Sujatha Kannan

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Nanomedicine in cerebral palsy
    Bindu Balakrishnan
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University Baltimore, MD, USA
    Int J Nanomedicine 8:4183-95. 2013
  2. pmc Dendrimer-based postnatal therapy for neuroinflammation and cerebral palsy in a rabbit model
    Sujatha Kannan
    Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Detroit, MI 48201, USA
    Sci Transl Med 4:130ra46. 2012
  3. pmc Magnitude of [(11)C]PK11195 binding is related to severity of motor deficits in a rabbit model of cerebral palsy induced by intrauterine endotoxin exposure
    Sujatha Kannan
    Department of Pediatrics, Wayne State University, Detroit, MI, USA
    Dev Neurosci 33:231-40. 2011
  4. pmc Stimuli-responsive star poly(ethylene glycol) drug conjugates for improved intracellular delivery of the drug in neuroinflammation
    Raghavendra S Navath
    Department of Chemical Engineering and Material Science, and Biomedical Engineering, Wayne State University, Detroit, MI 48202, USA
    J Control Release 142:447-56. 2010
  5. pmc Amino acid-functionalized dendrimers with heterobifunctional chemoselective peripheral groups for drug delivery applications
    Raghavendra S Navath
    Department of Chemical Engineering and Material Science, Wayne State University, Detroit, Michigan 48202, USA
    Biomacromolecules 11:1544-63. 2010
  6. pmc Inhibition of bacterial growth and intramniotic infection in a guinea pig model of chorioamnionitis using PAMAM dendrimers
    Bing Wang
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, United States
    Int J Pharm 395:298-308. 2010
  7. ncbi request reprint Preparation, cellular transport, and activity of polyamidoamine-based dendritic nanodevices with a high drug payload
    Parag Kolhe
    Department of Chemical Engineering and Material Science, and Biomedical Engineering, Wayne State University, 5050, Anthony Wayne Drive, Detroit, MI 48202, USA
    Biomaterials 27:660-9. 2006
  8. pmc Intrauterine administration of endotoxin leads to motor deficits in a rabbit model: a link between prenatal infection and cerebral palsy
    Fadoua Saadani-Makki
    Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA
    Am J Obstet Gynecol 199:651.e1-7. 2008
  9. pmc Poly(amidoamine) dendrimer-drug conjugates with disulfide linkages for intracellular drug delivery
    Yunus E Kurtoglu
    Department of Chemical Engineering, Wayne State University, Detroit, MI 48202, USA
    Biomaterials 30:2112-21. 2009
  10. pmc Positron emission tomography imaging of neuroinflammation
    Sujatha Kannan
    Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Child Neurol 24:1190-9. 2009

