Affiliation: Johns Hopkins University
- Neuromyelitis optica pathogenesis and aquaporin 4David J Graber
Department of Pathology, Dartmouth Medical School, Lebanon, New Hampshire, USA
J Neuroinflammation 5:22. 2008..Thus an AQP4 animal model would provide a means to manipulate events which are now associated with NMO and thus demonstrate what set of events or multiplicity of events can push the anti-AQP4 response to be pathogenic...
- Immunopathogenesis of acute transverse myelitisDouglas A Kerr
Department of Neurology, School of Medicine, Johns Hopkins University, Pathology 627 C, 6000 N Wolfe Street, Baltimore, MD 21287 6965, USA
Curr Opin Neurol 15:339-47. 2002..Developing a further understanding of how the immune system induces neural injury will depend upon confirmation and extension of these findings and will require multicenter collaborative efforts...
- Human embryonic germ cell derivatives facilitate motor recovery of rats with diffuse motor neuron injuryDouglas A Kerr
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Neurosci 23:5131-40. 2003..We conclude that cells derived from human pluripotent stem cells have the capacity to restore neurologic function in animals with diffuse motor neuron disease via enhancement of host neuron survival and function...
- The immune system and neuropsychiatric diseasesDouglas Kerr
Department of Neurology, Johns Hopkins Hospital, 600 N Wolfe St, Pathology 627C, Baltimore MD 21287, USA
Int Rev Psychiatry 17:443-9. 2005..By understanding the principles of the immune system and how these principles relate to nervous system function, the reader will be prepared to interpret subsequent manuscripts in this issue...
- Optic neuritis and recurrent myelitis in a woman with systemic lupus erythematosusJulius Birnbaum
Division of Rheumatology, The Johns Hopkins University of Medicine, Baltimore, MD 21224, USA
Nat Clin Pract Rheumatol 4:381-6. 2008..Brain MRI was initially suggestive of small-vessel disease developing in the context of neuropsychiatric systemic lupus erythematosus. Several months later, the patient developed optic neuritis, followed by recurrent attacks of myelitis...
- Altered immune response to CNS viral infection in mice with a conditional knock-down of macrophage-lineage cellsJessica Carmen
Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA
Glia 54:71-80. 2006..The authors, therefore, conclude that although macrophage-lineage cells in the CNS may contribute to neurodegeneration in certain situations, they also serve a protective role, such as control of viral replication...
- Glial restricted precursors protect against chronic glutamate neurotoxicity of motor neurons in vitroNicholas J Maragakis
Department of Neurology and Neuroscience, Johns Hopkins University, Baltimore, Maryland 21287, USA
Glia 50:145-59. 2005..The seeding of G3s resulted in a reduction of motor neuron cell death. Hence, we believe that these cells may potentially play a role in cell-based neuroprotection from glutamate excitotoxicity...
- Using global statistical tests in long-term Parkinson's disease clinical trialsPeng Huang
Division of Oncology Biostatistics, Johns Hopkins University, Baltimore, Maryland, USA
Mov Disord 24:1732-9. 2009..In future long term trials, use of GST for primary statistical analysis would allow the assessment of clinically relevant outcomes rather than the artificial selection of a single primary outcome...
- Is neuromyelitis optica distinct from multiple sclerosis?: something for "lumpers" and "splitters"Elliot M Frohman
Department of Neurology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75235, USA
Arch Neurol 64:903-5. 2007
- Treatment of relapsing-remitting multiple sclerosis with high-dose cyclophosphamide induction followed by glatiramer acetate maintenanceDaniel M Harrison
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Mult Scler 18:202-9. 2012..The long-term benefit of this stabilization followed by conventional therapy has not been explored...
- Differential expression of aquaporin-4 isoforms localizes with neuromyelitis optica disease activityHarleen Saini
Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, USA
J Neuroimmunol 221:68-72. 2010..The ratio of M1:M23 mRNA is highest in the optic nerve and spinal cord, followed by brainstem, then the cerebral and cerebellar cortices...
