Lauren Jansson

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi request reprint Methadone maintenance and breastfeeding in the neonatal period
    Lauren M Jansson
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Pediatrics 121:106-14. 2008
  2. pmc Pregnancies exposed to methadone, methadone and other illicit substances, and poly-drugs without methadone: a comparison of fetal neurobehaviors and infant outcomes
    L M Jansson
    Johns Hopkins University School of Medicine, Department of Pediatrics, Baltimore, MD 21224, USA
    Drug Alcohol Depend 122:213-9. 2012
  3. doi request reprint Neonatal abstinence syndrome
    Lauren M Jansson
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Curr Opin Pediatr 24:252-8. 2012
  4. pmc Fetal neurobehavioral effects of exposure to methadone or buprenorphine
    Lauren M Jansson
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore MD 21224, USA
    Neurotoxicol Teratol 33:240-3. 2011
  5. pmc Infant autonomic functioning and neonatal abstinence syndrome
    Lauren M Jansson
    Johns Hopkins University School of Medicine, Department of Pediatrics, Baltimore, MD 21224, USA
    Drug Alcohol Depend 109:198-204. 2010
  6. pmc Maternal methadone dosing schedule and fetal neurobehaviour
    Lauren M Jansson
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Matern Fetal Neonatal Med 22:29-35. 2009
  7. pmc Methadone maintenance and long-term lactation
    Lauren M Jansson
    Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Breastfeed Med 3:34-7. 2008
  8. ncbi request reprint Maternal vagal tone change in response to methadone is associated with neonatal abstinence syndrome severity in exposed neonates
    Lauren M Jansson
    Johns Hopkins University School of Medicine, Department of Pediatrics, Baltimore, Maryland 21224, USA
    J Matern Fetal Neonatal Med 20:677-85. 2007
  9. ncbi request reprint The impact of managed care on drug-dependent pregnant and postpartum women and their children
    Lauren M Jansson
    School of Medicine, Department of Pediatrics, The Johns Hopkins University, Baltimore, MD 21224, USA
    Subst Use Misuse 42:961-74. 2007
  10. ncbi request reprint Effectiveness of child case management services for offspring of drug-dependent women
    Lauren M Jansson
    Johns Hopkins University School of Medicine, The Center for Addiction and Pregnancy, Baltimore, Maryland 21224, USA
    Subst Use Misuse 38:1933-52. 2003

