D A Jabs

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Characteristics of patients with cytomegalovirus retinitis in the era of highly active antiretroviral therapy
    Douglas A Jabs
    Wilmer Eye Institute, 550 North Broadway, Suite 700, Baltimore, Maryland 21205, USA
    Am J Ophthalmol 133:48-61. 2002
  2. ncbi request reprint Mutations conferring ganciclovir resistance in a cohort of patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis
    D A Jabs
    Departments of Ophthalmology and Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Infect Dis 183:333-337. 2001
  3. ncbi request reprint The role of Fas-Fas ligand-mediated apoptosis in autoimmune lacrimal gland disease in MRL/MpJ mice
    D A Jabs
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Invest Ophthalmol Vis Sci 42:399-401. 2001
  4. ncbi request reprint Cytomegalovirus (CMV) blood DNA load, CMV retinitis progression, and occurrence of resistant CMV in patients with CMV retinitis
    Douglas A Jabs
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Infect Dis 192:640-9. 2005
  5. ncbi request reprint Cytokines in autoimmune lacrimal gland disease in MRL/MpJ mice
    D A Jabs
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Invest Ophthalmol Vis Sci 42:2567-71. 2001
  6. ncbi request reprint Longitudinal observations on mutations conferring ganciclovir resistance in patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis: The Cytomegalovirus and Viral Resistance Study Group Report Number 8
    D A Jabs
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Ophthalmol 132:700-10. 2001
  7. ncbi request reprint Ocular manifestations of vasculitis
    J E Thorne
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Rheum Dis Clin North Am 27:761-79, vi. 2001
  8. ncbi request reprint Risk factors for mortality in patients with AIDS in the era of highly active antiretroviral therapy
    Douglas A Jabs
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 112:771-9. 2005
  9. ncbi request reprint Immunosuppression for posterior uveitis
    Douglas A Jabs
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Retina 25:1-18. 2005
  10. ncbi request reprint Course of cytomegalovirus retinitis in the era of highly active antiretroviral therapy: 2. Second eye involvement and retinal detachment
    Douglas A Jabs
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 111:2232-9. 2004

Detail Information

Publications92

  1. ncbi request reprint Characteristics of patients with cytomegalovirus retinitis in the era of highly active antiretroviral therapy
    Douglas A Jabs
    Wilmer Eye Institute, 550 North Broadway, Suite 700, Baltimore, Maryland 21205, USA
    Am J Ophthalmol 133:48-61. 2002
    ..To describe the characteristics of patients with AIDS and cytomegalovirus retinitis in the era of highly active antiretroviral therapy (HAART)...
  2. ncbi request reprint Mutations conferring ganciclovir resistance in a cohort of patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis
    D A Jabs
    Departments of Ophthalmology and Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Infect Dis 183:333-337. 2001
    ..5% of cases. High-level ganciclovir resistance (IC(50), >30 microM) typically, but not invariably, was associated with a mutation in both the UL97 and UL54 genes...
  3. ncbi request reprint The role of Fas-Fas ligand-mediated apoptosis in autoimmune lacrimal gland disease in MRL/MpJ mice
    D A Jabs
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Invest Ophthalmol Vis Sci 42:399-401. 2001
    ..This mutation results in defective Fas protein, defective lymphocytic apoptosis, and accelerated autoimmune lacrimal gland disease in MRL/lpr mice. We evaluated apoptosis in the lacrimal glands of MRL/lpr and MRL/+ mice...
  4. ncbi request reprint Cytomegalovirus (CMV) blood DNA load, CMV retinitis progression, and occurrence of resistant CMV in patients with CMV retinitis
    Douglas A Jabs
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Infect Dis 192:640-9. 2005
    ..CMV load has limited clinical utility, because of its low positive predictive value. Its high negative predictive value for occurrence of resistant CMV suggests that it may have utility as a screening tool to exclude resistance...
  5. ncbi request reprint Cytokines in autoimmune lacrimal gland disease in MRL/MpJ mice
    D A Jabs
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Invest Ophthalmol Vis Sci 42:2567-71. 2001
    ....
  6. ncbi request reprint Longitudinal observations on mutations conferring ganciclovir resistance in patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis: The Cytomegalovirus and Viral Resistance Study Group Report Number 8
    D A Jabs
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Ophthalmol 132:700-10. 2001
    ..We evaluated longitudinal changes in the cytomegalovirus genotype in patients with cytomegalovirus retinitis who developed ganciclovir resistance that was demonstrated in either the blood or urine...
