E H Kossoff

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Decreased relative efficacy of the ketogenic diet for children with surgically approachable epilepsy
    Rebecca S Stainman
    Department of Neurology and Pediatrics, The John M Freeman Pediatric Epilepsy Center, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Seizure 16:615-9. 2007
  2. ncbi request reprint Discontinuing the ketogenic diet in seizure-free children: recurrence and risk factors
    Celina C Martinez
    School of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Epilepsia 48:187-90. 2007
  3. doi request reprint Use of dietary therapy for status epilepticus
    Eric H Kossoff
    John M Freeman Pediatric Epilepsy Center, Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    J Child Neurol 28:1049-51. 2013
  4. doi request reprint Transitioning pediatric patients receiving ketogenic diets for epilepsy into adulthood
    Eric H Kossoff
    Department of Pediatrics, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Seizure 22:487-9. 2013
  5. doi request reprint Nonpharmacological approaches: diet and neurostimulation
    Eric H Kossoff
    John M Freeman Pediatric Epilepsy Center, The Johns Hopkins Hospital, Baltimore, MD, USA Electronic address
    Handb Clin Neurol 111:803-8. 2013
  6. doi request reprint Dietary therapies for epilepsy
    Eric H Kossoff
    Department of Neurology, The Johns Hopkins University, Baltimore, MD 21287, USA
    Biomed J 36:2-8. 2013
  7. doi request reprint Efficacy of dietary therapy for juvenile myoclonic epilepsy
    Eric H Kossoff
    Department of Pediatrics, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Epilepsy Behav 26:162-4. 2013
  8. doi request reprint How do parents find out about the ketogenic diet?
    Eric H Kossoff
    Department of Pediatrics, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Epilepsy Behav 24:445-8. 2012
  9. doi request reprint Ketogenic diets: where do we go from here?
    Eric H Kossoff
    The John M Freeman Pediatric Epilepsy Center, Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Epilepsy Res 100:344-6. 2012
  10. doi request reprint Dietary therapies: a worldwide phenomenon
    Eric H Kossoff
    The John M Freeman Pediatric Epilepsy Center, Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Epilepsy Res 100:205-9. 2012

Detail Information

Publications81

  1. ncbi request reprint Decreased relative efficacy of the ketogenic diet for children with surgically approachable epilepsy
    Rebecca S Stainman
    Department of Neurology and Pediatrics, The John M Freeman Pediatric Epilepsy Center, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Seizure 16:615-9. 2007
    ..In children with intractable, surgically approachable epilepsy, the ketogenic diet is often perceived as less efficacious than surgery...
  2. ncbi request reprint Discontinuing the ketogenic diet in seizure-free children: recurrence and risk factors
    Celina C Martinez
    School of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Epilepsia 48:187-90. 2007
    ..The presence of recent EEG epileptiform activity, abnormal MRI, lower initial seizure frequency, and tuberous sclerosis complex all significantly increased the likelihood of recurrence...
  3. doi request reprint Use of dietary therapy for status epilepticus
    Eric H Kossoff
    John M Freeman Pediatric Epilepsy Center, Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    J Child Neurol 28:1049-51. 2013
    ..Prospective, multicenter studies are under way to help clarify who best will respond, how quickly, and the optimal diet duration after success. ..
  4. doi request reprint Transitioning pediatric patients receiving ketogenic diets for epilepsy into adulthood
    Eric H Kossoff
    Department of Pediatrics, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Seizure 22:487-9. 2013
    ..To examine the process for transitioning adolescents on dietary management for intractable epilepsy to adult neurologic care...
  5. doi request reprint Nonpharmacological approaches: diet and neurostimulation
    Eric H Kossoff
    John M Freeman Pediatric Epilepsy Center, The Johns Hopkins Hospital, Baltimore, MD, USA Electronic address
    Handb Clin Neurol 111:803-8. 2013
    ..However, other treatments such as deep brain stimulation and cortical responsive stimulation (NeuroPace) are under active development...
