RAYMOND CHARLES KOEHLER

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Poly(ADP-ribose) (PAR) polymer is a death signal
    Shaida A Andrabi
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 103:18308-13. 2006
  2. doi request reprint Boosting oxygenation during acute respiratory failure
    Raymond C Koehler
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, 600 North Wolfe Street Blalock 1404, Baltimore, MD 21287, USA
    Sci Transl Med 4:140fs21. 2012
  3. pmc Relative contribution of cyclooxygenases, epoxyeicosatrienoic acids, and pH to the cerebral blood flow response to vibrissal stimulation
    Xiaoguang Liu
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21287 4961, USA
    Am J Physiol Heart Circ Physiol 302:H1075-85. 2012
  4. pmc Insensitivity of cerebral oxygen transport to oxygen affinity of hemoglobin-based oxygen carriers
    Raymond C Koehler
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, Maryland 21287, USA
    Biochim Biophys Acta 1784:1387-94. 2008
  5. ncbi request reprint Hypothermia for 24 hours after asphyxic cardiac arrest in piglets provides striatal neuroprotection that is sustained 10 days after rewarming
    Dawn M Agnew
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Hospital, Blalock 1404, 600 N Wolfe Street, Baltimore, MD 21287 U S A
    Pediatr Res 54:253-62. 2003
  6. pmc Role of astrocytes in cerebrovascular regulation
    Raymond C Koehler
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Appl Physiol 100:307-17. 2006
  7. doi request reprint Astrocytes and the regulation of cerebral blood flow
    Raymond C Koehler
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Trends Neurosci 32:160-9. 2009
  8. ncbi request reprint Cerebrovascular effects of carbon monoxide
    Raymond C Koehler
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, MD 21287 4961, USA
    Antioxid Redox Signal 4:279-90. 2002
  9. pmc Epoxyeicosatrienoic acid-dependent cerebral vasodilation evoked by metabotropic glutamate receptor activation in vivo
    Xiaoguang Liu
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Am J Physiol Heart Circ Physiol 301:H373-81. 2011
  10. pmc Development of zero-link polymers of hemoglobin, which do not extravasate and do not induce pressure increases upon infusion
    Enrico Bucci
    Department of Biochemistry and Molecular Biology, University of Maryland Medical School, Baltimore, Maryland, USA
    Artif Cells Blood Substit Immobil Biotechnol 35:11-8. 2007

Research Grants

Collaborators

Detail Information

Publications46

  1. pmc Poly(ADP-ribose) (PAR) polymer is a death signal
    Shaida A Andrabi
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 103:18308-13. 2006
    ..These results reveal PAR polymer as a signaling molecule that induces cell death and suggests that interference with PAR polymer signaling may offer innovative therapeutic approaches for the treatment of cellular injury...
  2. doi request reprint Boosting oxygenation during acute respiratory failure
    Raymond C Koehler
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, 600 North Wolfe Street Blalock 1404, Baltimore, MD 21287, USA
    Sci Transl Med 4:140fs21. 2012
    ..A new microparticle-based oxygen-delivery technology has been developed for short-term resuscitation of pulmonary function (Kheir et al., this issue)...
  3. pmc Relative contribution of cyclooxygenases, epoxyeicosatrienoic acids, and pH to the cerebral blood flow response to vibrissal stimulation
    Xiaoguang Liu
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21287 4961, USA
    Am J Physiol Heart Circ Physiol 302:H1075-85. 2012
    ..An unidentified mechanism apparently is responsible for the rapid, residual cortical vasodilation during vibrissal stimulation...
  4. pmc Insensitivity of cerebral oxygen transport to oxygen affinity of hemoglobin-based oxygen carriers
    Raymond C Koehler
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, Maryland 21287, USA
    Biochim Biophys Acta 1784:1387-94. 2008
    ..Cell-free hemoglobins do not require a P50 as high as red blood cell hemoglobin to facilitate oxygen delivery...
  5. ncbi request reprint Hypothermia for 24 hours after asphyxic cardiac arrest in piglets provides striatal neuroprotection that is sustained 10 days after rewarming
    Dawn M Agnew
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Hospital, Blalock 1404, 600 N Wolfe Street, Baltimore, MD 21287 U S A
    Pediatr Res 54:253-62. 2003
    ....
