L P Jacobson

Summary

Affiliation: Johns Hopkins Bloomberg School of Public Health
Country: USA

Publications

  1. pmc CD4 count at presentation for HIV care in the United States and Canada: are those over 50 years more likely to have a delayed presentation?
    Keri N Althoff
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD, 21205, USA
    AIDS Res Ther 7:45. 2010
  2. ncbi request reprint Virologic and immunologic response to highly active antiretroviral therapy
    Lisa P Jacobson
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Curr HIV/AIDS Rep 1:74-81. 2004
  3. ncbi request reprint Evaluation of the effectiveness of highly active antiretroviral therapy in persons with human immunodeficiency virus using biomarker-based equivalence of disease progression
    L P Jacobson
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Am J Epidemiol 155:760-70. 2002
  4. ncbi request reprint Impact of potent antiretroviral therapy on the incidence of Kaposi's sarcoma and non-Hodgkin's lymphomas among HIV-1-infected individuals. Multicenter AIDS Cohort Study
    L P Jacobson
    Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    J Acquir Immune Defic Syndr 21:S34-41. 1999
  5. ncbi request reprint Interaction of human immunodeficiency virus type 1 and human herpesvirus type 8 infections on the incidence of Kaposi's sarcoma
    L P Jacobson
    Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA
    J Infect Dis 181:1940-9. 2000
  6. ncbi request reprint Therapy naivete in the era of potent antiretroviral therapy
    L P Jacobson
    Department of Epidemiology, The Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205, USA
    J Clin Epidemiol 54:149-56. 2001
  7. ncbi request reprint Immunologic and virologic response to highly active antiretroviral therapy in the Multicenter AIDS Cohort Study
    T E Yamashita
    Johns Hopkins School of Public Health, Baltimore, Maryland 21205, USA
    AIDS 15:735-46. 2001
  8. ncbi request reprint Thrush and fever as markers of immune competence in the era of highly active antiretroviral therapy
    R L Skolasky
    Department of Epidemiology, Johns Hopkins University School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205, USA
    AIDS Res Hum Retroviruses 17:1311-6. 2001
  9. ncbi request reprint Oltipraz chemoprevention trial in Qidong, People's Republic of China: modulation of serum aflatoxin albumin adduct biomarkers
    T W Kensler
    Department of Environmental Health Sciences, Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    Cancer Epidemiol Biomarkers Prev 7:127-34. 1998
  10. ncbi request reprint Determinants of heterogeneous adherence to HIV-antiretroviral therapies in the Multicenter AIDS Cohort Study
    C A Kleeberger
    Department of Epidemiology, The Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    J Acquir Immune Defic Syndr 26:82-92. 2001

Research Grants

Detail Information

Publications68

  1. pmc CD4 count at presentation for HIV care in the United States and Canada: are those over 50 years more likely to have a delayed presentation?
    Keri N Althoff
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD, 21205, USA
    AIDS Res Ther 7:45. 2010
    ..10%, respectively). Due to the increasing proportion, consistently lower CD4 counts, and more advanced HIV disease in adults ≥50-year-old at first presentation for HIV care, renewed HIV testing efforts are needed...
  2. ncbi request reprint Virologic and immunologic response to highly active antiretroviral therapy
    Lisa P Jacobson
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Curr HIV/AIDS Rep 1:74-81. 2004
    ....
  3. ncbi request reprint Evaluation of the effectiveness of highly active antiretroviral therapy in persons with human immunodeficiency virus using biomarker-based equivalence of disease progression
    L P Jacobson
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Am J Epidemiol 155:760-70. 2002
    ....
  4. ncbi request reprint Impact of potent antiretroviral therapy on the incidence of Kaposi's sarcoma and non-Hodgkin's lymphomas among HIV-1-infected individuals. Multicenter AIDS Cohort Study
    L P Jacobson
    Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    J Acquir Immune Defic Syndr 21:S34-41. 1999
    ..With additional follow-up, an impact on NHL may yet be observed...
