Affiliation: Johns Hopkins University
Jun J, Polotsky V. Metabolic consequences of sleep-disordered breathing. ILAR J. 2009;50:289-306 pubmed
..Identification of OSA as a potential causative factor in MetS would have immense clinical impact and could improve the management and understanding of both disorders. ..
Jun J, Reinke C, Bedja D, Berkowitz D, Bevans Fonti S, Li J, et al
. Effect of intermittent hypoxia on atherosclerosis in apolipoprotein E-deficient mice. Atherosclerosis. 2010;209:381-6 pubmed publisher
..IH accelerates atherosclerotic plaque growth in ApoE(-/-) mice without affecting plaque composition. The mechanisms may include non-additive increases in serum lipids, and cumulative increases in blood pressure. ..
Jun J, Shin M, Devera R, Yao Q, Mesarwi O, Bevans Fonti S, et al
. Intermittent hypoxia-induced glucose intolerance is abolished by Î±-adrenergic blockade or adrenal medullectomy. Am J Physiol Endocrinol Metab. 2014;307:E1073-83 pubmed publisher
..Acutely hypoxia causes hyperglycemia, glucose intolerance, and insulin resistance in a dose-dependent manner. During IH, circulating catecholamines act upon Î±-adrenoreceptors to cause hyperglycemia and glucose intolerance. ..
Jun J, Polotsky V. Are we waking up to the effects of NEFA?. Diabetologia. 2015;58:651-3 pubmed publisher
..Here, we address the potential clinical relevance of these findings and pose questions for further research. ..
Jun J, Shin M, Yao Q, Bevans Fonti S, Poole J, Drager L, et al
. Acute hypoxia induces hypertriglyceridemia by decreasing plasma triglyceride clearance in mice. Am J Physiol Endocrinol Metab. 2012;303:E377-88 pubmed publisher
..We conclude that acute hypoxia increases plasma TG due to decreased tissue uptake, not increased hepatic TG secretion. ..
Jun J, Chopra S, Schwartz A. Sleep apnoea. Eur Respir Rev. 2016;25:12-8 pubmed publisher
..In this Clinical Year in Review, we summarise high-impact research from the past year pertaining to management, diagnosis and cardio-metabolic consequences of sleep apnoea. ..
Jun J, Devera R, Unnikrishnan D, Shin M, Bevans Fonti S, Yao Q, et al
. Adipose HIF-1α causes obesity by suppressing brown adipose tissue thermogenesis. J Mol Med (Berl). 2017;95:287-297 pubmed publisher
..The weight gain is associated with reduced brown adipose tissue function and oxygen consumption. Reduced oxygen consumption may be mediated by reductions in mitochondria. ..
Jun J, Savransky V, Nanayakkara A, Bevans S, Li J, Smith P, et al
. Intermittent hypoxia has organ-specific effects on oxidative stress. Am J Physiol Regul Integr Comp Physiol. 2008;295:R1274-81 pubmed publisher
..In p47(phox)-deficient mice, MDA levels were higher at baseline and, unexpectedly, decreased during IH. In conclusion, oxidative stress levels and pathways under IH conditions are organ and duration specific. ..
Gu C, Younas H, Jun J. Sleep apnea: An overlooked cause of lipotoxicity?. Med Hypotheses. 2017;108:161-165 pubmed publisher
..If this hypothesis is correct, then OSA may represent a reversible risk factor for cardio-metabolic dysfunction, and this risk might be mitigated by preventing OSA-induced lipolysis during sleep. ..