Research Topics
| Gregory KirkSummaryAffiliation: Johns Hopkins Bloomberg School of Public Health Country: USA Publications
Research Grants
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Detail Information
Publications
Provider and clinic-level correlates of deferring antiretroviral therapy for people who inject drugs: a survey of North American HIV providersRyan P Westergaard
Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI, USA
J Int AIDS Soc 15:10. 2012..We sought to estimate the degree to which providers of HIV care defer initiation of ART because of injection drug use and to identify clinic and provider-level factors associated with resistance to prescribing ART to IDUs...- Cross sectional analysis of respiratory symptoms in an injection drug user cohort: the impact of obstructive lung disease and HIVM Bradley Drummond
Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
BMC Pulm Med 10:27. 2010..We characterized the independent and joint effects of HIV and OLD on respiratory symptoms of a cohort of inner-city IDUs... - CD4 count at presentation for HIV care in the United States and Canada: are those over 50 years more likely to have a delayed presentation?Keri N Althoff
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD, 21205, USA
AIDS Res Ther 7:45. 2010..10%, respectively). Due to the increasing proportion, consistently lower CD4 counts, and more advanced HIV disease in adults ≥50-year-old at first presentation for HIV care, renewed HIV testing efforts are needed... 
249(ser) TP53 mutation in plasma DNA, hepatitis B viral infection, and risk of hepatocellular carcinomaGregory D Kirk
Gambia Hepatitis Intervention Study, Banjul
Oncogene 24:5858-67. 2005..6-3270). These results suggest a multiplicative effect on HCC risk resulting from the mutational effect of aflatoxin on TP53, as monitored by detection of plasma 249(ser), with concomitant chronic infection with HBV...- Assessment of liver fibrosis by transient elastography in persons with hepatitis C virus infection or HIV-hepatitis C virus coinfectionGregory D Kirk
Department of Epidemiology, Schools of Public Health and Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
Clin Infect Dis 48:963-72. 2009..We compared elastography with histologic methods among hepatitis C virus (HCV)-infected and human immunodeficiency virus (HIV)-HCV-coinfected participants in an urban, predominantly black study population... - Molecular epidemiology of human liver cancer: insights into etiology, pathogenesis and prevention from The Gambia, West AfricaGregory D Kirk
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Carcinogenesis 27:2070-82. 2006.... - HIV infection is associated with an increased risk for lung cancer, independent of smokingGregory D Kirk
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
Clin Infect Dis 45:103-10. 2007..Human immunodeficiency virus (HIV)-infected persons have an elevated risk for lung cancer, but whether the increase reflects solely their heavy tobacco use remains an open question... - HIV infection in the etiology of lung cancer: confounding, causality, and consequencesGregory D Kirk
Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland 21205, USA
Proc Am Thorac Soc 8:326-32. 2011..Substantial efforts are needed to promote smoking cessation and to control lung cancer among HIV-infected populations... - Progression of liver fibrosis among injection drug users with chronic hepatitis CLucy E Wilson
Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21231-1002, USA
Hepatology 43:788-95. 2006..In this setting with low fibrosis prevalence, FibroSURE, ALT, and APRI tests predict insignificant fibrosis; however, further work is needed to find noninvasive markers of significant liver fibrosis... - Effect of micronutrients and iron supplementation on hemoglobin, iron status, and plasma hepatitis C and HIV RNA levels in female injection drug users: a controlled clinical trialRichard D Semba
Department of Ophthalmology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
J Acquir Immune Defic Syndr 45:298-303. 2007..Iron deficiency is common among female injection drug users, but it is unclear whether iron supplementation can reduce anemia and improve iron status without increasing plasma hepatitis C virus (HCV) or HIV RNA levels... 