  5. ncbi request reprint Interaction of human immunodeficiency virus type 1 and human herpesvirus type 8 infections on the incidence of Kaposi's sarcoma
    L P Jacobson
    Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA
    J Infect Dis 181:1940-9. 2000
    ..The quicker development of KS in men acquiring HHV-8 after HIV-1 and its association with CD4 slope argues that KS is more likely if HHV-8 infection occurs in an immunocompromised person...
  6. ncbi request reprint Therapy naivete in the era of potent antiretroviral therapy
    L P Jacobson
    Department of Epidemiology, The Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205, USA
    J Clin Epidemiol 54:149-56. 2001
    ..In this era of effective ART, use was not universal. Besides disease markers, these nonclinical determinants need to be considered for promoting population therapy effectiveness...
  7. ncbi request reprint Immunologic and virologic response to highly active antiretroviral therapy in the Multicenter AIDS Cohort Study
    T E Yamashita
    Johns Hopkins School of Public Health, Baltimore, Maryland 21205, USA
    AIDS 15:735-46. 2001
    ..Age, level of immune competence and immunogenetics appeared to play a role in the subsequent immune reconstitution following use of highly effective HIV therapy...
  8. ncbi request reprint Thrush and fever as markers of immune competence in the era of highly active antiretroviral therapy
    R L Skolasky
    Department of Epidemiology, Johns Hopkins University School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205, USA
    AIDS Res Hum Retroviruses 17:1311-6. 2001
    ..These results provide evidence that increases in CD4+ T cell count due to HAART represent a reconstitution of immune function...
  9. ncbi request reprint Oltipraz chemoprevention trial in Qidong, People's Republic of China: modulation of serum aflatoxin albumin adduct biomarkers
    T W Kensler
    Department of Environmental Health Sciences, Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    Cancer Epidemiol Biomarkers Prev 7:127-34. 1998
    ..A follow-up Phase IIb trial with a longer intervention period will be necessary to determine the full extent to which aflatoxin biomarker burden can be reduced and whether diminution of biomarkers can be sustained over the long term...
  10. ncbi request reprint Determinants of heterogeneous adherence to HIV-antiretroviral therapies in the Multicenter AIDS Cohort Study
    C A Kleeberger
    Department of Epidemiology, The Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    J Acquir Immune Defic Syndr 26:82-92. 2001
    ..Identification of individuals with characteristics associated with lower adherence provides the basis for interventions to enhance adherence and optimize effective therapies...
  11. ncbi request reprint Interruption and discontinuation of highly active antiretroviral therapy in the multicenter AIDS cohort study
    Xiuhong Li
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Acquir Immune Defic Syndr 38:320-8. 2005
    ..Identify the determinants and consequences of interrupting and discontinuing highly active antiretroviral therapy (HAART) among a population-based cohort of HIV-infected men...
  12. ncbi request reprint Zidovudine use in AIDS-free HIV-1-seropositive homosexual men in the Multicenter AIDS Cohort Study (MACS), 1987-1989
    N M Graham
    Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland
    J Acquir Immune Defic Syndr 4:267-76. 1991
    ..No important differences were found in demographic or major clinical variables between clinical trial participants and zidovudine nonusers in this study...
  13. pmc Relationship between a frailty-related phenotype and progressive deterioration of the immune system in HIV-infected men
    Loic Desquilbet
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    J Acquir Immune Defic Syndr 50:299-306. 2009
    ..Using a frailty-related phenotype (FRP), we investigated in the Multicenter AIDS Cohort Study whether progressive deterioration of the immune system among HIV-positive individuals independently predicts onset of FRP...
  14. pmc Emergence and persistence of CXCR4-tropic HIV-1 in a population of men from the multicenter AIDS cohort study
    James C Shepherd
    School of Medicine, Johns Hopkins University, MD, USA
    J Infect Dis 198:1104-12. 2008
    ..We conclude that HIV-1 variants that used X4 frequently emerged at high CD4(+) T cell counts and may contribute to the decrease in T cell numbers during late HIV-1 infection...
