Douglas Kerr

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Neuromyelitis optica pathogenesis and aquaporin 4
    David J Graber
    Department of Pathology, Dartmouth Medical School, Lebanon, New Hampshire, USA
    J Neuroinflammation 5:22. 2008
  2. ncbi request reprint Immunopathogenesis of acute transverse myelitis
    Douglas A Kerr
    Department of Neurology, School of Medicine, Johns Hopkins University, Pathology 627 C, 6000 N Wolfe Street, Baltimore, MD 21287 6965, USA
    Curr Opin Neurol 15:339-47. 2002
  3. ncbi request reprint Human embryonic germ cell derivatives facilitate motor recovery of rats with diffuse motor neuron injury
    Douglas A Kerr
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Neurosci 23:5131-40. 2003
  4. ncbi request reprint The immune system and neuropsychiatric diseases
    Douglas Kerr
    Department of Neurology, Johns Hopkins Hospital, 600 N Wolfe St, Pathology 627C, Baltimore MD 21287, USA
    Int Rev Psychiatry 17:443-9. 2005
  5. doi request reprint Optic neuritis and recurrent myelitis in a woman with systemic lupus erythematosus
    Julius Birnbaum
    Division of Rheumatology, The Johns Hopkins University of Medicine, Baltimore, MD 21224, USA
    Nat Clin Pract Rheumatol 4:381-6. 2008
  6. ncbi request reprint Altered immune response to CNS viral infection in mice with a conditional knock-down of macrophage-lineage cells
    Jessica Carmen
    Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA
    Glia 54:71-80. 2006
  7. ncbi request reprint Glial restricted precursors protect against chronic glutamate neurotoxicity of motor neurons in vitro
    Nicholas J Maragakis
    Department of Neurology and Neuroscience, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Glia 50:145-59. 2005
  8. pmc Using global statistical tests in long-term Parkinson's disease clinical trials
    Peng Huang
    Division of Oncology Biostatistics, Johns Hopkins University, Baltimore, Maryland, USA
    Mov Disord 24:1732-9. 2009
  9. ncbi request reprint Is neuromyelitis optica distinct from multiple sclerosis?: something for "lumpers" and "splitters"
    Elliot M Frohman
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75235, USA
    Arch Neurol 64:903-5. 2007
  10. pmc Treatment of relapsing-remitting multiple sclerosis with high-dose cyclophosphamide induction followed by glatiramer acetate maintenance
    Daniel M Harrison
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Mult Scler 18:202-9. 2012

