L Kleinberg

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Polifeprosan 20, 3.85% carmustine slow-release wafer in malignant glioma: evidence for role in era of standard adjuvant temozolomide
    Lawrence Kleinberg
    Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Oncology Center Johns Hopkins University, Baltimore, MD, USA
    Core Evid 7:115-30. 2012
  2. doi request reprint Therapy for locally advanced adenocarcinoma of the gastroesophageal junction: optimizing outcome
    Lawrence Kleinberg
    Department of Radiation Oncology and Molecular Radiation Sciences, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21231, USA
    Semin Radiat Oncol 23:38-50. 2013
  3. pmc Genetic variation in DNA-repair pathways and response to radiochemotherapy in esophageal adenocarcinoma: a retrospective cohort study of the Eastern Cooperative Oncology Group
    Harry H Yoon
    Mayo Clinic, Rochester, MN 55905, USA
    BMC Cancer 11:176. 2011
  4. ncbi request reprint Clinical course and pathologic findings after Gliadel and radiotherapy for newly diagnosed malignant glioma: implications for patient management
    Lawrence R Kleinberg
    Johns Hopkins Oncology Center, Johns Hopkins University, 401 North Broadway, Baltimore, MD 21231, USA
    Cancer Invest 22:1-9. 2004
  5. ncbi request reprint Evolving management of newly diagnosed brain metastases: expanding role of radiosurgery in lieu of whole brain radiation
    Jana Fox
    Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Future Oncol 3:285-93. 2007
  6. ncbi request reprint Mature survival results with preoperative cisplatin, protracted infusion 5-fluorouracil, and 44-Gy radiotherapy for esophageal cancer
    Lawrence Kleinberg
    Sidney Kimmel Oncology Center at Johns Hopkins, Baltimore, MD 21231, USA
    Int J Radiat Oncol Biol Phys 56:328-34. 2003
  7. ncbi request reprint Chemoradiation in the management of esophageal cancer
    Lawrence Kleinberg
    Department of Radiation Oncology and Molecular Sciences, Division of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231 2410, USA
    J Clin Oncol 25:4110-7. 2007
  8. ncbi request reprint Survival of patients with newly diagnosed glioblastoma multiforme treated with RSR13 and radiotherapy: results of a phase II new approaches to brain tumor therapy CNS consortium safety and efficacy study
    L Kleinberg
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231 2410, USA
    J Clin Oncol 20:3149-55. 2002
  9. ncbi request reprint Phase I trial to determine the safety, pharmacodynamics, and pharmacokinetics of RSR13, a novel radioenhancer, in newly diagnosed glioblastoma multiforme
    L Kleinberg
    Johns Hopkins Oncology Center, Baltimore, MD, USA
    J Clin Oncol 17:2593-603. 1999
  10. ncbi request reprint Phase II study of continuous infusion carmustine and cisplatin followed by cranial irradiation in adults with newly diagnosed high-grade astrocytoma
    S A Grossman
    The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Clin Oncol 15:2596-603. 1997

Collaborators

Detail Information

Publications31

  1. pmc Polifeprosan 20, 3.85% carmustine slow-release wafer in malignant glioma: evidence for role in era of standard adjuvant temozolomide
    Lawrence Kleinberg
    Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Oncology Center Johns Hopkins University, Baltimore, MD, USA
    Core Evid 7:115-30. 2012
    ..Available data support the safety of using carmustine wafers in this circumstance, although special attention to surgical guidelines for implanting the wafers is warranted...
  2. doi request reprint Therapy for locally advanced adenocarcinoma of the gastroesophageal junction: optimizing outcome
    Lawrence Kleinberg
    Department of Radiation Oncology and Molecular Radiation Sciences, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21231, USA
    Semin Radiat Oncol 23:38-50. 2013
    ..There is a need to identify more effective approaches to identifying optimal systemic regimens for individual patients that may be combined with local therapy to further improve outcome...
