KENNETH KINZLERSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Patient-oriented gene set analysis for cancer mutation dataSimina M Boca
Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, 615 N, Wolfe Street, Baltimore, MD 21205, USA
Genome Biol 11:R112. 2010..In mutation analysis, these patient-oriented methods are more transparent, interpretable, and statistically powerful than traditional gene-oriented methods...- Identification of microbial DNA in human cancerChristopher G Duncan
Preston Robert Tisch Brain Tumor Center, Pediatric Brain Tumor Foundation Institute, Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
BMC Med Genomics 2:22. 2009..CONCLUSION: DK-MICROBE can identify previously unknown infectious agents in human tumors, and is now available for further applications for the identification of pathogen DNA in human cancer and other diseases... 
The role of companion diagnostics in the development and use of mutation-targeted cancer therapiesNickolas Papadopoulos
Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, The Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, 1650 Orleans Street, CRB1, Baltimore, MD 21231, USA
Nat Biotechnol 24:985-95. 2006..These tests can simplify the drug discovery process, make clinical trials more efficient and informative, and be used to individualize the therapy of cancer patients...- Synthesis and evaluation of aminophosphinic acid derivatives as inhibitors of renal dipeptidaseHallur Gurulingappa
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
Bioorg Med Chem Lett 14:3531-3. 2004..Compounds 3a and 3c in which the phenyl ring was para substituted with F and Br and olefin with Z geometry, showed better inhibitory activity against RDP enzyme (IC50 = 5-6 nM)... - Analysis of mutations in DNA isolated from plasma and stool of colorectal cancer patientsFrank Diehl
The Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute and Sidney Kimmel Cancer Center, Baltimore, Maryland, USA
Gastroenterology 135:489-98. 2008..A secondary purpose was to compare the results of plasma and stool DNA testing using the same technology... - Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancersRebecca J Leary
The Ludwig Center for Cancer Genetics and Therapeutics and The Howard Hughes Medical Institute at The Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
Proc Natl Acad Sci U S A 105:16224-9. 2008..These analyses provide an integrated view of copy number and sequencing alterations on a genome-wide scale and identify genes and pathways that could prove useful for cancer diagnosis and therapy... - The colorectal microRNAomeJordan M Cummins
The Sidney Kimmel Comprehensive Cancer Center and Howard Hughes Medical Institute, Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA
Proc Natl Acad Sci U S A 103:3687-92. 2006..These studies suggest that the human genome contains many more miRNAs than currently identified and provide an approach for the large-scale experimental cloning of novel human miRNAs in human tissues... - Detection and quantification of mutations in the plasma of patients with colorectal tumorsFrank Diehl
Howard Hughes Medical Institute and The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Medical Institutions, 1650 Orleans Street, Baltimore, MD 21231, USA
Proc Natl Acad Sci U S A 102:16368-73. 2005..01% to 1.7% of the total APC molecules. These results have implications for the mechanisms through which tumor DNA is released into the circulation and for diagnostic tests based on this phenomenon... - Colorectal cancer: mutations in a signalling pathwayD Williams Parsons
The Sidney Kimmel Comprehensive Cancer Center and The Howard Hughes Medical Institute, The Johns Hopkins University Medical Institutions, Baltimore, Maryland 21231, USA
Nature 436:792. 2005..The discovery of this mutational activation of a key cell-signalling pathway may provide new targets for therapeutic intervention... - Discodermolide analogues as the chemical component of combination bacteriolytic therapyAmos B Smith
Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA
Bioorg Med Chem Lett 15:3623-6. 2005..A single intravenous injection of (+)-3 plus genetically modified Clostridium novyi-NT spores caused rapid and complete regressions of tumors in mice bearing HCT116 colorectal cancer xenografts... - Identification of compounds that inhibit growth of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine-resistant cancer cellsKurtis E Bachman
