Alison P Klein

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Incorporating tumor immunohistochemical markers in BRCA1 and BRCA2 carrier prediction
    Yu Chuan Tai
    Breast Cancer Res 10:401. 2008
  2. pmc Identifying people at a high risk of developing pancreatic cancer
    Alison P Klein
    Department of Oncology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, Maryland 21231, USA
    Nat Rev Cancer 13:66-74. 2013
  3. pmc Identification of functional genetic variation in exome sequence analysis
    Andrew Jaffe
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    BMC Proc 5:S13. 2011
  4. pmc Investigation of altering single-nucleotide polymorphism density on the power to detect trait loci and frequency of false positive in nonparametric linkage analyses of qualitative traits
    Alison P Klein
    Inherited Disease Research Branch, NHGRI NIH, Baltimore, MD, USA
    BMC Genet 6:S20. 2005
  5. pmc Linkage analysis of quantitative refraction and refractive errors in the Beaver Dam Eye Study
    Alison P Klein
    Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Invest Ophthalmol Vis Sci 52:5220-5. 2011
  6. pmc Linkage analysis of chromosome 4 in families with familial pancreatic cancer
    Alison P Klein
    The Sol Goldman Pancreatic Research Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Cancer Biol Ther 6:320-3. 2007
  7. pmc Heritability analysis of spherical equivalent, axial length, corneal curvature, and anterior chamber depth in the Beaver Dam Eye Study
    Alison P Klein
    Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA
    Arch Ophthalmol 127:649-55. 2009
  8. pmc Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene
    Sian Jones
    Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Baltimore, MD 21231, USA
    Science 324:217. 2009
  9. pmc Absence of deleterious palladin mutations in patients with familial pancreatic cancer
    Alison P Klein
    Department of Pathology, The John Hopkins University School of Medicine, Baltimore, MD, USA
    Cancer Epidemiol Biomarkers Prev 18:1328-30. 2009
  10. ncbi request reprint Confirmation of linkage to ocular refraction on chromosome 22q and identification of a novel linkage region on 1q
    Alison P Klein
    Departments of Oncology and Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    Arch Ophthalmol 125:80-5. 2007

Detail Information

Publications58

  1. pmc Incorporating tumor immunohistochemical markers in BRCA1 and BRCA2 carrier prediction
    Yu Chuan Tai
    Breast Cancer Res 10:401. 2008
  2. pmc Identifying people at a high risk of developing pancreatic cancer
    Alison P Klein
    Department of Oncology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, Maryland 21231, USA
    Nat Rev Cancer 13:66-74. 2013
    ....
  3. pmc Identification of functional genetic variation in exome sequence analysis
    Andrew Jaffe
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    BMC Proc 5:S13. 2011
    ..Analysis was conducted without knowledge of the simulation model. Agreement between programs was modest ranging from 59.4% to 71.4% and only 3.5% of variants were classified as deleterious and 10.9% as tolerated across all four programs...
  4. pmc Investigation of altering single-nucleotide polymorphism density on the power to detect trait loci and frequency of false positive in nonparametric linkage analyses of qualitative traits
    Alison P Klein
    Inherited Disease Research Branch, NHGRI NIH, Baltimore, MD, USA
    BMC Genet 6:S20. 2005
    ..The presence of LD between markers may have led to an increased number of false positive regions but no clear relationship between regions of high LD and locations of false positive linkage signals was observed...
  5. pmc Linkage analysis of quantitative refraction and refractive errors in the Beaver Dam Eye Study
    Alison P Klein
    Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Invest Ophthalmol Vis Sci 52:5220-5. 2011
    ....
  6. pmc Linkage analysis of chromosome 4 in families with familial pancreatic cancer
    Alison P Klein
    The Sol Goldman Pancreatic Research Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Cancer Biol Ther 6:320-3. 2007
    ....
  7. pmc Heritability analysis of spherical equivalent, axial length, corneal curvature, and anterior chamber depth in the Beaver Dam Eye Study
    Alison P Klein
    Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA
    Arch Ophthalmol 127:649-55. 2009
    ..However, the measured phenotype of spherical equivalent is in large part dictated by the relationship between the underlying optical components of axial length, corneal curvature, and anterior chamber depth...
  8. pmc Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene
    Sian Jones
    Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Baltimore, MD 21231, USA
    Science 324:217. 2009
    ..These results illustrate that complete, unbiased sequencing of protein-coding genes can lead to the identification of a gene responsible for a hereditary disease...
