Christine A Iacobuzio-Donahue

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Genetic evolution of pancreatic cancer: lessons learnt from the pancreatic cancer genome sequencing project
    Christine A Iacobuzio-Donahue
    Johns Hopkins Medical Institutions, Department of Pathology, GI Liver Division, Baltimore, MD 21232, USA
    Gut 61:1085-94. 2012
  2. pmc Small cell and large cell neuroendocrine carcinomas of the pancreas are genetically similar and distinct from well-differentiated pancreatic neuroendocrine tumors
    Shinichi Yachida
    Departments of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Am J Surg Pathol 36:173-84. 2012
  3. pmc Serial analysis of gene expression of lobular carcinoma in situ identifies down regulation of claudin 4 and overexpression of matrix metalloproteinase 9
    Dengfeng Cao
    Departments of Pathology and Immunology, Washington University, St Louis, MO, USA
    Breast Cancer Res 10:R91. 2008
  4. pmc DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer
    Christine A Iacobuzio-Donahue
    Department of Pathology, Surgery, and Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    J Clin Oncol 27:1806-13. 2009
  5. doi Epigenetic changes in cancer
    Christine A Iacobuzio-Donahue
    Departments of Pathology and Oncology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Annu Rev Pathol 4:229-49. 2009
  6. ncbi Highly expressed genes in pancreatic ductal adenocarcinomas: a comprehensive characterization and comparison of the transcription profiles obtained from three major technologies
    Christine A Iacobuzio-Donahue
    Departments of Pathology, Surgery, Oncology, and Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Cancer Res 63:8614-22. 2003
  7. ncbi Gene expression in neoplasms of the pancreas: applications to diagnostic pathology
    Christine A Iacobuzio-Donahue
    Division of Gastrointestinal Liver Pathology, Department of Pathology, Ross Building, Room 632, The Johns Hopkins Hospital, 720 Rutland Avenue, Baltimore, MD 21205 2196, USA
    Adv Anat Pathol 10:125-34. 2003
  8. pmc Gene expression profiling identifies genes associated with invasive intraductal papillary mucinous neoplasms of the pancreas
    Norihiro Sato
    Departments of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 2196, USA
    Am J Pathol 164:903-14. 2004
  9. pmc Immortalizing the complexity of cancer metastasis: genetic features of lethal metastatic pancreatic cancer obtained from rapid autopsy
    Erlinda E Embuscado
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA
    Cancer Biol Ther 4:548-54. 2005
  10. ncbi Missense mutations of MADH4: characterization of the mutational hot spot and functional consequences in human tumors
    Christine A Iacobuzio-Donahue
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Clin Cancer Res 10:1597-604. 2004

Research Grants

  1. TARGETS OF METASTATIC PANCREATIC CANCER
    Christine Iacobuzio Donahue; Fiscal Year: 2007
  2. TGF-beta Signaling in Pancreatic Cancer Progression
    Christine A Iacobuzio Donahue; Fiscal Year: 2010

Detail Information

Publications94

  1. pmc Genetic evolution of pancreatic cancer: lessons learnt from the pancreatic cancer genome sequencing project
    Christine A Iacobuzio-Donahue
    Johns Hopkins Medical Institutions, Department of Pathology, GI Liver Division, Baltimore, MD 21232, USA
    Gut 61:1085-94. 2012
    ....
  2. pmc Small cell and large cell neuroendocrine carcinomas of the pancreas are genetically similar and distinct from well-differentiated pancreatic neuroendocrine tumors
    Shinichi Yachida
    Departments of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Am J Surg Pathol 36:173-84. 2012
    ..The finding of Bcl-2 overexpression in poorly differentiated NECs, particularly small cell NEC, suggests that Bcl-2 antagonists/inhibitors may be a viable treatment option for these patients...
  3. pmc Serial analysis of gene expression of lobular carcinoma in situ identifies down regulation of claudin 4 and overexpression of matrix metalloproteinase 9
    Dengfeng Cao
    Departments of Pathology and Immunology, Washington University, St Louis, MO, USA
    Breast Cancer Res 10:R91. 2008
    ..Global gene expression profiling of LCIS has not been performed...
  4. pmc DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer
    Christine A Iacobuzio-Donahue
    Department of Pathology, Surgery, and Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    J Clin Oncol 27:1806-13. 2009
    ..A comprehensive study of pancreatic cancers from patients who have succumbed to their disease has the potential to greatly expand our understanding of the most lethal stage of this disease and identify novel areas for intervention...
  5. doi Epigenetic changes in cancer
    Christine A Iacobuzio-Donahue
    Departments of Pathology and Oncology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Annu Rev Pathol 4:229-49. 2009
    ....