  6. doi request reprint Dietary therapies for epilepsy
    Eric H Kossoff
    Department of Neurology, The Johns Hopkins University, Baltimore, MD 21287, USA
    Biomed J 36:2-8. 2013
    ..Additionally, neurologists are studying ketogenic diets for conditions other than epilepsy, including Alzheimer's disease, autism, and brain tumors...
  7. doi request reprint Efficacy of dietary therapy for juvenile myoclonic epilepsy
    Eric H Kossoff
    Department of Pediatrics, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Epilepsy Behav 26:162-4. 2013
    ..In this limited experience, the modified Atkins diet was an efficacious adjunctive therapy for young adults with very medically resistant JME...
  8. doi request reprint How do parents find out about the ketogenic diet?
    Eric H Kossoff
    Department of Pediatrics, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Epilepsy Behav 24:445-8. 2012
    ..A score of 10 was more likely seen in those who also scored their pediatrician with 10 (69% vs. 15%, p<0.001) and who were self-referred from our institution (56% vs. 27%, p=0.001)...
  9. doi request reprint Ketogenic diets: where do we go from here?
    Eric H Kossoff
    The John M Freeman Pediatric Epilepsy Center, Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Epilepsy Res 100:344-6. 2012
    ..Clinical researchers, basic scientists, dietitians, and parents discussed their goals and the results are presented in this article...
  10. doi request reprint Dietary therapies: a worldwide phenomenon
    Eric H Kossoff
    The John M Freeman Pediatric Epilepsy Center, Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Epilepsy Res 100:205-9. 2012
    ..Additionally, future clinical and research goals for each area were discussed. This article summarizes these talks and the use of the ketogenic diet worldwide...
  11. doi request reprint Ketogenic diets: new advances for metabolism-based therapies
    Eric H Kossoff
    Departments of Neurology and Pediatrics, The John M Freeman Pediatric Epilepsy Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Curr Opin Neurol 25:173-8. 2012
    ..Many of these patients will now turn to dietary therapies such as the ketogenic diet, medium-chain triglyceride diet, modified Atkins diet, and low glycemic index treatment...
  12. doi request reprint Intractable childhood epilepsy: choosing between the treatments
    Eric H Kossoff
    Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Semin Pediatr Neurol 18:145-9. 2011
    ..In this review and special issue, a practical approach to management options for children who have refractory epilepsy will be presented from experts in the field...
  13. doi request reprint A case-control evaluation of the ketogenic diet versus ACTH for new-onset infantile spasms
    Eric H Kossoff
    Department of Neurology, John M Freeman Pediatric Epilepsy Center, Johns Hopkins Medical Institutes, Baltimore, Maryland 21287 1000, USA
    Epilepsia 49:1504-9. 2008
    ..We hypothesized the ketogenic diet (KD), previously reported as beneficial for intractable infantile spasms, would have similar efficacy, but better tolerability than ACTH when used first-line...
  14. doi request reprint The modified Atkins diet: a potential treatment for developing countries
    Eric H Kossoff
    The Johns Hopkins Medical Institutions, Baltimore, Maryland, U S A
    Epilepsia 49:1646-7. 2008
  15. doi request reprint An infantile-onset, severe, yet sporadic seizure pattern is common in Sturge-Weber syndrome
    Eric H Kossoff
    The Johns Hopkins Hospital, Baltimore, MD 21287 1000, USA
    Epilepsia 50:2154-7. 2009
    ..This seizure pattern appears to be common with SWS and leads to difficult treatment decisions, especially in regard to the timing of potential surgical resection...
  16. ncbi request reprint When do seizures usually improve with the ketogenic diet?
    Eric H Kossoff
    Department of Neurology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Epilepsia 49:329-33. 2008
    ..The purpose of this study was to determine the typical time to seizure reduction as well as the time after which it was unlikely to be helpful in those children started on the KD...
  17. ncbi request reprint A pilot study transitioning children onto levetiracetam monotherapy to improve language dysfunction associated with benign rolandic epilepsy
    Eric H Kossoff
    The Johns Hopkins Hospital, Baltimore, MD, USA
    Epilepsy Behav 11:514-7. 2007
    ..08). Seizures improved in five, decreasing from 2.7 to 1.0 seizure per 6 months (P=0.11). Results from this pilot study suggest that levetiracetam may have a beneficial effect on language in children with BRE...