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Mol Cancer Ther 4:1026-30. 2005..These compounds may prove useful for the treatment or prevention of gastrointestinal tumors arising after exposure to PhIP and related carcinogens... - Mutant PIK3CA promotes cell growth and invasion of human cancer cellsYardena Samuels
The Sidney Kimmel Comprehensive Cancer Center and The Howard Hughes Medical Institute, The Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA
Cancer Cell 7:561-73. 2005..Treatment with the PI3K inhibitor LY294002 abrogated PIK3CA signaling and preferentially inhibited growth of PIK3CA mutant cells. These data have important implications for therapy of cancers harboring PIK3CA alterations... - Contribution of bone marrow-derived endothelial cells to human tumor vasculatureBrock A Peters
The Sidney Kimmel Comprehensive Cancer Center and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, 1650 Orleans Street, Baltimore, Maryland 21231, USA
Nat Med 11:261-2. 2005..These results illustrate substantial differences between human tumors and many mouse models with respect to angiogenesis and have important implications for the translation of experimental antiangiogenic therapies to the clinic... - Somatic mutations of EGFR in colorectal cancers and glioblastomasThomas D Barber
N Engl J Med 351:2883. 2004 - Identification of a binding partner for the endothelial cell surface proteins TEM7 and TEM7RAkash Nanda
The Howard Hughes Medical Institute, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Cancer Res 64:8507-11. 2004..These studies establish the overexpression of TEM7 protein in tumor endothelium and provide new opportunities for the delivery of therapeutic and imaging agents to the vessels of solid tumors... - Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancersLaura D Wood
The Ludwig Center for Cancer Genetics and Therapeutics, The Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland 21231, USA
Hum Mutat 27:1060-1. 2006..Our results implicate these tyrosine kinase genes in the pathogenesis of other tumor types and suggest that they may be useful targets for diagnostic and therapeutic intervention in selected patients... - The consensus coding sequences of human breast and colorectal cancersTobias Sjoblom
Ludwig Center and Howard Hughes Medical Institute, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
Science 314:268-74. 2006..These data define the genetic landscape of two human cancer types, provide new targets for diagnostic and therapeutic intervention, and open fertile avenues for basic research in tumor biology... - Prediction of germline mutations and cancer risk in the Lynch syndromeSining Chen
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
JAMA 296:1479-87. 2006..Current clinical guidelines are effective but limited by applicability and cost... - Dissecting isoform selectivity of PI3K inhibitors: the role of non-conserved residues in the catalytic pocketMark Frazzetto
Australian Centre for Blood Diseases, Monash University, Melbourne, VIC 3004, Australia
Biochem J 414:383-90. 2008.... - Chromatid cohesion defects may underlie chromosome instability in human colorectal cancersThomas D Barber
The Ludwig Center and Howard Hughes Medical Institute at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
Proc Natl Acad Sci U S A 105:3443-8. 2008..These results suggest that defective sister chromatid cohesion as a result of somatic mutations may represent a major cause of chromosome instability in human cancers... - The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutationsChuan Hsiang Huang
Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Science 318:1744-8. 2007..In addition to providing new insights about the structure of PI3Kalpha, these results suggest specific mechanisms for the effect of oncogenic mutations in p110alpha and p85alpha... - Genetic progression and the waiting time to cancerNiko Beerenwinkel
Program for Evolutionary Dynamics, Harvard University, Cambridge, Massachusetts, United States of America
PLoS Comput Biol 3:e225. 2007..The complexity of cancer progression can be understood as the result of multiple sequential mutations, each of which has a relatively small but positive effect on net cell growth... - The genomic landscapes of human breast and colorectal cancersLaura D Wood
Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute at Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