  6. ncbi Highly expressed genes in pancreatic ductal adenocarcinomas: a comprehensive characterization and comparison of the transcription profiles obtained from three major technologies
    Christine A Iacobuzio-Donahue
    Departments of Pathology, Surgery, Oncology, and Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Cancer Res 63:8614-22. 2003
    ....
  7. ncbi Gene expression in neoplasms of the pancreas: applications to diagnostic pathology
    Christine A Iacobuzio-Donahue
    Division of Gastrointestinal Liver Pathology, Department of Pathology, Ross Building, Room 632, The Johns Hopkins Hospital, 720 Rutland Avenue, Baltimore, MD 21205 2196, USA
    Adv Anat Pathol 10:125-34. 2003
    ..Emphasis will be placed on applications that are practical and useful to the daily practice of pathology...
  8. pmc Gene expression profiling identifies genes associated with invasive intraductal papillary mucinous neoplasms of the pancreas
    Norihiro Sato
    Departments of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 2196, USA
    Am J Pathol 164:903-14. 2004
    ..0001). Our findings suggest that preoperative assessment of gene expression profiles may be able to differentiate invasive from noninvasive IPMNs...
  9. pmc Immortalizing the complexity of cancer metastasis: genetic features of lethal metastatic pancreatic cancer obtained from rapid autopsy
    Erlinda E Embuscado
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA
    Cancer Biol Ther 4:548-54. 2005
    ..The invaluable tissue resources generated by the success of the GICRMDP will provide an unparalleled resource for study of metastatic pancreatic cancer and of the metastatic process in general...
  10. ncbi Missense mutations of MADH4: characterization of the mutational hot spot and functional consequences in human tumors
    Christine A Iacobuzio-Donahue
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Clin Cancer Res 10:1597-604. 2004
    ..We present the MADH4 genetic status determined on a new set of pancreatic, biliary, and duodenal cancers with comparison to the mutational data reported for various tumor types...
  11. ncbi Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice
    Takashi Sakatani
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 307:1976-8. 2005
    ..A similar shift in differentiation was seen in the normal colonic mucosa of humans with LOI. Thus, altered maturation of nonneoplastic tissue may be one mechanism by which epigenetic changes affect cancer risk...
  12. ncbi Gene expression profiling identifies markers of ampullary adenocarcinoma
    N Tjarda Van Heek
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 2196, USA
    Cancer Biol Ther 3:651-6. 2004
    ..001). Measurement of markers of ampullary cancer such as osteopontin may aid in the early detection and differential diagnosis of patients with periampullary lesions...
  13. ncbi Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma
    Norihiro Sato
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Cancer Res 63:4158-66. 2003
    ..These results indicate that gene hypomethylation is a frequent epigenetic event in pancreatic cancer and is commonly associated with the overexpression of affected genes...
  14. ncbi Epigenetic inactivation of TFPI-2 as a common mechanism associated with growth and invasion of pancreatic ductal adenocarcinoma
    Norihiro Sato
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Oncogene 24:850-8. 2005
    ..We thus conclude that epigenetic inactivation of TFPI-2 is a common mechanism that contributes to the aggressive phenotype of pancreatic ductal adenocarcinoma...
  15. pmc Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays
    Christine A Iacobuzio-Donahue
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Am J Pathol 162:1151-62. 2003
    ..The genes and expressed sequence tags presented in this study provide clues to the pathobiology of pancreatic cancer and implicate a large number of potentially new molecular markers for the detection and treatment of pancreatic cancer...
  16. pmc Distant metastasis occurs late during the genetic evolution of pancreatic cancer
    Shinichi Yachida
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Nature 467:1114-7. 2010
    ..These data provide novel insights into the genetic features underlying pancreatic cancer progression and define a broad time window of opportunity for early detection to prevent deaths from metastatic disease...
  17. ncbi Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis
    Yoshiharu Miyamoto
    Departments of Surgery, Oncology, and Pathology, The Sidney Kimmel Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Cancer Cell 3:565-76. 2003
    ..These findings suggest that Notch mediates the tumor-initiating effects of TG alpha by expanding a population of undifferentiated precursor cells...
  18. pmc Discovery of novel tumor markers of pancreatic cancer using global gene expression technology
    Christine A Iacobuzio-Donahue
    Department of Pathology, The Johns Hopkins MedicalInstitutions, Baltimore, Maryland 21231 2410, USA
    Am J Pathol 160:1239-49. 2002
    ..The remaining 69 genes have not been implicated in pancreatic cancer before, and have immediate potential as novel therapeutic targets and tumor markers of pancreatic cancer...