  7. ncbi request reprint Ocular manifestations of vasculitis
    J E Thorne
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Rheum Dis Clin North Am 27:761-79, vi. 2001
    ..This article reviews the major types of ocular inflammation and then addresses the ocular manifestations of specific systemic vasculitides...
  8. ncbi request reprint Risk factors for mortality in patients with AIDS in the era of highly active antiretroviral therapy
    Douglas A Jabs
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 112:771-9. 2005
    ..To evaluate risk factors for mortality among patients with AIDS in the era of highly active antiretroviral therapy (HAART), particularly the effect of cytomegalovirus (CMV)...
  9. ncbi request reprint Immunosuppression for posterior uveitis
    Douglas A Jabs
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Retina 25:1-18. 2005
  10. ncbi request reprint Course of cytomegalovirus retinitis in the era of highly active antiretroviral therapy: 2. Second eye involvement and retinal detachment
    Douglas A Jabs
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 111:2232-9. 2004
    ..To describe the course of cytomegalovirus (CMV) retinitis in patients with AIDS in the era of highly active antiretroviral therapy (HAART)...
  11. ncbi request reprint Inflammatory mediators in autoimmune lacrimal gland disease in MRL/Mpj mice
    Douglas A Jabs
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Invest Ophthalmol Vis Sci 45:2293-8. 2004
    ..The presence of the inducible form of nitric oxide synthase (iNOS), which catalyzes the production of NO, and the presence TNF-alpha in the lacrimal glands of MRL/MpJ mice were assessed...
  12. ncbi request reprint Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop
    Douglas A Jabs
    Wilmer Eye Institute, 5650 North Broadway, Suite 700, Baltimore, MD 21205, USA
    Am J Ophthalmol 140:509-16. 2005
    ..To begin a process of standardizing the methods for reporting clinical data in the field of uveitis...
  13. ncbi request reprint Guidelines for the use of immunosuppressive drugs in patients with ocular inflammatory disorders: recommendations of an expert panel
    D A Jabs
    Wilmer Eye Institute and the Departments of Ophthalmology and Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Ophthalmol 130:492-513. 2000
    ..To provide recommendations for the use of immunosuppressive drugs in the treatment of patients with ocular inflammatory disorders...
  14. ncbi request reprint Detection of ganciclovir resistance in patients with AIDS and cytomegalovirus retinitis: correlation of genotypic methods with viral phenotype and clinical outcome
    Douglas A Jabs
    Department of Ophthalmology, School of Medicine, The Johns Hopkins University, Baltimore, Maryland, USA
    J Infect Dis 193:1728-37. 2006
    ..The cytomegalovirus (CMV) UL97 gene can be sequenced either from blood specimens directly amplified by polymerase chain reaction (PCR) or from culture isolates, to detect resistance to ganciclovir...
  15. ncbi request reprint Cytomegalovirus resistance to ganciclovir and clinical outcomes of patients with cytomegalovirus retinitis
    Douglas A Jabs
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Ophthalmol 135:26-34. 2003
    ..To evaluate whether cytomegalovirus resistant to ganciclovir, detected in either the blood or urine, correlates with adverse ocular outcomes...
  16. ncbi request reprint Longitudinal study of the ocular complications of AIDS: 1. Ocular diagnoses at enrollment
    Douglas A Jabs
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 114:780-6. 2007
    ..To report the prevalence of ocular complications of AIDS in the era of highly active antiretroviral therapy (HAART)...
  17. ncbi request reprint Longitudinal study of the ocular complications of AIDS: 2. Ocular examination results at enrollment
    Douglas A Jabs
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 114:787-93. 2007
    ..To report the clinical features on eye examination of patients with AIDS in the era of highly active antiretroviral therapy (HAART)...
  18. ncbi request reprint Course of cytomegalovirus retinitis in the era of highly active antiretroviral therapy: 1. Retinitis progression
    Douglas A Jabs
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 111:2224-31. 2004
    ..To describe the course of cytomegalovirus (CMV) retinitis in patients with AIDS in the era of highly active antiretroviral therapy (HAART)...
