolic and non-metabolic stresses
    Steven M Mooney
    Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Cell Biochem 112:1066-75. 2011
    ..Taken together, these data demonstrate that the downregulation of CKB may play an important role in colon cancer progression by promoting EMT...
  12. doi request reprint The Stress-response protein prostate-associated gene 4, interacts with c-Jun and potentiates its transactivation
    Krithika Rajagopalan
    Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Biochim Biophys Acta 1842:154-63. 2014
    ..To our knowledge, this is the first report demonstrating crosstalk between a CTA and a proto-oncogene. Disrupting PAGE4/c-Jun interactions using small molecules may represent a novel therapeutic strategy for PCa. ..
  13. pmc Cyr61 is a potential prognostic marker for prostate cancer
    Naoki Terada
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Asian J Androl 14:405-8. 2012
    ..Considered together, these results indicate that Cyr61 is a potential and clinically useful tissue, as well as serum-based biomarker for differentiating lethal and non-lethal PCa...
  14. doi request reprint Tumor necrosis factor receptor associated factor-4: an adapter protein overexpressed in metastatic prostate cancer is regulated by microRNA-29a
    Fozia Ahmed
    James Buchanan Brady Urological Institute, Department of Urology, The Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Oncol Rep 30:2963-8. 2013
    ..Considered together, our results suggest that the tumor suppressor microRNA, miR-29a, is one of the regulators of TRAF4 expression in metastatic prostate cancer. ..
  15. doi request reprint Expression of cancer/testis antigens in prostate cancer is associated with disease progression
    Takahito Suyama
    Department of Urology, James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Prostate 70:1778-87. 2010
    ..The cancer/testis antigens (CTAs) are a unique group of proteins normally expressed in germ cells but aberrantly expressed in several types of cancers including prostate cancer (PCa). However, their role in PCa has not been fully explored...