  19. ncbi Identifying allelic loss and homozygous deletions in pancreatic cancer without matched normals using high-density single-nucleotide polymorphism arrays
    Eric S Calhoun
    Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center at the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutes, Baltimore, MD 21231, USA
    Cancer Res 66:7920-8. 2006
    ..This study provides previously unavailable high-resolution allelotype and deletion breakpoint maps in widely shared pancreatic cancer cell lines and effectively eliminates the need for matched normal tissue to define informative loci...
  20. pmc Beta-catenin nuclear labeling is a common feature of sessile serrated adenomas and correlates with early neoplastic progression after BRAF activation
    Shinichi Yachida
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Am J Surg Pathol 33:1823-32. 2009
    ....
  21. ncbi MAP2K4/MKK4 expression in pancreatic cancer: genetic validation of immunohistochemistry and relationship to disease course
    Wei Xin
    Department of Pathology, The University of Michigan Medical Center, Ann Arbor, Michigan, USA
    Clin Cancer Res 10:8516-20. 2004
    ..The correlation of MKK4 genetic status with immunolabeling patterns validate this approach for the evaluation of MKK4 status in routine histologic sections and may provide useful information regarding patient prognosis...
  22. ncbi Analysis of novel tumor markers in pancreatic and biliary carcinomas using tissue microarrays
    Sharon L Swierczynski
    Department of Pathology, The Johns Hopkinds University School of Medicine, Baltimore, MD 21231, USA
    Hum Pathol 35:357-66. 2004
    ..Therefore, these markers are potentially useful in developing diagnostic tests and treatment paradigms for tumors involving the biliary system...
  23. pmc CpG island methylator phenotype-positive tumors in the absence of MLH1 methylation constitute a distinct subset of duodenal adenocarcinomas and are associated with poor prognosis
    Tao Fu
    Department of Surgery, Johns Hopkins University, Baltimore, MD 21287, USA
    Clin Cancer Res 18:4743-52. 2012
    ..The purpose was to identify possible subsets of duodenal adenocarcinomas based on microsatellite instability (MSI), DNA methylation, mutations in the KRAS and BRAF genes, clinicopathologic features, and prognosis...
  24. pmc Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types
    Sian Jones
    Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, USA
    Hum Mutat 33:100-3. 2012
    ..These findings suggest that the aberrant chromatin remodeling consequent to ARID1A inactivation contributes to a variety of different types of neoplasms...
  25. ncbi High cancer-specific expression of mesothelin (MSLN) is attributable to an upstream enhancer containing a transcription enhancer factor dependent MCAT motif
    Tomas Hucl
    Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD 21231, USA
    Cancer Res 67:9055-65. 2007
    ..The CanScript sequence represents a modular element for cancer-specific targeting, potentially suitable for nearly a third of human malignancies...
  26. pmc Clinical significance of the genetic landscape of pancreatic cancer and implications for identification of potential long-term survivors
    Shinichi Yachida
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Clin Cancer Res 18:6339-47. 2012
    ..Genetic alterations of KRAS, CDKN2A, TP53, and SMAD4 are the most frequent events in pancreatic cancer. We determined the extent to which these 4 alterations are coexistent in the same carcinoma, and their impact on patient outcome...
  27. pmc Clinicopathologic and genetic characterization of traditional serrated adenomas of the colon
    Baojin Fu
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Am J Clin Pathol 138:356-66. 2012
    ..However, conventional epithelial dysplasia and abnormal p53 labeling in a TSA are seen more often in the setting of BRAF mutation...
  28. pmc Establishment and characterization of a new cell line, A99, from a primary small cell carcinoma of the pancreas
    Shinichi Yachida
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Pancreas 40:905-10. 2011
    ..Small cell carcinoma (SCC) of the pancreas is a rare malignancy with a poor prognosis. We established and characterized a primary human pancreatic SCC cell line, designated A99...
  29. pmc The developmental transcription factor Gata4 is overexpressed in pancreatic ductal adenocarcinoma
    Matthew S Karafin
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Int J Clin Exp Pathol 3:47-55. 2009
    ..01). These findings support previous studies implicating GATA4 in pancreatic cancer and offer new avenues for investigation into this aggressive tumor type...
  30. pmc Genetic mutations associated with cigarette smoking in pancreatic cancer
    Amanda Blackford
    Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Cancer Res 69:3681-8. 2009
    ..Pancreatic carcinomas from cigarette smokers harbor more mutations than do carcinomas from never smokers. The types and patterns of these mutations provide insight into the mechanisms by which cigarette smoking causes pancreatic cancer...
  31. ncbi Aberrant methylation of Reprimo correlates with genetic instability and predicts poor prognosis in pancreatic ductal adenocarcinoma
    Norihiro Sato
    Department of Pathology, The Sol Goldman Pancreatic Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Cancer 107:251-7. 2006
    ..The biological and clinical relevance of Reprimo methylation in pancreatic cancer was investigated...
