Alison P Klein
Affiliation: Johns Hopkins University
- Klein A, Wolpin B, Risch H, Stolzenberg Solomon R, Mocci E, Zhang M, et al. Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer. Nat Commun. 2018;9:556 pubmed publisher..Expression quantitative trait locus analysis in three independent pancreatic data sets provides molecular support of NOC2L as a pancreatic cancer susceptibility gene. ..
- Klein A, Tsai Y, Duggal P, Gillanders E, Barnhart M, Mathias R, et al. Investigation of altering single-nucleotide polymorphism density on the power to detect trait loci and frequency of false positive in nonparametric linkage analyses of qualitative traits. BMC Genet. 2005;6 Suppl 1:S20 pubmed..The presence of LD between markers may have led to an increased number of false positive regions but no clear relationship between regions of high LD and locations of false positive linkage signals was observed. ..
- Childs E, Chaffee K, Gallinger S, Syngal S, Schwartz A, Cote M, et al. Association of Common Susceptibility Variants of Pancreatic Cancer in Higher-Risk Patients: A PACGENE Study. Cancer Epidemiol Biomarkers Prev. 2016;25:1185-91 pubmed publisher..1) and COL6A2 (21q22.3). Even in high-risk populations, common variants influence pancreatic cancer susceptibility. Cancer Epidemiol Biomarkers Prev; 25(7); 1185-91. ©2016 AACR. ..
- Chen F, Roberts N, Klein A. Inherited pancreatic cancer. Chin Clin Oncol. 2017;6:58 pubmed publisher..The goal of this chapter is to discuss the importance of family history of pancreatic cancer, and the known genes that account for a portion of the familial clustering of pancreatic cancer. ..
- Klein A, Suktitipat B, Duggal P, Lee K, Klein R, Bailey Wilson J, et al. Heritability analysis of spherical equivalent, axial length, corneal curvature, and anterior chamber depth in the Beaver Dam Eye Study. Arch Ophthalmol. 2009;127:649-55 pubmed publisher..However, the measured phenotype of spherical equivalent is in large part dictated by the relationship between the underlying optical components of axial length, corneal curvature, and anterior chamber depth...