Research Topics
Genomes and Genes
| Christine A Iacobuzio-DonahueSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Genetic evolution of pancreatic cancer: lessons learnt from the pancreatic cancer genome sequencing projectChristine A Iacobuzio-Donahue
Johns Hopkins Medical Institutions, Department of Pathology, GI Liver Division, Baltimore, MD 21232, USA
Gut 61:1085-94. 2012....- Small cell and large cell neuroendocrine carcinomas of the pancreas are genetically similar and distinct from well-differentiated pancreatic neuroendocrine tumorsShinichi Yachida
Departments of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
Am J Surg Pathol 36:173-84. 2012..The finding of Bcl-2 overexpression in poorly differentiated NECs, particularly small cell NEC, suggests that Bcl-2 antagonists/inhibitors may be a viable treatment option for these patients... - Serial analysis of gene expression of lobular carcinoma in situ identifies down regulation of claudin 4 and overexpression of matrix metalloproteinase 9Dengfeng Cao
Departments of Pathology and Immunology, Washington University, St Louis, MO, USA
Breast Cancer Res 10:R91. 2008..Global gene expression profiling of LCIS has not been performed... 
Gene expression in neoplasms of the pancreas: applications to diagnostic pathologyChristine A Iacobuzio-Donahue
Division of Gastrointestinal Liver Pathology, Department of Pathology, Ross Building, Room 632, The Johns Hopkins Hospital, 720 Rutland Avenue, Baltimore, MD 21205 2196, USA
Adv Anat Pathol 10:125-34. 2003..Emphasis will be placed on applications that are practical and useful to the daily practice of pathology...- Highly expressed genes in pancreatic ductal adenocarcinomas: a comprehensive characterization and comparison of the transcription profiles obtained from three major technologiesChristine A Iacobuzio-Donahue
Departments of Pathology, Surgery, Oncology, and Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
Cancer Res 63:8614-22. 2003.... - DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancerChristine A Iacobuzio-Donahue
Department of Pathology, Surgery, and Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
J Clin Oncol 27:1806-13. 2009..A comprehensive study of pancreatic cancers from patients who have succumbed to their disease has the potential to greatly expand our understanding of the most lethal stage of this disease and identify novel areas for intervention... 
Epigenetic changes in cancerChristine A Iacobuzio-Donahue
Departments of Pathology and Oncology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
Annu Rev Pathol 4:229-49. 2009....- Immortalizing the complexity of cancer metastasis: genetic features of lethal metastatic pancreatic cancer obtained from rapid autopsyErlinda E Embuscado
Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA
Cancer Biol Ther 4:548-54. 2005..The invaluable tissue resources generated by the success of the GICRMDP will provide an unparalleled resource for study of metastatic pancreatic cancer and of the metastatic process in general... - Gene expression profiling identifies genes associated with invasive intraductal papillary mucinous neoplasms of the pancreasNorihiro Sato
Departments of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205-2196, USA
Am J Pathol 164:903-14. 2004..0001). Our findings suggest that preoperative assessment of gene expression profiles may be able to differentiate invasive from noninvasive IPMNs... - Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarraysChristine A Iacobuzio-Donahue
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
Am J Pathol 162:1151-62. 2003..The genes and expressed sequence tags presented in this study provide clues to the pathobiology of pancreatic cancer and implicate a large number of potentially new molecular markers for the detection and treatment of pancreatic cancer... - Missense mutations of MADH4: characterization of the mutational hot spot and functional consequences in human tumorsChristine A Iacobuzio-Donahue
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
Clin Cancer Res 10:1597-604. 2004..We present the MADH4 genetic status determined on a new set of pancreatic, biliary, and duodenal cancers with comparison to the mutational data reported for various tumor types... - Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in miceTakashi Sakatani
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Science 307:1976-8. 2005..A similar shift in differentiation was seen in the normal colonic mucosa of humans with LOI. Thus, altered maturation of nonneoplastic tissue may be one mechanism by which epigenetic changes affect cancer risk... - Gene expression profiling identifies markers of ampullary adenocarcinomaN Tjarda Van Heek