Limited uptake of hepatitis C treatment among injection drug usersShruti H Mehta
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
J Community Health 33:126-33. 2008..Low HCV treatment effectiveness was observed in this IDU population. Comprehensive integrated care strategies that incorporate education, case-management and peer support are needed to improve care and treatment of HCV-infected IDUs...- Survival during renal replacement therapy among African Americans infected with HIV type 1 in urban Baltimore, MarylandMohamed G Atta
Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Clin Infect Dis 45:1625-32. 2007..It is unknown how the widespread use of highly active antiretroviral therapy (HAART) has affected survival during RRT in this vulnerable population... - Nonstructured treatment interruptions among injection drug users in Baltimore, MDRavi Kavasery
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
J Acquir Immune Defic Syndr 50:360-6. 2009..We characterized patterns of highly active antiretroviral therapy (HAART) use and predictors of nonstructured treatment interruptions (NTIs) among injection drug users (IDUs) in Baltimore, MD... - Hepatitis B virus infection and hepatocellular carcinoma among parous Taiwanese women: nationwide cohort studyChyng Wen Fwu
Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
J Natl Cancer Inst 101:1019-27. 2009..We used a nationwide cohort of reproductive-aged Taiwanese women to study relationships of HBV infection and parity with hepatocellular carcinoma risk... - Changes in blood-borne infection risk among injection drug usersShruti H Mehta
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
J Infect Dis 203:587-94. 2011..Population-level hepatitis C virus (HCV) infection incidence is a surrogate for community drug-related risk... - Prevalence, correlates, and viral dynamics of hepatitis delta among injection drug usersLauren M Kucirka
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
J Infect Dis 202:845-52. 2010..Accurate estimates of prevalence and risk factors are important to help clinicians decide who to screen... - Temporal trends in highly active antiretroviral therapy initiation among injection drug users in Baltimore, Maryland, 1996-2008Shruti H Mehta
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Clin Infect Dis 50:1664-71. 2010..We characterized temporal trends in highly active antiretroviral therapy (HAART) initiation (1996-2008) among treatment-eligible persons in a community-based cohort of current and former injection drug users (IDUs) in Baltimore, Maryland... - Liver enzyme flares and occult hepatitis B in persons with chronic hepatitis C infectionRajesh Kannangai
Department of Pathology, The Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
J Clin Virol 39:101-5. 2007..Given that typical chronic HBV infections often have periodic flairs in viral replication and liver damage, we hypothesized that occult HBV may also have flares in viral replication that are associated with increased liver enzymes... - Adherence and retention of female injection drug users in a phase III clinical trial in inner city BaltimoreRichard D Semba
Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
Am J Drug Alcohol Abuse 33:71-80. 2007..Women lost to follow-up were younger, more often white, not on methadone, and injecting drugs daily. Fair-moderate adherence to visits and treatment occurs among female IDUs in a clinical trial... - Quantitative analysis of plasma TP53 249Ser-mutated DNA by electrospray ionization mass spectrometryMatilde E Lleonart
Johns Hopkins Bloomberg School of Public Health, Department of Environmental Health Sciences, 615 North Wolfe Street, Room E7032, Baltimore, MD 21205, USA
Cancer Epidemiol Biomarkers Prev 14:2956-62. 2005..Potential applications for the quantification of 249(Ser) DNA in plasma include estimation of long-term, cumulative aflatoxin exposure and selection of appropriate high-risk individuals for targeted intervention... - Human immunodeficiency virus-related microbial translocation and progression of hepatitis CAshwin Balagopal
Division of Infectious Diseases, Viral Hepatitis Center, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Gastroenterology 135:226-33. 2008..We hypothesized that HIV promotes liver disease by enhancing microbial translocation... - Mortality after chronic hepatitis B virus infection: a linkage study involving 2 million parous women from TaiwanChyng Wen Fwu
Johns Hopkins University, Baltimore, Maryland, USA
J Infect Dis 201:1016-23. 2010..We investigated the overall and disease-specific mortality rates in a nationwide cohort of women after they were screened for hepatitis B surface antigen (HBsAg) during pregnancy... - Aflatoxin exposure and viral hepatitis in the etiology of liver cirrhosis in the Gambia, West AfricaMark H Kuniholm
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Environ Health Perspect 116:1553-7. 2008..Cirrhosis of the liver is thought to be a major cause of morbidity and mortality in sub-Saharan Africa, but few controlled studies on the etiology of cirrhosis have been conducted in this region... - Long-term effectiveness of diagnosing and treating latent tuberculosis infection in a cohort of HIV-infected and at-risk injection drug usersJonathan E Golub
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