  15. ncbi request reprint A case-control study of HIV-1-related dementia and co-infection with HHV-8
    S Polk
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Neurology 59:950-3. 2002
    ..The HHV-8 seropositivity of 210 male age- and HIV disease stage-matched cases and controls was compared. The overall HHV-8 seropositivity of 66% was similar among demented HIV-infected cases and nondemented HIV-infected controls...
  16. pmc Time scale and adjusted survival curves for marginal structural cox models
    Daniel Westreich
    Department of Epidemiology, Universityof North Carolina, Chapel Hill, NorthCarolina, USA
    Am J Epidemiol 171:691-700. 2010
    ..In the present example, use of time on treatment yielded a hazard ratio further from the null and more precise than use of time on study as the time scale...
  17. pmc Sexual activity and Kaposi's sarcoma among human immunodeficiency virus type 1 and human herpesvirus type 8-coinfected men
    Eric W Nawar
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Ann Epidemiol 18:517-21. 2008
    ..Here, we explore sexual activity as a proxy for a sexually transmitted determinant beyond HIV-1 and HHV-8...
  18. pmc A comparison of ad hoc methods to account for non-cancer AIDS and deaths as competing risks when estimating the effect of HAART on incident cancer AIDS among HIV-infected men
    Meredith S Shiels
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    J Clin Epidemiol 63:459-67. 2010
    ....
  19. pmc Effect of tuberculosis on the survival of HIV-infected men in a country with low tuberculosis incidence
    Hugo Lopez-Gatell
    Directorate of Epidemiology, Ministry of Health, Mexico, Mexico
    AIDS 22:1869-73. 2008
    ..2-4.7). Results underscore the importance of avoiding TB by using preventive interventions such as treatment of latent TB infection, particularly in populations with a large prevalence of HIV/TB co-infected individuals...
  20. ncbi request reprint Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China
    Thomas W Kensler
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Room E7541, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 14:2605-13. 2005
    ..29). Understanding factors influencing glucosinolate hydrolysis and bioavailability will be required for optimal use of broccoli sprouts in human interventions...
  21. pmc Cancer incidence in the multicenter AIDS Cohort Study before and during the HAART era: 1984 to 2007
    Eric C Seaberg
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Cancer 116:5507-16. 2010
    ....
  22. ncbi request reprint Impacts of HIV infection and HAART use on quality of life
    Chenglong Liu
    Bloomberg School of Public Health, Johns Hopkins University, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Qual Life Res 15:941-9. 2006
    ..Changes in QOL related to the use of highly active antiretroviral therapy (HAART) have been inconsistent and it is unknown how QOL after HAART compares to pre-infection levels...
  23. ncbi request reprint HIV-1 infection is associated with an earlier occurrence of a phenotype related to frailty
    Loic Desquilbet
    Department of Epidemiology, Bloomberg School of Public Health, John Hopkins University, Baltimore, Maryland 21205, USA
    J Gerontol A Biol Sci Med Sci 62:1279-86. 2007
    ..We investigated whether HIV infection increases the prevalence of a frailty-related phenotype (FRP) that approximates a clinical definition of frailty...
  24. ncbi request reprint Patterns and predictors of changes in adherence to highly active antiretroviral therapy: longitudinal study of men and women
    Mariana Lazo
    Johns Hopkins University Bloomberg School of Public Health, Epidemiology, Baltimore, MD 21205, USA
    Clin Infect Dis 45:1377-85. 2007
    ..Adherence to therapy is a dynamic behavior. However, few studies have identified factors associated with changes in adherence to highly active antiretroviral therapy (HAART) among men and women...
  25. pmc The relationship between antibody to R7V and progression of HIV type 1 infection
    Joseph B Margolick
    Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    AIDS Res Hum Retroviruses 26:389-94. 2010
    ..The early presence of anti-R7VAb in HIV-1 seroconverters was not associated with slower progression of HIV-1 disease...
  26. pmc Failure to restore the Vgamma2-Jgamma1.2 repertoire in HIV-infected men receiving highly active antiretroviral therapy (HAART)
    Andrew M Hebbeler
    Institute of Human Virology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, Maryland 21201, USA
    Clin Immunol 128:349-57. 2008
    ..2Vdelta2 T cell repertoire did not recover after HAART initiation irrespective of treatment duration. These studies highlight important defects among cell subsets lost due to indirect effects of HIV...