- Devic's syndrome in a woman with systemic lupus erythematosus: diagnostic and therapeutic implications of testing for the neuromyelitis optica IgG autoantibodyJulius Birnbaum
The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Arthritis Rheum 57:347-51. 2007
- BCL-2 and BAX protect adult mice from lethal Sindbis virus infection but do not protect spinal cord motor neurons or prevent paralysisDouglas A Kerr
Department of Neurology, School of Medicine, The Johns Hopkins University, 615 N. Wolfe Street, Baltimore, MD 21287, USA
J Virol 76:10393-400. 2002..Thus, divergent cell death pathways are activated in different target populations of neurons during neurovirulent SV infection of weanling mice...
- Interleukin-17 in transverse myelitis and multiple sclerosisJerome J Graber
The Johns Hopkins University School of Medicine, Department of Neurology, Baltimore, MD 21287 6965, United States
J Neuroimmunol 196:124-32. 2008..We conclude that IL-17 and IL-6 production from PBMC in TM and early MS are increased and induce astrocyte IL-6 production through IL-6...
- Diagnosis and management of acute myelopathiesAdam I Kaplin
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Osler 320, 600 N Wolfe Street, Baltimore, MD 21287, USA
Neurologist 11:2-18. 2005..TM may exist as part of a multifocal CNS disease (eg, MS), multisystemic disease (eg, systemic lupus erythematosus), or as an isolated, idiopathic entity...
- Recovery from paralysis in adult rats using embryonic stem cellsDeepa M Deshpande
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287-6965, USA
Ann Neurol 60:32-44. 2006..To our knowledge, this is the first report of the anatomical and functional replacement of a motor neuron circuit within the adult mammalian host...
- Transverse Myelitis: pathogenesis, diagnosis and treatmentChitra Krishnan
Department of Neurology, Johns Hopkins Transverse Myelitis Center, 600 N Wolfe Street Pathology 627C, Baltimore MD 21287 6965, USA
Front Biosci 9:1483-99. 2004..Additionally, we will review current concepts on the natural history, immunopathogenesis and treatment strategies for patients with TM...
- Viral-induced spinal motor neuron death is non-cell-autonomous and involves glutamate excitotoxicityJessica Darman
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Neurosci 24:7566-75. 2004..Similar changes may occur in other motor neuron disorders such as amyotrophic lateral sclerosis or West Nile Virus-induced poliomyelitis, suggesting a common tissue injury pathway...
- Recurrent transverse myelitis following neurobrucellosis: immunologic features and beneficial response to immunosuppressionChitra Krishnan
Department of Neurology, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
J Neurovirol 11:225-31. 2005..IL-6 levels returned to baseline following treatment of the patient with intravenous cyclophosphamide and plasma exchange and the patient experienced a significant and sustained recovery of function...
- The lumping and splitting of inflammatory CNS diseasesDouglas A Kerr
Neurology 66:1466-7. 2006
- Idiopathic transverse myelitisChitra Krishnan
Department of Neurology, Johns Hopkins Transverse Myelitis Center, The Johns Hopkins University, Baltimore, MD, USA
Arch Neurol 62:1011-3. 2005
- BAK alters neuronal excitability and can switch from anti- to pro-death function during postnatal developmentYihru Fannjiang
Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Dev Cell 4:575-85. 2003..BAK can alter neurotransmitter release in a direction consistent with its protective effects on neurons and mice. These findings suggest that BAK inhibits cell death by modifying neuronal excitability...
- IL-6 induces regionally selective spinal cord injury in patients with the neuroinflammatory disorder transverse myelitisAdam I Kaplin
Department of Psychiatry and Behavioral Sciences, Bloomberg School of Public Health, Baltimore, Maryland, USA
J Clin Invest 115:2731-41. 2005..The elucidation of this pathway identifies specific therapeutic targets in the management of CNS autoimmune conditions...