J Acquir Immune Defic Syndr 49:532-7. 2008..Between 1990 and 1998, tuberculin skin tests (TST) and isoniazid preventive therapy (IPT) were provided to injection drug users participating in the AIDS Linked to the Intravenous Experiences cohort... - Effect of cigarette smoking on HIV acquisition, progression, and mortalityMariah M Marshall
Department of Epidemiology, Johns Hopkins University, Baltimore, MD 21205, USA
AIDS Educ Prev 21:28-39. 2009..Future investigation of the biological and clinical effects of smoking, and of preventive approaches to reduce the heavy burden among individuals with HIV is warranted... - Evaluation of human immunodeficiency virus biomarkers: inferences from interval and clinical cohort studiesBryan Lau
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Epidemiology 20:664-72. 2009..No studies have evaluated the impact of the frequency of marker measurements for either their predictive value of mortality or how they may influence inference of the effect of therapy initiation in analyses from observational data... - End-stage renal disease and chronic kidney disease in a cohort of African-American HIV-infected and at-risk HIV-seronegative participants followed between 1988 and 2004Gregory M Lucas
Department of Medicine, Divisions of Infectious Diseases, Bloomberg School of Public Health, John Hopkins University, Baltimore, Maryland, USA
AIDS 21:2435-43. 2007..HIV-infected African-Americans are at increased risk of end-stage renal disease requiring renal replacement therapy (RRT)... - Genetic variation in IL28B and spontaneous clearance of hepatitis C virusDavid L Thomas
Johns Hopkins University, Division of Infectious Diseases, Baltimore, Maryland 21205, USA
Nature 461:798-801. 2009..To our knowledge, this is the strongest and most significant genetic effect associated with natural clearance of HCV, and these results implicate a primary role for IL28B in resolution of HCV infection... - Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virusTimothy L Mosbruger
Johns Hopkins University, Baltimore, MD, USA
J Infect Dis 201:1371-80. 2010..In this large-scale analysis of 1426 genotyped SNPs in 112 candidate genes, we identified 4 gene regions that are likely candidates for a role in HCV clearance or persistence in both African Americans and European Americans... - Late presentation for human immunodeficiency virus care in the United States and CanadaKeri N Althoff
Johns Hopkins University, Baltimore, Maryland, USA
Clin Infect Dis 50:1512-20. 2010..CONCLUSION. CD4 count at first presentation for HIV care has increased annually over the past 11 years but has remained <350 cells/mm(3), which suggests the urgent need for earlier HIV diagnosis and treatment... - A meta-analysis of the incidence of non-AIDS cancers in HIV-infected individualsMeredith S Shiels
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
J Acquir Immune Defic Syndr 52:611-22. 2009..To estimate summary standardized incidence ratios (SIRs) of non-AIDS cancers among HIV-infected individuals compared with general population rates overall and stratified by gender, AIDS, and highly active antiretroviral therapy (HAART) era... - Low frequency of GB virus C viremia in a cohort of HIV-1-infected elite suppressorsJoel N Blankson
Department of Medicine, John Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
AIDS 22:2398-400. 2008..Thus, GB virus C does not appear to explain the nonprogressive course seen in this cohort of elite suppressors... - Determinants of alcohol consumption in HIV-uninfected injection drug usersPetra M Sander
Department of Epidemiology, The Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA
Drug Alcohol Depend 111:173-6. 2010..This study demonstrates that in a large urban cohort of persons with a history of injection drug use, risky drug use and sexual risk behavior are associated with subsequent alcohol consumption... - Cohort profile: the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD)Stephen J Gange
NA-ACCORD Coordinating Center, Baltimore, MD 21287, USA
Int J Epidemiol 36:294-301. 2007 - Mannose binding lectin genotypes influence recovery from hepatitis B virus infectionChloe L Thio
Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
J Virol 79:9192-6. 2005..76; 95% CI, 1.02 to 3.01; P = 0.04). These data are consistent with the hypothesis that functional MBL plays a central role in the pathogenesis of acute hepatitis B... - Effectiveness of highly active antiretroviral therapy among injection drug users with late-stage human immunodeficiency virus infectionDavid Vlahov
Center for Urban Epidemiologic Studies, New York Academy of Medicine, New York, NY 10029, USA
Am J Epidemiol 161:999-1012. 2005..37/microl, respectively), suggesting that changing indications for treatment may have contributed to improved survival and that analyses restricted to the HAART era probably underestimate HAART effectiveness... - Hepatocellular carcinoma and polymorphisms in carcinogen-metabolizing and DNA repair enzymes in a population with aflatoxin exposure and hepatitis B virus endemicityGregory D Kirk
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH Department of Health and Human Services, Bethesda, MD 20892, USA