  27. pmc Investigation of pre-diagnostic virological markers for progressive multifocal leukoencephalopathy in human immunodeficiency virus-infected patients
    Mary K Grabowski
    Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Med Virol 81:1140-50. 2009
    ..0, 95% CI: 1.2-394.5). The results suggest that persistent JCV viruria and increasing urinary concentration of JCV DNA may be predictive of PML for some patients...
  28. doi request reprint Incidence and epidemiology of anal cancer in the multicenter AIDS cohort study
    Gypsyamber D'Souza
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Acquir Immune Defic Syndr 48:491-9. 2008
    ..To examine the incidence and risk factors for anal cancer in a multicenter cohort of human immunodeficiency virus (HIV) positive and HIV-negative men who have sex with men followed between 1984 and 2006 (Multicenter AIDS Cohort Study)...
  29. pmc Effect of HAART on incident cancer and noncancer AIDS events among male HIV seroconverters
    Meredith S Shiels
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, Room E7133, Baltimore, MD 21205, USA
    J Acquir Immune Defic Syndr 48:485-90. 2008
    ..To explore the impact of highly active antiretroviral therapy (HAART) on the prevention of AIDS-defining cancers relative to other AIDS-defining events...
  30. ncbi request reprint Individual variation in CD4 cell count trajectory among human immunodeficiency virus-infected men and women on long-term highly active antiretroviral therapy: an application using a Bayesian random change-point model
    Haitao Chu
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Am J Epidemiol 162:787-97. 2005
    ..At the individual level, 35% of men in the Multicenter AIDS Cohort Study versus 25% of women in the Women's Interagency HIV Study had a statistically significant change in CD4 cell count trajectory within 7 years after HAART initiation...
  31. ncbi request reprint Changes in adherence to highly active antiretroviral therapy medications in the Multicenter AIDS Cohort Study
    Cynthia A Kleeberger
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    AIDS 18:683-8. 2004
    ..To characterize the determinants of changes in adherence to antiretroviral therapy and examine whether there are persistent lower adherers...
  32. ncbi request reprint Strategies for chemoprevention of liver cancer
    Thomas W Kensler
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Eur J Cancer Prev 11:S58-64. 2002
    ..Both chemopreventive agents modulated levels of aflatoxin biomarkers in the study participants in manners consonant with protection...
  33. ncbi request reprint Chemoprevention of hepatocellular carcinoma in aflatoxin endemic areas
    Thomas W Kensler
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, Maryland 21205, USA
    Gastroenterology 127:S310-8. 2004
    ....
  34. ncbi request reprint When to initiate highly active antiretroviral therapy: a cohort approach
    Linda Ahdieh-Grant
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Am J Epidemiol 157:738-46. 2003
    ..Furthermore, results suggest a potential threshold for HAART initiation in the neighborhood of 275 cells/microl...
  35. pmc Bioavailability of Sulforaphane from two broccoli sprout beverages: results of a short-term, cross-over clinical trial in Qidong, China
    Patricia A Egner
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    Cancer Prev Res (Phila) 4:384-95. 2011
    ..Cancer Prev Res; 4(3); 384-95. ©2011 AACR...
  36. pmc Age and racial/ethnic differences in the prevalence of reported symptoms in human immunodeficiency virus-infected persons on antiretroviral therapy
    Michael J Silverberg
    Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
    J Pain Symptom Manage 38:197-207. 2009
    ..Clinicians should consider these factors when counseling patients regarding potential adverse effects of antiretrovirals or symptoms associated with HIV disease...
  37. ncbi request reprint Predictors for lower quality of life in the HAART era among HIV-infected men
    Chenglong Liu
    Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    J Acquir Immune Defic Syndr 42:470-7. 2006
    ..Modifiable determinants of lower QOL should be identified for interventions specifically targeted to the HAART-using individuals to improve their QOL...