  18. ncbi request reprint A prospective study of the modified Atkins diet for intractable epilepsy in adults
    Eric H Kossoff
    Department of Neurology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Epilepsia 49:316-9. 2008
    ..The modified Atkins diet has been recently demonstrated to be therapeutic for children without the need for an admission, fasting period, weighing of foods, or fluid, calorie, and protein restriction...
  19. ncbi request reprint Self-reported treatment patterns in patients with Sturge-Weber syndrome and migraines
    Eric H Kossoff
    Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Child Neurol 22:720-6. 2007
    ..The small sample size precludes any safety analysis, however, and future prospective trials of both treatment options are needed...
  20. ncbi request reprint Home-guided use of the ketogenic diet in a patient for more than 20 years
    Eric H Kossoff
    John M Freeman Pediatric Epilepsy Center, Departments of Neurology and Pediatrics, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Pediatr Neurol 36:424-5. 2007
    ..He remains on the diet to date, now for 21 years of continuous duration...
  21. ncbi request reprint A randomized, crossover comparison of daily carbohydrate limits using the modified Atkins diet
    Eric H Kossoff
    The Pediatric Epilepsy Center, Departments of Neurology and Pediatrics, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Epilepsy Behav 10:432-6. 2007
    ..A starting carbohydrate limit of 10 g per day for children starting the modified Atkins diet may be ideal, with a planned increase to a more tolerable 20 g per day after 3 months...
  22. doi request reprint Optimal clinical management of children receiving the ketogenic diet: recommendations of the International Ketogenic Diet Study Group
    Eric H Kossoff
    The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Epilepsia 50:304-17. 2009
    ..This paper highlights recommendations based on best evidence, including areas of agreement and controversy, unanswered questions, and future research...
  23. doi request reprint International consensus statement on clinical implementation of the ketogenic diet: agreement, flexibility, and controversy
    Eric H Kossoff
    The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Epilepsia 49:11-3. 2008
    ..This group effort highlights recommendations based on best evidence, including areas of agreement and controversy, unanswered questions, and future research...
  24. doi request reprint A pilot study of the modified Atkins diet for Sturge-Weber syndrome
    Eric H Kossoff
    The John M Freeman Pediatric Epilepsy Center, Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Epilepsy Res 92:240-3. 2010
    ..Five children aged 4-18 years with SWS and at least monthly intractable seizures were started prospectively on the MAD for 6 months. All children had urinary ketosis and seizure improvement, including 3 with > 50% seizure reduction...
  25. doi request reprint Prospective study of the modified atkins diet in combination with a ketogenic liquid supplement during the initial month
    Eric H Kossoff
    The John M Freeman Pediatric Epilepsy Center, Departments of Neurology and Pediatrics, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Child Neurol 26:147-51. 2011
    ..8:1 versus 1.0:1 in the modified Atkins diet alone, P = .0002), but did not change urinary or serum ketosis. The addition of a ketogenic supplement to the modified Atkins diet during its initial month appears to be beneficial...
  26. doi request reprint Migraine and epilepsy
    Eric H Kossoff
    Johns Hopkins Hospital, Baltimore, MD, USA
    Semin Pediatr Neurol 17:117-22. 2010
    ..Although the abortive agents used are vastly different, the preventative treatments share mostly similarities, and are commonly anticonvulsant drugs...
  27. doi request reprint Infantile spasms
    Eric H Kossoff
    Department of Neurology, The John M Freeman Pediatric Epilepsy Center, The Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Neurologist 16:69-75. 2010
    ..Despite its existence in the literature since 1841, proven therapies are limited because of efficacy, tolerability, at times even availability...
  28. doi request reprint Ketogenic diets: an update for child neurologists
    Eric H Kossoff
    The John M Freeman Pediatric Epilepsy Center, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    J Child Neurol 24:979-88. 2009
    ..Researchers are also highly interested in using diets for neurologic disorders other than epilepsy, including autism and brain tumors. This review will update child neurologists on the recent advances in the use of ketogenic diets...