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 2196, USA
Cancer Biol Ther 3:651-6. 2004..001). Measurement of markers of ampullary cancer such as osteopontin may aid in the early detection and differential diagnosis of patients with periampullary lesions... - Epigenetic inactivation of TFPI-2 as a common mechanism associated with growth and invasion of pancreatic ductal adenocarcinomaNorihiro Sato
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
Oncogene 24:850-8. 2005..We thus conclude that epigenetic inactivation of TFPI-2 is a common mechanism that contributes to the aggressive phenotype of pancreatic ductal adenocarcinoma... - Discovery of novel tumor markers of pancreatic cancer using global gene expression technologyChristine A Iacobuzio-Donahue
Department of Pathology, The Johns Hopkins MedicalInstitutions, Baltimore, Maryland 21231-2410, USA
Am J Pathol 160:1239-49. 2002..The remaining 69 genes have not been implicated in pancreatic cancer before, and have immediate potential as novel therapeutic targets and tumor markers of pancreatic cancer... - Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinomaNorihiro Sato
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
Cancer Res 63:4158-66. 2003..These results indicate that gene hypomethylation is a frequent epigenetic event in pancreatic cancer and is commonly associated with the overexpression of affected genes... - Distant metastasis occurs late during the genetic evolution of pancreatic cancerShinichi Yachida
Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
Nature 467:1114-7. 2010..These data provide novel insights into the genetic features underlying pancreatic cancer progression and define a broad time window of opportunity for early detection to prevent deaths from metastatic disease... - Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesisYoshiharu Miyamoto
Departments of Surgery, Oncology, and Pathology, The Sidney Kimmel Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Cancer Cell 3:565-76. 2003..These findings suggest that Notch mediates the tumor-initiating effects of TG alpha by expanding a population of undifferentiated precursor cells... - Beta-catenin nuclear labeling is a common feature of sessile serrated adenomas and correlates with early neoplastic progression after BRAF activationShinichi Yachida
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
Am J Surg Pathol 33:1823-32. 2009.... - Identifying allelic loss and homozygous deletions in pancreatic cancer without matched normals using high-density single-nucleotide polymorphism arraysEric S Calhoun
Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center at the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutes, Baltimore, MD 21231, USA
Cancer Res 66:7920-8. 2006..This study provides previously unavailable high-resolution allelotype and deletion breakpoint maps in widely shared pancreatic cancer cell lines and effectively eliminates the need for matched normal tissue to define informative loci... - MAP2K4/MKK4 expression in pancreatic cancer: genetic validation of immunohistochemistry and relationship to disease courseWei Xin
Department of Pathology, The University of Michigan Medical Center, Ann Arbor, Michigan, USA
Clin Cancer Res 10:8516-20. 2004..The correlation of MKK4 genetic status with immunolabeling patterns validate this approach for the evaluation of MKK4 status in routine histologic sections and may provide useful information regarding patient prognosis... - CpG island methylator phenotype-positive tumors in the absence of MLH1 methylation constitute a distinct subset of duodenal adenocarcinomas and are associated with poor prognosisTao Fu
Department of Surgery, Johns Hopkins University, Baltimore, MD 21287, USA
Clin Cancer Res 18:4743-52. 2012..The purpose was to identify possible subsets of duodenal adenocarcinomas based on microsatellite instability (MSI), DNA methylation, mutations in the KRAS and BRAF genes, clinicopathologic features, and prognosis... - Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor typesSian Jones
Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, USA
Hum Mutat 33:100-3. 2012..These findings suggest that the aberrant chromatin remodeling consequent to ARID1A inactivation contributes to a variety of different types of neoplasms... - High cancer-specific expression of mesothelin (MSLN) is attributable to an upstream enhancer containing a transcription enhancer factor dependent MCAT motifTomas Hucl
Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD 21231, USA
Cancer Res 67:9055-65. 2007..The CanScript sequence represents a modular element for cancer-specific targeting, potentially suitable for nearly a third of human malignancies... - Clinical significance of the genetic landscape of pancreatic cancer and implications for identification of potential long-term survivorsShinichi Yachida
Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Clin Cancer Res 18:6339-47. 2012..Genetic alterations of KRAS, CDKN2A, TP53, and SMAD4 are the most frequent events in pancreatic cancer. We determined the extent to which these 4 alterations are coexistent in the same carcinoma, and their impact on patient outcome... - Clinicopathologic and genetic characterization of traditional serrated adenomas of the colonBaojin Fu
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
Am J Clin Pathol 138:356-66. 2012..However, conventional epithelial dysplasia and abnormal p53 labeling in a TSA are seen more often in the setting of BRAF mutation... - Pancreatic cancerTheresa Pluth Yeo
Departments of Surgery, Oncology, Pathology and Medicine Johns Hopkins Medical Institutions Baltimore, Maryland, USA
Curr Probl Cancer 26:176-275. 2002 - Establishment and characterization of a new cell line, A99, from a primary small cell carcinoma of the pancreasShinichi Yachida
Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Pancreas 40:905-10. 2011..Small cell carcinoma (SCC) of the pancreas is a rare malignancy with a poor prognosis. We established and characterized a primary human pancreatic SCC cell line, designated A99... - Aberrant methylation of Reprimo correlates with genetic instability and predicts poor prognosis in pancreatic ductal adenocarcinomaNorihiro Sato
Department of Pathology, The Sol Goldman Pancreatic Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Cancer 107:251-7. 2006..The biological and clinical relevance of Reprimo methylation in pancreatic cancer was investigated... - The developmental transcription factor Gata4 is overexpressed in pancreatic ductal adenocarcinomaMatthew S Karafin
Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
Int J Clin Exp Pathol 3:47-55. 2009..01). These findings support previous studies implicating GATA4 in pancreatic cancer and offer new avenues for investigation into this aggressive tumor type... - Genetic mutations associated with cigarette smoking in pancreatic cancerAmanda Blackford
Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
Cancer Res 69:3681-8. 2009..Pancreatic carcinomas from cigarette smokers harbor more mutations than do carcinomas from never smokers. The types and patterns of these mutations provide insight into the mechanisms by which cigarette smoking causes pancreatic cancer... - Analysis of novel tumor markers in pancreatic and biliary carcinomas using tissue microarraysSharon L Swierczynski
Department of Pathology, The Johns Hopkinds University School of Medicine, Baltimore, MD 21231, USA
Hum Pathol 35:357-66. 2004..Therefore, these markers are potentially useful in developing diagnostic tests and treatment paradigms for tumors involving the biliary system... - Increased cyclooxygenase-2 expression in duodenal compared with colonic tissues in familial adenomatous polyposis and relationship to the -765G -> C COX-2 polymorphismLodewijk A A Brosens
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Clin Cancer Res 11:4090-6. 2005.... - GATA6 activates Wnt signaling in pancreatic cancer by negatively regulating the Wnt antagonist Dickkopf-1Yi Zhong
Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America
PLoS ONE 6:e22129. 2011..These findings illustrate that one mechanism by which GATA6 promotes pancreatic carcinogenesis is by virtue of its activation of canonical Wnt signaling via regulation of DKK1... - Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility geneSian Jones
Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Baltimore, MD 21231, USA
Science 324:217. 2009..These results illustrate that complete, unbiased sequencing of protein-coding genes can lead to the identification of a gene responsible for a hereditary disease... - Results of pancreaticoduodenectomy for lymphoplasmacytic sclerosing pancreatitisJeffrey M Hardacre
Department of Surgery, The Johns Hopkins Hospital, 600 N. Wolfe Street, Baltimore, MD 21287-4688, USA