  38. pmc Anthropometry in the prediction of sleep disordered breathing in HIV-positive and HIV-negative men
    Todd T Brown
    Division of Endocrinology and Metabolism, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Antivir Ther 15:651-9. 2010
    ....
  39. pmc Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver cancer
    P A Egner
    Department of Environmental Health Sciences and Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 98:14601-6. 2001
    ....
  40. ncbi request reprint Factors associated with human herpesvirus type 8 infection in an injecting drug user cohort
    Kyle T Bernstein
    Department of Epidemiology, The Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    Sex Transm Dis 30:199-204. 2003
    ..Human herpesvirus type 8 (HHV-8) has been infrequently studied in injecting drug user (IDU) populations...
  41. pmc Plasma antibodies against Chlamydia trachomatis, human papillomavirus, and human herpesvirus type 8 in relation to prostate cancer: a prospective study
    Siobhan Sutcliffe
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Room E6132 A, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 16:1573-80. 2007
    ..70; 95% CI, 0.52-0.95). As this study is the first, to our knowledge, to observe such an inverse association, similar additional studies are warranted...
  42. pmc Late presentation for human immunodeficiency virus care in the United States and Canada
    Keri N Althoff
    Johns Hopkins University, Baltimore, Maryland, USA
    Clin Infect Dis 50:1512-20. 2010
    ..CONCLUSION. CD4 count at first presentation for HIV care has increased annually over the past 11 years but has remained <350 cells/mm(3), which suggests the urgent need for earlier HIV diagnosis and treatment...
  43. pmc Cohort profile: the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD)
    Stephen J Gange
    NA ACCORD Coordinating Center, Baltimore, MD 21287, USA
    Int J Epidemiol 36:294-301. 2007
  44. pmc The major histocompatibility complex conserved extended haplotype 8.1 in AIDS-related non-Hodgkin lymphoma
    Brahim Aissani
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
    J Acquir Immune Defic Syndr 52:170-9. 2009
    ..Which gene variant on this highly conserved extended haplotype (CEH 8.1) in whites most likely represents a true etiologic factor remains uncertain...
  45. ncbi request reprint The association of backpack use and back pain in adolescents
    Geraldine I Sheir-Neiss
    Department of Research, Alfred I duPont Hospital for Children, Wilmington, Delaware 19899, USA
    Spine (Phila Pa 1976) 28:922-30. 2003
    ..A cross-sectional study comprising the first phase of an ongoing, longitudinal prospective study was conducted...
  46. pmc Low CD4+ T-cell count as a major atherosclerosis risk factor in HIV-infected women and men
    Robert C Kaplan
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    AIDS 22:1615-24. 2008
    ..To assess the association of HIV infection, HIV disease parameters (including CD4+ T-cell counts, HIV viral load, and AIDS) and antiretroviral medication use with subclinical carotid artery atherosclerosis...
  47. ncbi request reprint The complexity of HLA class II (DRB1, DQB1, DM) associations with disseminated Mycobacterium avium complex infection among HIV-1-seropositive whites
    Eknath Naik
    Department of Epidemiology and Biostatistics, University of South Florida, Tampa, Florida, USA
    J Acquir Immune Defic Syndr 33:140-5. 2003
    ....
  48. ncbi request reprint Association of polymorphisms in human leukocyte antigen class I and transporter associated with antigen processing genes with resistance to human immunodeficiency virus type 1 infection
    Chenglong Liu
    School of Public Health, University of California, Los Angeles, CA 90095, USA
    J Infect Dis 187:1404-10. 2003
    ..In multivariate logistic analysis, only the A*0205 subgroup (OR, 5.56; 95% CI, 1.34-23.10; P=.018) and the TAP2 Ala665 (OR, 2.22; 95% CI, 1.28-3.84; P=.005) were associated with resistance...
  49. ncbi request reprint Effect of highly active antiretroviral therapy on survival among HIV-infected men with Kaposi sarcoma or non-Hodgkin lymphoma
    Henry K Tam
    School of Public Health, University of California, Los Angeles, CA 90095 1772, USA
    Int J Cancer 98:916-22. 2002
    ..The use of HAART prolongs overall survival among HIV-positive men diagnosed with KS and NHL. HAART appears to be effective in improving survival even when initiated after the diagnosis of NHL and KS...