  19. ncbi request reprint Cytomegalovirus retinitis and viral resistance: 3. Culture results. CMV Retinitis and Viral Resistance Study Group
    D A Jabs
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Ophthalmol 126:543-9. 1998
    ..To evaluate the relationship between blood and urine cultures for cytomegalovirus and clinical outcomes in patients with cytomegalovirus retinitis...
  20. ncbi request reprint Th1 versus Th2 immune responses in autoimmune lacrimal gland disease in MRL/Mp mice
    D A Jabs
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Invest Ophthalmol Vis Sci 41:826-31. 2000
    ..The lacrimal gland lesions in these mice were evaluated by immunohistochemistry for the relative contributions of T-helper (Th)1 versus Th2 immune responses...
  21. ncbi request reprint Cyclosporine therapy suppresses ocular and lacrimal gland disease in MRL/Mp-lpr/lpr mice
    D A Jabs
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Invest Ophthalmol Vis Sci 37:377-83. 1996
    ..Cyclosporine therapy was evaluated for its effect on the autoimmune disease, particularly in the eye and lacrimal gland...
  22. ncbi request reprint Retinal detachment risk in cytomegalovirus retinitis related to the acquired immunodeficiency syndrome
    J H Kempen
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Arch Ophthalmol 119:33-40. 2001
    ....
  23. ncbi request reprint Discontinuing anticytomegalovirus therapy in patients with immune reconstitution after combination antiretroviral therapy
    D A Jabs
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Ophthalmol 126:817-22. 1998
    ..To describe our experience with discontinuation of anticytomegalovirus maintenance therapy in patients who have had immune reconstitution after initiation of highly active antiretroviral therapy...
  24. ncbi request reprint Effects of early and late treatment with anti-CD4 monoclonal antibody on autoimmune disease in MRL/MP-lpr/lpr mice
    D A Jabs
    Wilmer Ophthalmological Institute, Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland
    Cell Immunol 154:66-76. 1994
    ....
  25. ncbi request reprint Cytomegalovirus retinitis and viral resistance: ganciclovir resistance. CMV Retinitis and Viral Resistance Study Group
    D A Jabs
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Infect Dis 177:770-3. 1998
    ..5% by 9 months. The development of ganciclovir resistance during follow-up correlated with the occurrence of CMV retinitis in the contralateral eye (odds ratio = 9.06, P = .003)...
  26. pmc Incidence of foscarnet resistance and cidofovir resistance in patients treated for cytomegalovirus retinitis. The Cytomegalovirus Retinitis and Viral Resistance Study Group
    D A Jabs
    Departments of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland
    Antimicrob Agents Chemother 42:2240-4. 1998
    ..87 [P = 0.19] and 2.28 [P = 0.15], respectively)...
  27. ncbi request reprint Multifocal choroiditis with panuveitis and punctate inner choroidopathy: comparison of clinical characteristics at presentation
    Sanjay R Kedhar
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Retina 27:1174-9. 2007
    ..To compare the clinical characteristics at presentation of multifocal choroiditis with panuveitis (MFCPU) and punctate inner choroidopathy (PIC)...
  28. ncbi request reprint Risk of immune recovery uveitis in patients with AIDS and cytomegalovirus retinitis
    John H Kempen
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 113:684-94. 2006
    ..To evaluate the prevalence of and risk factors for immune recovery uveitis (IRU) in eyes of patients with AIDS and cytomegalovirus (CMV) retinitis...
  29. ncbi request reprint Risk factors for advancement of cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome. Studies of Ocular Complications of AIDS Research Group
    J T Holbrook
    Center for Clinical Trials, Department of Epidemiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Arch Ophthalmol 118:1196-204. 2000
    ..To identify ocular and systemic factors that predict advancement of cytomegalovirus (CMV) retinitis during treatment...
  30. pmc Course of cytomegalovirus retinitis in the era of highly active antiretroviral therapy: five-year outcomes
    Douglas A Jabs
    Department of Ophthalmology, The Mount Sinai School of Medicine, New York, New York, USA
    Ophthalmology 117:2152-61.e1-2. 2010
    ..To describe the 5-year outcomes of patients with cytomegalovirus (CMV) retinitis and AIDS in the era of highly active antiretroviral therapy (HAART)...
  31. ncbi request reprint Photographic measures of cytomegalovirus retinitis as surrogates for visual outcomes in treated patients
    J T Holbrook
    Center for Clinical Trials, Johns Hopkins University, 615 N Wolfe St, Room 5010, Baltimore, MD 21205
    Arch Ophthalmol 119:554-63. 2001
    ..To evaluate photographic measures of cytomegalovirus (CMV) retinitis as surrogate outcomes for changes in vision in patients with CMV retinitis related to the acquired immunodeficiency syndrome...
