Research Topics
| Hendree E JonesSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Maternal Opioid Treatment: Human Experimental Research (MOTHER)--approach, issues and lessons learnedHendree E Jones
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Addiction 107:28-35. 2012..This study is the most current--and single most comprehensive--research effort to investigate the safety and efficacy of maternal and prenatal exposure to methadone and buprenorphine...- Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive reviewHendree E Jones
Department of Psychiatry and Behavioral Sciences, Hopkins University School of Medicine, Baltimore, MD, USA
Addiction 107:5-27. 2012..This paper reviews the published literature regarding outcomes following maternal treatment with buprenorphine in five areas: maternal efficacy, fetal effects, neonatal effects, effects on breast milk and longer-term developmental effects... 
Neonatal abstinence syndrome after methadone or buprenorphine exposureHendree E Jones
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
N Engl J Med 363:2320-31. 2010..Buprenorphine, a partial mu-opioid agonist, is an alternative treatment for opioid dependence but has not been extensively studied in pregnancy...- Infant neurobehavior following prenatal exposure to methadone or buprenorphine: results from the neonatal intensive care unit network neurobehavioral scaleHendree E Jones
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
Subst Use Misuse 45:2244-57. 2010..Results suggest the NNNS may detect subtle differences over time between both neonates prenatally exposed to methadone or buprenorphine and neonates pharmacologically treated or untreated for NAS... - Treatment of opioid-dependent pregnant women: clinical and research issuesHendree E Jones
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
J Subst Abuse Treat 35:245-59. 2008..Lastly, other important clinical issues including managing co-occurring psychiatric disorders and medication interactions are discussed... - Methadone, cocaine, opiates, and metabolite disposition in umbilical cord and correlations to maternal methadone dose and neonatal outcomesAna de Castro
Chemical and Drug Metabolism Section, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA
Ther Drug Monit 33:443-52. 2011.... 
Umbilical cord monitoring of in utero drug exposure to buprenorphine and correlation with maternal dose and neonatal outcomesMarta Concheiro
Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
J Anal Toxicol 34:498-505. 2010..Buprenorphine provided a controlled drug administration model for evaluating drug disposition in the maternal-fetal dyad...- Contingent incentives reduce cigarette smoking among pregnant, methadone-maintained women: results of an initial feasibility and efficacy randomized clinical trialMichelle Tuten
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Addiction 107:1868-77. 2012..This study examined the feasibility and efficacy of behavioral incentives for reducing cigarette smoking among pregnant methadone-maintained patients... - Maternal methadone dose, placental methadone concentrations, and neonatal outcomesAna de Castro
Chemistry and Drug Metabolism, National Institute on Drug Abuse, NIH, Baltimore, MD 21224, USA
Clin Chem 57:449-58. 2011.... - Fetal neurobehavioral effects of exposure to methadone or buprenorphineLauren M Jansson
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore MD 21224, USA
Neurotoxicol Teratol 33:240-3. 2011..05). These results may have implications for the optimal treatment of the opioid-dependent pregnant woman... - Prenatal methadone exposure, meconium biomarker concentrations and neonatal abstinence syndromeTeresa R Gray
Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
Addiction 105:2151-9. 2010..This research evaluated whether quantification of fetal methadone and drug exposure via meconium would reflect maternal dose and predict neonatal outcomes... - Transferring methadone-stabilized pregnant patients to buprenorphine using an immediate release morphine transition: an open-label exploratory studyHendree E Jones
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Addict 15:61-70. 2006..Withdrawal symptoms appeared during buprenorphine induction; however, these data suggest that the intensity of withdrawal symptoms may be lessened by the dose and frequency of buprenorphine administration... - Co-occurring psychiatric symptoms are associated with increased psychological, social, and medical impairment in opioid dependent pregnant womenMargaret M Benningfield
Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, Tennessee 37216, USA
Am J Addict 19:416-21. 2010..Further investigation is warranted to understand the effect of psychiatric symptoms on long-term maternal and neonatal outcomes... - Relationship between cigarette use and mood/anxiety disorders among pregnant methadone-maintained patientsMargaret S Chisolm
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Addict 18:422-9. 2009.... - Reinforcement-based treatment improves the maternal treatment and neonatal outcomes of pregnant patients enrolled in comprehensive care treatmentHendree E Jones
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Addict 20:196-204. 2011..Integrating RBT into a rich array of comprehensive care treatment components may be a promising approach to increase maternal treatment retention and reduce neonatal length of hospital stay... - Cigarette smoking knowledge, attitudes, and practices of patients and staff at a perinatal substance abuse treatment centerMargaret S Chisolm
The Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Subst Abuse Treat 39:298-305. 2010.... - The impact of mood disorders on the delivery and neonatal outcomes of methadone-maintained pregnant patientsMichelle Tuten
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Drug Alcohol Abuse 35:358-63. 2009..Findings emphasize the need to treat mood disorders in methadone-maintained pregnant patients... - Comparison of characteristics of opioid-using pregnant women in rural and urban settingsSarah H Heil
Department of Psychiatry, University of Vermont, Burlington, Vermont, USA
Am J Drug Alcohol Abuse 34:463-71. 2008..g., less severe drug use, greater employment). However, they may face additional barriers in accessing treatment (e.g., greater distance from treatment clinic)... - Methadone and metabolites in hair of methadone-assisted pregnant women and their infantsSarah K Himes
Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
Ther Drug Monit 34:337-44. 2012.... - Opioid dependence during pregnancy: relationships of anxiety and depression symptoms to treatment outcomesMargaret M Benningfield
Department of Psychiatry, Vanderbilt University, Nashville, TN, USA
Addiction 107:74-82. 2012.... - Buprenorphine versus methadone in the treatment of pregnant opioid-dependent patients: effects on the neonatal abstinence syndromeHendree E Jones
The Department of Psychiatry and Behavioral Sciences, Johns Hopkins Bayview Medical Campus, Johns Hopkins University School of Medicine, D 3 East, 4940 Eastern Avenue, Baltimore, MD 21224, USA
Drug Alcohol Depend 79:1-10. 2005..25). Results suggest that buprenorphine is not inferior to methadone on outcome measures assessing NAS and maternal and neonatal safety when administered starting in the second trimester of pregnancy... - Use of buprenorphine in pregnancy: patient management and effects on the neonateRolley E Johnson
Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Drug Alcohol Depend 70:S87-101. 2003..From a review of the literature, buprenorphine appears to be safe and effective in both mother and infant with an NAS that may differ from methadone both qualitatively and quantitatively... - Methadone maintenance vs. methadone taper during pregnancy: maternal and neonatal outcomesHendree E Jones
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Addict 17:372-86. 2008..Given the poor maternal MAW outcomes, methadone maintenance should be considered as the primary treatment approach for opioid-dependent pregnant women... - Abstinence-contingent recovery housing and reinforcement-based treatment following opioid detoxificationMichelle Tuten
Johns Hopkins University School of Medicine, Psychiatry and Behavioral Sciences, Baltimore, MD 21224, USA
Addiction 107:973-82. 2012..To conduct a randomized, controlled trial of abstinence-contingent recovery housing delivered with or without intensive day treatment among individuals exiting residential opioid detoxification... - Methadone disposition in oral fluid during pharmacotherapy for opioid-dependenceTeresa R Gray
Chemistry and Drug Metabolism, National Institute on Drug Abuse, National Institutes of Health, 251 Bayview Blvd, Suite 200, Room 05A721, Baltimore, MD 21224, USA
Forensic Sci Int 206:98-102. 2011..Oral fluid testing is widely used for detecting drug exposure, but data describing methadone and metabolites in oral fluid during pharmacotherapy for opioid-dependence are relatively limited... - Maternal buprenorphine dose, placenta buprenorphine, and metabolite concentrations and neonatal outcomesMarta Concheiro
Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA
Ther Drug Monit 32:206-15. 2010.... - Management of acute postpartum pain in patients maintained on methadone or buprenorphine during pregnancyHendree E Jones
Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland, USA
Am J Drug Alcohol Abuse 35:151-6. 2009..Empirical evidence is needed to guide adequate postpartum pain relief of methadone and buprenorphine stabilized patients... - Urinary excretion of buprenorphine, norbuprenorphine, buprenorphine-glucuronide, and norbuprenorphine-glucuronide in pregnant women receiving buprenorphine maintenance treatmentSherri L Kacinko
Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, MD, USA
Clin Chem 55:1177-87. 2009..We investigated BUP and metabolite disposition in urine from women maintained on BUP during the second and third trimesters of pregnancy and postpartum... - Buprenorphine and norbuprenorphine in hair of pregnant women and their infants after controlled buprenorphine administrationRobert S Goodwin
Chemistry and Drug Metabolism Section, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
Clin Chem 53:2136-43. 2007..We hypothesized that there would be a relationship between the cumulative maternal dose of buprenorphine during pregnancy and the concentration of buprenorphine and norbuprenorphine in maternal and infant hair... - Differences in the profile of neonatal abstinence syndrome signs in methadone- versus buprenorphine-exposed neonatesDiann E Gaalema
Department of Psychiatry, University of Vermont, Burlington, VT 05401, USA
Addiction 107:53-62. 2012..To compare the profile of signs of neonatal abstinence syndrome (NAS) in methadone- versus buprenorphine-exposed infants... - Practical considerations for the clinical use of buprenorphineHendree E Jones
Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