Collaborators

Detail Information

Publications31

  1. pmc Neuromyelitis optica pathogenesis and aquaporin 4
    David J Graber
    Department of Pathology, Dartmouth Medical School, Lebanon, New Hampshire, USA
    J Neuroinflammation 5:22. 2008
    ..Thus an AQP4 animal model would provide a means to manipulate events which are now associated with NMO and thus demonstrate what set of events or multiplicity of events can push the anti-AQP4 response to be pathogenic...
  2. ncbi request reprint Immunopathogenesis of acute transverse myelitis
    Douglas A Kerr
    Department of Neurology, School of Medicine, Johns Hopkins University, Pathology 627 C, 6000 N Wolfe Street, Baltimore, MD 21287 6965, USA
    Curr Opin Neurol 15:339-47. 2002
    ..Developing a further understanding of how the immune system induces neural injury will depend upon confirmation and extension of these findings and will require multicenter collaborative efforts...
  3. ncbi request reprint Human embryonic germ cell derivatives facilitate motor recovery of rats with diffuse motor neuron injury
    Douglas A Kerr
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Neurosci 23:5131-40. 2003
    ..We conclude that cells derived from human pluripotent stem cells have the capacity to restore neurologic function in animals with diffuse motor neuron disease via enhancement of host neuron survival and function...
  4. ncbi request reprint The immune system and neuropsychiatric diseases
    Douglas Kerr
    Department of Neurology, Johns Hopkins Hospital, 600 N Wolfe St, Pathology 627C, Baltimore MD 21287, USA
    Int Rev Psychiatry 17:443-9. 2005
    ..By understanding the principles of the immune system and how these principles relate to nervous system function, the reader will be prepared to interpret subsequent manuscripts in this issue...
  5. doi request reprint Optic neuritis and recurrent myelitis in a woman with systemic lupus erythematosus
    Julius Birnbaum
    Division of Rheumatology, The Johns Hopkins University of Medicine, Baltimore, MD 21224, USA
    Nat Clin Pract Rheumatol 4:381-6. 2008
    ..Brain MRI was initially suggestive of small-vessel disease developing in the context of neuropsychiatric systemic lupus erythematosus. Several months later, the patient developed optic neuritis, followed by recurrent attacks of myelitis...
  6. ncbi request reprint Altered immune response to CNS viral infection in mice with a conditional knock-down of macrophage-lineage cells
    Jessica Carmen
    Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA
    Glia 54:71-80. 2006
    ..The authors, therefore, conclude that although macrophage-lineage cells in the CNS may contribute to neurodegeneration in certain situations, they also serve a protective role, such as control of viral replication...
  7. ncbi request reprint Glial restricted precursors protect against chronic glutamate neurotoxicity of motor neurons in vitro
    Nicholas J Maragakis
    Department of Neurology and Neuroscience, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Glia 50:145-59. 2005
    ..The seeding of G3s resulted in a reduction of motor neuron cell death. Hence, we believe that these cells may potentially play a role in cell-based neuroprotection from glutamate excitotoxicity...
  8. pmc Using global statistical tests in long-term Parkinson's disease clinical trials
    Peng Huang
    Division of Oncology Biostatistics, Johns Hopkins University, Baltimore, Maryland, USA
    Mov Disord 24:1732-9. 2009
    ..In future long term trials, use of GST for primary statistical analysis would allow the assessment of clinically relevant outcomes rather than the artificial selection of a single primary outcome...
  9. ncbi request reprint Is neuromyelitis optica distinct from multiple sclerosis?: something for "lumpers" and "splitters"
    Elliot M Frohman
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75235, USA
    Arch Neurol 64:903-5. 2007
  10. pmc Treatment of relapsing-remitting multiple sclerosis with high-dose cyclophosphamide induction followed by glatiramer acetate maintenance
    Daniel M Harrison
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Mult Scler 18:202-9. 2012
    ..The long-term benefit of this stabilization followed by conventional therapy has not been explored...
  11. doi request reprint Differential expression of aquaporin-4 isoforms localizes with neuromyelitis optica disease activity
    Harleen Saini
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, USA
    J Neuroimmunol 221:68-72. 2010
    ..The ratio of M1:M23 mRNA is highest in the optic nerve and spinal cord, followed by brainstem, then the cerebral and cerebellar cortices...
  12. ncbi request reprint Devic's syndrome in a woman with systemic lupus erythematosus: diagnostic and therapeutic implications of testing for the neuromyelitis optica IgG autoantibody
    Julius Birnbaum
    The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Arthritis Rheum 57:347-51. 2007
  13. pmc BCL-2 and BAX protect adult mice from lethal Sindbis virus infection but do not protect spinal cord motor neurons or prevent paralysis
    Douglas A Kerr
    Department of Neurology, School of Medicine, The Johns Hopkins University, 615 N Wolfe Street, Baltimore, MD 21287, USA
    J Virol 76:10393-400. 2002
    ..Thus, divergent cell death pathways are activated in different target populations of neurons during neurovirulent SV infection of weanling mice...
  14. doi request reprint Interleukin-17 in transverse myelitis and multiple sclerosis
    Jerome J Graber
    The Johns Hopkins University School of Medicine, Department of Neurology, Baltimore, MD 21287 6965, United States
    J Neuroimmunol 196:124-32. 2008
    ..We conclude that IL-17 and IL-6 production from PBMC in TM and early MS are increased and induce astrocyte IL-6 production through IL-6...
  15. ncbi request reprint Diagnosis and management of acute myelopathies
    Adam I Kaplin
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Osler 320, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Neurologist 11:2-18. 2005
    ..TM may exist as part of a multifocal CNS disease (eg, MS), multisystemic disease (eg, systemic lupus erythematosus), or as an isolated, idiopathic entity...
  16. ncbi request reprint Recovery from paralysis in adult rats using embryonic stem cells
    Deepa M Deshpande
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 6965, USA
    Ann Neurol 60:32-44. 2006
    ..We explored the potential of embryonic stem cell-derived motor neurons to functionally replace those cells destroyed in paralyzed adult rats...
  17. ncbi request reprint Transverse Myelitis: pathogenesis, diagnosis and treatment
    Chitra Krishnan
    Department of Neurology, Johns Hopkins Transverse Myelitis Center, 600 N Wolfe Street Pathology 627C, Baltimore MD 21287 6965, USA
