Vassilis Koliatsos

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Early involvement of small inhibitory cortical interneurons in Alzheimer's disease
    Vassilis E Koliatsos
    Department of Pathology, Division of Neuropathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Acta Neuropathol 112:147-62. 2006
  2. ncbi request reprint Nonhuman sialic acid Neu5Gc is very low in human embryonic stem cell-derived neural precursors differentiated with B27/N2 and noggin: implications for transplantation
    Igor O Nasonkin
    Department of Pathology, Division of Neuropathology, Baltimore, MD 21205, USA
    Exp Neurol 201:525-9. 2006
  3. ncbi request reprint Human stem cell grafts as therapies for motor neuron disease
    Vassilis E Koliatsos
    The Johns Hopkins University School of Medicine, Department of Pathology, Division of Neuropathology, Baltimore, MD 21205, USA
    Expert Opin Biol Ther 8:137-41. 2008
  4. doi request reprint A mouse model of blast injury to brain: initial pathological, neuropathological, and behavioral characterization
    Vassilis E Koliatsos
    Division of Neuropathology, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    J Neuropathol Exp Neurol 70:399-416. 2011
  5. pmc Cortical interneurons become activated by deafferentation and instruct the apoptosis of pyramidal neurons
    V E Koliatsos
    Department of Pathology, Division of Neuropathology, Institute for Cell Engineering, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 101:14264-9. 2004
  6. pmc Long-term, stable differentiation of human embryonic stem cell-derived neural precursors grafted into the adult mammalian neostriatum
    Igor Nasonkin
    Department of Pathology, Division of Neuropathology, Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Stem Cells 27:2414-26. 2009
  7. ncbi request reprint Human neural stem cell grafts ameliorate motor neuron disease in SOD-1 transgenic rats
    Leyan Xu
    Department of Pathology, Division of Neuropathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Transplantation 82:865-75. 2006
  8. ncbi request reprint Combined immunosuppressive agents or CD4 antibodies prolong survival of human neural stem cell grafts and improve disease outcomes in amyotrophic lateral sclerosis transgenic mice
    Jun Yan
    Department of Pathology, Neuropathology Division, The Johns Hopkins University School of Medicine, Ross Building, Room 558, 720 Rutland Avenue, Baltimore, Maryland 21205, USA
    Stem Cells 24:1976-85. 2006
  9. pmc Human neural stem cell grafts in the spinal cord of SOD1 transgenic rats: differentiation and structural integration into the segmental motor circuitry
    Leyan Xu
    Department of Pathology, Division of Neuropathology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    J Comp Neurol 514:297-309. 2009
  10. pmc Targeted knock-down of neuronal nitric oxide synthase expression in basal forebrain with RNA interference
    Vasiliki Mahairaki
    The Johns Hopkins University School of Medicine, Department of Pathology, Division of Neuropathology, Baltimore, MD 21205, USA
    J Neurosci Methods 179:292-9. 2009

Research Grants

  1. Structural/Trophic Hypothesis for Antidepressant Actions
    Vassilis Koliatsos; Fiscal Year: 2004
  2. TRANSYNAPTIC CORTICAL APOPTOSIS--MECHANISMS & THERAPIES
    Vassilis Koliatsos; Fiscal Year: 2004
  3. Models of Motor Neuron Disease: Stem Cell Therapies
    Vassilis Koliatsos; Fiscal Year: 2007