  29. doi request reprint High-dose oral prednisolone for infantile spasms: an effective and less expensive alternative to ACTH
    Eric H Kossoff
    Department of Neurology, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Epilepsy Behav 14:674-6. 2009
    ..16. Oral prednisolone had fewer adverse effects (53% vs 80%, P=0.10) and was less expensive ($200 vs approximately $70,000) than ACTH. We now routinely recommend oral prednisolone to all families of children with infantile spasms...
  30. doi request reprint Ketogenic diets: evidence for short- and long-term efficacy
    Eric H Kossoff
    John M Freeman Pediatric Epilepsy Center, Department of Neurology, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Neurotherapeutics 6:406-14. 2009
    ..This potential antiepileptogenic activity has been recently demonstrated in some animal studies as well. This review discusses the animal and human evidence for both short- and long-term benefits of dietary therapies...
  31. doi request reprint The modified Atkins diet
    Eric H Kossoff
    The Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Epilepsia 49:37-41. 2008
    ..Lastly, the possible future benefits of this treatment for new-onset seizures, adults, neurologic conditions other than epilepsy, and developing countries of the world will be discussed...
  32. ncbi request reprint Combined ketogenic diet and vagus nerve stimulation: rational polytherapy?
    Eric H Kossoff
    The Johns Hopkins Hospital, Baltimore, Maryland 21287 1000, USA
    Epilepsia 48:77-81. 2007
    ..The concept of "rational polypharmacy" has been associated with anticonvulsant management for decades, but the term has not been applied to nonpharmacologic therapies...
  33. ncbi request reprint Treatment of infantile spasms
    Philip J Overby
    Department of Pediatric Neurology, Johns Hopkins Hospital, 600 North Wolfe Street, Jefferson 123, Baltimore, MD 21287, USA
    Curr Treat Options Neurol 8:457-64. 2006
    ..There is urgent need for further treatment trials comparing anticonvulsants with ACTH and a satisfactory animal model for the study of spasms...
  34. ncbi request reprint Hemispherectomy for intractable unihemispheric epilepsy etiology vs outcome
    E H Kossoff
    Department of Neurology, The Pediatric Epilepsy Center, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Neurology 61:887-90. 2003
    ..A prior case series focused on the outcomes after 58 surgeries at Johns Hopkins Hospital in 1997. This series, and an additional 53 cases, were reviewed to bring the outcomes up to date...
  35. ncbi request reprint Comorbidity of epilepsy and headache in patients with Sturge-Weber syndrome
    Eric H Kossoff
    Department of Neurology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Child Neurol 20:678-82. 2005
    ..Correlations of family history with both age at symptom onset and behavior problems suggest that genetic substrate could be one factor determining the variable neurologic manifestations seen in Sturge-Weber syndrome...
  36. ncbi request reprint Tuberous sclerosis complex and the ketogenic diet
    Eric H Kossoff
    Departments of Neurology and Pediatrics, The John M Freeman Pediatric Epilepsy Center, Johns Hopkins University, Baltimore, MD 212871000, USA
    Epilepsia 46:1684-6. 2005
    ..If medications fail and no clear epileptogenic tuber is identified, nonpharmacologic therapies are often attempted. The use of the ketogenic diet specifically for children with TSC and epilepsy has not been previously described...
  37. ncbi request reprint Efficacy of the Atkins diet as therapy for intractable epilepsy
    Eric H Kossoff
    Department of Neurology, The Johns Hopkins Medical Institutions, Baltimore, MD 21287 1000, USA
    Neurology 61:1789-91. 2003
    ..This provides preliminary evidence that the Atkins diet may have a role as therapy for patients with medically resistant epilepsy...
  38. ncbi request reprint A modified Atkins diet is effective for the treatment of intractable pediatric epilepsy
    Eric H Kossoff
    John M Freeman Pediatric Epilepsy Center, Departments of Neurology and Pediatrics, The Johns Hopkins Medical Institutions, Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MS 21287 1000, U S A
    Epilepsia 47:421-4. 2006
    ..Our objective was to evaluate the efficacy and tolerability of a modified Atkins diet for intractable childhood epilepsy...