  32. ncbi Increased cyclooxygenase-2 expression in duodenal compared with colonic tissues in familial adenomatous polyposis and relationship to the -765G -> C COX-2 polymorphism
    Lodewijk A A Brosens
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin Cancer Res 11:4090-6. 2005
    ....
  33. doi Cancer gene profiling in pancreatic cancer
    Felip Vilardell
    Department of Pathology, GI Liver Division, Johns Hopkins Medical Institutions, The Sol Goldman Pancreatic Cancer Research Center, Baltimore, MD, USA
    Methods Mol Biol 576:279-92. 2010
    ..Here, we describe some of these techniques...
  34. pmc GATA6 activates Wnt signaling in pancreatic cancer by negatively regulating the Wnt antagonist Dickkopf-1
    Yi Zhong
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America
    PLoS ONE 6:e22129. 2011
    ..These findings illustrate that one mechanism by which GATA6 promotes pancreatic carcinogenesis is by virtue of its activation of canonical Wnt signaling via regulation of DKK1...
  35. pmc RPL38, FOSL1, and UPP1 are predominantly expressed in the pancreatic ductal epithelium
    Fikret Sahin
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Pancreas 30:158-67. 2005
    ..Identification of a ductal epithelium-specific gene can contribute not only to our knowledge of pancreatic tumorigenesis, tumor marker discovery, and effective drug targeting but also is crucial for making a reliable animal model...
  36. ncbi Pancreatic cancer
    Theresa Pluth Yeo
    Departments of Surgery, Oncology, Pathology and Medicine Johns Hopkins Medical Institutions Baltimore, Maryland, USA
    Curr Probl Cancer 26:176-275. 2002
  37. pmc Results of pancreaticoduodenectomy for lymphoplasmacytic sclerosing pancreatitis
    Jeffrey M Hardacre
    Department of Surgery, The Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, MD 21287 4688, USA
    Ann Surg 237:853-8; discussion 858-9. 2003
    ....
  38. pmc Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene
    Sian Jones
    Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Baltimore, MD 21231, USA
    Science 324:217. 2009
    ..These results illustrate that complete, unbiased sequencing of protein-coding genes can lead to the identification of a gene responsible for a hereditary disease...
  39. ncbi Frequent genomic copy number gain and overexpression of GATA-6 in pancreatic carcinoma
    Baojin Fu
    Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Cancer Biol Ther 7:1593-601. 2008
    ..Gain and overexpression of the development-related transcription factor GATA-6 may play an important and hitherto unrecognized role in pancreatic carcinogenesis...
  40. ncbi Evaluation of GATA-4 and GATA-5 methylation profiles in human pancreatic cancers indicate promoter methylation patterns distinct from other human tumor types
    Baojin Fu
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Cancer Biol Ther 6:1546-52. 2007
    ..While hypermethylation of GATA-5 seems to be a universal feature among human tumors, infrequent methylation of GATA-4, and its corresponding overexpression, appears unique to pancreatic cancer from other tumor types reported thus far...
  41. pmc FAM190A deficiency creates a cell division defect
    Kalpesh Patel
    Department of Oncology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Am J Pathol 183:296-303. 2013
    ....
  42. pmc Genetically defined subsets of human pancreatic cancer show unique in vitro chemosensitivity
    YunFeng Cui
    Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Clin Cancer Res 18:6519-30. 2012
    ..Chemotherapy for pancreatic cancer might be improved by adjusting it to individual genetic profiles. We attempt to identify genetic predictors of chemosensitivity to broad classes of anticancer drugs...
  43. pmc Absence of E-cadherin expression distinguishes noncohesive from cohesive pancreatic cancer
    Jordan M Winter
    Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Clin Cancer Res 14:412-8. 2008
    ..The role of E-cadherin in carcinogenesis is of great interest, but few studies have examined its relevance to pancreatic carcinoma...
  44. doi Frequent beta-catenin nuclear labeling in sessile serrated polyps of the colorectum with neoplastic potential
    Julie M Wu
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Am J Clin Pathol 129:416-23. 2008
    ..002). We propose that beta-catenin and/or CDX2 immunolabeling may have diagnostic usefulness in the evaluation of serrated polyps. These findings also suggest that Wnt signaling has a role in SSA development...
  45. pmc Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk
    Atsushi Kaneda
    Center for Epigenetics and Department of Medicine, Johns Hopkins University School of Medicine, 1064 Ross, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:20926-31. 2007
    ....