  6. pmc Role of astrocytes in cerebrovascular regulation
    Raymond C Koehler
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Appl Physiol 100:307-17. 2006
    ..Future work using in vivo imaging and genetic manipulation will be required to provide more direct evidence for a role of astrocytes in neurovascular coupling...
  7. doi request reprint Astrocytes and the regulation of cerebral blood flow
    Raymond C Koehler
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Trends Neurosci 32:160-9. 2009
    ..Thus, astrocytes have a pivotal role in dynamic signaling within the neurovascular unit. Important questions remain on how this signaling is integrated with other pathways in health and disease...
  8. ncbi request reprint Cerebrovascular effects of carbon monoxide
    Raymond C Koehler
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, MD 21287 4961, USA
    Antioxid Redox Signal 4:279-90. 2002
    ....
  9. pmc Epoxyeicosatrienoic acid-dependent cerebral vasodilation evoked by metabotropic glutamate receptor activation in vivo
    Xiaoguang Liu
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Am J Physiol Heart Circ Physiol 301:H373-81. 2011
    ..Epoxide hydrolase activity and 20-HETE synthesis limit the duration of the response to prolonged mGluR activation...
  10. pmc Development of zero-link polymers of hemoglobin, which do not extravasate and do not induce pressure increases upon infusion
    Enrico Bucci
    Department of Biochemistry and Molecular Biology, University of Maryland Medical School, Baltimore, Maryland, USA
    Artif Cells Blood Substit Immobil Biotechnol 35:11-8. 2007
    ..It was also proven that cell free hemoglobins are more efficient than red cells in delivering oxygen to tissues...
  11. pmc Role of nitric oxide in cerebrovascular reactivity to NMDA and hypercapnia during prenatal development in sheep
    Andrew P Harris
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
    Int J Dev Neurosci 26:47-55. 2008
    ..Hence, cerebrovascular reactivities to different stimuli do not mature concurrently...
  12. pmc Dopamine receptor modulation of hypoxic-ischemic neuronal injury in striatum of newborn piglets
    Zeng Jin Yang
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Cereb Blood Flow Metab 27:1339-51. 2007
    ..Furthermore, mechanisms of D1 receptor toxicity may involve DARPP-32-dependent phosphorylation of NMDA receptor NR1 and Na(+),K(+)-ATPase...
  13. pmc Salvage of focal cerebral ischemic damage by transfusion of high O2-affinity recombinant hemoglobin polymers in mouse
    Masaaki Nemoto
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    J Appl Physiol 100:1688-91. 2006
    ..The assumption that the P50 of blood substitutes should be similar to that of blood might not be warranted when used during ischemic conditions...
  14. pmc Recombinant hemoglobins as artificial oxygen carriers
    Clara Fronticelli
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Artif Cells Blood Substit Immobil Biotechnol 35:45-52. 2007
    ....
  15. pmc Estradiol augments peri-infarct cerebral vascular density in experimental stroke
    Agnieszka A Ardelt
    University of Alabama at Birmingham, Department of Neurology, Comprehensive Stroke Center, 1813 6th Avenue South, Suite M226 RWUH, Birmingham, AL 35294, USA
    Exp Neurol 206:95-100. 2007
    ..Loss of estradiol may limit repair in the peri-infarct region by limiting angiogenesis, but functional significance in stroke recovery requires further investigation...
  16. pmc Continuous time-domain analysis of cerebrovascular autoregulation using near-infrared spectroscopy
    Ken M Brady
    Johns Hopkins University School of Medicine, Department of Anesthesiology, Division of Pediatric Anesthesiology and Critical Care Medicine, 600 North Wolfe Street, Blalock 904, Baltimore, MD 21287, USA
    Stroke 38:2818-25. 2007
    ....