Research Grants

Detail Information

Publications23

  1. doi request reprint Methadone maintenance and breastfeeding in the neonatal period
    Lauren M Jansson
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Pediatrics 121:106-14. 2008
    ....
  2. pmc Pregnancies exposed to methadone, methadone and other illicit substances, and poly-drugs without methadone: a comparison of fetal neurobehaviors and infant outcomes
    L M Jansson
    Johns Hopkins University School of Medicine, Department of Pediatrics, Baltimore, MD 21224, USA
    Drug Alcohol Depend 122:213-9. 2012
    ..Exposure groups include: Methadone+other illicit substances (MM+Poly) and two groups currently abstinent for poly drug exposures: Methadone only (MM/A) and Non-Methadone (NM/A)...
  3. doi request reprint Neonatal abstinence syndrome
    Lauren M Jansson
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Curr Opin Pediatr 24:252-8. 2012
    ....
  4. pmc Fetal neurobehavioral effects of exposure to methadone or buprenorphine
    Lauren M Jansson
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore MD 21224, USA
    Neurotoxicol Teratol 33:240-3. 2011
    ..05). These results may have implications for the optimal treatment of the opioid-dependent pregnant woman...
  5. pmc Infant autonomic functioning and neonatal abstinence syndrome
    Lauren M Jansson
    Johns Hopkins University School of Medicine, Department of Pediatrics, Baltimore, MD 21224, USA
    Drug Alcohol Depend 109:198-204. 2010
    ..The current study examines whether cardiac vagal tone, an indicator of parasympathetic neuroregulation, provides a marker for autonomic dysregulation subsequently expressed as NAS in prenatally opioid-exposed newborns...
  6. pmc Maternal methadone dosing schedule and fetal neurobehaviour
    Lauren M Jansson
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Matern Fetal Neonatal Med 22:29-35. 2009
    ..The purpose of this study was to determine if split-dosing would have less impact on fetal neurobehaviour than single-dose administration...
  7. pmc Methadone maintenance and long-term lactation
    Lauren M Jansson
    Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Breastfeed Med 3:34-7. 2008
    ..The concentrations of methadone in blood and breastmilk were low, contributing to the recommendation of breastfeeding for some methadone-maintained women...
  8. ncbi request reprint Maternal vagal tone change in response to methadone is associated with neonatal abstinence syndrome severity in exposed neonates
    Lauren M Jansson
    Johns Hopkins University School of Medicine, Department of Pediatrics, Baltimore, Maryland 21224, USA
    J Matern Fetal Neonatal Med 20:677-85. 2007
    ....
  9. ncbi request reprint The impact of managed care on drug-dependent pregnant and postpartum women and their children
    Lauren M Jansson
    School of Medicine, Department of Pediatrics, The Johns Hopkins University, Baltimore, MD 21224, USA
    Subst Use Misuse 42:961-74. 2007
    ..While these data are correlational and need to be interpreted with caution, they suggest poorer outcomes for drug-exposed children under MC and invite further study of short- and long-term consequences of such change...
  10. ncbi request reprint Effectiveness of child case management services for offspring of drug-dependent women
    Lauren M Jansson
    Johns Hopkins University School of Medicine, The Center for Addiction and Pregnancy, Baltimore, Maryland 21224, USA
    Subst Use Misuse 38:1933-52. 2003
    ..Study findings support clinical and economic efficacy of this model of care...
  11. pmc Concentrations of methadone in breast milk and plasma in the immediate perinatal period
    Lauren M Jansson
    Center for Addiction and Pregnancy, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224, USA
    J Hum Lact 23:184-90. 2007
    ..Results obtained from this study contribute to the recommendation of breastfeeding for methadone-maintained women regardless of methadone dose...
  12. ncbi request reprint Fetal response to maternal methadone administration
    Lauren M Jansson
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Obstet Gynecol 193:611-7. 2005
    ..The purpose of this study was to investigate the effect of methadone on fetal neurobehavioral functions and maternal physiologic indicators...
  13. pmc The opioid-exposed newborn: assessment and pharmacologic management
    Lauren M Jansson
    Department of Pediatrics, Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, Maryland, USA
    J Opioid Manag 5:47-55. 2009
    ..This review is intended to provide the healthcare professional with a brief review of current evidence and practical guidelines for optimal evaluation and pharmacologic management of the opioid-exposed newborn...
  14. ncbi request reprint Parenting knowledge among substance abusing women in treatment
    Martha L Velez
    The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Subst Abuse Treat 27:215-22. 2004
    ....
  15. ncbi request reprint Variability in the evaluation and management of opiate-exposed newborns in Maryland
    Michael T Crocetti
    Department of Pediatrics, Johns Hopkins Bayview Medical Center, Baltimore, Maryland, USA
    Clin Pediatr (Phila) 46:632-5. 2007
    ..Significant variability exists in the evaluation and management of opiate-exposed newborns in Maryland. Validated, evidence-based guidelines are needed to standardize the care of these vulnerable newborns across all hospital settings...
  16. pmc Exposure to violence among substance-dependent pregnant women and their children
    Martha L Velez
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Subst Abuse Treat 30:31-8. 2006
    ..This study affirmed the value of routine screening for violence exposure in this at-risk population as well as the need to train therapists in specific strategies for helping such women address this complex array of problems...
  17. doi request reprint Infant neurobehavior following prenatal exposure to methadone or buprenorphine: results from the neonatal intensive care unit network neurobehavioral scale
    Hendree E Jones
    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Subst Use Misuse 45:2244-57. 2010
    ..Results suggest the NNNS may detect subtle differences over time between both neonates prenatally exposed to methadone or buprenorphine and neonates pharmacologically treated or untreated for NAS...
  18. ncbi request reprint Buprenorphine versus methadone in the treatment of pregnant opioid-dependent patients: effects on the neonatal abstinence syndrome
    Hendree E Jones
    The Department of Psychiatry and Behavioral Sciences, Johns Hopkins Bayview Medical Campus, Johns Hopkins University School of Medicine, D 3 East, 4940 Eastern Avenue, Baltimore, MD 21224, USA
    Drug Alcohol Depend 79:1-10. 2005
    ..25). Results suggest that buprenorphine is not inferior to methadone on outcome measures assessing NAS and maternal and neonatal safety when administered starting in the second trimester of pregnancy...
  19. pmc Clonidine as an adjunct therapy to opioids for neonatal abstinence syndrome: a randomized, controlled trial
    Alexander G Agthe
    Department of Pediatrics, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Pediatrics 123:e849-56. 2009
    ..To determine if oral clonidine would reduce the duration of opioid detoxification for neonatal abstinence syndrome...
  20. pmc A validated liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometric method for the quantification of methadone, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), and 2-Ethyl-5-methyl-3,3-diphenylpyroline (EMDP) in
    Robin E Choo
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institute of Health, Baltimore, Maryland 21224, USA
    J Anal Toxicol 31:265-9. 2007
    ..The method proved suitable for quantification of methadone and metabolites in breast milk of methadone-maintained opiate-dependent women...
  21. ncbi request reprint Methadone maintenance and lactation: a review of the literature and current management guidelines
    Lauren M Jansson
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Hum Lact 20:62-71. 2004
    ..A comprehensive review of existing literature on the subject is offered, along with clinical advice for practitioners providing care to this population of women and children...
  22. pmc Prenatal methadone exposure and neonatal neurobehavioral functioning
    Martha L Velez
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Pediatr Res 66:704-9. 2009
    ..The determination of the range of the methadone-exposed infant's neurobehavioral repertoire could guide the optimal treatment of all such infants, particularly those requiring only nonpharmacologic care...
  23. ncbi request reprint Validation of a LC-APCI-MS/MS method for quantification of methadone, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) and 2-ethyl-5-methyl-3,3-diphenylpyraline (EMDP) in infant plasma following protein precipitation
    Diaa M Shakleya
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, United States
    J Chromatogr B Analyt Technol Biomed Life Sci 856:267-72. 2007
    ..4% R.S.D. and recovery >or=87.5% for all analytes at 40 ng/mL. This analytical method is suitable for the accurate and precise determination of methadone and metabolites in human plasma specimens...