  32. ncbi request reprint Change over time in incidence of ganciclovir resistance in patients with cytomegalovirus retinitis
    Barbara K Martin
    Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
    Clin Infect Dis 44:1001-8. 2007
    ..In the mid-1990s, the incidence of cytomegalovirus (CMV) resistance to ganciclovir was estimated to be approximately 25% by 1 year after diagnosis of retinitis in patients with acquired immunodeficiency syndrome...
  33. ncbi request reprint The effect of cytomegalovirus retinitis on the quality of life of patients with AIDS in the era of highly active antiretroviral therapy
    John H Kempen
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 110:987-95. 2003
    ..To evaluate the effect of cytomegalovirus (CMV) retinitis on quality of life (QOL) in patients with the acquired immune deficiency syndrome (AIDS)...
  34. ncbi request reprint Reliability, validity, and responsiveness of general and disease-specific quality of life measures in a clinical trial for cytomegalovirus retinitis
    B K Martin
    Department of Epidemiology, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA
    J Clin Epidemiol 54:376-86. 2001
    ..Over time, scale scores were associated with Karnofsky scores and clinical measures of CMV retinitis and vision. General and CMV retinitis-specific quality of life measures appear reliable, valid, and responsive...
  35. ncbi request reprint Cytomegalovirus retinitis in the era of highly active antiretroviral therapy
    Sanjay R Kedhar
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Herpes 14:66-71. 2007
    ..Still, immune recovery does not guarantee protection from recurrent disease. CMV retinitis and uveitis associated with immune recovery remain causes of vision loss in this population and demand vigilance on the part of physicians...
  36. ncbi request reprint Effect of cytomegalovirus retinitis on the risk of visual acuity loss among patients with AIDS
    Jennifer E Thorne
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 114:591-8. 2007
    ....
  37. ncbi request reprint Visual loss in patients with cytomegalovirus retinitis and acquired immunodeficiency syndrome before widespread availability of highly active antiretroviral therapy
    Janet T Holbrook
    Center for Clinical Trials, Johns Hopkins University, 615 N Wolfe St, Room W5010, Baltimore, MD 21205, USA
    Arch Ophthalmol 121:99-107. 2003
    ..To evaluate rates and causes of visual loss among patients with acquired immunodeficiency syndrome (AIDS) and cytomegalovirus (CMV) retinitis before widespread availability of highly active antiretroviral therapy (HAART)...
  38. ncbi request reprint Episcleritis and scleritis: clinical features and treatment results
    D A Jabs
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Ophthalmol 130:469-76. 2000
    ..To evaluate the clinical experience with episcleritis and scleritis at a tertiary care eye center...
  39. pmc Comparison of cytomegalovirus loads in plasma and leukocytes of patients with cytomegalovirus retinitis. The Cytomegalovirus Retinitis and Viral Resistance Study Group
    D A Jabs
    Departments of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Clin Microbiol 37:1431-5. 1999
    ..0078). Agreement with CMV blood cultures was slightly better for plasma (kappa = 0. 68) than for leukocytes (kappa = 0.53), due to a greater proportion of patients with detectable viral loads in leukocytes having negative blood cultures...
  40. ncbi request reprint Anti-CD4 monoclonal antibody therapy suppresses autoimmune disease in MRL/Mp-lpr/lpr mice
    D A Jabs
    Wilmer Ophthalmological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    Cell Immunol 141:496-507. 1992
    ..These data support the hypothesis that CD4+ T cells play a central role in the disease process in this autoimmune strain...
  41. pmc Risk factors for ocular complications and poor visual acuity at presentation among patients with uveitis associated with juvenile idiopathic arthritis
    Fasika Woreta
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Ophthalmol 143:647-55. 2007
    ..To describe the frequencies of and risk factors for ocular complications and poor visual acuity at presentation in a cohort of patients with juvenile idiopathic arthritis (JIA)-associated uveitis...
  42. ncbi request reprint Complications of ganciclovir implant surgery in patients with cytomegalovirus retinitis: the Ganciclovir Cidofovir Cytomegalovirus Retinitis Trial
    James P Dunn
    Department of Ophthalmology, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, 550 North Broadway, Baltimore, MD 21205, USA
    Retina 24:41-50. 2004
    ..To describe the complications of ganciclovir implant surgery in patients with cytomegalovirus retinitis...