  3. pmc Genetic variation in DNA-repair pathways and response to radiochemotherapy in esophageal adenocarcinoma: a retrospective cohort study of the Eastern Cooperative Oncology Group
    Harry H Yoon
    Mayo Clinic, Rochester, MN 55905, USA
    BMC Cancer 11:176. 2011
    ..As a secondary aim, we investigated the rate of allelic imbalance between germline and tumor DNA...
  4. ncbi request reprint Clinical course and pathologic findings after Gliadel and radiotherapy for newly diagnosed malignant glioma: implications for patient management
    Lawrence R Kleinberg
    Johns Hopkins Oncology Center, Johns Hopkins University, 401 North Broadway, Baltimore, MD 21231, USA
    Cancer Invest 22:1-9. 2004
    ..Therefore, the possibility of necrosis/treatment effect should be considered for each patient with radiographic findings suspicious for local recurrence...
  5. ncbi request reprint Evolving management of newly diagnosed brain metastases: expanding role of radiosurgery in lieu of whole brain radiation
    Jana Fox
    Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Future Oncol 3:285-93. 2007
    ..Patient selection for radiosurgery alone will also be addressed...
  6. ncbi request reprint Mature survival results with preoperative cisplatin, protracted infusion 5-fluorouracil, and 44-Gy radiotherapy for esophageal cancer
    Lawrence Kleinberg
    Sidney Kimmel Oncology Center at Johns Hopkins, Baltimore, MD 21231, USA
    Int J Radiat Oncol Biol Phys 56:328-34. 2003
    ..To assess the long-term survival results after cisplatin, protracted infusion 5-fluorouracil, and concurrent radiotherapy (RT) followed by surgical resection of esophageal cancer...
  7. ncbi request reprint Chemoradiation in the management of esophageal cancer
    Lawrence Kleinberg
    Department of Radiation Oncology and Molecular Sciences, Division of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231 2410, USA
    J Clin Oncol 25:4110-7. 2007
    ....
  8. ncbi request reprint Survival of patients with newly diagnosed glioblastoma multiforme treated with RSR13 and radiotherapy: results of a phase II new approaches to brain tumor therapy CNS consortium safety and efficacy study
    L Kleinberg
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231 2410, USA
    J Clin Oncol 20:3149-55. 2002
    ..RSR13, a synthetic allosteric modifier of hemoglobin, is a radiation-enhancing agent that noncovalently binds to hemoglobin, reduces oxygen-binding affinity, and increases oxygen unloading to hypoxic tissue...
  9. ncbi request reprint Phase I trial to determine the safety, pharmacodynamics, and pharmacokinetics of RSR13, a novel radioenhancer, in newly diagnosed glioblastoma multiforme
    L Kleinberg
    Johns Hopkins Oncology Center, Baltimore, MD, USA
    J Clin Oncol 17:2593-603. 1999
    ..RSR13, a synthetic allosteric modifier of hemoglobin (HgB), is a novel radioenhancing agent that noncovalently binds to HgB, thereby reducing oxygen binding affinity and increasing tissue oxygen release to hypoxic tissues...
  10. ncbi request reprint Phase II study of continuous infusion carmustine and cisplatin followed by cranial irradiation in adults with newly diagnosed high-grade astrocytoma
    S A Grossman
    The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Clin Oncol 15:2596-603. 1997
    ..To evaluate the activity and toxicity of carmustine (BCNU) and cisplatin administered as a 72-hour continuous intravenous infusion before radiation in adults with newly diagnosed high-grade astrocytomas...
  11. ncbi request reprint The effects of sequential versus concurrent chemotherapy and radiotherapy on survival and toxicity in patients with newly diagnosed high-grade astrocytoma
    L Kleinberg
    Division of Radiation Oncology, Johns Hopkins Oncology Center, Baltimore, MD, USA
    Int J Radiat Oncol Biol Phys 44:535-43. 1999
    ..To determine the effects of sequential versus concurrent administration of cranial radiotherapy and cisplatin/carmustine (BCNU) chemotherapy on survival and toxicity in newly diagnosed high-grade astrocytomas...