  9. pmc Absence of deleterious palladin mutations in patients with familial pancreatic cancer
    Alison P Klein
    Department of Pathology, The John Hopkins University School of Medicine, Baltimore, MD, USA
    Cancer Epidemiol Biomarkers Prev 18:1328-30. 2009
    ..We sequenced the coding regions of PALLD in 48 individuals with familial pancreatic cancer. We did not find any deleterious mutations and find no evidence to implicate mutations in PALLD as a cause of familial pancreatic cancer...
  10. ncbi request reprint Confirmation of linkage to ocular refraction on chromosome 22q and identification of a novel linkage region on 1q
    Alison P Klein
    Departments of Oncology and Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    Arch Ophthalmol 125:80-5. 2007
    ....
  11. pmc Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways
    Jian Wu
    Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 108:21188-93. 2011
    ..These results highlight the essential role of ubiquitin ligases in these neoplasms and have important implications for the diagnosis and treatment of patients with cystic tumors...
  12. pmc Elevated cancer mortality in the relatives of patients with pancreatic cancer
    Li Wang
    1Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21231, USA
    Cancer Epidemiol Biomarkers Prev 18:2829-34. 2009
    ..Our results show that relatives of pancreatic cancer patients are at higher risk of developing cancers at other sites and highlight the importance of complete family history in clinical risk assessment...
  13. pmc Identification of novel genetic loci for intraocular pressure: a genomewide scan of the Beaver Dam Eye Study
    Priya Duggal
    Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD, USA
    Arch Ophthalmol 125:74-9. 2007
    ..To identify genetic loci that control intraocular pressure (IOP)...
  14. pmc Frequent detection of pancreatic lesions in asymptomatic high-risk individuals
    Marcia Irene Canto
    Department of Medicine Division of Gastroenterology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Gastroenterology 142:796-804; quiz e14-5. 2012
    ..We determined the baseline prevalence and characteristics of pancreatic abnormalities using 3 imaging tests to screen asymptomatic, high-risk individuals (HRIs)...
  15. ncbi request reprint Polygenic effects and cigarette smoking account for a portion of the familial aggregation of nuclear sclerosis
    Alison P Klein
    Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, Baltimore, MD, USA
    Am J Epidemiol 161:707-13. 2005
    ..Cigarette smoking was an important covariate in these analyses. Overall, results highlight the complex etiology of nuclear sclerosis...
  16. pmc Importance of age of onset in pancreatic cancer kindreds
    Kieran A Brune
    Department of Pathology, Sol Goldman Pancreatic Cancer Research Center at Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
    J Natl Cancer Inst 102:119-26. 2010
    ..Young-onset cancer is a hallmark of many familial cancer syndromes, yet the implications of young-onset disease in predicting risk of pancreatic cancer among familial pancreatic cancer (FPC) kindred members remain unclear...
  17. pmc Genome-wide sequencing to identify the cause of hereditary cancer syndromes: with examples from familial pancreatic cancer
    Nicholas J Roberts
    Ludwig Center for Cancer Genetics and Therapeutics, The Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Cancer Lett 340:227-33. 2013
    ..In this review we discuss the use of genome-wide sequencing in both Mendelian diseases and hereditary cancer syndromes, highlighting the potential and challenges of this approach using familial pancreatic cancer as an example. ..
  18. pmc Genetic and epigenetic alterations of familial pancreatic cancers
    Kieran Brune
    Department of Pathology, Medicine, Oncology, Johns Hopkins Medical Institutions, The Sol Goldman Pancreatic Cancer Research Center, 1550 Orleans Street, CRB2, Room 342, Baltimore, MD 21231, USA
    Cancer Epidemiol Biomarkers Prev 17:3536-42. 2008
    ..The aim of this study was to compare the prevalence of common genetic and epigenetic alterations in sporadic and familial pancreatic ductal adenocarcinomas...
  19. pmc DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer
    Christine A Iacobuzio-Donahue
    Department of Pathology, Surgery, and Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    J Clin Oncol 27:1806-13. 2009
    ..A comprehensive study of pancreatic cancers from patients who have succumbed to their disease has the potential to greatly expand our understanding of the most lethal stage of this disease and identify novel areas for intervention...