  17. pmc Rapid NMDA receptor phosphorylation and oxidative stress precede striatal neurodegeneration after hypoxic ischemia in newborn piglets and are attenuated with hypothermia
    Dawn Mueller-Burke
    School of Nursing, University of Maryland at Baltimore, Baltimore, MD 21201, USA
    Int J Dev Neurosci 26:67-76. 2008
    ..Postasphyxic, mild whole body hypothermia provides neuroprotection by suppressing N-methyl-d-aspartate receptor phosphorylation and protein oxidation...
  18. pmc Delayed tolerance with repetitive transient focal ischemic preconditioning in the mouse
    Jian Zhang
    Department of Neurosurgery, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Blalock 1404, Baltimore, MD 21287, USA
    Stroke 39:967-74. 2008
    ..The present objective was to develop an ischemic preconditioning (IPC) model of delayed tolerance in the mouse based on repetitive, transient middle cerebral artery occlusion (MCAO)...
  19. pmc Role of heme oxygenase-2 in pial arteriolar response to acetylcholine in mice with and without transfusion of cell-free hemoglobin polymers
    Xinyue Qin
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, 600 North Wolfe St, Blalock 1404, Baltimore, MD 21205, USA
    Am J Physiol Regul Integr Comp Physiol 295:R498-504. 2008
    ....
  20. pmc Interaction of nitric oxide, 20-HETE, and EETs during functional hyperemia in whisker barrel cortex
    Xiaoguang Liu
    Dept of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, 600 North Wolfe St Blalock 1404, Baltimore, MD 21287 4961, USA
    Am J Physiol Heart Circ Physiol 295:H619-31. 2008
    ..With the chronic loss of neuronal NOS in mice, other mechanisms apparently suppress 20-HETE synthesis or signaling...
  21. pmc Continuous measurement of autoregulation by spontaneous fluctuations in cerebral perfusion pressure: comparison of 3 methods
    Ken M Brady
    Department of Anesthesiology, Division of Pediatric Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 600 N Wolfe St, Blalock 904, Baltimore MD 21287, USA
    Stroke 39:2531-7. 2008
    ..We characterized the accuracy of 3 continuous monitors of autoregulation in a piglet model of hypotension...
  22. ncbi request reprint Stroke outcomes in mice lacking the genes for neuronal heme oxygenase-2 and nitric oxide synthase
    Khodadad Namiranian
    Johns Hopkins School of Medicine, Baltimore MD, USA
    Curr Neurovasc Res 2:23-7. 2005
    ..The results suggest that the deleterious action of nNOS would counteract the role of HO-2 in neuroprotection...
  23. ncbi request reprint Regional cerebral blood flow in cats with cross-linked hemoglobin transfusion during focal cerebral ischemia
    Annette Rebel
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Am J Physiol Heart Circ Physiol 282:H832-41. 2002
    ..Moreover, an end-artery region such as the caudate nucleus is less likely to benefit from hemodilution...
  24. ncbi request reprint Vascular response to infusions of a nonextravasating hemoglobin polymer
    Barbara Matheson
    Department of Physiology, Dental School, University of Maryland, Baltimore 21201, Maryland, USA
    J Appl Physiol 93:1479-86. 2002
    ..Constriction observed in the cerebrovascular bed with a nonextravasating hemoglobin polymer at low hematocrit is presumably a regulatory response to prevent overoxygenation at low blood viscosity...
  25. ncbi request reprint Potent sigma 1-receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine provides ischemic neuroprotection without altering dopamine accumulation in vivo in rats
    Toru Goyagi
    Department of Anesthesiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Anesth Analg 96:532-8, table of contents. 2003
    ..Therefore, PPBP provides significant ischemic neuroprotection in the CP complex without altering the acute accumulation of dopamine in vivo during transient focal ischemia in the rat...
  26. ncbi request reprint Cerebrovascular response to decreased hematocrit: effect of cell-free hemoglobin, plasma viscosity, and CO2
    Annette Rebel
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, 600 N Wolfe St, Baltimore, MD 21205, USA
    Am J Physiol Heart Circ Physiol 285:H1600-8. 2003
    ....