  12. ncbi request reprint Phase II evaluation of preoperative chemoradiation and postoperative adjuvant chemotherapy for squamous cell and adenocarcinoma of the esophagus
    E I Heath
    Departments of Oncology, Surgery, Medicine, and Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 8934, USA
    J Clin Oncol 18:868-76. 2000
    ....
  13. ncbi request reprint Treatment of recurrent glioblastoma multiforme with GliaSite brachytherapy
    Timothy A Chan
    Department of Radiation Oncology, The Johns Hopkins School of Medicine, 401 N Broadway, Baltimore, MD 21231, USA
    Int J Radiat Oncol Biol Phys 62:1133-9. 2005
    ..In this study, we assess the efficacy of GliaSite brachytherapy in the treatment of patients with recurrent glioblastoma multiforme (GBM)...
  14. ncbi request reprint Short course radiotherapy is an appropriate option for most malignant glioma patients
    L Kleinberg
    Division of Radiation Oncology, The Johns Hopkins Oncology Center, Baltimore, MD 21287 8922, USA
    Int J Radiat Oncol Biol Phys 38:31-6. 1997
    ..To determine whether a shortened course of radiotherapy (RT) is an appropriate treatment option for malignant glioma patients...
  15. ncbi request reprint A dose texture plot in a moving frame as a new planning tool for single-plane implants in HDR brachytherapy
    S Li
    Division of Radiation Oncology, Johns Hopkins Oncology Center, Baltimore, Maryland 21287, USA
    Med Phys 28:97-103. 2001
    ..The results of the iteration optimization on clinical cases demonstrated significant improvements over the optimization algorithms used in a commercial planning system...
  16. pmc Brain-sparing total meningeal radiation for a patient with widespread progressive meningiomas using helical intensity modulated radiation
    J P Christodouleas
    Johns Hopkins Hospital, Department of Radiation Oncology and Molecular Radiation Sciences, 401 North Broadway Avenue, Suite 1440, Baltimore, MD 21231, USA
    Clin Neurol Neurosurg 110:310-4. 2008
    ..The brain-sparing technique allowed us to treat the patient's meninges with higher doses than would have been possible with whole brain radiation and with the goal of achieving long-term disease control...
  17. doi request reprint Stereotactic radiosurgery for spine tumors: review of current literature
    Wesley Hsu
    Department of Neurosurgery, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Stereotact Funct Neurosurg 88:315-21. 2010
    ..The purpose of this review is to summarize the pertinent literature regarding the use of SR for lesions of the spine and spinal cord. Particular emphasis will be placed on large clinical series of both primary and secondary spine tumors...
  18. ncbi request reprint An inflatable balloon catheter and liquid 125I radiation source (GliaSite Radiation Therapy System) for treatment of recurrent malignant glioma: multicenter safety and feasibility trial
    Stephen B Tatter
    Department of Neurosurgery, Wake Forest University, Winston Salem, North Carolina, USA
    J Neurosurg 99:297-303. 2003
    ..In this study the authors evaluated the safety and performance of the GliaSite Radiation Therapy System (RTS) in patients with recurrent malignant brain tumors who were undergoing tumor resection...
  19. ncbi request reprint Postesophagectomy morbidity, mortality, and length of hospital stay after preoperative chemoradiation therapy
    John R Doty
    Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Ann Thorac Surg 74:227-31; discussion 231. 2002
    ..Whether preoperative therapy increases postesophagectomy morbidity and mortality has not been determined. This study evaluates our postoperative results after chemoradiation therapy...
  20. doi request reprint Imaging after GliaSite brachytherapy: prognostic MRI indicators of disease control and recurrence
    Lawrence Kleinberg
    Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Hospital, Baltimore, MD 10065, USA
    Int J Radiat Oncol Biol Phys 75:1385-91. 2009
    ..In this study, we analyzed the magnetic resonance imaging (MRI) changes in patients after GliaSite treatment and characterized the prognostic MRI indicators in these patients...