Ann Surg 237:853-8; discussion 858-9. 2003..Nevertheless, differentiation from pancreatic neoplasia remains difficult. Patients undergoing pancreaticoduodenectomy for LPSP have durable relief of symptoms and a subjectively improved quality of life... - Cancer gene profiling in pancreatic cancerFelip Vilardell
Department of Pathology, GI Liver Division, Johns Hopkins Medical Institutions, The Sol Goldman Pancreatic Cancer Research Center, Baltimore, MD, USA
Methods Mol Biol 576:279-92. 2010..Here, we describe some of these techniques... - Frequent genomic copy number gain and overexpression of GATA-6 in pancreatic carcinomaBaojin Fu
Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
Cancer Biol Ther 7:1593-601. 2008..Gain and overexpression of the development-related transcription factor GATA-6 may play an important and hitherto unrecognized role in pancreatic carcinogenesis... - Evaluation of GATA-4 and GATA-5 methylation profiles in human pancreatic cancers indicate promoter methylation patterns distinct from other human tumor typesBaojin Fu
Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
Cancer Biol Ther 6:1546-52. 2007..While hypermethylation of GATA-5 seems to be a universal feature among human tumors, infrequent methylation of GATA-4, and its corresponding overexpression, appears unique to pancreatic cancer from other tumor types reported thus far... - Frequent beta-catenin nuclear labeling in sessile serrated polyps of the colorectum with neoplastic potentialJulie M Wu
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
Am J Clin Pathol 129:416-23. 2008..002). We propose that beta-catenin and/or CDX2 immunolabeling may have diagnostic usefulness in the evaluation of serrated polyps. These findings also suggest that Wnt signaling has a role in SSA development... - Aberrant methylation of CpG islands in intraductal papillary mucinous neoplasms of the pancreasNorihiro Sato
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
Gastroenterology 123:365-72. 2002..CONCLUSIONS: These results suggest that de novo methylation of multiple CpG islands is one of the critical pathways that contributes to the malignant progression of IPMNs... - The desmoplastic response to infiltrating breast carcinoma: gene expression at the site of primary invasion and implications for comparisons between tumor typesChristine A Iacobuzio-Donahue
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
Cancer Res 62:5351-7. 2002..Some of the genes presented are novel markers of the invasive process, imply communication at the host/tumor interface, and suggest potential therapeutic targets... - Absence of E-cadherin expression distinguishes noncohesive from cohesive pancreatic cancerJordan M Winter
Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Clin Cancer Res 14:412-8. 2008..The role of E-cadherin in carcinogenesis is of great interest, but few studies have examined its relevance to pancreatic carcinoma... - Large-scale allelotype of pancreaticobiliary carcinoma provides quantitative estimates of genome-wide allelic lossChristine A Iacobuzio-Donahue
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Cancer Res 64:871-5. 2004..01). These findings offer new loci for investigation of the genetic alterations common to pancreaticobiliary cancers and aid the understanding of mechanisms of allelic loss in human carcinogenesis... - Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor riskAtsushi Kaneda
Center for Epigenetics and Department of Medicine, Johns Hopkins University School of Medicine, 1064 Ross, 720 Rutland Avenue, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 104:20926-31. 2007.... - Evidence of selection for clones having genetic inactivation of the activin A type II receptor (ACVR2) gene in gastrointestinal cancersPaula M Hempen
Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
Cancer Res 63:994-9. 2003..This evidence is compatible with a high degree of selection for inactivation of the ACVR2 gene in tumorigenesis, supporting ACVR2 as a candidate tumor suppressor gene in gastrointestinal cancers... - RPL38, FOSL1, and UPP1 are predominantly expressed in the pancreatic ductal epitheliumFikret Sahin
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Pancreas 30:158-67. 2005..We also demonstrated that all 3 genes are highly expressed in a panel of pancreatic cancer cell lines and can potentially be useful in tumor targeting or as tumor markers... - Genetic basis of pancreas cancer development and progression: insights from whole-exome and whole-genome sequencingChristine A Iacobuzio-Donahue