    Front Biosci 9:1483-99. 2004
    ..Additionally, we will review current concepts on the natural history, immunopathogenesis and treatment strategies for patients with TM...
  18. ncbi request reprint Viral-induced spinal motor neuron death is non-cell-autonomous and involves glutamate excitotoxicity
    Jessica Darman
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Neurosci 24:7566-75. 2004
    ..Similar changes may occur in other motor neuron disorders such as amyotrophic lateral sclerosis or West Nile Virus-induced poliomyelitis, suggesting a common tissue injury pathway...
  19. ncbi request reprint Recurrent transverse myelitis following neurobrucellosis: immunologic features and beneficial response to immunosuppression
    Chitra Krishnan
    Department of Neurology, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    J Neurovirol 11:225-31. 2005
    ..IL-6 levels returned to baseline following treatment of the patient with intravenous cyclophosphamide and plasma exchange and the patient experienced a significant and sustained recovery of function...
  20. ncbi request reprint The lumping and splitting of inflammatory CNS diseases
    Douglas A Kerr
    Neurology 66:1466-7. 2006
  21. ncbi request reprint Idiopathic transverse myelitis
    Chitra Krishnan
    Department of Neurology, Johns Hopkins Transverse Myelitis Center, The Johns Hopkins University, Baltimore, MD, USA
    Arch Neurol 62:1011-3. 2005
  22. ncbi request reprint BAK alters neuronal excitability and can switch from anti- to pro-death function during postnatal development
    Yihru Fannjiang
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Dev Cell 4:575-85. 2003
    ..BAK can alter neurotransmitter release in a direction consistent with its protective effects on neurons and mice. These findings suggest that BAK inhibits cell death by modifying neuronal excitability...
  23. pmc IL-6 induces regionally selective spinal cord injury in patients with the neuroinflammatory disorder transverse myelitis
    Adam I Kaplin
    Department of Psychiatry and Behavioral Sciences, Bloomberg School of Public Health, Baltimore, Maryland, USA
    J Clin Invest 115:2731-41. 2005
    ..The elucidation of this pathway identifies specific therapeutic targets in the management of CNS autoimmune conditions...
  24. doi request reprint Selective ablation of proliferating astrocytes does not affect disease outcome in either acute or chronic models of motor neuron degeneration
    Angelo C Lepore
    Department of Neurology, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Meyer 6 119, Baltimore, MD 21287, USA
    Exp Neurol 211:423-32. 2008
    ..These findings demonstrate that while normal astrocyte function is an important factor in the etiology of motor neuron diseases such as ALS, astrocyte proliferation itself does not play a significant role...
  25. pmc Neuropsychiatric manifestations of depression in multiple sclerosis: neuroinflammatory, neuroendocrine, and neurotrophic mechanisms in the pathogenesis of immune-mediated depression
    Michele L Pucak
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Dialogues Clin Neurosci 9:125-39. 2007
    ..This makes treating MS depression a neuropsychiatric imperative...
  26. pmc Axonal growth of embryonic stem cell-derived motoneurons in vitro and in motoneuron-injured adult rats
    James M Harper
    Department of Neurology, Johns Hopkins University School of Medicine, Pathology 627C, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 101:7123-8. 2004
    ....
  27. ncbi request reprint High resolution diffusion tensor imaging of axonal damage in focal inflammatory and demyelinating lesions in rat spinal cord
    Cynthia A Deboy
    Department of Neurology, Johns Hopkins University, School of Medicine, USA
    Brain 130:2199-210. 2007
    ..These data suggest that high resolution DTI may be a more sensitive method than conventional imaging for detecting axonal damage at sites distant from inflammation...
  28. ncbi request reprint Cleavage of cystatin C in the cerebrospinal fluid of patients with multiple sclerosis
    David N Irani
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA
    Ann Neurol 59:237-47. 2006
    ..The diagnosis of multiple sclerosis (MS) can be challenging because of the lack of a specific diagnostic test. Recent advances in proteomics, however, offer new opportunities for biomarker discovery and the study of disease pathogenesis...
  29. ncbi request reprint Demyelinating disorders: update on transverse myelitis
    Chitra Krishnan
    Department of Neurology, Johns Hopkins University School of Medicine, Pathology 627, 600 North Wolfe Street, Baltimore, MD 21287 6965, USA
    Curr Neurol Neurosci Rep 6:236-43. 2006
    ..Clinical trials testing the efficacy of promising axonoprotective agents in combination with intravenous steroids in the treatment of TM are currently underway...
  30. ncbi request reprint Cellular therapies in motor neuron diseases
    Mamatha S Nayak
    Department of Neurology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Biochim Biophys Acta 1762:1128-38. 2006
    ..We review pre-clinical data in rodents with each of these approaches and discuss advances and regulatory issues regarding the use of cellular therapies in human motor neuron diseases...
  31. ncbi request reprint Correction of humoral derangements from mutant superoxide dismutase 1 spinal cord
    Yun Sook Kim
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Neurol 60:716-28. 2006
    ..We sought to define molecular and cellular participants that mediate motor neuron injury in amyotrophic lateral sclerosis using a coculture system...

Research Grants10

  1. Stem Cell-Derived Motoneurons in the Adult Mammalian CNS
    Douglas Kerr; Fiscal Year: 2007
    ..These studies will define an important transplantation approach for motoneuron disease such as ALS and SMA and for spinal cord injury and other spinal disorders. ..
  2. ES Cell-Derived Motoneurons from SMA transgenic mice
    Douglas Kerr; Fiscal Year: 2007
    ..This project will identify critical molecular clues to motoneuron dysfunction in SMA and will identify potential strategies to halt or reverse this dysfunction. ..
  3. 2nd International Pathogenesis of Rare Neuroimmunologic Disorders
    Douglas Kerr; Fiscal Year: 2006
    ..The workshop will solicit participation from both senior and junior scientists/students in order to stimulate long-term research in these disorders. The proceedings will be disseminated in the medical literature. ..
  4. Pathogenesis of Rare Neuroimmunologic Disorders
    Douglas Kerr; Fiscal Year: 2004
    ..We believe this workshop will serve a critical role in advancing our understanding of disorders that are pathophysiologically linked yet, because of their rarity, are poorly understood. ..