Sci Pract Perspect 2:4-20. 2004..This article reviews these important issues as well as requirements for physician and staff training and needs for additional research on this unique medication... - The relationship between antidepressant use and smoking cessation in pregnant women in treatment for substance abuseMargaret S Chisolm
The Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Drug Alcohol Abuse 36:46-51. 2010..Bupropion's efficacy for smoking cessation in pregnant women is unknown... - Randomized controlled study transitioning opioid-dependent pregnant women from short-acting morphine to buprenorphine or methadoneHendree E Jones
The Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Drug Alcohol Depend 78:33-8. 2005..Transitioning opioid-dependent pregnant women from IRM to methadone or buprenorphine during the second trimester of pregnancy can be conducted with similar comfort and safety... - Males and females differ in response to opioid agonist medicationsHendree E Jones
Department of Psychiatry and Behavioral Sciences, The Jhons Hopkins University School of Medicine, Baltimore, MD 21224, USA
Am J Addict 14:223-33. 2005..Within-subject change results indicate that all three medications benefit both sexes. Clinical trials should be designed to examine the impact of sex on outcomes... - Excretion of methadone in sweat of pregnant women throughout gestation after controlled methadone administrationAllan J Barnes
Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
Ther Drug Monit 32:497-503. 2010.... - Neonatal abstinence scores in opioid-exposed and nonexposed neonates: a blinded comparisonHendree E Jones
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Opioid Manag 6:409-13. 2010..Although a potentially useful screening tool, the 3-sign screening tool should not replace the full assessment of the opioid-exposed infant after birth... - Dosing adjustments in postpartum patients maintained on buprenorphine or methadoneHendree E Jones
From the Departments of Psychiatry and Behavioral Sciences HEJ, REJ, MT, Medicine DRJ, and Obstetrics and Gynecology LM, Johns Hopkins University School of Medicine, Baltimore, MD Reckitt Benckiser Pharmaceuticals Inc REJ, Richmond, VA and the Department of Psychology KEO, University of Maryland, College Park, College Park, MD
J Addict Med 2:103-7. 2008..Buprenorphine-maintained participants required dose changes postpartum only after they transferred to methadone. Regardless of type of medication, postpartum patients should be monitored for signs of overmedication... - Treating the partners of opioid-dependent pregnant patients: feasibility and efficacyHendree E Jones
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Am J Drug Alcohol Abuse 37:170-8. 2011..Thus, developing a treatment to reduce a male partner's drug use is the first step in a line of research with a distal goal of improving pregnant patient's treatment outcomes... - Aftercare plans of inpatients undergoing detoxificationMichelle Tuten
Cornerstone Treatment Research Clinic, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Drug Alcohol Abuse 33:547-55. 2007..With low rates of enrollment in aftercare programs, the findings of this study may be of help in determining what services will best assist individuals recovering from addiction... - Mood disorders affect drug treatment success of drug-dependent pregnant womenHeather E Fitzsimons
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
J Subst Abuse Treat 32:19-25. 2007..These findings highlight the need to treat co-occurring Axis I disorders, particularly given the higher relapse risk for those with mood disorders... - Patient compliance and maternal/infant outcomes in pregnant drug-using womenHendree E Jones
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Subst Use Misuse 37:1411-22. 2002..These data support an association between treatment compliance and birth outcomes, and highlight the need to develop strategies for improving compliance with such interventions... - Lessons learned from a randomized trial of fixed and escalating contingency management schedules in opioid-dependent pregnant womenMichelle Tuten
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD 21224, USA
Am J Drug Alcohol Abuse 38:286-92. 2012..Contingency management (CM) has shown promise for treating substance use disorders in pregnant women... - The impact of managed care on drug-dependent pregnant and postpartum women and their childrenLauren M Jansson
School of Medicine, Department of Pediatrics, The Johns Hopkins University, Baltimore, MD 21224, USA
Subst Use Misuse 42:961-74. 2007..While these data are correlational and need to be interpreted with caution, they suggest poorer outcomes for drug-exposed children under MC and invite further study of short- and long-term consequences of such change... - What if they do not want treatment?: lessons learned from intervention studies of non-treatment-seeking, drug-using pregnant womenHendree E Jones
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Am J Addict 13:342-57. 2004..The addition of CM resulted in less drug use and fewer psychosocial needs, but similar levels of poor participation in the intervention was observed with both models. The intensity of effort expended to retain participants is discussed... - Oral caffeine maintenance potentiates the reinforcing and stimulant subjective effects of intravenous nicotine in cigarette smokersHendree E Jones
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224 6823, USA