  39. ncbi request reprint The impact of early versus late anticonvulsant reduction after ketogenic diet initiation
    Eric H Kossoff
    Pediatric Epilepsy Center, Departments of Neurology and Pediatrics, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Epilepsy Behav 5:499-502. 2004
    ..Early reduction of anticonvulsants in children initiated on the ketogenic diet appears to be safe and well tolerated. However, it offers no specific advantage compared with a later taper...
  40. doi request reprint Will seizure control improve by switching from the modified Atkins diet to the traditional ketogenic diet?
    Eric H Kossoff
    Neurology, The Johns Hopkins University, Baltimore, Maryland, USA
    Epilepsia 51:2496-9. 2010
    ..004), including all who became seizure-free. These results suggest that the KD probably represents a "higher dose" of dietary therapy than the MAD, which may particularly benefit those with myoclonic-astatic epilepsy...
  41. ncbi request reprint More fat and fewer seizures: dietary therapies for epilepsy
    Eric H Kossoff
    The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 1000, USA
    Lancet Neurol 3:415-20. 2004
    ..Dietary therapies may become even more valuable in the therapy of epilepsy when the mechanisms underlying their success are understood...
  42. ncbi request reprint Medication-overuse headache in children: is initial preventive therapy necessary?
    Eric H Kossoff
    Department of Neurology, The John Hopkins Medical Institutions, Baltimore, MD 21287, USA
    J Child Neurol 21:45-8. 2006
    ..Should headaches persist after 1 month, such agents can be added. (J Child Neurol 2006;21:45-48)...
  43. ncbi request reprint Effect of an external responsive neurostimulator on seizures and electrographic discharges during subdural electrode monitoring
    Eric H Kossoff
    Department of Pediatrics and Neurology, Johns Hopkins Hospital, Baltimore, Maryland 21287 1000, USA
    Epilepsia 45:1560-7. 2004
    ..Approved neural-stimulation therapies for epilepsy use prolonged intermittent stimulation paradigms with no ability to respond automatically to seizures...
  44. ncbi request reprint Outcomes of 32 hemispherectomies for Sturge-Weber syndrome worldwide
    Eric H Kossoff
    Pediatric Epilepsy Center, Department of Neurology, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Neurology 59:1735-8. 2002
    ..Epilepsy affects 80% of patients with Sturge-Weber syndrome; the majority of seizures begin before the age of 1. When seizures are intractable to medications and unihemispheric, hemispherectomy is often advised...
  45. ncbi request reprint The postoperative course and management of 106 hemidecortications
    E H Kossoff
    Department of Neurology and Pediatrics, The Pediatric Epilepsy Center, Johns Hopkins Medicla Institutions, Baltimore, MD, USA
    Pediatr Neurosurg 37:298-303. 2002
    ..The purpose of this study was to evaluate the short-term issues surrounding hemispherectomy and their management in a series of patients from our institution...
  46. ncbi request reprint Kidney stones, carbonic anhydrase inhibitors, and the ketogenic diet
    Eric H Kossoff
    The Pediatric Epilepsy Center, Departments of Neurology and Pediatrics, and Division of Pediatric Nephrology, Department of Pediatrics, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 1000, USA
    Epilepsia 43:1168-71. 2002
    ..The objective of this study was to establish the prevalence of nephrolithiasis in children in this combination-therapy population...
  47. ncbi request reprint Neonatal hypocalcemic seizures: case report and literature review
    Eric H Kossoff
    Pediatric Epilepsy, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    J Child Neurol 17:236-9. 2002
    ..This case highlights the clinical course of neonatal hypocalcemic seizures, EEG findings in several cases, and possible mechanisms for both hypocalcemic precipitation of seizures and anticonvulsant ineffectiveness...
