FRANCIS KUHAJDA

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology
    F P Kuhajda
    From the Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Nutrition 16:202-8. 2000
  2. ncbi request reprint FDG-PET for pharmacodynamic assessment of the fatty acid synthase inhibitor C75 in an experimental model of lung cancer
    Jae Sung Lee
    Department of Radiology, Johns Hopkins Medical Institutions, 1550 Orleans Street, 492 CRB II, Baltimore, Maryland 21231, USA
    Pharm Res 24:1202-7. 2007
  3. ncbi request reprint Modulation of carnitine palmitoyltransferase-1 for the treatment of obesity
    Francis P Kuhajda
    The Johns Hopkins University School of Medicine, Department of Pathology, UMB BioPark, Building 1, 800 West Baltimore Street, Suite 150, Baltimore, MD 21201, USA
    Curr Opin Investig Drugs 8:312-7. 2007
  4. ncbi request reprint Fatty acid synthase and cancer: new application of an old pathway
    Francis P Kuhajda
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Cancer Res 66:5977-80. 2006
  5. ncbi request reprint The connections between C75 and obesity drug-target pathways
    Francis P Kuhajda
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Trends Pharmacol Sci 26:541-4. 2005
  6. doi request reprint AMP-activated protein kinase and human cancer: cancer metabolism revisited
    F P Kuhajda
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21201, USA
    Int J Obes (Lond) 32:S36-41. 2008
  7. pmc Synthesis and antitumor activity of an inhibitor of fatty acid synthase
    F P Kuhajda
    Department of Pathology, The Johns Hopkins University School of Medicine, 4940 Eastern Avenue, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 97:3450-4. 2000
  8. pmc C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity
    Jagan N Thupari
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 99:9498-502. 2002
  9. ncbi request reprint Fatty acid synthase inhibition activates AMP-activated protein kinase in SKOV3 human ovarian cancer cells
    Weibo Zhou
    Departments of Pathology, Neuroscience, Neurology, Oncology, and Biological Chemistry, The Johns Hopkins University School of Medicine, USA
    Cancer Res 67:2964-71. 2007
  10. ncbi request reprint Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells
    Weibo Zhou
    Department of Pathology, The Johns Hopkins University School of Medicine, Hopkins Bayview Medical Center, 4940 Eastern Avenue, Baltimore, MD 21205, USA
    Cancer Res 63:7330-7. 2003