  27. ncbi request reprint Characterization of a new double-filament model of focal cerebral ischemia in heme oxygenase-2-deficient mice
    Shozo Goto
    Dept of Anesthesiology Critical Care Medicine, The Johns Hopkins Medical Institutions, 600 N Wolfe St, Blalock 1404, Baltimore, MD 21287 4961, USA
    Am J Physiol Regul Integr Comp Physiol 285:R222-30. 2003
    ..The double-filament model may be of use as an alternative in other murine knockout strains in which the standard filament model does not yield consistent infarcts...
  28. ncbi request reprint A recombinant polymeric hemoglobin with conformational, functional, and physiological characteristics of an in vivo O2 transporter
    Kevin M Bobofchak
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287, USA
    Am J Physiol Heart Circ Physiol 285:H549-61. 2003
    ..Polymerization maintains physiologically relevant oxygen and heme affinity, stability toward denaturation and oxidation, and effective oxygen delivery as indicated by reduced cerebral ischemic damage...
  29. ncbi request reprint Neuroprotective kappa-opioid receptor agonist BRL 52537 attenuates ischemia-evoked nitric oxide production in vivo in rats
    Toru Goyagi
    Department of Anesthesiology Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Stroke 34:1533-8. 2003
    ....
  30. ncbi request reprint Prolonged opportunity for ischemic neuroprotection with selective kappa-opioid receptor agonist in rats
    Tsung Ying Chen
    Department of Anesthesiology Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Stroke 35:1180-5. 2004
    ....
  31. ncbi request reprint Distinct protective mechanisms of HO-1 and HO-2 against hydroperoxide-induced cytotoxicity
    Yun Sook Kim
    Department of Anesthesiology Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
    Free Radic Biol Med 38:85-92. 2005
    ..The differences in subcellular localization of HO-1 and HO-2 could explain some of the discrepancies in their cellular activity and enzymatic protective mechanisms...
  32. ncbi request reprint Neuroprotective effect of selective kappa opioid receptor agonist is gender specific and linked to reduced neuronal nitric oxide
    Emil Zeynalov
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Cereb Blood Flow Metab 26:414-20. 2006
    ..Neuroprotective effects of BRL 52537 are lost in the male when nNOS is not present; therefore, BRL 52537 likely acts upstream from NO generation and its subsequent neurotoxicity...
  33. ncbi request reprint Ischemic neuroprotection with selective kappa-opioid receptor agonist is gender specific
    Chih Hung Chen
    Department of Anesthesiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Stroke 36:1557-61. 2005
    ..We tested the hypothesis that BRL provides significant neuroprotection from transient focal ischemia in male but not in female rats...
  34. pmc Role of nitric oxide scavenging in vascular response to cell-free hemoglobin transfusion
    Kenji Sampei
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, 600 N Wolfe St, Blalock 1404, Baltimore, MD 21287, USA
    Am J Physiol Heart Circ Physiol 289:H1191-201. 2005
    ..The data support increasing the molecular size of Hb by polymerization or conjugation to limit extravasation in all vascular beds to preserve normal vascular reactivity...
  35. pmc Glutamine-dependent inhibition of pial arteriolar dilation to acetylcholine with and without hyperammonemia in the rat
    Tetsu Kawaguchi
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, 600 North Wolfe St Blalock 1404 E, Baltimore, MD 21287 4961, USA
    Am J Physiol Regul Integr Comp Physiol 288:R1612-9. 2005
    ....
  36. pmc Estradiol alters only GAD67 mRNA levels in ischemic rat brain with no consequent effects on GABA
    Hung Dong Joh
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Cereb Blood Flow Metab 26:518-26. 2006
    ..It may be that estradiol under ischemic conditions is attenuating GABA metabolism rather than enhancing synthesis or is augmenting other aspects of GABAergic transmission such as GABA transporters and receptors...
  37. ncbi request reprint Suppression of cortical functional hyperemia to vibrissal stimulation in the rat by epoxygenase inhibitors
    Xinqi Peng
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe Street Blalock 1404 E, Baltimore, MD 21287, USA
    Am J Physiol Heart Circ Physiol 283:H2029-37. 2002
    ..The marked reduction of the cortical flow response to whisker stimulation with two different types of epoxygenase inhibitors indicates that EETs play an important role in the physiological coupling of blood flow to neural activation...