  48. ncbi request reprint Efficacy of the ketogenic diet for infantile spasms
    Eric H Kossoff
    Department of Neurology, Pediatric Epilepsy Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Pediatrics 109:780-3. 2002
    ..The objective of this study was to determine whether the ketogenic diet is safe, well-tolerated, and efficacious in the treatment of infantile spasms...
  49. ncbi request reprint Worldwide use of the ketogenic diet
    Eric H Kossoff
    The Pediatric Epilepsy Center, Department of Neurology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 1000, USA
    Epilepsia 46:280-9. 2005
    ..Over the past decade, the use of the ketogenic diet internationally has increased dramatically. The purpose of this survey was to evaluate the use of the diet worldwide...
  50. ncbi request reprint Landau-Kleffner syndrome responsive to levetiracetam
    Eric H Kossoff
    Department of Neurology, The Johns Hopkins Hospital, Jefferson 128, 600 North Wolfe Street, Baltimore, MD 21287 1000, USA
    Epilepsy Behav 4:571-5. 2003
    ..Levetiracetam should be considered as therapy for Landau-Kleffner syndrome...
  51. ncbi request reprint Improvement in alertness and behavior in children treated with combination topiramate and vagus nerve stimulation
    Eric H Kossoff
    Department of Neurology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Epilepsy Behav 5:256-9. 2004
    ..This did not appear to be due solely to seizure reduction, which was observed only differentially at 12 months...
  52. ncbi request reprint The outcome of children with intractable seizures: a 3- to 6-year follow-up of 67 children who remained on the ketogenic diet less than one year
    Elisabeth B Marsh
    John M Freeman Pediatric Epilepsy Center, Departments of Neurology and Pediatrics, The Johns Hopkins Medical Institutions, Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MS 21287 1000, U S A
    Epilepsia 47:425-30. 2006
    ..To determine the long-term outcome of children with difficult-to-control seizures who remained on the ketogenic diet for <1 year...
  53. ncbi request reprint Lack of influence of body mass index on the efficacy of the ketogenic diet
    Rana F Hamdy
    Johns Hopkins University School of Medicine, Hopkins Medical Institutions, Baltimore, MD 21287, USA
    J Child Neurol 22:1167-71. 2007
    ..Attributing changes in seizure control to a rapid weight gain or loss may be unjustified...
  54. ncbi request reprint The ketogenic diet: adolescents can do it, too
    Mackenzie A Mady
    Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Epilepsia 44:847-51. 2003
    ..To determine both the efficacy of and compliance with the ketogenic diet in the adolescent population...
  55. ncbi request reprint Can you predict an immediate, complete, and sustained response to the ketogenic diet?
    Khoi D Than
    The Johns Hopkins University School of Medicine, Department of Neurology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Epilepsia 46:580-2. 2005
    ..Although the ketogenic diet has been in use for >80 years, little agreement exists as to which patients are most likely to have dramatic, sudden, and complete seizure control...
  56. doi request reprint Management and risk factors for dyslipidemia with the ketogenic diet
    Junaid Nizamuddin
    Johns Hopkins University School of Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Child Neurol 23:758-61. 2008
    ..11). Hypercholesterolemia occurs in most children receiving a solid food based ketogenic diet but improved in approximately half, even without interventions...
  57. ncbi request reprint Levetiracetam psychosis in children with epilepsy
    E H Kossoff
    Department of Neurology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 7247, USA
    Epilepsia 42:1611-3. 2001
    ..Observations in children are limited; levetiracetam is not yet approved by the Food and Drug Administration for use in children...
  58. ncbi request reprint Kidney stones and the ketogenic diet: risk factors and prevention
    Amitha Sampath
    School of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Child Neurol 22:375-8. 2007
    ..As oral potassium citrate was preventative, prospective studies using this medication empirically are warranted...
  59. doi request reprint Empiric use of potassium citrate reduces kidney-stone incidence with the ketogenic diet
    Melanie A McNally
    School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Pediatrics 124:e300-4. 2009
    ..Potassium citrate (Polycitra K) is a daily oral supplement that alkalinizes the urine and solubilizes urine calcium, theoretically reducing the risk for kidney stones...