  43. ncbi request reprint Mucous membrane pemphigoid and pseudopemphigoid
    Jennifer E Thorne
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Ophthalmology 111:45-52. 2004
    ..To describe the clinical characteristics of patients with mucous membrane pemphigoid (MMP) and pseudopemphigoid...
  44. ncbi request reprint Incidence and management of cataract after retinal detachment repair with silicone oil in immune compromised patients with cytomegalovirus retinitis
    Angelo P Tanna
    Department of Ophthalmology, Northwestern University Medical School, Chicago, Illinois, USA
    Am J Ophthalmol 136:1009-15. 2003
    ..To determine the incidence of and risk factors for cataract and to describe the visual outcomes of cataract surgery in eyes with cytomegalovirus-related retinal detachments repaired with silicone oil...
  45. pmc Methotrexate for ocular inflammatory diseases
    Sapna Gangaputra
    Department of Ophthalmology, The Fundus Photograph Reading Center, University of Wisconsin, Madison, Wisconsin, USA
    Ophthalmology 116:2188-98.e1. 2009
    ..To evaluate the outcome of treatment with methotrexate for noninfectious ocular inflammation...
  46. ncbi request reprint Influence of filgrastim (granulocyte colony-stimulating factor) on human immunodeficiency virus type 1 RNA in patients with cytomegalovirus retinitis
    Michael Davidson
    Center for Clinical Trials, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    J Infect Dis 186:1013-8. 2002
    ..87 (P=.12) and respective log mean rates of change per month of -0.08 versus -0.21 (P=.08). This latter difference has borderline statistical significance, which suggests that filgrastim may reduce the decline of HIV-1 RNA loads...
  47. pmc The multicenter uveitis steroid treatment trial: rationale, design, and baseline characteristics
    John H Kempen
    Center for Preventive Ophthalmology and Biostatistics, Department of Ophthalmology, University of Pennsylvania, 3535 Market Street, Suite 700, Philadelphia, PA 19104, USA
    Am J Ophthalmol 149:550-561.e10. 2010
    ..To describe the design and methods of the Multicenter Uveitis Steroid Treatment (MUST) trial and the baseline characteristics of enrolled patients...
  48. ncbi request reprint Factors affecting attrition in a longitudinal study of patients with AIDS
    D M Brown
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    AIDS Care 18:821-9. 2006
    ..29; 95%CI: 1.07, 1.53; P < 0.001 for HIV viral load >400 copies/mL). These data suggest that patients with compromised immunologic status are at an increased risk for being lost to follow-up...
  49. ncbi request reprint Incremental cost effectiveness of prophylaxis for cytomegalovirus disease in patients with AIDS
    J H Kempen
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Pharmacoeconomics 19:1199-208. 2001
    ....
  50. ncbi request reprint Pars planitis: clinical features and class II HLA associations
    S C Raja
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 106:594-9. 1999
    ....
  51. ncbi request reprint Multifocal choroiditis with panuveitis incidence of ocular complications and of loss of visual acuity
    Jennifer E Thorne
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Ophthalmology 113:2310-6. 2006
    ..To estimate the incidences of ocular complications and vision loss in patients with multifocal choroiditis with panuveitis (MFCPU) and to describe the association between therapy and the incidences thereof...
  52. pmc Risk of cataract development among children with juvenile idiopathic arthritis-related uveitis treated with topical corticosteroids
    Jennifer E Thorne
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 117:1436-41. 2010
    ..We sought to investigate the risk of cataract development among patients with juvenile idiopathic arthritis (JIA)-associated uveitis treated with topical corticosteroids...
  53. ncbi request reprint Juvenile idiopathic arthritis-associated uveitis: incidence of ocular complications and visual acuity loss
    Jennifer E Thorne
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Am J Ophthalmol 143:840-846. 2007
    ....
  54. pmc Optic neuropathy complicating multifocal choroiditis and panuveitis
    Jennifer E Thorne
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Ophthalmol 143:721-3. 2007
    ..To describe the clinical characteristics of patients with optic neuropathy complicating multifocal choroiditis and panuveitis (MFCPU)...