  46. ncbi The desmoplastic response to infiltrating breast carcinoma: gene expression at the site of primary invasion and implications for comparisons between tumor types
    Christine A Iacobuzio-Donahue
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Cancer Res 62:5351-7. 2002
    ..Some of the genes presented are novel markers of the invasive process, imply communication at the host/tumor interface, and suggest potential therapeutic targets...
  47. ncbi Aberrant methylation of CpG islands in intraductal papillary mucinous neoplasms of the pancreas
    Norihiro Sato
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Gastroenterology 123:365-72. 2002
    ..We hypothesized that an alternative mechanism for gene inactivation (notably, transcriptional silencing by promoter methylation) could be important in the pathogenesis of IPMNs...
  48. ncbi Large-scale allelotype of pancreaticobiliary carcinoma provides quantitative estimates of genome-wide allelic loss
    Christine A Iacobuzio-Donahue
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Cancer Res 64:871-5. 2004
    ..01). These findings offer new loci for investigation of the genetic alterations common to pancreaticobiliary cancers and aid the understanding of mechanisms of allelic loss in human carcinogenesis...
  49. pmc Genetic basis of pancreas cancer development and progression: insights from whole-exome and whole-genome sequencing
    Christine A Iacobuzio-Donahue
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Clin Cancer Res 18:4257-65. 2012
    ..In addition, recent genetic discoveries have created new opportunities to develop gene-based approaches for early detection, personalized treatment, and molecular classification of pancreatic neoplasms...
  50. doi The pathology and genetics of metastatic pancreatic cancer
    Shinichi Yachida
    The Johns Hopkins Medical Institutions, The Sol Goldman Pancreatic Cancer Research Center, Baltimore, Maryland 21231, USA
    Arch Pathol Lab Med 133:413-22. 2009
    ..Thus, a better understanding of metastatic pancreatic cancer will afford new opportunities for therapeutic intervention...
  51. pmc Histopathologic basis for the favorable survival after resection of intraductal papillary mucinous neoplasm-associated invasive adenocarcinoma of the pancreas
    George A Poultsides
    Department of Surgery, Sidney Kimmel Cancer Center, Johns Hopkins Hospital, Baltimore, MD, USA
    Ann Surg 251:470-6. 2010
    ....
  52. ncbi Dual mitogen-activated protein kinase and epidermal growth factor receptor inhibition in biliary and pancreatic cancer
    Antonio Jimeno
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, School of Medicine, The Johns Hopkins University, The Baunting and Blaustein Cancer Research Building, 1650 Orleans Street, Room 1M89, Baltimore, MD 21231, USA
    Mol Cancer Ther 6:1079-88. 2007
    ..In addition, the data support the efficacy of combined epidermal growth factor receptor and MAPK inhibitors in biliary and pancreatic cancers, providing the basis to test this combination in the clinic...
  53. ncbi Evidence of selection for clones having genetic inactivation of the activin A type II receptor (ACVR2) gene in gastrointestinal cancers
    Paula M Hempen
    Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Cancer Res 63:994-9. 2003
    ..This evidence is compatible with a high degree of selection for inactivation of the ACVR2 gene in tumorigenesis, supporting ACVR2 as a candidate tumor suppressor gene in gastrointestinal cancers...
  54. pmc Sessile serrated adenomas: high-risk lesions?
    Safia N Salaria
    The Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Hum Pathol 43:1808-14. 2012
    ..Those with follow-up were managed as per advanced adenomas; their clinical outcomes supported this. These results suggest that guidelines for following up patients with sessile serrated adenomas as per advanced adenomas are warranted...
  55. ncbi Claudin 4 protein expression in primary and metastatic pancreatic cancer: support for use as a therapeutic target
    Lynette S Nichols
    Department of Pathology, Johns Hopkins Hospital, Baltimore, MD 21205, USA
    Am J Clin Pathol 121:226-30. 2004
    ....
  56. ncbi Sessile serrated adenomas with low- and high-grade dysplasia and early carcinomas: an immunohistochemical study of serrated lesions "caught in the act"
    Todd B Sheridan
    Department of Pathology, Johns Hopkins Hospital, Baltimore, MD 21231 2401, USA
    Am J Clin Pathol 126:564-71. 2006
    ..No patient was known to have hereditary nonpolyposis colorectal cancer/Lynch syndrome. This study offers additional strong evidence that SSA is truly a precursor to at least a subset of sporadic microsatellite-unstable colorectal cancer...
