Affiliation: Johns Hopkins University
- Drugs used in the treatment of schizophrenia and bipolar disorder inhibit the replication of Toxoplasma gondiiLorraine Jones-Brando
Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University School of Medicine, 600 N Wolfe Street Blalock 1149, Baltimore, MD 21287 4933, USA
Schizophr Res 62:237-44. 2003..Several medications used to treat schizophrenia and bipolar disorder have the ability to inhibit the in vitro replication of T. gondii...
- In vitro inhibition of Toxoplasma gondii by four new derivatives of artemisininLorraine Jones-Brando
Stanley Division of Developmental Neurovirology, Dept of Pediatrics, Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287 4988, USA
Antimicrob Agents Chemother 50:4206-8. 2006..We synthesized novel, nonacetal, hydrolytically stable derivatives of artemisinin and showed that they inhibit the replication of Toxoplasma gondii in cell culture...
- Transactivation of elements in the human endogenous retrovirus W family by viral infectionChristoffer Nellåker
The Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 171 77 Stockholm, Sweden
Retrovirology 3:44. 2006....
- Artemisinin derivatives inhibit Toxoplasma gondii in vitro at multiple steps in the lytic cycleJohn G D'Angelo
Department of Chemistry and The Malaria Research Institute, Johns Hopkins University, 3400 N Charles St, Baltimore, MD 21218, USA
J Antimicrob Chemother 63:146-50. 2009....
- Thiazole, oxadiazole, and carboxamide derivatives of artemisinin are highly selective and potent inhibitors of Toxoplasma gondiiChristopher P Hencken
Department of Chemistry, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA
J Med Chem 53:3594-601. 2010..Some of the new derivatives of artemisinin described here represent effective anti-Toxoplasma trioxanes as well as molecular probes for elucidating the mechanism of action of the DART class of artemisinin derivatives...
- Artemisinin-derived dimers have greatly improved anti-cytomegalovirus activity compared to artemisinin monomersRavit Arav-Boger
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
PLoS ONE 5:e10370. 2010..Artesunate, an artemisinin-derived monomer, was reported to inhibit Cytomegalovirus (CMV) replication. We aimed to compare the in-vitro anti-CMV activity of several artemisinin-derived monomers and newly synthesized artemisinin dimers...
- Differential effects of three canonical Toxoplasma strains on gene expression in human neuroepithelial cellsJianchun Xiao
Stanley Division of Developmental Neurovirology, Johns Hopkins School of Medicine, 600 N Wolfe Street, 1105 Blalock, Baltimore, MD 21287 4933, USA
Infect Immun 79:1363-73. 2011..These observed differences may explain some of the variation in the neurobiological effects of different strains of Toxoplasma on infected individuals...
- Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogsBogdana Krivogorsky
Dept of Pediatrics, Johns Hopkins University School of Medicine, 600 N Wolfe St, Baltimore, MD 21287, USA
Antimicrob Agents Chemother 52:4466-9. 2008..Indirubin-3'-oxime analogs showed modest micromolar activity, while tryptanthrin derivatives displayed 50% inhibitory doses in the low nanomolar range. Tryptanthrins have potential as anti-Toxoplasma infection therapeutics...
- Toxoplasma gondii strain-dependent effects on mouse behaviourGeetha Kannan
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 5371, USA
Folia Parasitol (Praha) 57:151-5. 2010..No differences in parasite antibody titres were seen between PRU- and ME49-infected mice. The present data suggest the effect of T. gondii infection on mouse behaviour is parasite strain-dependent...