  55. pmc Cyclosporine for ocular inflammatory diseases
    R Oktay Kaçmaz
    Department of Ophthalmology, The Mount Sinai School of Medicine, New York, New York, USA
    Ophthalmology 117:576-84. 2010
    ..To evaluate the clinical outcomes of cyclosporine treatment for noninfectious ocular inflammation...
  56. pmc Hypopyon in patients with uveitis
    Ali A Zaidi
    Department of Ophthalmology, The University of Pennsylvania, The Ocular Inflammation Service and Center for Preventive Ophthalmology and Biostatistics, Philadelphia, Pennsylvania, USA
    Ophthalmology 117:366-72. 2010
    ..To evaluate the risk of and risk factors for hypopyon among patients with uveitis and to evaluate the risk of visual changes and complications after hypopyon...
  57. pmc Azathioprine for ocular inflammatory diseases
    Sirichai Pasadhika
    Department of Ophthalmology, Oregon Health and Science University, Portland, Oregon, USA
    Am J Ophthalmol 148:500-509.e2. 2009
    ..To evaluate treatment outcomes of azathioprine for noninfectious ocular inflammatory diseases...
  58. doi request reprint Treatment of ocular mucous membrane pemphigoid with immunosuppressive drug therapy
    Jennifer E Thorne
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 115:2146-2152.e1. 2008
    ..To evaluate the effectiveness of immunosuppressive drug therapy in the treatment of ocular mucous membrane pemphigoid (MMP)...
  59. ncbi request reprint Comparison of antimetabolite drugs as corticosteroid-sparing therapy for noninfectious ocular inflammation
    Anat Galor
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 115:1826-32. 2008
    ..To compare the relative effectiveness and side effect profiles of antimetabolite drugs in the treatment of noninfectious ocular inflammation...
  60. pmc Autoimmune Th2-mediated dacryoadenitis in MRL/MpJ mice becomes Th1-mediated in IL-4 deficient MRL/MpJ mice
    Douglas A Jabs
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Invest Ophthalmol Vis Sci 48:5624-9. 2007
    ..The dacryoadenitis in both substrains appears to be Th2 in nature, with little IFN-gamma and substantial IL-4 at the site of lacrimal gland inflammation...
  61. pmc Smoking as a risk factor for cystoid macular edema complicating intermediate uveitis
    Jennifer E Thorne
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Am J Ophthalmol 145:841-6. 2008
    ..To describe risk factors for the presence of cystoid macular edema (CME) among patients presenting with intermediate uveitis...
  62. ncbi request reprint Loss of visual field among patients with birdshot chorioretinopathy
    Jennifer E Thorne
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Ophthalmol 145:23-28. 2008
    ..To describe the prevalence and incidence of loss of visual field among patients with birdshot chorioretinopathy (BSCR) and to describe the effect of therapy on such field loss in these patients...
  63. ncbi request reprint Recurrent nodular scleritis preceding an adult TINU syndrome
    Ebenezer Daniel
    Division of Ocular Immunology, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Ocul Immunol Inflamm 14:239-40. 2006
    ..To describe the occurrence of nodular scleritis in a patient developing tubulointerstitial nephritis and uveitis (TINU) syndrome...
  64. ncbi request reprint Role of electron microscopy in the diagnosis of ocular mucous membrane pemphigoid
    Jennifer E Thorne
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Ophthalmology 113:1651-6. 2006
    ..To evaluate the role of electron microscopy (EM) for the diagnosis of ocular mucous membrane pemphigoid (MMP) among patients with cicatrizing conjunctivitis...
  65. ncbi request reprint Causes of visual acuity loss among patients with AIDS and cytomegalovirus retinitis in the era of highly active antiretroviral therapy
    Jennifer E Thorne
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 113:1441-5. 2006
    ..To quantitate the frequencies of the common causes of visual acuity loss for patients with AIDS and cytomegalovirus (CMV) retinitis in the era of highly active antiretroviral therapy (HAART)...
  66. ncbi request reprint HIV and cytomegalovirus viral load and clinical outcomes in AIDS and cytomegalovirus retinitis patients: Monoclonal Antibody Cytomegalovirus Retinitis Trial
    Douglas A Jabs
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    AIDS 16:877-87. 2002
    ..To determine the association of cytomegalovirus (CMV) viremia with mortality and CMV retinitis progression in newly diagnosed and relapsed CMV retinitis...
