Scott L Kominsky

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Claudins: emerging targets for cancer therapy
    Scott L Kominsky
    Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, 720 Rutland Ave, Baltimore, MD 21205, USA
    Expert Rev Mol Med 8:1-11. 2006
  2. ncbi request reprint Clostridium perfringens enterotoxin as a novel-targeted therapeutic for brain metastasis
    Scott L Kominsky
    Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cancer Res 67:7977-82. 2007
  3. doi request reprint MMP-13 is over-expressed in renal cell carcinoma bone metastasis and is induced by TGF-beta1
    Scott L Kominsky
    Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross Building, Room 209, Baltimore, MD 21205, USA
    Clin Exp Metastasis 25:865-70. 2008
  4. doi request reprint Macrophage inflammatory protein-1 delta: a novel osteoclast stimulating factor secreted by renal cell carcinoma bone metastasis
    Scott L Kominsky
    Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cancer Res 68:1261-6. 2008
  5. doi request reprint Identification of prospective factors promoting osteotropism in breast cancer: a potential role for CITED2
    Wen Min Lau
    Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Int J Cancer 126:876-84. 2010
  6. ncbi request reprint TGF-beta promotes the establishment of renal cell carcinoma bone metastasis
    Scott L Kominsky
    Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Bone Miner Res 22:37-44. 2007
  7. pmc CITED2 modulates estrogen receptor transcriptional activity in breast cancer cells
    Wen Min Lau
    Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Biochem Biophys Res Commun 437:261-6. 2013
  8. ncbi request reprint Very high frequency of hypermethylated genes in breast cancer metastasis to the bone, brain, and lung
    Jyoti Mehrotra
    Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Clin Cancer Res 10:3104-9. 2004
  9. pmc Clostridium perfringens enterotoxin elicits rapid and specific cytolysis of breast carcinoma cells mediated through tight junction proteins claudin 3 and 4
    Scott L Kominsky
    Breast Cancer Program, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Am J Pathol 164:1627-33. 2004
  10. ncbi request reprint Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast
    Scott L Kominsky
    Breast Cancer Program, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Oncogene 22:2021-33. 2003

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Claudins: emerging targets for cancer therapy
    Scott L Kominsky
    Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, 720 Rutland Ave, Baltimore, MD 21205, USA
    Expert Rev Mol Med 8:1-11. 2006
    ..Further studies are needed to determine the potential systemic toxicity of this approach considering the ubiquitous expression of CLDNs in the body, but CLDN-targeted therapeutics appear to have promise in the treatment of cancer...
  2. ncbi request reprint Clostridium perfringens enterotoxin as a novel-targeted therapeutic for brain metastasis
    Scott L Kominsky
    Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cancer Res 67:7977-82. 2007
    ..These data suggest that CPE therapy may have efficacy against a wide variety of brain metastases without CNS toxicity...
  3. doi request reprint MMP-13 is over-expressed in renal cell carcinoma bone metastasis and is induced by TGF-beta1
    Scott L Kominsky
    Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross Building, Room 209, Baltimore, MD 21205, USA
    Clin Exp Metastasis 25:865-70. 2008
    ..These data suggest that MMP-13 expression is elevated in RBM relative to primary RCC and adjacent normal kidney, and is regulated at the cellular level by TGF-beta1...
  4. doi request reprint Macrophage inflammatory protein-1 delta: a novel osteoclast stimulating factor secreted by renal cell carcinoma bone metastasis
    Scott L Kominsky
    Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cancer Res 68:1261-6. 2008
    ....
  5. doi request reprint Identification of prospective factors promoting osteotropism in breast cancer: a potential role for CITED2
    Wen Min Lau
    Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Int J Cancer 126:876-84. 2010
    ..In addition, reducing CITED2 expression in NT2.5 cells inhibited the establishment of bone metastasis and osteolysis in vivo, suggesting a potential role for CITED2 in promoting breast cancer bone metastasis...
  6. ncbi request reprint TGF-beta promotes the establishment of renal cell carcinoma bone metastasis
    Scott L Kominsky
    Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Bone Miner Res 22:37-44. 2007
    ..We found that TGF-beta1 stimulation of RCC bone metastasis cells promotes tumor growth and bone destruction possibly by stimulating paracrine interactions between tumor cells and the bone...
  7. pmc CITED2 modulates estrogen receptor transcriptional activity in breast cancer cells
    Wen Min Lau
    Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Biochem Biophys Res Commun 437:261-6. 2013
    ....
  8. ncbi request reprint Very high frequency of hypermethylated genes in breast cancer metastasis to the bone, brain, and lung
    Jyoti Mehrotra
    Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Clin Cancer Res 10:3104-9. 2004
    ....
  9. pmc Clostridium perfringens enterotoxin elicits rapid and specific cytolysis of breast carcinoma cells mediated through tight junction proteins claudin 3 and 4
    Scott L Kominsky
    Breast Cancer Program, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Am J Pathol 164:1627-33. 2004
    ..Thus, expression of CLDN 3 and 4 sensitizes primary breast carcinomas to CPE-mediated cytolysis and emphasizes the potential of CPE in breast cancer therapy...
  10. ncbi request reprint Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast
    Scott L Kominsky
    Breast Cancer Program, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Oncogene 22:2021-33. 2003
    ..In summary, these studies provide insight into the potential role of CLDN-7 in the progression and ability of breast cancer cells to disseminate...
  11. pmc MIP-1δ activates NFATc1 and enhances osteoclastogenesis: involvement of both PLCγ2 and NFκB signaling
    Kristy L Weber
    Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 7:e40799. 2012
    ..Taken together, these data highlight the potential of MIP-1δ as a mediator of pathological bone resorption and provide insight into the molecular mechanism through which MIP-1δ enhances osteoclastogenesis...
  12. pmc Enpp1: a potential facilitator of breast cancer bone metastasis
    Wen Min Lau
    Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    PLoS ONE 8:e66752. 2013
    ..Taken together, these data suggest a potential role for Enpp1 in the development of breast cancer bone metastasis. ..
  13. pmc Preclinical and clinical evaluation of intraductally administered agents in early breast cancer
    Vered Stearns
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Sci Transl Med 3:106ra108. 2011
    ..If successful, administration of agents directly into the ductal system may allow for "breast-sparing mastectomy" in select women...
  14. ncbi request reprint Ductal access for prevention and therapy of mammary tumors
    Satoshi Murata
    Department of Oncology, Johns Hopkins University School of Medicine, 1650 Orleans Street, Baltimore, MD 21231, USA
    Cancer Res 66:638-45. 2006
    ..These studies suggest that this approach has potential for application to prevention and neoadjuvant therapy of early breast cancer...
  15. ncbi request reprint A "bone" fide predictor of metastasis? Predicting breast cancer metastasis to bone
    Scott L Kominsky
    J Clin Oncol 24:2227-9. 2006