Collaborators

Detail Information

Publications29

  1. pmc Nanomedicine in cerebral palsy
    Bindu Balakrishnan
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University Baltimore, MD, USA
    Int J Nanomedicine 8:4183-95. 2013
    ..Future directions that would facilitate clinical translation in neonates and children are also addressed. ..
  2. pmc Dendrimer-based postnatal therapy for neuroinflammation and cerebral palsy in a rabbit model
    Sujatha Kannan
    Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Detroit, MI 48201, USA
    Sci Transl Med 4:130ra46. 2012
    ..The effectiveness of the dendrimer-NAC treatment, administered in the postnatal period for a prenatal insult, suggests a window of opportunity for treatment of CP in humans after birth...
  3. pmc Magnitude of [(11)C]PK11195 binding is related to severity of motor deficits in a rabbit model of cerebral palsy induced by intrauterine endotoxin exposure
    Sujatha Kannan
    Department of Pediatrics, Wayne State University, Detroit, MI, USA
    Dev Neurosci 33:231-40. 2011
    ..Molecular imaging of ongoing neuroinflammation in the neonatal period may be helpful as a screening biomarker for detecting patients at risk of developing cerebral palsy due to a perinatal insult...
  4. pmc Stimuli-responsive star poly(ethylene glycol) drug conjugates for improved intracellular delivery of the drug in neuroinflammation
    Raghavendra S Navath
    Department of Chemical Engineering and Material Science, and Biomedical Engineering, Wayne State University, Detroit, MI 48202, USA
    J Control Release 142:447-56. 2010
    ....
  5. pmc Amino acid-functionalized dendrimers with heterobifunctional chemoselective peripheral groups for drug delivery applications
    Raghavendra S Navath
    Department of Chemical Engineering and Material Science, Wayne State University, Detroit, Michigan 48202, USA
    Biomacromolecules 11:1544-63. 2010
    ..With this study, we demonstrate the development of biocompatible dendrimers bearing multiple orthogonal surface groups, enabling the attachment of drugs, imaging agents, and gel formation using minimal synthetic steps...
  6. pmc Inhibition of bacterial growth and intramniotic infection in a guinea pig model of chorioamnionitis using PAMAM dendrimers
    Bing Wang
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, United States
    Int J Pharm 395:298-308. 2010
    ..coli membrane and the G(3.5)-PAMAM-COOH acts as a polyanion, chelating the divalent ions in outer cell membrane of E. coli. This is the first study which shows that G(4)-PAMAM-OH dendrimer acts as an antibacterial agent...
  7. ncbi request reprint Preparation, cellular transport, and activity of polyamidoamine-based dendritic nanodevices with a high drug payload
    Parag Kolhe
    Department of Chemical Engineering and Material Science, and Biomedical Engineering, Wayne State University, 5050, Anthony Wayne Drive, Detroit, MI 48202, USA
    Biomaterials 27:660-9. 2006
    ..These dendrimer-drug conjugates can potentially be further modified by attaching antibodies and ligands for targeted drug delivery...
  8. pmc Intrauterine administration of endotoxin leads to motor deficits in a rabbit model: a link between prenatal infection and cerebral palsy
    Fadoua Saadani-Makki
    Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA
    Am J Obstet Gynecol 199:651.e1-7. 2008
    ..This study was undertaken to determine whether maternal intrauterine endotoxin administration leads to neurobehavioral deficits in newborn rabbits...
  9. pmc Poly(amidoamine) dendrimer-drug conjugates with disulfide linkages for intracellular drug delivery
    Yunus E Kurtoglu
    Department of Chemical Engineering, Wayne State University, Detroit, MI 48202, USA
    Biomaterials 30:2112-21. 2009
    ..When combined with intrinsic and ligand-based targeting with dendrimers, these types of GSH sensitive nanodevices can lead to improved drug release profiles and in vivo efficacy...
  10. pmc Positron emission tomography imaging of neuroinflammation
    Sujatha Kannan
    Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Child Neurol 24:1190-9. 2009
    ....
  11. pmc Effects of branching architecture and linker on the activity of hyperbranched polymer-drug conjugates
    Omathanu Perumal
    Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA
    Bioconjug Chem 20:842-6. 2009
    ..This has key implications in the eventual in vivo efficacy of these nanodevices...
  12. pmc Decreased cortical serotonin in neonatal rabbits exposed to endotoxin in utero
    Sujatha Kannan
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Cereb Blood Flow Metab 31:738-49. 2011
    ..This may be a common link in neurodevelopmental disorders resulting in impairment of the somatosensory system, such as cerebral palsy and autism...
  13. ncbi request reprint Concurrent quantification of tryptophan and its major metabolites
    Wojciech G Lesniak
    Department of Chemical Engineering and Material Science, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48202, USA The Center for Nanomedicine, Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA Perinatology Research Branch, National Institute of Child Health and Human Development, NIH, DHHS, Detroit, MI 48201, USA Perinatology Research Branch, National Institute of Child Health and Human Development, NIH, DHHS, Bethesda, MD 20892, USA
    Anal Biochem 443:222-31. 2013
    ....
  14. pmc Injectable PAMAM dendrimer-PEG hydrogels for the treatment of genital infections: formulation and in vitro and in vivo evaluation
    Raghavendra S Navath
    Department of Chemical Engineering and Materials Science, Wayne State University, Detroit, Michigan 48202, USA
    Mol Pharm 8:1209-23. 2011
    ....
  15. pmc Anti-inflammatory and anti-oxidant activity of anionic dendrimer-N-acetyl cysteine conjugates in activated microglial cells
    Bing Wang
    Department of Pediatrics Critical Care Medicine, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA
    Int J Pharm 377:159-68. 2009
