Annette M Jackson
Affiliation: Johns Hopkins University
- The problem of transplanting the sensitized patient: whose problem is it?Annette M Jackson
Immunogenetics Laboratory, Johns Hopkins University School of Medicine, 2041 E Monument Street, Baltimore, MD 21205 2222, USA
Front Biosci 13:1396-412. 2008..Thus, sensitization to HLA antigens is a problem for the patient, the transplant physician, and the histocompatibility laboratory...
- Immunogenetics and immunology in transplantationAndrea A Zachary
Immunogenetics Laboratory, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Immunol Res 47:232-9. 2010..Ongoing studies are investigating the mechanisms underlying the down-regulation of donor HLA-specific antibodies...
- A GPS for finding the route to transplantation for the sensitized patientAnnette M Jackson
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Curr Opin Organ Transplant 17:433-9. 2012..Use of these protocols has revealed various factors that influence which route is the most likely to work for a given patient...
- Multiple hyperacute rejections in the absence of detectable complement activation in a patient with endothelial cell reactive antibodyA M Jackson
Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
Am J Transplant 12:1643-9. 2012..Cultured splenocytes produced antibodies that bound donor ECs but not lymphocytes. Bortezomib was initiated on POD5. Despite aggressive therapy, the allograft never regained function...
- Clinical relevance and IgG subclass determination of non-HLA antibodies identified using endothelial cell precursors isolated from donor bloodAnnette M Jackson
Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
Transplantation 92:54-60. 2011..We investigated the relationship between AECAs identified using donor-derived endothelial cell precursors (ECPs) and kidney allograft rejection and function...
- Using donor exchange paradigms with desensitization to enhance transplant rates among highly sensitized patientsRobert A Montgomery
Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Curr Opin Organ Transplant 16:439-43. 2011..The options for these patients include: remaining on the deceased-donor list, entering a kidney-paired donation scheme, or undergoing desensitization with high-dose IVIg or plasmapheresis and low-dose IVIg...
- Impact of pronase on flow cytometric crossmatch outcomeSarah J Hetrick
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Hum Immunol 72:330-6. 2011..Treatment with 1 mg/mL of pronase significantly increased reactivity in 20 of 23 tests of T cells (87%, p = 6.0 × 10(-5)). These data indicate that pronase treatment may result in erroneous FCXM results...
- A flow cytometric crossmatch test using endothelial precursor cells isolated from peripheral bloodAnnette M Jackson
Immunogenetics Laboratory, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Methods Mol Biol 1034:319-29. 2013..Isolation of endothelial precursor cells (EPCs) from peripheral blood now allows testing for antibodies reactive with non-HLA endothelial cell antigens...