  57. doi Novel methylation biomarker panel for the early detection of pancreatic cancer
    Joo Mi Yi
    Authors Affiliations Departments of Oncology, Surgery, Urology, and Mechanic Engineering, Johns Hopkins University Department of Biomedical Engineering, Johns Hopkins School of Medicine Department of Pathology, The Sol Goldman Pancreatic Research Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland MDxHealth, Ghent, Belgium and Research Institute, Dongnam Institute of Radiological and Medical Sciences DIRAMS, Busan, South Korea
    Clin Cancer Res 19:6544-55. 2013
    ..Here, we identify cancer-specific promoter DNA methylation of BNC1 and ADAMTS1 as a promising biomarker detection strategy meriting investigation in pancreatic cancer...
  58. pmc Molecular pathways in pancreatic carcinogenesis
    Anne M Macgregor-Das
    Pathobiology Program, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Surg Oncol 107:8-14. 2013
    ..These alterations not only provide insight into the fundamental origins of pancreatic cancer but provide ample opportunity for improving early diagnosis and management of cystic precursors...
  59. pmc Differential expression of multiple genes in association with MADH4/DPC4/SMAD4 inactivation in pancreatic cancer
    Dengfeng Cao
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Hospital Baltimore, MD, USA
    Int J Clin Exp Pathol 1:510-7. 2008
    ..Further investigations to validate and to determine the significance of these candidate target genes in pancreatic carcinogenesis and progression are warranted...
  60. pmc Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes
    Christopher M Heaphy
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Am J Pathol 179:1608-15. 2011
    ..These findings may have therapeutic consequences, because ALT-positive cancers are predicted to be resistant to anti-telomerase therapies...
  61. pmc HMGA1 correlates with advanced tumor grade and decreased survival in pancreatic ductal adenocarcinoma
    Alexandra C Hristov
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mod Pathol 23:98-104. 2010
    ..These results suggest that HMGA1 promotes tumor progression in pancreatic ductal adenocarcinoma and could be a useful biomarker and rational therapeutic target in advanced disease...
  62. ncbi Assessment of Epidermal Growth Factor Receptor (EGFR) signaling in paired colorectal cancer and normal colon tissue samples using computer-aided immunohistochemical analysis
    Wells Messersmith
    Division of Medical Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Cancer Biol Ther 4:1381-6. 2005
    ..Colorectal tumors show higher staining of pEGFR and downstream effectors compared to matched normal colorectal tissues...
  63. ncbi Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray
    Anirban Maitra
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mod Pathol 16:902-12. 2003
    ....
  64. pmc Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers
    Georg Feldmann
    Department of Pathology, Johns Hopkins University School of Medicine, 1550 Orleans Street, Baltimore, MD 21231, USA
    Cancer Res 67:2187-96. 2007
    ....
  65. ncbi Optimizing the development of targeted agents in pancreatic cancer: tumor fine-needle aspiration biopsy as a platform for novel prospective ex vivo drug sensitivity assays
    Belen Rubio-Viqueira
    Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Mol Cancer Ther 6:515-23. 2007
    ..Ultimately, an approach of this nature may facilitate the further refinement of patient selection in favor of individuals with molecular profiles, predicting a greater likelihood of therapeutic benefit...
  66. doi Considerations for sequencing analyses of pancreatic cancer progression and metastasis
    Alvin Makohon-Moore
    Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Methods Mol Biol 980:121-9. 2013
    ..This chapter aims to review these issues and provide examples of the types of data generated...
  67. ncbi Telomere length abnormalities occur early in the initiation of epithelial carcinogenesis
    Alan K Meeker
    Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Clin Cancer Res 10:3317-26. 2004
    ..In the present study, we address whether the previous findings are broadly applicable to human epithelial cancer precursors in general...
  68. pmc SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer
    Amanda Blackford
    Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Clin Cancer Res 15:4674-9. 2009
    ..Recently, the majority of protein coding genes were sequenced in a collection of pancreatic cancers, providing an unprecedented opportunity to identify genetic markers of prognosis for patients with adenocarcinoma of the pancreas...
  69. pmc Exploring the host desmoplastic response to pancreatic carcinoma: gene expression of stromal and neoplastic cells at the site of primary invasion
    Christine A Iacobuzio-Donahue
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Am J Pathol 160:91-9. 2002
    ..We have identified a highly organized structure of gene expression within the host stromal response to invasive pancreatic cancer that may reflect tumor-host communication and serve as a target for therapeutic intervention...
  70. pmc Patterns of EphA2 protein expression in primary and metastatic pancreatic carcinoma and correlation with genetic status
    Shiyama V Mudali
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Hospital, Baltimore, MD, USA
    Clin Exp Metastasis 23:357-65. 2006
    ..Our data confirms that EphA2 is overexpressed in pancreatic cancer, but suggests a relative loss of EphA2 in co-existent pancreatic cancer metastases as well as a role for EPHA2 in organ specific metastasis...