Science 318:1108-13. 2007..These results have implications for understanding the nature and heterogeneity of human cancers and for using personal genomics for tumor diagnosis and therapy... - A multidimensional analysis of genes mutated in breast and colorectal cancersJimmy Lin
Ludwig Center for Cancer Genetics and Therapeutics, and The Howard Hughes Medical Institute at The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland 21231, USA
Genome Res 17:1304-18. 2007..These studies provide a multidimensional framework to guide further research and help identify cellular processes critical for malignant progression and therapeutic intervention... - Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase TXiaodong Zhang
Department of Genetics and Case Comprehensive Cancer Center, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
Proc Natl Acad Sci U S A 104:4060-4. 2007..These studies illuminate a mechanism regulating the STAT3 pathway and suggest that this signaling pathway plays an important role in colorectal tumorigenesis... - Lynch syndrome (hereditary nonpolyposis colorectal cancer) diagnosticsKristina Lagerstedt Robinson
Department of Clinical Genetics, Karolinska University Hospital, S 17176 Stockholm, Sweden
J Natl Cancer Inst 99:291-9. 2007..The syndrome is explained by germline mutations in DNA mismatch repair (MMR) genes, and there is a need for diagnostic tools to preselect patients for genetic testing to diagnose those with HNPCC... - A bacterial protein enhances the release and efficacy of liposomal cancer drugsIan Cheong
Howard Hughes Medical Institute and the Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins Kimmel Comprehensive Cancer Center, Baltimore, MD 21231, USA
Science 314:1308-11. 2006..This protein could potentially be incorporated into diverse experimental approaches for the specific delivery of chemotherapeutic agents to tumors... - Circulating mutant DNA to assess tumor dynamicsFrank Diehl
The Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute and Sidney Kimmel Cancer Center at the Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
Nat Med 14:985-90. 2008..We suggest that this personalized genetic approach could be generally applied to individuals with other types of cancer... - The genome and transcriptomes of the anti-tumor agent Clostridium novyi-NTChetan Bettegowda
The Howard Hughes Medical Institute, The Ludwig Center for Cancer Genetics and Therapeutics, The Sidney Kimmel Comprehensive Cancer Center, Department of Pharmacology and Molecular Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
Nat Biotechnol 24:1573-80. 2006..Through this analysis, we found that C. novyi-NT spores contained mRNA and that the spore transcripts were distinct from those in vegetative forms of the bacterium... - Cancer genes and the pathways they controlBert Vogelstein
Howard Hughes Medical Institute and The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University Medical Institutions, Baltimore, Maryland 21231, USA
Nat Med 10:789-99. 2004..The purposes of this review are to highlight examples of progress in these areas, indicate where knowledge is scarce and point out fertile grounds for future investigation... - Mutational analysis of the tyrosine phosphatome in colorectal cancersZhenghe Wang
Sidney Kimmel Comprehensive Cancer Center, Howard Hughes Medical Institute, Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA
Science 304:1164-6. 2004..These observations suggest that the mutated tyrosine phosphatases are tumor suppressor genes, regulating cellular pathways that may be amenable to therapeutic intervention... - PUMA mediates the apoptotic response to p53 in colorectal cancer cellsJian Yu
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD 21231, USA
Proc Natl Acad Sci U S A 100:1931-6. 2003..These results suggest that the balance between PUMA and p21 is pivotal in determining the responses to p53 activation and provide a model for understanding the basis of p53 mutations in human cancer... - Histone modifications and silencing prior to DNA methylation of a tumor suppressor geneKurtis E Bachman
The Howard Hughes Medical Institute, The Sidney Kimmel Comprehensive Cancer Center, and Program in Cellular and Molecular Medicine, The Johns Hopkins University School of Medicine, 1650 Orleans Street, Baltimore, MD 21231, USA
Cancer Cell 3:89-95. 2003..These results have important implications for understanding the biochemical events underlying the silencing of tumor suppressor genes and the resultant growth suppression... - Digital karyotypingTian-Li Wang