  60. doi request reprint Aicardi syndrome mimicking intrauterine hydrocephalus
    Deivasumathy Muthugovindan
    Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Brain Dev 31:638-40. 2009
    ..Aicardi syndrome most commonly comes to medical attention because of seizures later in infancy...
  61. ncbi request reprint Children with seizures exhibit preferences for foods compatible with the ketogenic diet
    Adrianna Amari
    Department of Behavioral Psychology, The Kennedy Krieger Institute, 707 North Broadway, Baltimore, MD 21205, USA
    Epilepsy Behav 11:98-104. 2007
    ..Research into the underlying metabolic basis for this preference and possible related neurophysiological mechanisms in seizure etiology and treatment is warranted...
  62. pmc Ischemic stroke in children with critical illness: a poor prognostic sign
    Lori C Jordan
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Pediatr Neurol 36:244-6. 2007
    ..Mortality resulted primarily from the underlying illness. Prognosis after stroke is markedly worsened in children with premorbid critical illness...
  63. ncbi request reprint The importance of parental expectations of cognitive improvement for their children with epilepsy prior to starting the ketogenic diet
    Sharifeh Farasat
    Department of Pediatrics, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Epilepsy Behav 8:406-10. 2006
    ..001) and >90% seizure reduction (P=0.04) at 6 months positively correlated with longer eventual diet duration. Expectations for cognitive improvement need to be discussed prior to beginning the ketogenic diet...
  64. doi request reprint Cortical auditory dysfunction in benign rolandic epilepsy
    Dana F Boatman
    Department of Neurology, John Hopkins Hospital, Baltimore 21287, USA
    Epilepsia 49:1018-26. 2008
    ..To evaluate cortical auditory function, including speech recognition, in children with benign rolandic epilepsy (BRE)...
  65. ncbi request reprint The ketogenic diet: one decade later
    John M Freeman
    John M Freeman Pediatric Epilepsy Center, Johns Hopkins Medical Institutions, Baltimore, MD 21287 7247, USA
    Pediatrics 119:535-43. 2007
    ..Finally, this review looks toward possible future uses of the ketogenic diet for conditions other than epilepsy...
  66. doi request reprint A blinded, crossover study of the efficacy of the ketogenic diet
    John M Freeman
    Departments of Neurology and Pediatrics, The John M Freeman Pediatric Epilepsy Center, Baltimore, Maryland, USA
    Epilepsia 50:322-5. 2009
    ..5 seizures per day (p = 0.07). There was no reduction in the number of EEG-identified events, with a median reduction of 7 events per day (p = 0.33). Ketosis was not completely eliminated in the glucose-added arm...
  67. ncbi request reprint Experience in the use of the ketogenic diet as early therapy
    James E Rubenstein
    Department of Neurology, Pediatric Epilepsy Center, Johns Hopkins Medical Institutions, Baltimore, MD 21287 1000, USA
    J Child Neurol 20:31-4. 2005
    ..6). The ketogenic diet can be a valuable therapy before epilepsy becomes intractable. In the 13 patients reported, efficacy without side effects was achieved similarly to that with patients with intractable epilepsy...
  68. ncbi request reprint Myoclonic-astatic epilepsy in a child with Sturge-Weber syndrome
    Joshua B Ewen
    Department of Neurology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Pediatr Neurol 36:115-7. 2007
    ..In such cases, treatment with a broad-spectrum antiepileptic may be advantageous...
  69. ncbi request reprint Quantitative EEG asymmetry correlates with clinical severity in unilateral Sturge-Weber syndrome
    Laura A Hatfield
    Department of Neurology, Kennedy Krieger Institute, Baltimore, MD 21205, USA
    Epilepsia 48:191-5. 2007
    ..SWS results in ischemic brain injury, seizures, and neurologic deficits. We hypothesized that a decrease in quantitative EEG (qEEG) power, on the affected side, correlates with clinical severity in subjects with SWS...