  71. ncbi Pathologically and biologically distinct types of epithelium in intraductal papillary mucinous neoplasms: delineation of an "intestinal" pathway of carcinogenesis in the pancreas
    N Volkan Adsay
    Departments of Pathology, Karmanos Cancer Institute and Wayne State University, Detroit, MI 48201, USA
    Am J Surg Pathol 28:839-48. 2004
    ....
  72. pmc A new branch on the tree: next-generation sequencing in the study of cancer evolution
    Jacqueline A Brosnan
    Graduate Program in Pathobiology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Semin Cell Dev Biol 23:237-42. 2012
    ....
  73. ncbi When should one subtract background fluorescence in 2-color microarrays?
    Robert B Scharpf
    Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Biostatistics 8:695-707. 2007
    ..Using these results, we develop recommendations for diagnostic visualizations that can help decisions about background subtraction...
  74. pmc Prognostic significance of tumorigenic cells with mesenchymal features in pancreatic adenocarcinoma
    Zeshaan A Rasheed
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Natl Cancer Inst 102:340-51. 2010
    ..Aldehyde dehydrogenase (ALDH) activity can identify tumor-initiating cells and normal stem cells from several human tissues. We examined the prognostic significance and functional features of ALDH expression in pancreatic adenocarcinoma...
  75. pmc Risk of colorectal cancer in juvenile polyposis
    Lodewijk A A Brosens
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Gut 56:965-7. 2007
    ..However, the relative and absolute risk of colorectal malignancy in these patients is not known...
  76. ncbi Homozygous deletion of the MTAP gene in invasive adenocarcinoma of the pancreas and in periampullary cancer: a potential new target for therapy
    Steven R Hustinx
    Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Cancer Biol Ther 4:83-6. 2005
    ..Thus, pancreatic cancer is a promising cancer type in which to explore novel chemotherapeutic strategies to exploit the selective loss of MTAP function...
  77. doi Coordinated epidermal growth factor receptor pathway gene overexpression predicts epidermal growth factor receptor inhibitor sensitivity in pancreatic cancer
    Antonio Jimeno
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21231 1000, USA
    Cancer Res 68:2841-9. 2008
    ..These results suggest a phenomenon of pathway addiction and support the value of unbiased system biology approaches in drug development...
  78. pmc Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients
    Tian Li Wang
    The Howard Hughes Medical Institute, Sidney Kimmel Comprehensive Cancer Center and Department of Surgery, The Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 101:3089-94. 2004
    ..01). These data suggest that genetic amplification of TYMS is a major mechanism of 5-FU resistance in vivo and have important implications for the management of colorectal cancer patients with recurrent disease...
  79. pmc HMGA2 protein expression correlates with lymph node metastasis and increased tumor grade in pancreatic ductal adenocarcinoma
    Alexandra C Hristov
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mod Pathol 22:43-9. 2009
    ..Our results support a role for HMGA2 in the progression of pancreatic ductal adenocarcinoma and suggest that it could be a useful biomarker and rational therapeutic target in more advanced disease...
  80. pmc Methylation of TFPI2 in stool DNA: a potential novel biomarker for the detection of colorectal cancer
    Sabine C Glöckner
    Departments of Surgery, Oncology, and Pathology, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Cancer Res 69:4691-9. 2009
    ..Detection of TFPI2 methylation in stool DNA may act as a useful adjunct to the noninvasive strategies for screening of CRCs in the future...
  81. ncbi Reed-Sternberg-like cells in lymph node aspirates in the absence of Hodgkin's disease: pathologic significance and differential diagnosis
    Christine A Iacobuzio-Donahue
    John K Frost Cytopathology Laboratory, Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21287 6940, USA
    Diagn Cytopathol 27:335-9. 2002
    ..The significance and differential diagnosis of Reed-Sternberg-like cells in lymph nodes in the absence of Hodgkin's disease is discussed...
  82. pmc Genomic and epigenomic integration identifies a prognostic signature in colon cancer
    Joo Mi Yi
    Department of Oncology, Johns Hopkins University, Baltimore, Maryland 20892 8110, USA
    Clin Cancer Res 17:1535-45. 2011
    ..The importance of genetic and epigenetic alterations maybe in their aggregate role in altering core pathways in tumorigenesis...
  83. ncbi Peritumoral fibroblast SPARC expression and patient outcome with resectable pancreatic adenocarcinoma
    Jeffrey R Infante
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    J Clin Oncol 25:319-25. 2007
    ..We evaluated the prognostic significance of tumor and peritumoral SPARC expression in patients with pancreatic adenocarcinoma...