  20. pmc SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer
    Amanda Blackford
    Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Clin Cancer Res 15:4674-9. 2009
    ..Recently, the majority of protein coding genes were sequenced in a collection of pancreatic cancers, providing an unprecedented opportunity to identify genetic markers of prognosis for patients with adenocarcinoma of the pancreas...
  21. pmc ATM mutations in patients with hereditary pancreatic cancer
    Nicholas J Roberts
    Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, USA
    Cancer Discov 2:41-6. 2012
    ..009). Our results indicate that inherited ATM mutations play an important role in familial pancreatic cancer predisposition...
  22. pmc Genome-wide somatic copy number alterations in low-grade PanINs and IPMNs from individuals with a family history of pancreatic cancer
    Seung Mo Hong
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Clin Cancer Res 18:4303-12. 2012
    ..Characterizing the earliest chromosomal alterations of pancreatic precursor neoplasms from individuals with a familial aggregation of pancreatic cancer may provide clues as to the loci of pancreatic cancer susceptibility genes...
  23. pmc Identification of tag single-nucleotide polymorphisms in regions with varying linkage disequilibrium
    Priya Duggal
    Inherited Disease Research Branch, NHGRI NIH, Baltimore, MD, USA
    BMC Genet 6:S73. 2005
    ..In addition, we compared the selected SNPs in a multipoint linkage analysis for one region with strong LD. As the number of selected SNPs increased, the LOD score, mean information content, and type I error also increased...
  24. doi request reprint Familial pancreatic cancer: from genes to improved patient care
    Ralph H Hruban
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Hospital, Weinberg Building 2242, 401 North Broadway, Baltimore, MD 21231, USA
    Expert Rev Gastroenterol Hepatol 1:81-8. 2007
    ..This review focuses on the genetic basis for the familial aggregation of pancreatic cancer, with emphasis placed on the implications of the genetic alterations on clinical patient care...
  25. pmc PancPRO: risk assessment for individuals with a family history of pancreatic cancer
    Wenyi Wang
    Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins School of Medicine, Baltimore, MD, USA
    J Clin Oncol 25:1417-22. 2007
    ..The goal of this study was to develop and validate PancPRO, a Mendelian model for pancreatic cancer risk prediction in individuals with familial pancreatic cancer, to identify high-risk individuals...
  26. ncbi request reprint Tumor COX-2 expression and prognosis of patients with resectable pancreatic cancer
    Hiroyuki Matsubayashi
    Department of Pathology, The Sol Goldman Pancreatic Research Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Cancer Biol Ther 6:1569-75. 2007
    ..We evaluated the prognostic significance of COX-2 expression in pancreatic adenocarcinomas...
  27. pmc Recent progress in pancreatic cancer
    Christopher L Wolfgang
    Associate Professor, Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD Associate Professor, Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD Associate Professor, Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD
    CA Cancer J Clin 63:318-48. 2013
    ..It is clear that multidisciplinary care that provides comprehensive and coordinated evaluation and treatment is the most effective way to manage patients with pancreatic cancer...
  28. pmc Absence of germline BRCA1 mutations in familial pancreatic cancer patients
    Jennifer E Axilbund
    Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, Maryland, USA
    Cancer Biol Ther 8:131-5. 2009
    ....
  29. ncbi request reprint A genetic contribution to intraocular pressure: the beaver dam eye study
    Priya Duggal
    Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland, USA
    Invest Ophthalmol Vis Sci 46:555-60. 2005
    ..IOP is a principal risk factor for primary open-angle glaucoma (POAG) a leading cause of blindness worldwide...
  30. ncbi request reprint Support for polygenic influences on ocular refractive error
    Alison P Klein
    Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, Baltimore, Maryland, USA
    Invest Ophthalmol Vis Sci 46:442-6. 2005
    ..This study examined the familial aggregation and pattern of inheritance of ocular refraction in an adult population, by using data from the Beaver Dam Eye Study...
  31. pmc Prognosis of minimally invasive carcinoma arising in mucinous cystic neoplasms of the pancreas
    Gloria H Lewis
    Departments of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Am J Surg Pathol 37:601-5. 2013
    ..Our study demonstrates that the majority of patients with minimally invasive adenocarcinoma arising in MCNs are cured by surgery, particularly if the neoplasms are completely examined histologically...