  67. ncbi request reprint Comparison of cytomegalovirus (CMV) UL97 gene sequences in the blood and vitreous of patients with acquired immunodeficiency syndrome and CMV retinitis
    Huiling Hu
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Infect Dis 185:861-7. 2002
    ..Although the number of mutations limits definitive interpretation, these data suggest that blood specimens may reflect the events occurring in the eyes of patients with CMV retinitis...
  68. ncbi request reprint Clinical characteristics and outcomes of cytomegalovirus retinitis in persons without human immunodeficiency virus infection
    Irene C Kuo
    Department of Ophthalmology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
    Am J Ophthalmol 138:338-46. 2004
    ..To describe the characteristics and outcomes of patients with cytomegalovirus (CMV) retinitis in the absence of human immunodeficiency virus (HIV) infection...
  69. ncbi request reprint Successful treatment of serpiginous choroiditis with alkylating agents
    Esen Karamursel Akpek
    The Wilmer Eye Institute, Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Ophthalmology 109:1506-13. 2002
    ..To describe the management and long-term outcomes of patients with serpiginous choroiditis treated with alkylating agents...
  70. ncbi request reprint Evaluation of patients with scleritis for systemic disease
    Esen Karamursel Akpek
    The Wilmer Eye Institute, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Maumenee Building 321, Baltimore, MD 21287 9238, USA
    Ophthalmology 111:501-6. 2004
    ..To evaluate the relationship between associated medical conditions and scleritis-particularly, the timing of the diagnosis of these diseases...
  71. ncbi request reprint Chemokines in autoimmune lacrimal gland disease in MRL/MpJ mice
    Esen Karamursel Akpek
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore Maryland, USA
    Invest Ophthalmol Vis Sci 45:185-90. 2004
    ..The relative contributions of selected chemokines associated with Th1 and Th2 immune responses were assessed...
  72. ncbi request reprint Mortality risk for patients with cytomegalovirus retinitis and acquired immune deficiency syndrome
    John H Kempen
    Department of Ophthalmology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Clin Infect Dis 37:1365-73. 2003
    ....
  73. ncbi request reprint Risk of vision loss in patients with cytomegalovirus retinitis and the acquired immunodeficiency syndrome
    John H Kempen
    Department of Ophthalmology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Arch Ophthalmol 121:466-76. 2003
    ..To characterize the effect of cytomegalovirus (CMV) retinitis and its treatment on visual acuity in patients with the acquired immunodeficiency syndrome...
  74. ncbi request reprint Multifocal choroiditis in patients with familial juvenile systemic granulomatosis
    Paul A Latkany
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Ophthalmol 134:897-904. 2002
    ..To document clinical features of uveitis in patients with familial juvenile systemic granulomatosis...
  75. ncbi request reprint Posterior intracorneal opacities in patients with HIV infection
    Jennifer E Thorne
    Department of Ophthalmology, The Wilmer Eye Institute, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Ocul Immunol Inflamm 13:25-31. 2005
    ..To describe a keratopathy in patients with the human immunodeficiency virus (HIV) infection...
  76. ncbi request reprint Discoid lupus erythematosus and cicatrizing conjunctivitis: clinicopathologic study of two cases
    Jennifer E Thorne
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Ocul Immunol Inflamm 10:287-92. 2002
    ..Mucosal involvement is typically limited to the oral and anogenital mucosa. Conjunctival involvement in DLE is rare, especially in the absence of accompanying cutaneous disease...
  77. ncbi request reprint Vogt-Koyanagi-Harada disease: clinical outcomes
    Irina Bykhovskaya
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Ophthalmol 140:674-8. 2005
    ..To evaluate the effect of treatment on the incidence of vision impairment and structural ocular complications among patients with Vogt-Koyanagi-Harada (VKH) disease...
  78. ncbi request reprint Retinal vascular occlusion in patients infected with human immunodeficiency virus
    James P Dunn
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Retina 25:759-66. 2005
    ..To describe the clinical features of retinal vascular occlusions (macrovasculopathy) and the proportion of affected patients with human immunodeficiency virus (HIV) infection...
  79. ncbi request reprint Lichen planus and cicatrizing conjunctivitis: characterization of five cases
    Jennifer E Thorne
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Am J Ophthalmol 136:239-43. 2003
    ..To report the clinical and immunopathologic features and the response to therapy in a series of six patients with cicatrizing conjunctivitis due to lichen planus...