  84. ncbi Pancreaticobiliary cancers with deficient methylenetetrahydrofolate reductase genotypes
    Hiroyuki Matsubayashi
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 2196, USA
    Clin Gastroenterol Hepatol 3:752-60. 2005
    ..Methyl group deficiency might promote carcinogenesis by inducing DNA breaks and DNA hypomethylation. We hypothesized that deficient methylenetetrahydrofolate reductase (MTHFR) genotypes could promote pancreatic cancer development...
  85. doi Patchy distribution of pathologic abnormalities in autoimmune pancreatitis: implications for preoperative diagnosis
    Vishal S Chandan
    Department of Pathology, Division of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Am J Surg Pathol 32:1762-9. 2008
    ..IgG4 immunostaining of apparently negative biopsies may be helpful, but only in a small minority of cases...
  86. ncbi Cathepsin D protein levels in colorectal tumors: divergent expression patterns suggest complex regulation and function
    Christine Iacobuzio-Donahue
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Int J Oncol 24:473-85. 2004
    ..Loss of cathepsin D protein may provide an advantage to colorectal tumors related to a loss of cathepsin D function in proapototic or antiangiogenic pathways while increased cathepsin D may promote cancer cell proliferation or invasion...
  87. pmc Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    Sian Jones
    Sol Goldman Pancreatic Cancer Research Center, Ludwig Center and Howard Hughes Medical Institute at the Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Science 321:1801-6. 2008
    ..Dysregulation of these core pathways and processes through mutation can explain the major features of pancreatic tumorigenesis...
  88. pmc Histologic variations in juvenile polyp phenotype correlate with genetic defect underlying juvenile polyposis
    Willem Arnout van Hattem
    Department of Pathology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Am J Surg Pathol 35:530-6. 2011
    ..This study compares the histologic phenotype of juvenile polyps with a SMAD4 or BMPR1A germline mutation and sporadic juvenile polyps...
  89. pmc Occurrence of colorectal adenomas in younger adults: an epidemiologic necropsy study
    Cheryl J Pendergrass
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Clin Gastroenterol Hepatol 6:1011-5. 2008
    ..The colorectal adenoma is the precursor lesion in virtually all colorectal cancers. Occurrence of colorectal adenomas has been studied in older adults but analysis in younger adults is lacking...
  90. doi Integrin alpha2 mediates selective metastasis to the liver
    Kiyoshi Yoshimura
    Department of Surgery, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, 600 North Wolfe Street, Blalock 685, Baltimore, MD 21287, USA
    Cancer Res 69:7320-8. 2009
    ..These findings define integrin alpha2 as a molecule conferring selective potential for formation of hepatic metastasis, as well as a possible target to prevent their formation...
  91. pmc Heteroplasmic mitochondrial DNA mutations in normal and tumour cells
    Yiping He
    The Ludwig Center for Cancer Genetics and Therapeutics and The Howard Hughes Medical Institute at The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland 21231, USA
    Nature 464:610-4. 2010
    ..In particular, they demonstrate that individual humans are characterized by a complex mixture of related mitochondrial genotypes rather than a single genotype...
  92. ncbi Stromal responses to carcinomas of the pancreas: juxtatumoral gene expression conforms to the infiltrating pattern and not the biologic subtype
    Francesca Ricci
    Department of Pathology, University La Sapienza, Roma, Italy
    Cancer Biol Ther 4:302-7. 2005
    ....
  93. pmc Immunohistochemical and genetic evaluation of deoxycytidine kinase in pancreatic cancer: relationship to molecular mechanisms of gemcitabine resistance and survival
    Valeria Sebastiani
    Department of Pathology, University La Sapienza, Rome, Italy
    Clin Cancer Res 12:2492-7. 2006
    ..In summary, pretreatment levels of dCK protein are most correlated with overall survival following gemcitabine treatment and are stable even after resistance to gemcitabine is clinically documented...
  94. ncbi Claudin-4, mitogen-activated protein kinase kinase 4, and stratifin are markers of gastric adenocarcinoma precursor lesions
    Steven C Cunningham
    Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore Maryland 21231, USA
    Cancer Epidemiol Biomarkers Prev 15:281-7. 2006
    ..These findings may prove useful in the diagnosis and therapeutic targeting of gastric adenocarcinoma precursor lesions...

Research Grants4

  1. TARGETS OF METASTATIC PANCREATIC CANCER
    Christine Iacobuzio Donahue; Fiscal Year: 2007
    ..abstract_text> ..
  2. TGF-beta Signaling in Pancreatic Cancer Progression
    Christine A Iacobuzio Donahue; Fiscal Year: 2010
    ..In this proposal we will study one of the most common pathways that control growth and normal development, the TGF-b pathway, and the mechanisms by which it is altered to promote pancreatic cancer formation and spread. ..