  21. ncbi request reprint Current concepts and controversies in the treatment of parenchymal brain metastases: improved outcomes with aggressive management
    Gopal K Bajaj
    Department of Radiation Oncology and Molecular Radiation Sciences, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Cancer Invest 23:363-76. 2005
    ....
  22. pmc The impact of thrombocytopenia from temozolomide and radiation in newly diagnosed adults with high-grade gliomas
    David E Gerber
    Division of Medical Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Neuro Oncol 9:47-52. 2007
    ....
  23. pmc Localized CT-guided irradiation inhibits neurogenesis in specific regions of the adult mouse brain
    E C Ford
    Department of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Radiat Res 175:774-83. 2011
    ..001). Localized radiation in the rodent brain is a promising new tool for the study of neurogenesis...
  24. ncbi request reprint Primary brain tumors treated with steroids and radiotherapy: low CD4 counts and risk of infection
    Michael A Hughes
    Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Int J Radiat Oncol Biol Phys 62:1423-6. 2005
    ..The purpose of this study was to determine the occurrence of low CD4 counts and whether monitoring CD4 counts during and after radiotherapy (RT) is warranted...
  25. ncbi request reprint Chemoradiotherapy for localized esophageal cancer: regimen selection and molecular mechanisms of radiosensitization
    Lawrence Kleinberg
    Johns Hopkins University, MD, USA
    Nat Clin Pract Oncol 4:282-94. 2007
    ..The recent clinical development of biologic, targeted therapies provides a new avenue for the study of chemoradiotherapy and an opportunity to increase long-term survival...
  26. doi request reprint Radiosurgery for glomus jugulare: history and recent progress
    Zachary D Guss
    Department of Neurosurgery, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Neurosurg Focus 27:E5. 2009
    ..These preliminary reports demonstrate that the use of radiosurgery as a primary treatment for glomus jugulare should be extended to encompass more of the patients who are currently assigned to microsurgical treatment...
  27. doi request reprint Stereotactic radiosurgery in the management of brain metastases: an institutional retrospective analysis of survival
    James L Frazier
    Department of Neurosurgery, The Johns Hopkins University School of Medicine and Bloomberg School of Public Health, Baltimore, MD, USA
    Int J Radiat Oncol Biol Phys 76:1486-92. 2010
    ....
  28. pmc Interstitial chemotherapy for malignant gliomas: the Johns Hopkins experience
    H Christopher Lawson
    Department of Neurological Surgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Neurooncol 83:61-70. 2007
    ..Furthermore, we provide an overview of newer chemotherapeutic agents and other strategies used in interstitial treatment. Finally, we offer insight into some of the lessons we have learned from our unique perspective...
  29. ncbi request reprint CT number distribution and its association with local control and as a marker of lung tumor response to radiation
    R Mayer
    Division of Radiation Oncology, Johns Hopkins Oncology Center, Baltimore, Maryland, USA
    Radiat Oncol Investig 6:281-8. 1998
    ..001). In summary, radiation reduces the CT number and this reduction may be associated with local control at 10 months. A two-component model is consistent with lung tumor number distribution and its response to radiation...
  30. doi request reprint Fractionated conformal radiotherapy in the management of cavernous sinus meningiomas: long-term functional outcome and tumor control at a single institution
    Philippe Metellus
    Department of Neurosurgery, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Int J Radiat Oncol Biol Phys 78:836-43. 2010
    ..To evaluate long-term outcome of cavernous sinus meningioma (CSM) treated with fractionated conformal radiotherapy (FCR)...
  31. ncbi request reprint Phase II, parallel-design study of preoperative combined modality therapy and the matrix metalloprotease (mmp) inhibitor prinomastat in patients with esophageal adenocarcinoma
    Elisabeth I Heath
    Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
    Invest New Drugs 24:135-40. 2006
    ..The objectives of the trial were to determine pathologic complete response rate (pCR), overall response rate, progression-free survival, pattern of disease relapse, and two-year and overall survival...