The Howard Hughes Medical Institute and The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA
Proc Natl Acad Sci U S A 99:16156-61. 2002..Foreign DNA sequences not present in the normal human genome could also be readily identified. Digital karyotyping provides a broadly applicable means for systematic detection of DNA copy number changes on a genomic scale... - Tumorigenesis: RAF/RAS oncogenes and mismatch-repair statusHarith Rajagopalan
Sidney Kimmel Comprehensive Cancer Centre, Howard Hughes Medical Institution and Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Nature 418:934. 2002.... - Allelic variation in human gene expressionHai Yan
Sidney Kimmel Comprehensive Cancer Center and Howard Hughes Medical Institute, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
Science 297:1143. 2002 - Targeted inactivation of CTNNB1 reveals unexpected effects of beta-catenin mutationTimothy A Chan
The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Medical Institutions, 1650 Orleans Street, Baltimore, MD 21231, USA
Proc Natl Acad Sci U S A 99:8265-70. 2002..These findings pose several challenges to current models of APC/beta-catenin function... - DNMT1 and DNMT3b cooperate to silence genes in human cancer cellsIna Rhee
The Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Nature 416:552-6. 2002..Here we demonstrate that two enzymes cooperatively maintain DNA methylation and gene silencing in human cancer cells, and provide compelling evidence that such methylation is essential for optimal neoplastic proliferation... - DEC1 is a downstream target of TGF-beta with sequence-specific transcriptional repressor activitiesLeigh Zawel
The Howard Hughes Medical Institute and The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Medical Institutions, 1650 Orleans Street, Baltimore, MD 21231, USA
Proc Natl Acad Sci U S A 99:2848-53. 2002..However, DEC1 may function in concert with other signaling components to mediate certain biologic effects of TGF-beta... - Prevalence of somatic alterations in the colorectal cancer cell genomeTian-Li Wang
Howard Hughes Medical Institute and The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
Proc Natl Acad Sci U S A 99:3076-80. 2002..These data suggest that most sporadic colorectal cancers do not display a mutator phenotype at the nucleotide level. They also have significant implications for the interpretation of somatic mutations in candidate tumor-suppressor genes... - Detection of proximal colorectal cancers through analysis of faecal DNAGiovanni Traverso
Lancet 359:403-4. 2002..Using a sensitive method for microsatellite mutation detection, we found that 18 of 46 cancers had microsatellite alterations and that identical mutations could be identified in the faecal DNA of 17 of these 18 cases... - Detection of APC mutations in fecal DNA from patients with colorectal tumorsGiovanni Traverso
Graduate Program in Human Genetics, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins School of Medicine, Baltimore, USA
N Engl J Med 346:311-20. 2002..CONCLUSIONS: APC mutations can be detected in fecal DNA from patients with relatively early colorectal tumors. This feasibility study suggests a new approach for the early detection of colorectal neoplasms... - Counting alleles to predict recurrence of early-stage colorectal cancersWei Zhou
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Lancet 359:219-25. 2002..002). INTERPRETATION: In patients without metastasis, allelic imbalance is a better predictor of prognosis than histopathological stage... - Mutational analysis of the tyrosine kinome in colorectal cancersAlberto Bardelli
The Howard Hughes Medical Institute and The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
Science 300:949. 2003 - MIC-1 serum level and genotype: associations with progress and prognosis of colorectal carcinomaDavid A Brown
Centre for Immunology, St Vincent s Hospital and University of New South Wales, Sydney NSW, Australia
Clin Cancer Res 9:2642-50. 2003..In a separate cohort of 224 patients, we evaluated the relationship of MIC-1 serum level and genotype to standard tumor parameters and outcome measures... - Three classes of genes mutated in colorectal cancers with chromosomal instabilityZhenghe Wang