  70. doi request reprint Hemiparesis is a clinical correlate of general adaptive dysfunction in children and adolescents with Sturge-Weber syndrome
    Jennifer Reesman
    Kennedy Krieger Institute, Baltimore, Maryland 21231, USA
    J Child Neurol 24:701-8. 2009
    ..Information obtained during neurological examination of children and adolescents with Sturge-Weber syndrome particularly hemiparetic status is useful for identifying children who may need additional intervention...
  71. ncbi request reprint Secondary intracranial causes for headaches in children
    Rooman Ahad
    Department of Neurology, Division of Pediatric Neurology, Johns Hopkins Hospital, 200 N Wolfe Street, Baltimore, MD 21287, USA
    Curr Pain Headache Rep 12:373-8. 2008
    ..This article discusses these secondary causes of headaches due to primary brain etiologies, focusing on aspects of the history that should lead a neurologist to order neuroimaging or electroencephalographic studies for these children...
  72. ncbi request reprint The ketogenic diet
    Saurabh R Sinha
    Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Neurologist 11:161-70. 2005
    ..This dietary therapy has been enjoying increasing popularity in recent years, despite the availability of increasing numbers of new antiepileptic drugs and surgical treatments...
  73. ncbi request reprint Encephalofacial angiomatosis sparing the occipital lobe and without facial nevus: on the spectrum of Sturge-Weber syndrome variants?
    Anne M Comi
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Child Neurol 18:35-8. 2003
    ..This diagnosis should be considered in any child presenting with seizures or complicated migraines and intracranial calcifications...
  74. ncbi request reprint Long-term use of the ketogenic diet in the treatment of epilepsy
    Darcy K Groesbeck
    The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Dev Med Child Neurol 48:978-81. 2006
    ..Efficacy and overall tolerability for children are maintained after prolonged use of the ketogenic diet. However, side effects, such as slowed growth, kidney stones, and fractures, should be monitored closely...
  75. ncbi request reprint Recurrent hypoglycemic hemiparesis and aphasia in an adolescent patient
    E H Kossoff
    Department of Pediatric Neurology, Johns Hopkins Hospital-Pathology 509, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Pediatr Neurol 24:385-6. 2001
    ..Ten months later, she had a recurrence of the same symptoms, which also resolved rapidly. This potential complication of hypoglycemia is often mistaken for a cerebrovascular accident...
  76. doi request reprint Hemispherectomy-associated complications from the Kids' Inpatient Database
    Mohamad Z Koubeissi
    Department of Neurology, University Hospitals Case Medical Center, Case School of Medicine, Cleveland, OH, USA
    Epilepsy Res 87:47-53. 2009
    ..6% across studies, mostly due to acute hemorrhage. The purpose of this study was to evaluate in-hospital mortality and predictors of the need for blood transfusion during HS in a large, nationwide cohort in recent years...
  77. doi request reprint The influence of concurrent anticonvulsants on the efficacy of the ketogenic diet
    Peter F Morrison
    The Johns Hopkins Hospital, Baltimore, MD 21287 1000, USA
    Epilepsia 50:1999-2001. 2009
    ..04). These results provide practical information to clinicians who are treating children receiving both the KD and anticonvulsants...
  78. ncbi request reprint Benefits of an all-liquid ketogenic diet
    Eric H Kossoff
    Epilepsia 45:1163. 2004
  79. ncbi request reprint The intracerebral administration of phenytoin using controlled-release polymers reduces experimental seizures in rats
    Rafael J Tamargo
    Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Epilepsy Res 48:145-55. 2002
    ....
  80. ncbi request reprint State of the ketogenic diet(s) in epilepsy
    Jennifer Huffman
    Curr Neurol Neurosci Rep 6:332-40. 2006
    ..This review addresses these studies, as well as recent research regarding possible indications for the diet, variations in its initiation, side effect profiles, and the recent use of modified formulations to improve tolerability...
  81. ncbi request reprint Epilepsy surgery for the neurocutaneous disorders
    Adam L Hartman
    Johns Hopkins Medical Institutions, Baltimore, MD 21287 1000, USA
    Semin Pediatr Neurol 13:63-7. 2006
    ..Options for surgical resection range from focal resections (in those with localized disease) to hemispherectomies (in those with hemispheric involvement)...