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Early involvement of small inhibitory cortical interneurons in Alzheimer's disease
    Vassilis E Koliatsos
    Department of Pathology, Division of Neuropathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Acta Neuropathol 112:147-62. 2006
    ....
  2. ncbi request reprint Nonhuman sialic acid Neu5Gc is very low in human embryonic stem cell-derived neural precursors differentiated with B27/N2 and noggin: implications for transplantation
    Igor O Nasonkin
    Department of Pathology, Division of Neuropathology, Baltimore, MD 21205, USA
    Exp Neurol 201:525-9. 2006
    ..We find this concern has little relevance to neural differentiation protocols with B27/N2/noggin because of the gradual decline of Neu5Gc to less than 1% in differentiating cells upon switching to B27/N2 medium...
  3. ncbi request reprint Human stem cell grafts as therapies for motor neuron disease
    Vassilis E Koliatsos
    The Johns Hopkins University School of Medicine, Department of Pathology, Division of Neuropathology, Baltimore, MD 21205, USA
    Expert Opin Biol Ther 8:137-41. 2008
    ....
  4. doi request reprint A mouse model of blast injury to brain: initial pathological, neuropathological, and behavioral characterization
    Vassilis E Koliatsos
    Division of Neuropathology, Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    J Neuropathol Exp Neurol 70:399-416. 2011
    ..Prevention of some of these neurological effects by torso shielding may generate new ideas as to how to protect military and civilian populations in blast scenarios...
  5. pmc Cortical interneurons become activated by deafferentation and instruct the apoptosis of pyramidal neurons
    V E Koliatsos
    Department of Pathology, Division of Neuropathology, Institute for Cell Engineering, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 101:14264-9. 2004
    ..We propose that this mechanism may be generic to cortical degenerations and amenable to therapeutic interventions...
  6. pmc Long-term, stable differentiation of human embryonic stem cell-derived neural precursors grafted into the adult mammalian neostriatum
    Igor Nasonkin
    Department of Pathology, Division of Neuropathology, Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Stem Cells 27:2414-26. 2009
    ....
  7. ncbi request reprint Human neural stem cell grafts ameliorate motor neuron disease in SOD-1 transgenic rats
    Leyan Xu
    Department of Pathology, Division of Neuropathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Transplantation 82:865-75. 2006
    ..The adult spinal cord raises further challenges for NSC differentiation because of lack of intrinsic developmental potential and the negative outcomes of several prior attempts...
  8. ncbi request reprint Combined immunosuppressive agents or CD4 antibodies prolong survival of human neural stem cell grafts and improve disease outcomes in amyotrophic lateral sclerosis transgenic mice
    Jun Yan
    Department of Pathology, Neuropathology Division, The Johns Hopkins University School of Medicine, Ross Building, Room 558, 720 Rutland Avenue, Baltimore, Maryland 21205, USA
    Stem Cells 24:1976-85. 2006
    ....
  9. pmc Human neural stem cell grafts in the spinal cord of SOD1 transgenic rats: differentiation and structural integration into the segmental motor circuitry
    Leyan Xu
    Department of Pathology, Division of Neuropathology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    J Comp Neurol 514:297-309. 2009
    ..Our results indicate an advanced degree of structural integration, via functional synapses, of differentiated human NSCs into the segmental motor circuitry of SOD1-G93A rats...
  10. pmc Targeted knock-down of neuronal nitric oxide synthase expression in basal forebrain with RNA interference
    Vasiliki Mahairaki
    The Johns Hopkins University School of Medicine, Department of Pathology, Division of Neuropathology, Baltimore, MD 21205, USA
    J Neurosci Methods 179:292-9. 2009
    ..Furthermore, our findings raise the possibility for future considerations of lentiviral strategies as therapies for diseases of the nervous system involving NO neurotoxic cascades...
  11. ncbi request reprint Differentiation and tropic/trophic effects of exogenous neural precursors in the adult spinal cord
    Jun Yan
    Division of Neuropathology, Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    J Comp Neurol 480:101-14. 2004
    ....
  12. pmc Extensive neuronal differentiation of human neural stem cell grafts in adult rat spinal cord
    Jun Yan
    Department of Pathology, Division of Neuropathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America
    PLoS Med 4:e39. 2007
    ..In most cases, neural stem cell (NSC) transplants have shown either poor differentiation or a preferential choice of glial lineages...
  13. ncbi request reprint Disruption of corticocortical connections ameliorates amyloid burden in terminal fields in a transgenic model of Abeta amyloidosis
    Jin G Sheng
    Department of Pathology Division of Neuropathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 22:9794-9. 2002
    ....
  14. ncbi request reprint Direct, complex effects of estrogens on basal forebrain cholinergic neurons
    Susan H Bora
    Department of Pathology, Division of Neuropathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Exp Neurol 194:506-22. 2005
    ..Our findings support the idea that estrogens directly enhance cholinergic neuron function and that ERalpha plays a significant role in transducing these regulatory effects...
  15. ncbi request reprint An AMPA glutamatergic receptor activation-nitric oxide synthesis step signals transsynaptic apoptosis in limbic cortex
    Yueping Zhou
    Department of Pathology, Division of Neuropathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Neuropharmacology 51:67-76. 2006
    ..An AMPA-mediated upregulation of nNOS and release of NO by inhibitory interneurons may play a prominent role in this type of injury...
  16. pmc NMDA inhibitors cause apoptosis of pyramidal neurons in mature piriform cortex: evidence for a nitric oxide-mediated effect involving inhibitory interneurons
    Lijun Zhou
    Department of Pathology, Division of Neuropathology, Johns Hopkins Medical Institutions, Baltimore, MD 21205 2196, USA
    Neuropharmacology 52:1528-37. 2007
    ....
  17. ncbi request reprint Caspase activation in the limbic cortex of subjects with early Alzheimer's disease
    Myriam C Gastard
    Division of Neuropathology, Department of Neurology, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205 2196, USA
    Ann Neurol 54:393-8. 2003
    ..Caspase-3 immunoreactivity has a tangle-like appearance that coevolves with paired helical filament pathology within neurons. We propose that activation of apoptosis may occur very early in the medial temporal lobe in AD...
  18. ncbi request reprint The beta-amyloid-related proteins presenilin 1 and BACE1 are axonally transported to nerve terminals in the brain
    Jin G Sheng
    Division of Neuropathology and the Alzheimer s Disease Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Exp Neurol 184:1053-7. 2003
    ..Together, these data demonstrate that PS1 and BACE1 are transported from the entorhinal cortex to the hippocampus via axons of the perforant pathway...
  19. ncbi request reprint Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid beta peptide in APPswe transgenic mice
    Jin G Sheng
    Department of Pathology Division of Neuropathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neurobiol Dis 14:133-45. 2003
    ..It remains to be seen whether such events can cause neuronal dysfunction/degeneration and, with time, lead to extracellular Abeta deposits, as they occur in Alzheimer's disease...
  20. pmc BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions
    Fiona M Laird
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 25:11693-709. 2005
    ....
  21. ncbi request reprint Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited
    Orly Lazarov
    Department of Neurobiology, Pharmacology, and Physiology, The University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 25:2386-95. 2005
    ....

Research Grants11

  1. Structural/Trophic Hypothesis for Antidepressant Actions
    Vassilis Koliatsos; Fiscal Year: 2004
    ..abstract_text> ..
  2. TRANSYNAPTIC CORTICAL APOPTOSIS--MECHANISMS & THERAPIES
    Vassilis Koliatsos; Fiscal Year: 2004
    ..We expect that these carefully controlled investigations will shed light on critical intermediate mechanisms of cortical degenerations and will suggest clinically advantageous methods to treat these disorders. ..
  3. Models of Motor Neuron Disease: Stem Cell Therapies
    Vassilis Koliatsos; Fiscal Year: 2007
    ..In concert, we propose to examine the essential preclinical parameters for the consideration of NSCs as therapeutic tools for motor neuron disease. ..