  38. pmc Dependence of acetylcholine and ADP dilation of pial arterioles on heme oxygenase after transfusion of cell-free polymeric hemoglobin
    Annette Rebel
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, Maryland 21287, USA
    Am J Physiol Heart Circ Physiol 290:H1027-37. 2006
    ..e., ADP) in a another species (rat)...
  39. ncbi request reprint In situ immunoradiographic method for quantification of specific proteins in normal and ischemic brain regions
    Annette Rebel
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Neurosci Methods 143:227-35. 2005
    ..The disadvantage of the falsely positive overestimation of protein immunoreactivity after stroke with the immunoperoxidase method has to be weighted with the advantage of the cellular resolution...
  40. ncbi request reprint Metabotropic glutamate receptor activation enhances the activities of two types of Ca2+-activated k+ channels in rat hippocampal astrocytes
    Debebe Gebremedhin
    Department of Physiology and Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee 53226, USA
    J Neurosci 23:1678-87. 2003
    ....
  41. ncbi request reprint Potential mechanism by which resveratrol, a red wine constituent, protects neurons
    Hean Zhuang
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Ann N Y Acad Sci 993:276-86; discussion 287-8. 2003
    ..All together, increased heme oxygenase activity by resveratrol is a unique pathway by which this compound can exert its neuroprotective actions...
  42. ncbi request reprint Kappa-opioid receptor selectivity for ischemic neuroprotection with BRL 52537 in rats
    Zhizheng Zhang
    Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, Oregon, USA
    Anesth Analg 97:1776-83. 2003
    ..6% +/- 5.3%; CP, 40.9% +/- 6.2%) conferred by BRL 52537. BRL 52537 did not produce postischemic hypothermia. These data demonstrate that KORs may provide a therapeutic target during early reperfusion after ischemic stroke...
  43. ncbi request reprint Cytosolic phospholipase A alpha modulates NMDA neurotoxicity in mouse hippocampal cultures
    Ken M Brady
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Eur J Neurosci 24:3381-6. 2006
    ....
  44. pmc Interaction of mechanisms involving epoxyeicosatrienoic acids, adenosine receptors, and metabotropic glutamate receptors in neurovascular coupling in rat whisker barrel cortex
    Yanrong Shi
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland 21287 4961, USA
    J Cereb Blood Flow Metab 28:111-25. 2008
    ....
  45. ncbi request reprint Dependency of cortical functional hyperemia to forepaw stimulation on epoxygenase and nitric oxide synthase activities in rats
    Xinqi Peng
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Cereb Blood Flow Metab 24:509-17. 2004
    ....
  46. pmc Role of 20-HETE in the pial arteriolar constrictor response to decreased hematocrit after exchange transfusion of cell-free polymeric hemoglobin
    Xinyue Qin
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Appl Physiol 100:336-42. 2006
    ....

Research Grants15

  1. Therapeutic Strategies for Neonatal Hypoxic-Ischemic Encephalopathy
    Raymond Koehler; Fiscal Year: 2009
    ....
  2. Therapeutic Strategies for Neonatal Hypoxic-Ischemic Encephalopathy
    RAYMOND CHARLES KOEHLER; Fiscal Year: 2010
    ....
  3. Cell Free O2 Carriers: Cerebrovascular Control and Stroke
    RAYMOND CHARLES KOEHLER; Fiscal Year: 2010
    ....
  4. Cell-Free O2 Carriers: Cerebrovascular Control & Stroke
    Raymond Koehler; Fiscal Year: 2007
    ..Therefore, this proposal will provide new mechanistic insights into how cell-free Hb polymers can be used to promote 02 delivery during stroke and shock. ..
  5. CELL-FREE 02 CARRIERS: CEREBROVASCULAR CONTROL & STROKE
    Raymond Koehler; Fiscal Year: 2003
    ..These studies will render new insights into cerebrovascular regulation during anemia and into novel methodologies for hemodynamically ameliorating injury from stroke. ..
  6. Cell Free O2 Carriers: Cerebrovascular Control and Stroke
    RAYMOND CHARLES KOEHLER; Fiscal Year: 2010
    ....