    ..The improved efficacy of the conjugate, when combined with the intrinsic neuroinflammation-targeting ability of the PAMAM dendrimers, may provide new opportunities for in vivo applications...
  16. pmc Intrauterine endotoxin administration leads to white matter diffusivity changes in newborn rabbits
    Fadoua Saadani-Makki
    Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Child Neurol 24:1179-89. 2009
    ..Diffusion tensor imaging may be a clinically useful tool for detecting neuroinflammation induced by maternal infection in neonatal white matter...
  17. pmc Intrinsic targeting of inflammatory cells in the brain by polyamidoamine dendrimers upon subarachnoid administration
    Hui Dai
    Department of Pediatrics Critical Care Medicine, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA
    Nanomedicine (Lond) 5:1317-29. 2010
    ..This article explores the unusual neuroinflammation targeting of dendrimers (with no targeting ligands) in the brain, with significant consequences for nanoscale materials in medicine...
  18. ncbi request reprint Synthesis, cellular transport, and activity of polyamidoamine dendrimer-methylprednisolone conjugates
    Jayant Khandare
    Department of Chemical Engineering and Material Science, and Biomedical Engineering, Wayne State University, Detroit, Michigan 48202, USA
    Bioconjug Chem 16:330-7. 2005
    ..These conjugates can potentially be further conjugated with a targeting moiety to deliver the drugs to specific cells in vivo...
  19. ncbi request reprint Hyperbranched polymer-drug conjugates with high drug payload for enhanced cellular delivery
    Parag Kolhe
    Department of Chemical Engineering and Material Science, and Biomedical Engineering, Wayne State University, Detroit, Michigan 48202, USA
    Pharm Res 21:2185-95. 2004
    ..To synthesize and evaluate hyperbranched polymer (HBP)-drug conjugates with high drug payload for enhanced cellular delivery...
  20. ncbi request reprint Dynamics of cellular entry and drug delivery by dendritic polymers into human lung epithelial carcinoma cells
    Sujatha Kannan
    Critical Care Medicine, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA
    J Biomater Sci Polym Ed 15:311-30. 2004
    ..This suggests that these dendritic polymers can act as efficient drug carriers, delivering high 'payloads' of drug even with complexation and encapsulation...
  21. pmc Dendrimer-drug conjugates for tailored intracellular drug release based on glutathione levels
    Raghavendra S Navath
    Department of Chemical Engineering and Material Science, and Biomedical Engineering, Wayne State University, Detroit, Michigan 48202, USA
    Bioconjug Chem 19:2446-55. 2008
    ..The results indicate that PAMAM dendrimer conjugates produce higher local NAC concentration inside the cells, with GSH-sensitive disulfide linker enabling efficient and rapid cellular release of the drug...
  22. ncbi request reprint The effect of surface functionality on cellular trafficking of dendrimers
    Omathanu P Perumal
    Critical Care Medicine, Children s Hospital of Michigan, Wayne State University, Detroit, MI 48201, USA
    Biomaterials 29:3469-76. 2008
    ..These findings open up new possibilities of targeting therapeutic agents to specific cell organelles based on surface charge...
  23. pmc Transport and biodistribution of dendrimers across human fetal membranes: implications for intravaginal administration of dendrimer-drug conjugates
    Anupa R Menjoge
    Department of Chemical Engineering and Material Science, Wayne State University, Detroit, MI 48202, USA
    Biomaterials 31:5007-21. 2010
    ....
  24. doi request reprint Drug release characteristics of PAMAM dendrimer-drug conjugates with different linkers
    Yunus E Kurtoglu
    Department of Chemical Engineering and Materials Science, Wayne State University, Detroit, MI 48202, USA
    Int J Pharm 384:189-94. 2010
    ..Understanding these structural and steric effects on their drug release characteristics is crucial for the design of dendrimer conjugates with high efficacy...
  25. ncbi request reprint Synthesis, characterization, and in vitro activity of dendrimer-streptokinase conjugates
    Xiangtao Wang
    Critical Care Medicine, Department of Pediatrics, Children s Hospital of Michigan Wayne State University, Detroit, Michigan 48201, USA
    Bioconjug Chem 18:791-9. 2007
    ..The high coupling reaction efficiencies and the resulting high enzymatic activity retention achieved in this study could enable a desirable way for modifying many bioactive macromolecules with dendrimers...
  26. ncbi request reprint Microglial activation in perinatal rabbit brain induced by intrauterine inflammation: detection with 11C-(R)-PK11195 and small-animal PET
    Sujatha Kannan
    Carman and Ann Adams Department of Pediatrics, Wayne State University, Detroit, Michigan 48201, USA
    J Nucl Med 48:946-54. 2007
    ....
  27. pmc Applications of positron emission tomography in the newborn nursery
    Sujatha Kannan
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Semin Perinatol 34:39-45. 2010
    ....
  28. pmc Augmented annotation and orthologue analysis for Oryctolagus cuniculus: Better Bunny
    Douglas B Craig
    Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA
    BMC Bioinformatics 13:84. 2012
    ..We developed a web-based application that provides augmented annotation and orthologue analysis for rabbit genes. Importantly, the application allows comprehensive functional analysis through the use of orthologous relationships...
  29. ncbi request reprint Drug complexation, in vitro release and cellular entry of dendrimers and hyperbranched polymers
    Parag Kolhe
    Department of Chemical Engineering and Material Science, Wayne State University, 5050 Anthony Wayne Drive, Detroit, MI 48202, USA
    Int J Pharm 259:143-60. 2003
    ..Hyperbranched Polyol (with 128 --OH end groups) appears to encapsulate approximately 24 drug molecules. Perhaps the lack of strong interactions between the --OH end groups and the drugs prevents complex formation...