Research Topics
Genomes and Genes | Wen Hong Linda KaoSummaryAffiliation: Johns Hopkins Bloomberg School of Public Health Country: USA Publications
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Publications
Genetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in US white community-based populationsW H Linda Kao
Department of Epidemiology, Johns Hopkins University School of Medicine, 733 N Broadway, Baltimore, MD 21205, USA
Circulation 119:940-51. 2009....- Genetic variation of glucose transporter-1 (GLUT1) and albuminuria in 10,278 European Americans and African Americans: a case-control study in the Atherosclerosis Risk in Communities (ARIC) studyCharles C Hsu
Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
BMC Med Genet 12:16. 2011..Our aim was to evaluate associations with albuminuria of six GLUT1 single nucleotide polymorphisms(SNPs), particularly XbaI and the previously associated Enhancer-2 (Enh2) SNP... - Association of APOE polymorphism with chronic kidney disease in a nationally representative sample: a Third National Health and Nutrition Examination Survey (NHANES III) Genetic StudyAudrey Y Chu
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
BMC Med Genet 10:108. 2009..However, few data are available in non-European ethnic groups or in a population-based cohort... - Genome-wide association study for renal traits in the Framingham Heart and Atherosclerosis Risk in Communities StudiesAnna Kottgen
Department of Epidemiology and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, USA
BMC Med Genet 9:49. 2008..The study of 70,987 single nucleotide polymorphisms (SNPs) in 1,010 FHS participants provides a list of SNPs showing the strongest associations with renal traits which need to be verified in independent study samples... - The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohortsJan Bressler
Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
BMC Med Genet 10:56. 2009..The combined study sample is comprised of 24,722 white, African-American, and Mexican-American participants... 
Pro12Ala of the peroxisome proliferator-activated receptor-gamma2 gene is associated with lower serum insulin levels in nonobese African Americans: the Atherosclerosis Risk in Communities StudyW H Linda Kao
Department of Epidemiology, The Johns Hopkins University School of Hygiene and Public Health, 615 N Wolfe Street, Room W6513, Baltimore, MD 21205, USA
Diabetes 52:1568-72. 2003..We conclude that among nonobese African Americans, the Pro/Ala genotype is associated with markers of greater insulin sensitivity...- MYH9 is associated with nondiabetic end-stage renal disease in African AmericansW H Linda Kao
Department of Epidemiology, School of Medicine and Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21287, USA
Nat Genet 40:1185-92. 2008.... - Admixture mapping of obesity-related traits in African Americans: the Atherosclerosis Risk in Communities (ARIC) StudyChing Yu Cheng
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Obesity (Silver Spring) 18:563-72. 2010..92 kg/m(2) (P = 2.9 x 10(-5)). Further mapping in this region on chromosome 2 may be able to uncover causative variants underlying obesity, which may offer insights into the control of energy homeostasis... - Haplotype of signal transducer and activator of transcription 3 gene predicts cardiovascular disease in dialysis patientsLin Zhang
Department of Epidemiology, Epidemiology and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
J Am Soc Nephrol 17:2285-92. 2006..008). Variation in the STAT3 gene is associated with the risk for CVD among white dialysis patients independent of serum IL-6 and CRP levels... - SNP43 of CAPN10 and the risk of type 2 Diabetes in African-Americans: the Atherosclerosis Risk in Communities StudyMichael J Garant
Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
Diabetes 51:231-7. 2002..We conclude from this large prospective study that the G allele of SNP43 of CAPN10 or another allele or gene that is in linkage disequilibrium with it increases susceptibility to type 2 diabetes in African-Americans... - Association of scavenger receptor class B type I polymorphisms with subclinical atherosclerosis: the Multi-Ethnic Study of AtherosclerosisAdam C Naj
Department of Medicine, School of Medicine, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD, USA
Circ Cardiovasc Genet 3:47-52. 2010..We examined this relationship in the Multi-Ethnic Study of Atherosclerosis... - Association of single-nucleotide polymorphisms in JAK3, STAT4, and STAT6 with new cardiovascular events in incident dialysis patientsC John Sperati
Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Am J Kidney Dis 53:845-55. 2009.... - Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function alleleAdrienne Tin
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
Hum Mol Genet 20:4056-68. 2011..Our data support the importance of multi-ethnic GWAS in the identification of novel risk loci as well as functional variants... - Increased risk of type 2 diabetes from a family history of coronary heart disease and type 2 diabetesEdwina H Yeung
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
Diabetes Care 30:154-6. 2007 - The association of cell cycle checkpoint 2 variants and kidney function: findings of the Family Blood Pressure Program and the Atherosclerosis Risk In Communities studyNora Franceschini
