Research Topics
| Candace L KerrSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Detail Information
Publications
Pluripotent stem cells from germ cellsCandace L Kerr
Institute for Cell Engineering, Department of Obstetrics and Gynecology, Johns Hopkins School of Medicine, Baltimore, MD, USA
Methods Enzymol 419:400-26. 2006..Detailed protocols for EGC derivation and maintenance from human and mouse primordial germ cells (PGCs) will be presented...- Expression of pluripotent stem cell markers in the human fetal testisCandace L Kerr
Institute for Cellular Engineering, Department of Obstetrics and Gynecology, Johns Hopkins University, Broadway Research Building, Suite 771, 733 North Broadway, Baltimore, MD 21205, USA
Stem Cells 26:412-21. 2008..Together, these results suggest that PGCs maintain expression of pluripotent stem cell markers during and after sexual differentiation of the gonad, albeit in very low numbers... 
Expression of pluripotent stem cell markers in the human fetal ovaryCandace L Kerr
Institute for Cellular Engineering, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Broadway Research Building Suite 771, 733 N Broadway, MD 21205, USA
Hum Reprod 23:589-99. 2008..Human primordial germ cells (PGCs) can give rise to pluripotent stem cells such as embryonal carcinoma cells (ECCs) and embryonic germ cells (EGCs)...- Efficient differentiation of human embryonic stem cells into oligodendrocyte progenitors for application in a rat contusion model of spinal cord injuryCandace L Kerr
Department of Gynecology and Obstetrics and Stem Cell Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Int J Neurosci 120:305-13. 2010..The extent of injury and effect of early cell transplant was measured using behavioral and electrophysiological assessments which demonstrated increased neurological responses in rats transplanted with OPCs compared to controls... 
Genome-wide profiling of pluripotent cells reveals a unique molecular signature of human embryonic germ cellsNikta Pashai
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
PLoS ONE 7:e39088. 2012..Together, these findings provide the first glimpse into a unique genomic signature of human germ cells and pluripotent stem cells and provide genes potentially involved in defining different states of germ-line pluripotency...- Bone morphogenetic protein 4 mediates human embryonic germ cell derivationMarc Hiller
Department of Gynecology and Obstetrics, Institute for Cellular Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Stem Cells Dev 20:351-61. 2011..Downstream activators of the BMP4 pathway such as ID1 and phosphorylated SMADs 1 and 5 were also expressed, suggesting a role of this growth factor in EGC pluripotency... - Electrophysiological evaluation of sensory and motor pathways after incomplete unilateral spinal cord contusionFaith A Bazley
Departments of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Neurosurg Spine 16:414-23. 2012..The authors sought to quantify the functional integrity of the bilateral motor and sensory pathways following unilateral SCI by using measurements of motor and somatosensory evoked potentials (MEPs and SSEPs, respectively)... - MicroRNA expression profiling of oligodendrocyte differentiation from human embryonic stem cellsBrian S Letzen
Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
PLoS ONE 5:e10480. 2010..Here, we performed a global miRNA analysis to reveal and identify characteristic patterns in the multiple stages leading to OL maturation from hES cells including those targeting factors involved in myelin production... - Quantitative temporal proteomic analysis of human embryonic stem cell differentiation into oligodendrocyte progenitor cellsRaghothama Chaerkady
McKusick Nathans Institute of Genetic Medicine and Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Proteomics 11:4007-20. 2011..Thus, by providing the first extensive proteomic profiling of human ESC differentiation into OPCs, this study provides many novel proteins that are potentially involved in OL development... - Potential long-term benefits of acute hypothermia after spinal cord injury: assessments with somatosensory-evoked potentialsAnil Maybhate
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Crit Care Med 40:573-9. 2012..In our experiments, these effects lasted long after the acute hypothermia and were accompanied by potential long-term improvements in motor movement... - The dazzle in germ cell differentiationCandace L Kerr
Stem Cell Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Mol Cell Biol 2:26-9. 2010..Although factors that Dazl influences during this process have been identified, the underlying mechanisms warrant future studies... - Characterization of zona pellucida glycoprotein 3 (ZP3) and ZP2 binding sites on acrosome-intact mouse spermCandace L Kerr
Division of Reproductive Biology, Department of Biochemistry and Molecular Biology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205-2179, USA
Biol Reprod 66:1585-95. 2002..Finally, we demonstrate that extracellular calcium as well as capacitation and maturation of sperm are required for these sites to bind their respective ligands...