  32. pmc Expression of Yes-associated protein modulates Survivin expression in primary liver malignancies
    Haibo Bai
    Department of Pathology, Howard Hughes Medical Institute Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Hum Pathol 43:1376-85. 2012
    ..Our findings suggested that Yes-associated protein contributes to primary liver tumorigenesis and likely mediates its oncogenic effects through modulating Survivin expression...
  33. pmc Serotonin expression in pancreatic neuroendocrine tumors correlates with a trabecular histologic pattern and large duct involvement
    Chad M McCall
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Hum Pathol 43:1169-76. 2012
    ..Serotonin-expressing tumors are also less likely to have lymph node metastases and more likely to involve large pancreatic ducts...
  34. pmc Analysis of polymorphisms and haplotype structure of the human thymidylate synthase genetic region: a tool for pharmacogenetic studies
    Soma Ghosh
    Department of Oncology, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS ONE 7:e34426. 2012
    ..The presence of multiple long (up to 26 nt), polymorphic monothymidine repeats in the promoter region of the sole human thymidylate synthetic enzyme is intriguing...
  35. pmc Genetic susceptibility to pancreatic cancer
    Alison P Klein
    Department of Oncology and Pathology, Sol Goldman Pancreatic Cancer Research Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Mol Carcinog 51:14-24. 2012
    ..This review addresses our current understanding of the familial aggregation of pancreatic cancer, established pancreatic cancer susceptablity genes and how this knowledge informs risk assessment and screening for high-risk families...
  36. pmc Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    Sian Jones
    Sol Goldman Pancreatic Cancer Research Center, Ludwig Center and Howard Hughes Medical Institute at the Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Science 321:1801-6. 2008
    ..Dysregulation of these core pathways and processes through mutation can explain the major features of pancreatic tumorigenesis...
  37. pmc Palladin is overexpressed in the non-neoplastic stroma of infiltrating ductal adenocarcinomas of the pancreas, but is only rarely overexpressed in neoplastic cells
    Safia N Salaria
    The Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231 2410, USA
    Cancer Biol Ther 6:324-8. 2007
    ..This hypothesis was based on reverse transcriptase-polymerase chain reaction analyses of bulk pancreatic tissue, yet pancreatic cancer is a complex admixture of neoplastic epithelial cells and desmoplastic stroma...
  38. pmc Altered telomeres in tumors with ATRX and DAXX mutations
    Christopher M Heaphy
    Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Science 333:425. 2011
    ..ATRX mutations also correlate with abnormal telomeres in tumors of the central nervous system. These data suggest that an alternative telomere maintenance function may operate in human tumors with alterations in the ATRX or DAXX genes...
  39. ncbi request reprint Allele-specific expression in the germline of patients with familial pancreatic cancer: an unbiased approach to cancer gene discovery
    Aik Choon Tan
    The Institute for Computational Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Cancer Biol Ther 7:135-44. 2008
    ....
  40. ncbi request reprint Prospective risk of pancreatic cancer in familial pancreatic cancer kindreds
    Alison P Klein
    Statistical Genetics Section, Inherited Disease Research Branch, National Human Genome Research Institute, NIH, Baltimore, Maryland, USA
    Cancer Res 64:2634-8. 2004
    ..Risk was higher in smokers than in nonsmokers. Individuals with a strong family history of pancreatic cancer have a significantly increased risk of developing pancreatic cancer...
  41. pmc Clinical significance of the genetic landscape of pancreatic cancer and implications for identification of potential long-term survivors
    Shinichi Yachida
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Clin Cancer Res 18:6339-47. 2012
    ..Genetic alterations of KRAS, CDKN2A, TP53, and SMAD4 are the most frequent events in pancreatic cancer. We determined the extent to which these 4 alterations are coexistent in the same carcinoma, and their impact on patient outcome...
  42. ncbi request reprint Evidence for a major gene influencing risk of pancreatic cancer
    Alison P Klein
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    Genet Epidemiol 23:133-49. 2002
    ..This hospital-based segregation analysis of pancreatic cancer found evidence supporting the role of a rare major gene influencing risk of pancreatic cancer...
  43. pmc Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development
    Jian Wu
    Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Sci Transl Med 3:92ra66. 2011
    ..In addition to defining a new pathway for pancreatic neoplasia, these data suggest that GNAS mutations can inform the diagnosis and management of patients with cystic pancreatic lesions...
