Emmanouil D Karagiannis

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi request reprint Novel anti-angiogenic peptides derived from ELR-containing CXC chemokines
    Emmanouil D Karagiannis
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Cell Biochem 104:1356-63. 2008
  2. pmc Identification of novel short peptides derived from the alpha 4, alpha 5, and alpha 6 fibrils of type IV collagen with anti-angiogenic properties
    Emmanouil D Karagiannis
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Biochem Biophys Res Commun 354:434-9. 2007
  3. pmc Peptides derived from type I thrombospondin repeat-containing proteins of the CCN family inhibit proliferation and migration of endothelial cells
    Emmanouil D Karagiannis
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Int J Biochem Cell Biol 39:2314-23. 2007
  4. pmc Pentastatin-1, a collagen IV derived 20-mer peptide, suppresses tumor growth in a small cell lung cancer xenograft model
    Jacob E Koskimaki
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    BMC Cancer 10:29. 2010
  5. pmc Anti-angiogenic peptides identified in thrombospondin type I domains
    Emmanouil D Karagiannis
    Department of Biomedical Engineering, Johns Hopkins University, School of Medicine, 613 Traylor Building, 720 Rultland Avenue, Baltimore, MD 21205, USA
    Biochem Biophys Res Commun 359:63-9. 2007
  6. pmc Multiscale models of angiogenesis
    Amina A Qutub
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA
    IEEE Eng Med Biol Mag 28:14-31. 2009
  7. pmc Peptides derived from type IV collagen, CXC chemokines, and thrombospondin-1 domain-containing proteins inhibit neovascularization and suppress tumor growth in MDA-MB-231 breast cancer xenografts
    Jacob E Koskimaki
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Neoplasia 11:1285-91. 2009
  8. pmc A systematic methodology for proteome-wide identification of peptides inhibiting the proliferation and migration of endothelial cells
    Emmanouil D Karagiannis
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 105:13775-80. 2008
  9. doi request reprint A peptide derived from type 1 thrombospondin repeat-containing protein WISP-1 inhibits corneal and choroidal neovascularization
    Marisol del Valle Cano
    Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, School of Medicine, Baltimore, MD 21231, USA
    Invest Ophthalmol Vis Sci 50:3840-5. 2009
  10. ncbi request reprint Distinct modes of collagen type I proteolysis by matrix metalloproteinase (MMP) 2 and membrane type I MMP during the migration of a tip endothelial cell: insights from a computational model
    Emmanouil D Karagiannis
    Department of Biomedical Engineering, Johns Hopkins University, School of Medicine, Baltimore, MD, 21205, USA
    J Theor Biol 238:124-45. 2006

Collaborators

Detail Information

Publications11

  1. doi request reprint Novel anti-angiogenic peptides derived from ELR-containing CXC chemokines
    Emmanouil D Karagiannis
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Cell Biochem 104:1356-63. 2008
    ....
  2. pmc Identification of novel short peptides derived from the alpha 4, alpha 5, and alpha 6 fibrils of type IV collagen with anti-angiogenic properties
    Emmanouil D Karagiannis
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Biochem Biophys Res Commun 354:434-9. 2007
    ..These peptides may have potential as anti-angiogenic therapeutic agents...
  3. pmc Peptides derived from type I thrombospondin repeat-containing proteins of the CCN family inhibit proliferation and migration of endothelial cells
    Emmanouil D Karagiannis
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Int J Biochem Cell Biol 39:2314-23. 2007
    ....
  4. pmc Pentastatin-1, a collagen IV derived 20-mer peptide, suppresses tumor growth in a small cell lung cancer xenograft model
    Jacob E Koskimaki
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    BMC Cancer 10:29. 2010
    ....
  5. pmc Anti-angiogenic peptides identified in thrombospondin type I domains
    Emmanouil D Karagiannis
    Department of Biomedical Engineering, Johns Hopkins University, School of Medicine, 613 Traylor Building, 720 Rultland Avenue, Baltimore, MD 21205, USA
    Biochem Biophys Res Commun 359:63-9. 2007
    ....
  6. pmc Multiscale models of angiogenesis
    Amina A Qutub
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA
    IEEE Eng Med Biol Mag 28:14-31. 2009
    ..As bioengineers, we approach angiogenesis as a complex, interconnected system of events occurring in sequence and in parallel, on multiple levels, triggered by a main stimulus, e.g., hypoxia...
  7. pmc Peptides derived from type IV collagen, CXC chemokines, and thrombospondin-1 domain-containing proteins inhibit neovascularization and suppress tumor growth in MDA-MB-231 breast cancer xenografts
    Jacob E Koskimaki
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Neoplasia 11:1285-91. 2009
    ..We have demonstrated significant suppression of tumor growth in vivo and subsequent reductions in microvascular density, indicating the potential of these peptides as therapeutic agents for breast cancer...
  8. pmc A systematic methodology for proteome-wide identification of peptides inhibiting the proliferation and migration of endothelial cells
    Emmanouil D Karagiannis
    Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 105:13775-80. 2008
    ..In some cases, this combinatorial screening identified strong synergism between peptides. The current work provides a guideline for a computational-based peptidomics approach for the discovery of endogenous bioactive peptides...
  9. doi request reprint A peptide derived from type 1 thrombospondin repeat-containing protein WISP-1 inhibits corneal and choroidal neovascularization
    Marisol del Valle Cano
    Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, School of Medicine, Baltimore, MD 21231, USA
    Invest Ophthalmol Vis Sci 50:3840-5. 2009
    ..The peptide was also tested in vivo in the corneal micropocket and the laser-induced choroidal neovascularization (CNV) mouse models...
  10. ncbi request reprint Distinct modes of collagen type I proteolysis by matrix metalloproteinase (MMP) 2 and membrane type I MMP during the migration of a tip endothelial cell: insights from a computational model
    Emmanouil D Karagiannis
    Department of Biomedical Engineering, Johns Hopkins University, School of Medicine, Baltimore, MD, 21205, USA
    J Theor Biol 238:124-45. 2006
    ..It also identifies critical parameters whose values are not presently available and which should be determined in future experiments...
  11. ncbi request reprint A biochemical model of matrix metalloproteinase 9 activation and inhibition
    Prakash Vempati
    Department of Biomedical Engineering, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA
    J Biol Chem 282:37585-96. 2007
    ..In all, our analysis serves as a summary of existing kinetic data for MMP9 and a foundation for future models utilizing MMP9 or other MMPs under physiologically well defined microenvironments...