  50. ncbi request reprint Attitudes towards highly active antiretroviral therapy are associated with sexual risk taking among HIV-infected and uninfected homosexual men
    David E Ostrow
    Loyola University School of Medicine, Maywood, Illinois, USA
    AIDS 16:775-80. 2002
    ..To determine whether attitudes towards highly active antiretroviral therapy (HAART) are associated with unprotected anal sex among sexually active homosexual men...
  51. ncbi request reprint Changes in the incidence and predictors of wasting syndrome related to human immunodeficiency virus infection, 1987-1999
    Ellen Smit
    Department of Social and Preventive Medicine, School of Medicine and Biological Sciences, University at Buffalo, Buffalo, NY 14214 3000, USA
    Am J Epidemiol 156:211-8. 2002
    ..05) and potent ART (p = 0.097). Predictors of wasting have changed with potent ART. Further research is needed to determine whether lipodystrophy may be misdiagnosed as wasting syndrome...
  52. ncbi request reprint Non-Hodgkin's B cell lymphoma in persons with acquired immunodeficiency syndrome is associated with increased serum levels of IL10, or the IL10 promoter -592 C/C genotype
    Elizabeth Crabb Breen
    Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Clin Immunol 109:119-29. 2003
    ..009), even when controlling for race (P = 0.006). These results suggest that elevated serum IL10 or the IL10 promoter -592 C/C genotype are associated with development of AIDS lymphoma...
  53. doi request reprint Antiretroviral therapy is associated with an atherogenic lipoprotein phenotype among HIV-1-infected men in the Multicenter AIDS Cohort Study
    Sharon A Riddler
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Acquir Immune Defic Syndr 48:281-8. 2008
    ..Alterations in serum lipids and an increased risk of myocardial infarction have been associated with HIV-1 infection and its treatment...
  54. ncbi request reprint Dominant effects of CCR2-CCR5 haplotypes in HIV-1 disease progression
    Cheryl A Winkler
    Laboratory of Genomic Diversity, Division of Basic Research, SAIC Frederick, NCI, Frederick, MD, USA
    J Acquir Immune Defic Syndr 37:1534-8. 2004
    ....
  55. ncbi request reprint Early and delayed benefits of HIV-1 suppression: timeline of recovery of innate immunity effector cells
    Livio Azzoni
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    AIDS 21:293-305. 2007
    ..The kinetics of recovery for innate immune effectors following antiretroviral therapy are unknown...
  56. pmc The relationship between methamphetamine and popper use and risk of HIV seroconversion in the multicenter AIDS cohort study
    Michael W Plankey
    Department of Medicine, Division of Infectious Diseases, Georgetown University Medical Center, Washington, DC 20007, USA
    J Acquir Immune Defic Syndr 45:85-92. 2007
    ..The association between methamphetamine use and HIV seroconversion for men who have sex with men (MSM) was examined using longitudinal data from the Multicenter AIDS Cohort Study...
  57. ncbi request reprint Prospective study of attitudinal and relationship predictors of sexual risk in the multicenter AIDS cohort study
    David G Ostrow
    David Ostrow and Associates, Chicago MACS Howard Brown Health Center and Northwestern University School of Medicine, 5455 N Sheridan Rd, Suite 1207, Chicago, IL 60640, USA
    AIDS Behav 12:127-38. 2008
    ..We conclude that HIV prevention efforts should target modifiable attitudes (reduced concern about HIV and safer sex fatigue) and increases in sexual risk-taking of MSM, particularly among HIV+ men having sex with serodiscordant partners...
  58. ncbi request reprint Macrolide use and the risk of vascular disease in HIV-infected men in the Multicenter AIDS Cohort Study
    Ian J Woolley
    Infectious Diseases Department, Alfred Hospital, Monash University Medical School, Prahran 3004, Victoria, Australia
    Sex Health 4:111-9. 2007
    ..This study examined the risk of thromboembolic events in HIV-infected and non-infected individuals and the effect of macrolide prophylaxis on those outcomes...