Research Grants

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology
    F P Kuhajda
    From the Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Nutrition 16:202-8. 2000
    ..These findings will ultimately enhance our understanding of fatty acids in tumor biology and may provide new diagnostic and therapeutic moieties for patient care...
  2. ncbi request reprint FDG-PET for pharmacodynamic assessment of the fatty acid synthase inhibitor C75 in an experimental model of lung cancer
    Jae Sung Lee
    Department of Radiology, Johns Hopkins Medical Institutions, 1550 Orleans Street, 492 CRB II, Baltimore, Maryland 21231, USA
    Pharm Res 24:1202-7. 2007
    ..The aim of this study was to use positron emission tomography with [(18)F]fluorodeoxyglucose (FDG-PET) to monitor the effects of the FAS inhibitor C75 on tumor glucose metabolism in a rodent model of human A549 lung cancer...
  3. ncbi request reprint Modulation of carnitine palmitoyltransferase-1 for the treatment of obesity
    Francis P Kuhajda
    The Johns Hopkins University School of Medicine, Department of Pathology, UMB BioPark, Building 1, 800 West Baltimore Street, Suite 150, Baltimore, MD 21201, USA
    Curr Opin Investig Drugs 8:312-7. 2007
    ..In this review, key data on both sides of the 'CPT-1 activity balance' as they relate to obesity therapy are discussed...
  4. ncbi request reprint Fatty acid synthase and cancer: new application of an old pathway
    Francis P Kuhajda
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Cancer Res 66:5977-80. 2006
    ..Thus, FAS and fatty acid metabolism in cancer has become a focus for the potential diagnosis and treatment of cancer...
  5. ncbi request reprint The connections between C75 and obesity drug-target pathways
    Francis P Kuhajda
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Trends Pharmacol Sci 26:541-4. 2005
    ..In this article, we discuss the latest data challenging the relationship between fatty acid synthase inhibition and C75-induced anorexia...
  6. doi request reprint AMP-activated protein kinase and human cancer: cancer metabolism revisited
    F P Kuhajda
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21201, USA
    Int J Obes (Lond) 32:S36-41. 2008
    ..Now, AMPK and energy metabolism are linked to the development and maintenance of the malignant phenotype. These findings have led to renewed interest in AMPK and cancer cell metabolism in general as potential targets for cancer therapy...
  7. pmc Synthesis and antitumor activity of an inhibitor of fatty acid synthase
    F P Kuhajda
    Department of Pathology, The Johns Hopkins University School of Medicine, 4940 Eastern Avenue, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 97:3450-4. 2000
    ..This development will enable the in vivo study of FAS inhibition in human cancer and other metabolic diseases...
  8. pmc C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity
    Jagan N Thupari
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 99:9498-502. 2002
    ..The dual action of the C75 class of compounds as fatty acid synthase inhibitors and CPT-1 agonists has therapeutic implications in the treatment of obesity and type II diabetes...
  9. ncbi request reprint Fatty acid synthase inhibition activates AMP-activated protein kinase in SKOV3 human ovarian cancer cells
    Weibo Zhou
    Departments of Pathology, Neuroscience, Neurology, Oncology, and Biological Chemistry, The Johns Hopkins University School of Medicine, USA
    Cancer Res 67:2964-71. 2007
    ..Thus, pharmacologic FAS inhibition selectively activates AMPK in ovarian cancer cells, inducing cytotoxicity while sparing most normal human tissues from the pleiotropic effects of AMPK activation...
  10. ncbi request reprint Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells
    Weibo Zhou
    Department of Pathology, The Johns Hopkins University School of Medicine, Hopkins Bayview Medical Center, 4940 Eastern Avenue, Baltimore, MD 21205, USA
    Cancer Res 63:7330-7. 2003
    ..The continued ability of TOFA to rescue cancer cells from C75 cytotoxicity implies a proapoptotic role for malonyl-CoA independent of CPT-1 that selectively targets cancer cells as they progress into S phase...
  11. ncbi request reprint Selective inhibition of fatty acid synthase for lung cancer treatment
    Hajime Orita
    Department of Pathology and Johns Hopkins Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Clin Cancer Res 13:7139-45. 2007
    ..This study investigated pharmacologic inhibition of FAS using C93, a rationally designed molecule that inhibits FAS activity without affecting fatty acid oxidation in preclinical models of lung cancer...
  12. ncbi request reprint Pharmacological stimulation of brain carnitine palmitoyl-transferase-1 decreases food intake and body weight
    Susan Aja
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Am J Physiol Regul Integr Comp Physiol 294:R352-61. 2008
    ..These results suggest a role for brain CPT-1 in the regulation of energy balance and implicate CPT-1 stimulation as a pharmacological approach to weight loss...
  13. doi request reprint The obesity epidemic: pharmacological challenges
    Stephen R Bloom
    Hammersmith Hospital, Imperial College, London, UK W120NN
    Mol Interv 8:82-98. 2008
    ..These high rates have led to dramatic increases in diseases such as type 2 diabetes, cardiovascular and respiratory diseases, depression, and some forms of cancer...
  14. pmc Intraperitoneal injections of low doses of C75 elicit a behaviorally specific and vagal afferent-independent inhibition of eating in rats