  44. doi request reprint Familial pancreatic cancer
    Chanjuan Shi
    Department of Oncology, The Johns Hopkins School of Medicine, Baltimore, MD 21212, USA
    Arch Pathol Lab Med 133:365-74. 2009
    ..The known genes associated with these conditions can explain only a portion of the clustering of pancreatic cancer in families, and research to identify additional susceptibility genes is ongoing...
  45. pmc Expression of Yes-associated protein in common solid tumors
    Angela A Steinhardt
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Hum Pathol 39:1582-9. 2008
    ....
  46. pmc Multifocal neoplastic precursor lesions associated with lobular atrophy of the pancreas in patients having a strong family history of pancreatic cancer
    Kieran Brune
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Am J Surg Pathol 30:1067-76. 2006
    ..The multifocal nature of familial pancreatic neoplasia suggests that surveillance of these patients is warranted after partial pancreatectomy...
  47. ncbi request reprint Peritumoral fibroblast SPARC expression and patient outcome with resectable pancreatic adenocarcinoma
    Jeffrey R Infante
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    J Clin Oncol 25:319-25. 2007
    ..We evaluated the prognostic significance of tumor and peritumoral SPARC expression in patients with pancreatic adenocarcinoma...
  48. pmc Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape
    Janis M Taube
    Department of Dermatology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Sci Transl Med 4:127ra37. 2012
    ..These observations suggest that therapies that block this pathway may benefit patients with B7-H1(+) tumors...
  49. pmc Evaluation of random forests performance for genome-wide association studies in the presence of interaction effects
    Yoonhee Kim
    National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Baltimore, MD 21224, USA
    BMC Proc 3:S64. 2009
    ....
  50. pmc Importance sampling method of correction for multiple testing in affected sib-pair linkage analysis
    Alison P Klein
    Inherited Disease Research Branch, NHGRI, NIH, Baltimore, Maryland, USA
    BMC Genet 4:S73. 2003
    ..The ability of these methods to detect trait loci was also low. However, this may be partially due to a limitation inherent in our binary trait definitions...
  51. doi request reprint Pancreatic cancer and factors associated with the insulin resistance syndrome in the Korean cancer prevention study
    Amy Berrington de Gonzalez
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 17:359-64. 2008
    ..The association with elevated liver enzyme levels is a novel finding that warrants further investigation...
  52. pmc An absolute risk model to identify individuals at elevated risk for pancreatic cancer in the general population
    Alison P Klein
    Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States of America Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
    PLoS ONE 8:e72311. 2013
    ..We developed an absolute risk model to identify individuals in the general population at elevated risk of pancreatic cancer...
  53. pmc ABO blood group and other genetic variants associated with pancreatic cancer
    Anne Marie Lennon
    Department of Medicine, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21205 2196, USA
    Genome Med 2:39. 2010
    ..1...
  54. ncbi request reprint The GLC1H glaucoma locus may reflect glaucoma with elevated intraocular pressure
    Priya Duggal
    Arch Ophthalmol 125:1716-7; author reply 1717. 2007
  55. ncbi request reprint Pancreatic cancer genetic epidemiology consortium
    Gloria M Petersen
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 15:704-10. 2006
    ..Linkage studies are ongoing. The PACGENE Consortium will be a valuable family-based resource that will greatly enhance genetic epidemiology research in pancreatic cancer...
  56. ncbi request reprint Overview of linkage analysis: application to pancreatic cancer
    Alison P Klein
    Statistical Genetics Section, National Human Genome Research Institute, National Institute of Health, USA
    Methods Mol Med 103:329-41. 2005
    ..This chapter focuses on the basics of linkage analysis for qualitative traits (affected/unaffected) as could be applied to the study of pancreatic cancer...
  57. pmc GeneLink: a database to facilitate genetic studies of complex traits
    Elizabeth M Gillanders
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 8000, USA
    BMC Genomics 5:81. 2004
    ..To minimize the difficulties inherent in complex trait studies, we have developed GeneLink, a Web-accessible, password-protected Sybase database...
  58. ncbi request reprint Copy-number variants in patients with a strong family history of pancreatic cancer
    Robert Lucito
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    Cancer Biol Ther 6:1592-9. 2007
    ..Selected deletions and amplifications were confirmed using real-time PCR, including a germ-line amplification on chromosome 19. These genetic copy-number variants define potential candidate loci for the familial pancreatic cancer gene...