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Am J Hypertens 22:552-8. 2009..The checkpoint 2 gene (CHEK2) is an important transducer in DNA damage signaling pathways in response to injury, and therefore, CHEK2 variants may affect susceptibility to kidney disease... - Coffee and sweetened beverage consumption and the risk of type 2 diabetes mellitus: the atherosclerosis risk in communities studyNina P Paynter
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Am J Epidemiol 164:1075-84. 2006..In summary, increased coffee consumption was significantly associated with a decreased risk of diagnosed type 2 diabetes mellitus in community-based US adults... - Admixture mapping scans identify a locus affecting retinal vascular caliber in hypertensive African Americans: the Atherosclerosis Risk in Communities (ARIC) studyChing Yu Cheng
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
PLoS Genet 6:e1000908. 2010..001). Further mapping in the 6p21.1 region may uncover novel genetic variants affecting retinal vascular caliber and further insights into the interaction between genetic effects of the microvascular system and hypertension... - Admixture mapping of 15,280 African Americans identifies obesity susceptibility loci on chromosomes 5 and XChing Yu Cheng
Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
PLoS Genet 5:e1000490. 2009..27; genome-wide score = 3.46). Further mapping studies with dense sets of markers will be necessary to identify the alleles in these regions of chromosomes X and 5 that may be associated with variation in BMI... - Hemochromatosis gene and nonalcoholic fatty liver disease: a systematic review and meta-analysisRuben Hernaez
Department of Medicine, Division of General Internal Medicine, The Johns Hopkins School of Medicine, Baltimore, MD, USA
J Hepatol 55:1079-85. 2011..The goal of this study was to systematically evaluate and summarize data on the association between these two variants and the presence of NAFLD... - Association between parental history of type 2 diabetes and glycemic control in urban African AmericansLucy Gong
Department of Epidemiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Diabetes Care 31:1773-6. 2008..The purpose of this study was to examine the association between parental history of type 2 diabetes and glycemic control among diabetic urban African Americans... - Evaluation of a novel isotope biomarker for dietary consumption of sweetsEdwina H Yeung
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Am J Epidemiol 172:1045-52. 2010..Within the proper framework, serum δ¹³C value could be developed into an objective biomarker promoting more reliable assessment of dietary sweets intake... - Multiple loci associated with indices of renal function and chronic kidney diseaseAnna Kottgen
Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
Nat Genet 41:712-7. 2009..Our findings provide new insights into CKD pathogenesis and underscore the importance of common genetic variants influencing renal function and disease... - Associations between total serum IgE levels and the 6 potentially functional variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy StudyXin Liu
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
J Allergy Clin Immunol 112:382-8. 2003.... - Type 2 diabetes is associated with increased bone mineral density in Mexican-American womenW H Linda Kao
Department of Epidemiology, The Johns Hopkins University, Baltimore, MD, USA
Arch Med Res 34:399-406. 2003..Longitudinal studies may be required to better define the mechanisms underlying the observed association between BMD and diabetes... - Apolipoprotein E and progression of chronic kidney diseaseCharles C Hsu
Department of Epidemiology, The Welch Center for Prevention, Epidemiology, and Clinical Research, The Johns Hopkins Medical Institutions, Baltimore, MD 21205 2223, USA
JAMA 293:2892-9. 2005..APOE allelic associations with chronic kidney disease beyond diabetic nephropathy are unknown, with no studies reported in high-risk African American populations... - TCF7L2 variants associate with CKD progression and renal function in population-based cohortsAnna Kottgen
Department of Epidemiology and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, Maryland, USA
J Am Soc Nephrol 19:1989-99. 2008..In conclusion, several population-based samples suggest that variants in the TCF7L2 gene are associated with reduced kidney function or CKD progression, overall and specifically among participants without diabetes... - Short stature and the risk of adiposity, insulin resistance, and type 2 diabetes in middle age: the Third National Health and Nutrition Examination Survey (NHANES III), 1988-1994Keiko Asao
Department of Epidemiology, Johns Hopkins University, Baltimore, MD 21205, USA
Diabetes Care 29:1632-7. 2006..CONCLUSIONS: Our study supports the hypothesis that adult markers of prepubertal growth, especially leg length-to-height ratio, are associated with adiposity, insulin resistance, and type 2 diabetes in the general U.S. population... - A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarizationDan E Arking
McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Nat Genet 38:644-51. 2006..Approximately 60% of subjects of European ancestry carry at least one minor allele of the NOS1AP genetic variant, which explains up to 1.5% of QT interval variation... - Associations between genetic variants in the NOS1AP (CAPON) gene and cardiac repolarization in the old order AmishWendy Post
Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
Hum Hered 64:214-9. 2007..The purpose of the current study was to replicate this association in the Old Order Amish... 