Psychopharmacology (Berl) 165:280-90. 2003..Epidemiological, clinical and pre-clinical observations suggest that caffeine can potentiate the reinforcing and discriminative effects of nicotine... - HIV Sexual and Drug-Use Risk in Drug-Dependent Pregnant Patients in Comprehensive Drug TreatmentHendree E Jones
RTI International, 3040 Cornwallis Road, Research Triangle Park, NC 27709, USA Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA Department of Obstetrics and Gynecology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Int J Family Med 2011:872638. 2011..A relationship was found between number of lifetime drug treatment episodes and sexual and drug-use risk. The role of risk markers in the response of drug-dependent pregnant women to drug treatment require attention... - Reinforcement-based therapy: 12-month evaluation of an outpatient drug-free treatment for heroin abusersHendree E Jones
Cornerstone Treatment Research Clinic, Department of Psychiatry and Behavioral Sciences, Johns Hopkins Bayview Medical Center, Cornerstone D 3 E, 4940 Eastern Avenue, Baltimore, MD 21224, USA
Drug Alcohol Depend 79:119-28. 2005.... - Voucher reinforcement for heroin and cocaine abstinence in an outpatient drug-free programElizabeth C Katz
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
Exp Clin Psychopharmacol 10:136-43. 2002..7% voucher vs. 9% no voucher). Possible reasons for negative findings are discussed. Findings suggest that voucher programs must be better tailored to the clinical population and behavioral targets being addressed... - Neonatal abstinence syndrome in methadone-exposed infants is altered by level of prenatal tobacco exposureRobin E Choo
Chemistry and Drug Metabolism Section, Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institute of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224-6823, USA
Drug Alcohol Depend 75:253-60. 2004..0 h versus 37.8 h), than light smokers of 10 or fewer cigarettes per day. We concluded that tobacco use in conjunction with methadone plays an important role in the timing and severity of NAS in prenatally exposed infants... - Female partners of opioid-injecting men in the Republic of Georgia: an initial characterizationIngunn O Lund
Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University and RTI International, 3040 E Cornwallis Road, Research Triangle Park, NC 27709, USA
Subst Abuse Treat Prev Policy 7:46. 2012.... - Safety and efficacy of L-tryptophan and behavioral incentives for treatment of cocaine dependence: a randomized clinical trialHendree E Jones
Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Am J Addict 13:421-37. 2004..This study also showed that contingent vouchers were effective in the novel experimental model of relapse prevention... - Exposure to violence among substance-dependent pregnant women and their childrenMartha L Velez
Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Subst Abuse Treat 30:31-8. 2006..This study affirmed the value of routine screening for violence exposure in this at-risk population as well as the need to train therapists in specific strategies for helping such women address this complex array of problems... - Cash value of voucher reinforcers in pregnant drug-dependent womenJames Rosado
Department of Psychiatry, Harvard Medical School, Cambridge, MA, USA
Exp Clin Psychopharmacol 13:41-7. 2005..These results suggest that voucher discounting does occur among patients in drug treatment. However, vouchers retain 80%-90% of their cash value and thus remain relatively potent reinforcers... - Partner violence impacts the psychosocial and psychiatric status of pregnant, drug-dependent womenMichelle Tuten
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Addict Behav 29:1029-34. 2004..Results suggest that treatment should address the women's relationships with their partners, especially when substance abuse and violence issues are present... - Comparing homeless and domiciled pregnant substance dependent women on psychosocial characteristics and treatment outcomesMichelle Tuten
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Drug Alcohol Depend 69:95-9. 2003..Treatment retention was poorer for homeless than domiciled pregnant women. Results suggest that treatment should address the housing needs of pregnant drug abusers as well as their related social and psychiatric problems... - Determination of methadone, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine, 2-ethyl-5-methyl-3,3-diphenylpyraline and methadol in meconium by liquid chromatography atmospheric pressure chemical ionization tandem mass spectrometryRobin E Choo
Chemistry and Drug Metabolism Section, Intramural Research Program, National Institute on Drug Abuse, National Institute of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
J Chromatogr B Analyt Technol Biomed Life Sci 814:369-73. 2005..Literature review revealed no other published LC-APCI-MS/MS method for the detection of methadone and its three main metabolites in meconium specimens... - A partner's drug-using status impacts women's drug treatment outcomeMichelle Tuten
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Drug Alcohol Depend 70:327-30. 2003..A male partner's drug-using status should be considered when treating pregnant drug dependent women... - Usefulness of salivary trans-3'-hydroxycotinine concentration and trans-3'-hydroxycotinine/cotinine ratio as biomarkers of cigarette smoke in pregnant womenInsook Kim
Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
J Anal Toxicol 29:689-95. 2005..Determining the hydroxycotinine/cotinine ratio may differentiate light from heavy tobacco use and help predict increased fetal tobacco exposure...