Research Grants6

  1. METHADONE, BUPRENORPHINE AND FETAL DEVELOPMENT
    Lauren Jansson; Fiscal Year: 2004
    ..Upon completing the 5-year funding period, Dr. Jansson plans to have written an RO1 grant application to pursue research ideas identified during KO8 funding. ..
  2. Fetal and Infant Neurobehavior in Opiate Dependent Women
    Lauren Jansson; Fiscal Year: 2005
    ..Information gained from this proposal has the potential to significantly impact the way in which we treat the difficult and high-risk population of opiate dependent pregnant women. ..
  3. Fetal and Infant Neurobehavior in Opiate Dependent Women
    Lauren Jansson; Fiscal Year: 2006
    ..Information gained from this proposal has the potential to significantly impact the way in which we treat the difficult and high-risk population of opiate dependent pregnant women. ..
  4. Fetal and Infant Neurobehavior in Opiate Dependent Women
    Lauren Jansson; Fiscal Year: 2007
    ..Information gained from this proposal has the potential to significantly impact the way in which we treat the difficult and high-risk population of opiate dependent pregnant women. ..
  5. Fetal and Infant Neurobehavior in Opiate Dependent Women
    Lauren Jansson; Fiscal Year: 2009
    ..Information gained from this proposal has the potential to significantly impact the way in which we treat the difficult and high-risk population of opiate dependent pregnant women. ..