Hanna Jaaro-Peled

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi request reprint Gene models of schizophrenia: DISC1 mouse models
    Hanna Jaaro-Peled
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Prog Brain Res 179:75-86. 2009
  2. pmc Subcortical dopaminergic deficits in a DISC1 mutant model: a study in direct reference to human molecular brain imaging
    Hanna Jaaro-Peled
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Hum Mol Genet 22:1574-80. 2013
  3. pmc Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans
    Takatoshi Hikida
    Department of Psychiatry and Behavioral Sciences, Graduate Program in Cellular and Molecular Medicine, and Division of Neurobiology, The Johns Hopkins University, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 104:14501-6. 2007
  4. pmc Review of pathological hallmarks of schizophrenia: comparison of genetic models with patients and nongenetic models
    Hanna Jaaro-Peled
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Schizophr Bull 36:301-13. 2010
  5. pmc Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1-ErbB4 and DISC1
    Hanna Jaaro-Peled
    Department of Psychiatry and Behavioral Neurosciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Trends Neurosci 32:485-95. 2009
  6. pmc Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits
    Minae Niwa
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Neuron 65:480-9. 2010
  7. pmc Pharmacokinetics of oral D-serine in D-amino acid oxidase knockout mice
    Rana Rais
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Drug Metab Dispos 40:2067-73. 2012
  8. pmc Better understanding of mechanisms of schizophrenia and bipolar disorder: from human gene expression profiles to mouse models
    Chi Ying Lin
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Neurobiol Dis 45:48-56. 2012

Collaborators

Detail Information

Publications9

  1. doi request reprint Gene models of schizophrenia: DISC1 mouse models
    Hanna Jaaro-Peled
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Prog Brain Res 179:75-86. 2009
    ..Third, generation of a DISC1 KO. Fourth, combination of the DISC1 mouse models with other risk factors: crossing with other genetic models such as NRG1/ErbB4 mutants and exposure to environmental risk factors...
  2. pmc Subcortical dopaminergic deficits in a DISC1 mutant model: a study in direct reference to human molecular brain imaging
    Hanna Jaaro-Peled
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Hum Mol Genet 22:1574-80. 2013
    ..We hope that this study will also help bridge a major gap in translational psychiatry between basic characterization of animal models and clinico-pharmacological assessment of patients mainly through PET imaging...
  3. pmc Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans
    Takatoshi Hikida
    Department of Psychiatry and Behavioral Sciences, Graduate Program in Cellular and Molecular Medicine, and Division of Neurobiology, The Johns Hopkins University, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 104:14501-6. 2007
    ..DN-DISC1 mice also display several behavioral abnormalities, including hyperactivity, disturbance in sensorimotor gating and olfactory-associated behavior, and an anhedonia/depression-like deficit...
  4. pmc Review of pathological hallmarks of schizophrenia: comparison of genetic models with patients and nongenetic models
    Hanna Jaaro-Peled
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Schizophr Bull 36:301-13. 2010
    ..Finally, in comparison with the changes in patients and nongenetic models, we will discuss the anatomical and neuropathological manifestation in genetic models for schizophrenia...
  5. pmc Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1-ErbB4 and DISC1
    Hanna Jaaro-Peled
    Department of Psychiatry and Behavioral Neurosciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Trends Neurosci 32:485-95. 2009
    ..We provide an update on the role of these emerging concepts in understanding the complex time course of SZ from early neurodevelopmental disturbances to later onset and suggest ways of testing these in the future...
  6. pmc Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits
    Minae Niwa
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Neuron 65:480-9. 2010
    ....
  7. pmc Pharmacokinetics of oral D-serine in D-amino acid oxidase knockout mice
    Rana Rais
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Drug Metab Dispos 40:2067-73. 2012
    ..Thus, a potent DAAO inhibitor with a longer half-life should be capable of maintaining high plasma D-serine levels over a sustained period of time and might have therapeutic implications for the treatment of schizophrenia...
  8. pmc Better understanding of mechanisms of schizophrenia and bipolar disorder: from human gene expression profiles to mouse models
    Chi Ying Lin
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Neurobiol Dis 45:48-56. 2012
    ..We also point out that models in which the metabolic genes are modified are obviously untested from mental illness viewpoints, suggesting the potential to re-address these models with behavioral assays and neurochemical assessments...