  80. ncbi request reprint Mycophenolate mofetil therapy for inflammatory eye disease
    Jennifer E Thorne
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 112:1472-7. 2005
    ..To evaluate treatment outcomes with mycophenolate mofetil in patients with inflammatory eye disease...
  81. ncbi request reprint Incidence of and risk factors for visual acuity loss among patients with AIDS and cytomegalovirus retinitis in the era of highly active antiretroviral therapy
    Jennifer E Thorne
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 113:1432-40. 2006
    ..To describe the incidence of and risk factors for visual acuity loss among patients with AIDS and cytomegalovirus (CMV) retinitis in the era of highly active antiretroviral therapy (HAART)...
  82. ncbi request reprint Birdshot retinochoroidopathy: ocular complications and visual impairment
    Jennifer E Thorne
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD 21250, USA
    Am J Ophthalmol 140:45-51. 2005
    ..To describe the incidence of vision loss and of ocular complications attributable to birdshot retinochoroidopathy and to describe the association between therapy and the incidence thereof...
  83. ncbi request reprint Incidence of cytomegalovirus (CMV) retinitis in second eyes of patients with the acquired immune deficiency syndrome and unilateral CMV retinitis
    John H Kempen
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, 550 North Broadway, Suite 700, Baltimore, MD 21205, USA
    Am J Ophthalmol 139:1028-34. 2005
    ..To evaluate the risk and risk factors for developing cytomegalovirus (CMV) retinitis in previously uninvolved second eyes among patients with unilateral CMV retinitis...
  84. ncbi request reprint Clinician versus reading center assessment of cytomegalovirus retinitis lesion size
    David V Weinberg
    Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Ophthalmology 112:559-66. 2005
    ....
  85. ncbi request reprint Punctate inner choroidopathy: a survey analysis of 77 persons
    Adam T Gerstenblith
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 114:1201-4. 2007
    ..To evaluate the demographic and clinical features of punctate inner choroidopathy (PIC)...
  86. ncbi request reprint Paraneoplastic pemphigus. An autoimmune mucocutaneous disease associated with neoplasia
    G J Anhalt
    Department of Dermatology, Johns Hopkins University, School of Medicine, Baltimore, MD 21205
    N Engl J Med 323:1729-35. 1990
    ..IgG purified from the serum of one patient was passively transferred to four neonatal mice to test for pathogenicity...
  87. ncbi request reprint Protective immunity to cytomegalovirus (CMV) retinitis in AIDS is associated with CMV-specific T cells that express interferon- gamma and interleukin-2 and have a CD8+ cell early maturational phenotype
    Elizabeth Sinclair
    Division of Experimental Medicine, University of California, San Francisco, CA, USA
    J Infect Dis 194:1537-46. 2006
    ..Recovery from AIDS-related CMVR after the initiation of antiretroviral therapy may be mediated by CMV-specific CD4(+) and CD8(+) T cells capable of promoting antigen-specific CD8(+) T cell proliferation...
  88. ncbi request reprint AIDS and ophthalmology in 2004
    Douglas A Jabs
    Arch Ophthalmol 122:1040-2. 2004
  89. ncbi request reprint Pathogenesis of autoimmune lacrimal gland disease in MRL/MPJ mice
    Douglas A Jabs
    Department of Ophthalmology, The Johns Hopkins University School of Medicine Baltimore, Maryland, USA
    Adv Exp Med Biol 506:771-6. 2002
  90. ncbi request reprint Mutations conferring foscarnet resistance in a cohort of patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis
    Adriana Weinberg
    University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Infect Dis 187:777-84. 2003
    ..016). The incidence of foscarnet resistance after 6, 9, and 12 months of therapy was 13%, 24%, and 37%, respectively...
  91. pmc Poor predictive value of cytomegalovirus (CMV)-specific T cell assays for the development of CMV retinitis in patients with AIDS
    Mark A Jacobson
    Positive Health Program, Department of Medicine, University of California San Francisco, CA, USA
    Clin Infect Dis 46:458-66. 2008
    ..We examined the potential clinical utility of using a cytomegalovirus (CMV)-specific T cell immunoassay to determine the risk of developing new-onset CMV retinitis (CMVR) in patients with acquired immunodeficiency syndrome (AIDS)...
  92. doi request reprint AIDS and ophthalmology, 2008
    Douglas A Jabs
    Arch Ophthalmol 126:1143-6. 2008