    Abdelhak Mansouri
    Physiology and Behaviour Group, Institute of Animal Sciences, ETH Zurich, Schwerzenbach, Switzerland
    Am J Physiol Regul Integr Comp Physiol 295:R799-805. 2008
    ..We conclude that intraperitoneal injections of low doses of C75 inhibit eating in a behaviorally specific manner and that this effect does not require abdominal vagal afferents...
  15. ncbi request reprint Intracerebroventricular C75 decreases meal frequency and reduces AgRP gene expression in rats
    Susan Aja
    Department of Psychiatry and Behavioural Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Am J Physiol Regul Integr Comp Physiol 291:R148-54. 2006
    ..Overall, the data suggest that gene expression changes leading to altered melanocortin signaling are important for the hypophagic response to intracerebroventricular C75...
  16. ncbi request reprint Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells
    Hui Qin Wang
    Human Genetics Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    Oncogene 24:3574-82. 2005
    ..Collectively, our findings are consistent with a working model in which AKT activation regulates FAS expression, at least in part, whereas FAS activity modulates AKT activation...
  17. ncbi request reprint Expression of FAS within hypothalamic neurons: a model for decreased food intake after C75 treatment
    Eun Kyoung Kim
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Am J Physiol Endocrinol Metab 283:E867-79. 2002
    ..Collectively, these results demonstrate that FAS is present and active in neurons and suggests that C75 may alter food intake via interactions within the arcuate-PVN pathway mediated by NPY...
  18. ncbi request reprint Application of a flexible synthesis of (5R)-thiolactomycin to develop new inhibitors of type I fatty acid synthase
    Jill M McFadden
    Department of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Med Chem 48:946-61. 2005
    ..These studies identify thiolactomycin as a promising template for the development of new selective cancer and obesity treatments...
  19. ncbi request reprint Fatty acid synthase as a tumor marker: its extracellular expression in human breast cancer
    Young Y Wang
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    J Exp Ther Oncol 4:101-10. 2004
    ..In comparison with CA27.29, no correlation between these two tumor markers was found. Thus, the extracellular FAS may serve as a potential diagnostic and prognostic marker...
  20. ncbi request reprint C75 alters central and peripheral gene expression to reduce food intake and increase energy expenditure
    Yajun Tu
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Endocrinology 146:486-93. 2005
    ..The patterns of the changes in central and peripheral gene expression that occur with C75 treatment provide mechanisms to explain the reduced food intake and increased energy expenditure observed with C75...
  21. ncbi request reprint C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism
    Leslie E Landree
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 279:3817-27. 2004
    ..These data demonstrate that C75 modulates the levels of energy intermediates, thus, affecting the energy sensor AMPK. Similar effects in hypothalamic neurons could form the basis for the effects of C75 on feeding behavior...
  22. ncbi request reprint C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase
    Eun Kyoung Kim
    Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    J Biol Chem 279:19970-6. 2004
    ..These data indicate that modulation of FAS activity in the hypothalamus can alter energy perception via AMPK, which functions as a physiological energy sensor in the hypothalamus...
  23. ncbi request reprint Chronic C75 treatment of diet-induced obese mice increases fat oxidation and reduces food intake to reduce adipose mass
    Jagan N Thupari
    Johns Hopkins Univ School of Medicine, Bldg AA, Rm 154A, 4940 Eastern Ave, Baltimore, MD 21224, USA
    Am J Physiol Endocrinol Metab 287:E97-E104. 2004
    ..Inhibition of FAS and stimulation of CPT I provide a means to achieve stable, sustained weight loss in DIO mice...
  24. doi request reprint Inhibiting fatty acid synthase for chemoprevention of chemically induced lung tumors
    Hajime Orita
    Department of Pathology and Johns Hopkins Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Clin Cancer Res 14:2458-64. 2008
    ..Fatty acid synthase (FAS) is overexpressed in lung cancer, and we have investigated the potential use of FAS inhibitors for chemoprevention of lung cancer...
  25. ncbi request reprint Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice
    Patricia M Alli
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Oncogene 24:39-46. 2005
    ..Moreover, these data identify FAS as a potential novel drug target for breast cancer chemoprevention...
  26. ncbi request reprint A new model ELISA, based on two monoclonal antibodies, for quantification of fatty acid synthase
    Young Y Wang
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    J Immunoassay Immunochem 23:279-92. 2002
    ..In summary, this monoclonal-monoclonal FAS-ELISA is sensitive, accurate, and precise in quantification of fatty acid synthase and has potential as a complementary tool in testing clinical samples...

Research Grants4

  1. STUDIES OF FAS INHIBITION IN HUMAN BREAST CANCER CELLS
    FRANCIS KUHAJDA; Fiscal Year: 2003
    ..These studies will advance our understanding of the action of FAS inhibition, further the development of this pathway for drug development, and likely lead to additional novel therapeutic targets. ..