Sidney Kimmel Comprehensive Cancer Center and Howard Hughes Medical Institute at Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Cancer Res 64:2998-3001. 2004..This analysis buttresses the evidence that chromosomal instability has a genetic basis and provides clues to the mechanistic basis of instability in cancers... - Tumour suppression: disruption of HAUSP gene stabilizes p53Jordan M Cummins
Howard Hughes Medical Institute, The Sidney Kimmel Comprehensive Cancer Center, and Program in Cellular and Molecular Medicine, The Johns Hopkins University Medical Institutions, Baltimore, Maryland 21231, USA
Nature 428:1 p following 486. 2004 - High frequency of mutations of the PIK3CA gene in human cancersYardena Samuels
Sidney Kimmel Comprehensive Cancer Center, Howard Hughes Medical Institute, The Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA
Science 304:554. 2004 - Inactivation of hCDC4 can cause chromosomal instabilityHarith Rajagopalan
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Nature 428:77-81. 2004..Our data suggest that chromosomal instability is caused by specific genetic alterations in a large fraction of human cancers and can occur before malignant conversion... - Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patientsTian Li Wang
The Howard Hughes Medical Institute, Sidney Kimmel Comprehensive Cancer Center and Department of Surgery, The Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA
Proc Natl Acad Sci U S A 101:3089-94. 2004..01). These data suggest that genetic amplification of TYMS is a major mechanism of 5-FU resistance in vivo and have important implications for the management of colorectal cancer patients with recurrent disease... - TEM8 interacts with the cleaved C5 domain of collagen alpha 3(VI)Akash Nanda
Program in Human Genetics and Molecular Biology and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Cancer Res 64:817-20. 2004..These results suggest that the TEM8/C5 interaction may play an important biological role in tumor angiogenesis... - Targeting vascular and avascular compartments of tumors with C. novyi-NT and anti-microtubule agentsLong H Dang
Howard Hughes Medical Institute and Sidney Kimmel Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Cancer Biol Ther 3:326-37. 2004..novyi-NT spores could germinate. A single intravenous injection of C. novyi-NT plus selected anti-microtubule agents was able to cause regressions of several human tumor xenografts in nude mice in the absence of excessive toxicity... - Facile methods for generating human somatic cell gene knockouts using recombinant adeno-associated virusesManu Kohli
The Howard Hughes Medical Institute, The Sidney Kimmel Comprehensive Cancer Center, and The Cellular and Molecular Medicine Program, The Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA
Nucleic Acids Res 32:e3. 2004..This technology should be broadly applicable to in vitro studies that require the manipulation of the human genome... - Overcoming the hypoxic barrier to radiation therapy with anaerobic bacteriaChetan Bettegowda
Howard Hughes Medical Institute and Sidney Kimmel Cancer Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
Proc Natl Acad Sci U S A 100:15083-8. 2003..C. novyi-NT spores added little toxicity to the radiotherapeutic regimens, and the combination resulted in long-term remissions in a significant fraction of animals... - PRL-3 expression in metastatic cancersAlberto Bardelli
The Howard Hughes Medical Institute University Hospitals of Cleveland and Case Western Reserve University, Cleveland, Ohio, USA
Clin Cancer Res 9:5607-15. 2003..We sought to determine the cellular basis of this elevation and assess the expression of PRL-3 in metastatic lesions derived from cancers of the colon and other tissues... - Knudson's hypothesis and the TP53 revolutionSuzanne J Baker
Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
Genes Chromosomes Cancer 38:329. 2003 - Multicolor in vitro translationGiovanni Traverso
Howard Hughes Medical Institute, Sidney Kimmel Comprehensive Cancer Center, and Graduate Program in Human Genetics, Johns Hopkins School of Medicine, 1650 Orleans Street, Baltimore, Maryland 21231, USA
Nat Biotechnol 21:1093-7. 2003..This technology can be applied in various situations, including the simplified detection of rare truncating mutations in clinical samples from cancer patients... - Small changes in expression affect predisposition to tumorigenesisHai Yan
The Howard Hughes Medical Institute, The Oncology Center, and the Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
Nat Genet 30:25-6. 2002....