Research Topics
Species | Vassilis KoliatsosSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Nonhuman sialic acid Neu5Gc is very low in human embryonic stem cell-derived neural precursors differentiated with B27/N2 and noggin: implications for transplantationIgor O Nasonkin
Department of Pathology, Division of Neuropathology, Baltimore, MD 21205, USA
Exp Neurol 201:525-9. 2006..We find this concern has little relevance to neural differentiation protocols with B27/N2/noggin because of the gradual decline of Neu5Gc to less than 1% in differentiating cells upon switching to B27/N2 medium...
A mouse model of blast injury to brain: initial pathological, neuropathological, and behavioral characterizationVassilis E Koliatsos
Division of Neuropathology, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
J Neuropathol Exp Neurol 70:399-416. 2011..Prevention of some of these neurological effects by torso shielding may generate new ideas as to how to protect military and civilian populations in blast scenarios...- Human stem cell grafts as therapies for motor neuron diseaseVassilis E Koliatsos
The Johns Hopkins University School of Medicine, Department of Pathology, Division of Neuropathology, Baltimore, MD 21205, USA
Expert Opin Biol Ther 8:137-41. 2008.... 
Cortical interneurons become activated by deafferentation and instruct the apoptosis of pyramidal neuronsV E Koliatsos
Department of Pathology, Division of Neuropathology, Institute for Cell Engineering, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 101:14264-9. 2004..We propose that this mechanism may be generic to cortical degenerations and amenable to therapeutic interventions...- Early involvement of small inhibitory cortical interneurons in Alzheimer's diseaseVassilis E Koliatsos
Department of Pathology, Division of Neuropathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
Acta Neuropathol 112:147-62. 2006.... - Long-term, stable differentiation of human embryonic stem cell-derived neural precursors grafted into the adult mammalian neostriatumIgor Nasonkin
Department of Pathology, Division of Neuropathology, Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Stem Cells 27:2414-26. 2009.... - Human neural stem cell grafts ameliorate motor neuron disease in SOD-1 transgenic ratsLeyan Xu
Department of Pathology, Division of Neuropathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
Transplantation 82:865-75. 2006..The adult spinal cord raises further challenges for NSC differentiation because of lack of intrinsic developmental potential and the negative outcomes of several prior attempts... - Combined immunosuppressive agents or CD4 antibodies prolong survival of human neural stem cell grafts and improve disease outcomes in amyotrophic lateral sclerosis transgenic miceJun Yan
Department of Pathology, Neuropathology Division, The Johns Hopkins University School of Medicine, Ross Building, Room 558, 720 Rutland Avenue, Baltimore, Maryland 21205, USA
Stem Cells 24:1976-85. 2006.... - Human neural stem cell grafts in the spinal cord of SOD1 transgenic rats: differentiation and structural integration into the segmental motor circuitryLeyan Xu
Department of Pathology, Division of Neuropathology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
J Comp Neurol 514:297-309. 2009..Our results indicate an advanced degree of structural integration, via functional synapses, of differentiated human NSCs into the segmental motor circuitry of SOD1-G93A rats... - Targeted knock-down of neuronal nitric oxide synthase expression in basal forebrain with RNA interferenceVasiliki Mahairaki
The Johns Hopkins University School of Medicine, Department of Pathology, Division of Neuropathology, Baltimore, MD 21205, USA
J Neurosci Methods 179:292-9. 2009..Furthermore, our findings raise the possibility for future considerations of lentiviral strategies as therapies for diseases of the nervous system involving NO neurotoxic cascades... - Differentiation and tropic/trophic effects of exogenous neural precursors in the adult spinal cordJun Yan
Division of Neuropathology, Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
J Comp Neurol 480:101-14. 2004.... 
Extensive neuronal differentiation of human neural stem cell grafts in adult rat spinal cordJun Yan
Department of Pathology, Division of Neuropathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America
PLoS Med 4:e39. 2007..In most cases, neural stem cell (NSC) transplants have shown either poor differentiation or a preferential choice of glial lineages...- Disruption of corticocortical connections ameliorates amyloid burden in terminal fields in a transgenic model of Abeta amyloidosisJin G Sheng
Department of Pathology (Division of Neuropathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Neurosci 22:9794-9. 2002.... - Direct, complex effects of estrogens on basal forebrain cholinergic neuronsSusan H Bora
Department of Pathology, Division of Neuropathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
Exp Neurol 194:506-22. 2005..Our findings support the idea that estrogens directly enhance cholinergic neuron function and that ERalpha plays a significant role in transducing these regulatory effects... - An AMPA glutamatergic receptor activation-nitric oxide synthesis step signals transsynaptic apoptosis in limbic cortexYueping Zhou
Department of Pathology, Division of Neuropathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
Neuropharmacology 51:67-76. 2006..An AMPA-mediated upregulation of nNOS and release of NO by inhibitory interneurons may play a prominent role in this type of injury... - NMDA inhibitors cause apoptosis of pyramidal neurons in mature piriform cortex: evidence for a nitric oxide-mediated effect involving inhibitory interneuronsLijun Zhou
Department of Pathology, Division of Neuropathology, Johns Hopkins Medical Institutions, Baltimore, MD 21205 2196, USA
Neuropharmacology 52:1528-37. 2007.... - Caspase activation in the limbic cortex of subjects with early Alzheimer's diseaseMyriam C Gastard
Division of Neuropathology, Department of Neurology, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205-2196, USA
Ann Neurol 54:393-8. 2003..Caspase-3 immunoreactivity has a tangle-like appearance that coevolves with paired helical filament pathology within neurons. We propose that activation of apoptosis may occur very early in the medial temporal lobe in AD... - The beta-amyloid-related proteins presenilin 1 and BACE1 are axonally transported to nerve terminals in the brainJin G Sheng
Division of Neuropathology and the Alzheimer's Disease Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Exp Neurol 184:1053-7. 2003..Together, these data demonstrate that PS1 and BACE1 are transported from the entorhinal cortex to the hippocampus via axons of the perforant pathway... - Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid beta peptide in APPswe transgenic miceJin G Sheng
Department of Pathology (Division of Neuropathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neurobiol Dis 14:133-45. 2003..It remains to be seen whether such events can cause neuronal dysfunction/degeneration and, with time, lead to extracellular Abeta deposits, as they occur in Alzheimer's disease... - BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functionsFiona M Laird
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Neurosci 25:11693-709. 2005.... - Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisitedOrly Lazarov
Department of Neurobiology, Pharmacology, and Physiology, The University of Chicago, Chicago, Illinois 60637, USA
J Neurosci 25:2386-95. 2005....
Research Grants
- Structural/Trophic Hypothesis for Antidepressant ActionsVassilis Koliatsos; Fiscal Year: 2004..abstract_text> ..
- TRANSYNAPTIC CORTICAL APOPTOSIS--MECHANISMS & THERAPIESVassilis Koliatsos; Fiscal Year: 2004..We expect that these carefully controlled investigations will shed light on critical intermediate mechanisms of cortical degenerations and will suggest clinically advantageous methods to treat these disorders. ..
- Models of Motor Neuron Disease: Stem Cell TherapiesVassilis Koliatsos; Fiscal Year: 2007..In concert, we propose to examine the essential preclinical parameters for the consideration of NSCs as therapeutic tools for motor neuron disease. ..