- Selective ablation of proliferating astrocytes does not affect disease outcome in either acute or chronic models of motor neuron degenerationAngelo C Lepore
Department of Neurology, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Meyer 6 119, Baltimore, MD 21287, USA
Exp Neurol 211:423-32. 2008..These findings demonstrate that while normal astrocyte function is an important factor in the etiology of motor neuron diseases such as ALS, astrocyte proliferation itself does not play a significant role...
- Neuropsychiatric manifestations of depression in multiple sclerosis: neuroinflammatory, neuroendocrine, and neurotrophic mechanisms in the pathogenesis of immune-mediated depressionMichele L Pucak
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Dialogues Clin Neurosci 9:125-39. 2007..This makes treating MS depression a neuropsychiatric imperative...
- Axonal growth of embryonic stem cell-derived motoneurons in vitro and in motoneuron-injured adult ratsJames M Harper
Department of Neurology, Johns Hopkins University School of Medicine, Pathology 627C, 600 North Wolfe Street, Baltimore, MD 21287, USA
Proc Natl Acad Sci U S A 101:7123-8. 2004....
- High resolution diffusion tensor imaging of axonal damage in focal inflammatory and demyelinating lesions in rat spinal cordCynthia A Deboy
Department of Neurology, Johns Hopkins University, School of Medicine, USA
Brain 130:2199-210. 2007..These data suggest that high resolution DTI may be a more sensitive method than conventional imaging for detecting axonal damage at sites distant from inflammation...
- Cleavage of cystatin C in the cerebrospinal fluid of patients with multiple sclerosisDavid N Irani
Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA
Ann Neurol 59:237-47. 2006..The diagnosis of multiple sclerosis (MS) can be challenging because of the lack of a specific diagnostic test. Recent advances in proteomics, however, offer new opportunities for biomarker discovery and the study of disease pathogenesis...
- Demyelinating disorders: update on transverse myelitisChitra Krishnan
Department of Neurology, Johns Hopkins University School of Medicine, Pathology 627, 600 North Wolfe Street, Baltimore, MD 21287-6965, USA
Curr Neurol Neurosci Rep 6:236-43. 2006..Clinical trials testing the efficacy of promising axonoprotective agents in combination with intravenous steroids in the treatment of TM are currently underway...
- Cellular therapies in motor neuron diseasesMamatha S Nayak
Department of Neurology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
Biochim Biophys Acta 1762:1128-38. 2006..We review pre-clinical data in rodents with each of these approaches and discuss advances and regulatory issues regarding the use of cellular therapies in human motor neuron diseases...
- Correction of humoral derangements from mutant superoxide dismutase 1 spinal cordYun-Sook Kim
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Ann Neurol 60:716-28. 2006..Correction of these abnormalities as a group, but not individually, restores axonal length to near normal. Such a "cocktail" approach to the treatment of amyotrophic lateral sclerosis should be investigated further...
- Stem Cell-Derived Motoneurons in the Adult Mammalian CNSDouglas Kerr; Fiscal Year: 2007..These studies will define an important transplantation approach for motoneuron disease such as ALS and SMA and for spinal cord injury and other spinal disorders. ..
- ES Cell-Derived Motoneurons from SMA transgenic miceDouglas Kerr; Fiscal Year: 2007..This project will identify critical molecular clues to motoneuron dysfunction in SMA and will identify potential strategies to halt or reverse this dysfunction. ..
- 2nd International Pathogenesis of Rare Neuroimmunologic DisordersDouglas Kerr; Fiscal Year: 2006..The workshop will solicit participation from both senior and junior scientists/students in order to stimulate long-term research in these disorders. The proceedings will be disseminated in the medical literature. ..
- Pathogenesis of Rare Neuroimmunologic DisordersDouglas Kerr; Fiscal Year: 2004..We believe this workshop will serve a critical role in advancing our understanding of disorders that are pathophysiologically linked yet, because of their rarity, are poorly understood. ..