  59. ncbi request reprint Prognostic value of HIV-1 RNA, CD4 cell count, and CD4 Cell count slope for progression to AIDS and death in untreated HIV-1 infection
    John W Mellors
    JAMA 297:2349-50. 2007
  60. ncbi request reprint HLA-B, -DRB1/3/4/5, and -DQB1 gene polymorphisms in human immunodeficiency virus-related Kaposi's sarcoma
    M Tevfik Dorak
    Department of Epidemiology and Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0022, USA
    J Med Virol 76:302-10. 2005
    ..Alternatively, the relationship might hold a clue to the predilection of KS for men because that haplotype harbors the mutant form of the 21-hydroxylase gene...
  61. ncbi request reprint Estimating the benefit of an HIV-1 vaccine that reduces viral load set point
    Swati B Gupta
    Merck Research Laboratories, West Point, PA, USA
    J Infect Dis 195:546-50. 2007
    ..5-1.25 log(10) copies/mL lower than the reference group. By quantifying the anticipated clinical benefits associated with a reduction in viral set point, these findings support the use of virologic end points in HIV-1 vaccine trials...
  62. ncbi request reprint FcgammaRIIa genotype predicts progression of HIV infection
    Donald N Forthal
    Division of Infectious Diseases, Department of Medicine, University of California, Irvine School of Medicine, Irvine, CA 92697, USA
    J Immunol 179:7916-23. 2007
    ..These results demonstrate the importance of FcgammaRs in AIDS pathogenesis and point toward a critical role for interactions between FcgammaRs and immune complexes in disease progression...
  63. pmc Recreational drug use and T lymphocyte subpopulations in HIV-uninfected and HIV-infected men
    Chun Chao
    Department of Epidemiology and Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA 90095 1772, USA
    Drug Alcohol Depend 94:165-71. 2008
    ..These results indicate that use of these substances does not adversely affect the numbers and percentages of circulating CD4 or CD8 T cells in either HIV-uninfected or -infected MSM...
  64. pmc Lack of evidence for changing virulence of HIV-1 in North America
    Joshua T Herbeck
    University of Washington School of Medicine, Seattle, Washington, USA
    PLoS ONE 3:e1525. 2008
    ....
  65. doi request reprint Host genetic influences on highly active antiretroviral therapy efficacy and AIDS-free survival
    Sher L Hendrickson
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702 1201, USA
    J Acquir Immune Defic Syndr 48:263-71. 2008
    ..27; P=0.01). ARG influence after HAART suggests residual HIV-1 replication, and spread continues even in patients successfully suppressing detectable viral RNA...
  66. pmc HIV-1 variation before seroconversion in men who have sex with men: analysis of acute/early HIV infection in the multicenter AIDS cohort study
    Geoffrey S Gottlieb
    Division of Allergy and Infectious Diseases, Department of Medicine, School of Medicine, University of Washington, Seattle 98195, USA
    J Infect Dis 197:1011-5. 2008
    ..Nearly all variants were predicted to be CCR5 tropic. We found no correlation between these viral characteristics and the HIV outcomes of time to clinical AIDS or death and/or a CD4 cell count <200 cells/microL...
  67. ncbi request reprint Lack of associations between HLA class II alleles and resistance to HIV-1 infection among white, non-Hispanic homosexual men
    Chenglong Liu
    School of Public Health, University of California, Los Angeles, CA 90095 1772, USA
    J Acquir Immune Defic Syndr 37:1313-7. 2004
    ..Other genetic factors in the HLA class II-TAP region of the major histocompatibility complex might be involved...
  68. ncbi request reprint Seroprevalence of human herpesvirus 8 infection in Northern Thailand
    Nora Chen
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Clin Infect Dis 39:1052-8. 2004
    ..2% of reported patients with AIDS in Thailand had KS), we determined the HHV-8 seroprevalence among populations who were HIV positive or at risk of HIV infection...

Research Grants2

  1. Center/Coordination, Analysis and Management/MACS-Part B
    Lisa Jacobson; Fiscal Year: 2007
    ..abstract_text> ..