Cancer Epidemiol Biomarkers Prev 14:373-9. 2005..7; 95% CI, 1.27-169). Our findings suggest that genetic modulation of carcinogen metabolism and DNA repair can alter susceptibility to HCC and that these effects may be modified by environmental factors... - Polymorphisms of CUL5 are associated with CD4+ T cell loss in HIV-1 infected individualsPing An
Laboratory of Genomic Diversity, SAIC Frederick, Incorporated, National Cancer Institute, Frederick, Maryland, United States of America
PLoS Genet 3:e19. 2007.... - The Gambia Liver Cancer Study: Infection with hepatitis B and C and the risk of hepatocellular carcinoma in West AfricaGregory D Kirk
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Hepatology 39:211-9. 2004..If HCV transmission is not perpetuated in future cohorts, focusing available resources on HB vaccination efforts could greatly ameliorate a major cause of cancer death in sub-Saharan Africa... - Ser-249TP53 mutation in tumour and plasma DNA of hepatocellular carcinoma patients from a high incidence area in the Gambia, West AfricaKatarzyna Szymanska
International Agency for Research on Cancer and Gambia Hepatitis Intervention Study, Lyon, France
Int J Cancer 110:374-9. 2004..g., eastern China: >50%). Moreover, our studies indicate that plasma is a convenient source of liver tumour-derived DNA, thus holding promise for earlier detection and diagnosis of cancer... - Regulatory polymorphisms in the interleukin-18 promoter are associated with hepatitis C virus clearancePing An
Laboratory of Genomic Diversity, Science Applications International Corportation Frederick, MD, USA
J Infect Dis 198:1159-65. 2008..77-11.6]) was also strongly associated with viral clearance. No association was found among those with hemophilia. These results suggest that IL18 promoter polymorphism may affect the outcome of HCV infection in certain groups... - Improving survival among HIV-infected injection drug users: how should we define success?Gregory D Kirk
Clin Infect Dis 45:377-80. 2007 - Impact of race on the association between diabetes and HCVGregory D Kirk
Am J Gastroenterol 99:564; author reply 565. 2004 - Effects of human TRIM5alpha polymorphisms on antiretroviral function and susceptibility to human immunodeficiency virus infectionHassan Javanbakht
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Division of AIDS, Harvard Medical School, Boston, MA 02115, USA
Virology 354:15-27. 2006..05 for both SNPs and haplotypes. Thus, polymorphism in human TRIM5 may influence susceptibility to HIV-1 infection, a possibility that merits additional evaluation in independent cohorts... - NPHS2 variation in sporadic focal segmental glomerulosclerosisLouise M McKenzie
Laboratory of Genomic Diversity, SAIC Frederick, National Cancer Institute, NCI Frederick, Frederick, Maryland, USA
J Am Soc Nephrol 18:2987-95. 2007..5, P = 0.001). These results indicate that genetic variation or mutation of NPHS2 may play a role in late-onset sporadic FSGS... - Evaluation of IL10, IL19 and IL20 gene polymorphisms and chronic hepatitis B infection outcomeAnn L Truelove
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD, USA
Int J Immunogenet 35:255-64. 2008..01-0.04). These results suggest that IL10 and IL20 gene variants influence HBV infection outcome and encourage the pursuit of further studies of these cytokines in HBV pathogenesis... - Genetic variation in the CCL18-CCL3-CCL4 chemokine gene cluster influences HIV Type 1 transmission and AIDS disease progressionWilliam S Modi
SAIC Frederick, Inc, Basic Research Program, Frederick, MD 21702 1201, USA
Am J Hum Genet 79:120-8. 2006..01-.02). These results reiterate the importance of chemokine gene variation in HIV-1/AIDS pathogenesis and emphasize that localized linkage disequilibrium makes the identification of causal mutations difficult... - Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1Maureen P Martin
Laboratory of Genomic Diversity, Science Applications International Corporation Frederick, Inc, National Cancer Institute, P O Box B, Building 560, Frederick, Maryland 21702, USA
Nat Genet 39:733-40. 2007....
Research Grants
- NATURAL HISTORY OF HIV INFECTION IN INJECTION DRUG USERSGregory D Kirk; Fiscal Year: 2010..The ALIVE study can address this next generation of questions among African American IDUs with the intent to contribute to improved epidemiological, clinical and basic science and respond to the changing HIV epidemic. ..
- NATURAL HISTORY OF HIV INFECTION IN INJECTION DRUG USERSGregory Kirk; Fiscal Year: 2007..The ALIVE study can address this next generation of questions among African American IDUs with the intent to contribute to improved epidemiological, clinical and basic science and respond to the changing HIV epidemic. ..
- NATURAL HISTORY OF HIV INFECTION IN INJECTION DRUG USERSGregory Kirk; Fiscal Year: 2009..The ALIVE study can address this next generation of questions among African American IDUs with the intent to contribute to improved epidemiological, clinical and basic science and respond to the changing HIV epidemic. ..
- The Study of HIV Infection in the Etiology of Lung Disease (SHIELD)Gregory D Kirk; Fiscal Year: 2010....
- The Study of HIV Infection in the Etiology of Lung Disease (SHIELD)Gregory Kirk; Fiscal Year: 2009....
- Real Time Methods for Quantifying Exposure to Illicit Drugs & Psychosocial StressGregory Kirk; Fiscal Year: 2007....
- The Study of HIV Infection in the Etiology of Lung Disease (SHIELD)Gregory Kirk; Fiscal Year: 2007....