The association of sudden cardiac death with inflammation and other traditional risk factorsRulan S Parekh
Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
Kidney Int 74:1335-42. 2008..Hence, we found that sudden cardiac death is common among patients with end stage renal disease and that inflammation and malnutrition significantly increased its occurrence independent of traditional cardiovascular risk factors...- Preferences, knowledge, communication and patient-physician discussion of living kidney transplantation in African American familiesL Ebony Boulware
Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Am J Transplant 5:1503-12. 2005.... - Family history of type 2 diabetes is associated with increased carotid artery intimal-medial thickness in Mexican AmericansW H Linda Kao
Department of Epidemiology, Bloomberg School of Public Health, John's Hopkins University, Baltimore, Maryland, USA
Diabetes Care 28:1882-9. 2005.... - Genetic variation of the renin-angiotensin system and chronic kidney disease progression in black individuals in the atherosclerosis risk in communities studyCharles Chia Chuen Hsu
Department of Epidemiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
J Am Soc Nephrol 17:504-12. 2006..The AT1R C1166 allele may increase susceptibility but only in the presence of hypertension... - Comparison of SNP tagging methods using empirical data: association study of 713 SNPs on chromosome 12q14.3-12q24.21 for asthma and total serum IgE in an African Caribbean populationPeter B Chi
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Genet Epidemiol 30:609-19. 2006..We also found a high degree of consistency between TagSNP and Tagger. Using this set of 713 SNPs on chromosome 12q, our study provides insight towards analytic strategies for future studies of complex traits... - The association of podocin R229Q polymorphism with increased albuminuria or reduced estimated GFR in a large population-based sample of US adultsAnna Kottgen
Johns Hopkins University, Baltimore, MD, USA
Am J Kidney Dis 52:868-75. 2008.... - Does genetic ancestry explain higher values of glycated hemoglobin in African Americans?Nisa M Maruthur
Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Diabetes 60:2434-8. 2011..We investigated the relative contribution of genetic ancestry and nongenetic factors to HbA(1c) values and the effect of genetic ancestry on diabetes classification by HbA(1c) in African Americans... - Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy StudyXin Liu
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
J Allergy Clin Immunol 113:489-95. 2004..SNPs were commonly considered individually, and therefore the true effect could be masked by other genes or environmental factors... - Reliability of urinary albumin, total protein, and creatinine assays after prolonged storage: the Family Investigation of Nephropathy and DiabetesRulan S Parekh
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Clin J Am Soc Nephrol 2:1156-62. 2007.... - Pulmonary hypertension and risk of death in cardiomyopathy: patients with myocarditis are at higher riskThomas P Cappola
Department of Medicine, Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Circulation 105:1663-8. 2002..These findings suggest that secondary pulmonary hypertension may have different biological features in myocarditis and that patients with pulmonary hypertension and myocarditis should be targeted for aggressive medical therapy... - Delayed diagnosis of incident type 2 diabetes mellitus in the ARIC studyT Alafia Samuels
Department of Epidemiology, The Johns Hopkins University, Baltimore, MD, USA
Am J Manag Care 12:717-24. 2006..To estimate delays to physician diagnosis of incident cases of type 2 diabetes mellitus (DM) and to identify predictors of delayed diagnosis... - Role of a proline insertion in the insulin promoter factor 1 (IPF1) gene in African Americans with type 2 diabetesSteven C Elbein
Endocrinology Section, Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA
Diabetes 55:2909-14. 2006..1). InsCCG243 does not act in a dominant, highly penetrant fashion in African Americans and is not a significant risk factor for type 2 diabetes in this population... - Reliability of high-throughput genotyping of whole genome amplified DNA in SNP genotyping studiesYvette Berthier Schaad
Laboratory of Genomic Diversity, NCI Frederick, Frederick, MD, USA
Electrophoresis 28:2812-7. 2007..DNA amplification methodologies provide a useful solution for current and future large-scale genetic analyses especially with limited quantities of samples and DNA...
Research Grants
- Genetic Epidemiology of NAFLD and T2DMWen Hong Kao; Fiscal Year: 2007..A deeper understanding of the molecular pathogenesis of obesity, IR, NAFLD, and T2DM may suggest new approaches for the prevention and treatment of these conditions. ..
- Admixture Mapping to Identify T2DM Genes in African AmericansWen Hong Kao; Fiscal Year: 2007....
- Identification of Genes for ESRD in African AmericansWen Hong Kao; Fiscal Year: 2007..This study will provide key insights into the genetic control of susceptibility of ESRD ..