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Clin Cancer Res 18:4257-65. 2012..In addition, recent genetic discoveries have created new opportunities to develop gene-based approaches for early detection, personalized treatment, and molecular classification of pancreatic neoplasms... - The pathology and genetics of metastatic pancreatic cancerShinichi Yachida
The Johns Hopkins Medical Institutions, The Sol Goldman Pancreatic Cancer Research Center, Baltimore, Maryland 21231, USA
Arch Pathol Lab Med 133:413-22. 2009..Thus, a better understanding of metastatic pancreatic cancer will afford new opportunities for therapeutic intervention... - Histopathologic basis for the favorable survival after resection of intraductal papillary mucinous neoplasm-associated invasive adenocarcinoma of the pancreasGeorge A Poultsides
Department of Surgery, Sidney Kimmel Cancer Center, Johns Hopkins Hospital, Baltimore, MD, USA
Ann Surg 251:470-6. 2010.... - Dual mitogen-activated protein kinase and epidermal growth factor receptor inhibition in biliary and pancreatic cancerAntonio Jimeno
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, School of Medicine, The Johns Hopkins University, The Baunting and Blaustein Cancer Research Building, 1650 Orleans Street, Room 1M89, Baltimore, MD 21231, USA
Mol Cancer Ther 6:1079-88. 2007..In addition, the data support the efficacy of combined epidermal growth factor receptor and MAPK inhibitors in biliary and pancreatic cancers, providing the basis to test this combination in the clinic... - Sessile serrated adenomas: high-risk lesions?Safia N Salaria
The Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
Hum Pathol 43:1808-14. 2012..Those with follow-up were managed as per advanced adenomas; their clinical outcomes supported this. These results suggest that guidelines for following up patients with sessile serrated adenomas as per advanced adenomas are warranted... - Sessile serrated adenomas with low- and high-grade dysplasia and early carcinomas: an immunohistochemical study of serrated lesions "caught in the act"Todd B Sheridan
Department of Pathology, Johns Hopkins Hospital, Baltimore, MD 21231-2401, USA
Am J Clin Pathol 126:564-71. 2006..No patient was known to have hereditary nonpolyposis colorectal cancer/Lynch syndrome. This study offers additional strong evidence that SSA is truly a precursor to at least a subset of sporadic microsatellite-unstable colorectal cancer... - Claudin 4 protein expression in primary and metastatic pancreatic cancer: support for use as a therapeutic targetLynette S Nichols
Department of Pathology, Johns Hopkins Hospital, Baltimore, MD 21205, USA
Am J Clin Pathol 121:226-30. 2004.... - Molecular pathways in pancreatic carcinogenesisAnne M Macgregor-Das
Pathobiology Program, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Surg Oncol 107:8-14. 2013..These alterations not only provide insight into the fundamental origins of pancreatic cancer but provide ample opportunity for improving early diagnosis and management of cystic precursors... - Genetically defined subsets of human pancreatic cancer show unique in vitro chemosensitivityYunFeng Cui
Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
Clin Cancer Res 18:6519-30. 2012..Chemotherapy for pancreatic cancer might be improved by adjusting it to individual genetic profiles. We attempt to identify genetic predictors of chemosensitivity to broad classes of anticancer drugs... - Differential expression of multiple genes in association with MADH4/DPC4/SMAD4 inactivation in pancreatic cancerDengfeng Cao
Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Hospital Baltimore, MD, USA
Int J Clin Exp Pathol 1:510-7. 2008..Further investigations to validate and to determine the significance of these candidate target genes in pancreatic carcinogenesis and progression are warranted... - Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypesChristopher M Heaphy
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Am J Pathol 179:1608-15. 2011..These findings may have therapeutic consequences, because ALT-positive cancers are predicted to be resistant to anti-telomerase therapies... - HMGA1 correlates with advanced tumor grade and decreased survival in pancreatic ductal adenocarcinomaAlexandra C Hristov
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Mod Pathol 23:98-104. 2010..These results suggest that HMGA1 promotes tumor progression in pancreatic ductal adenocarcinoma and could be a useful biomarker and rational therapeutic target in advanced disease... - Assessment of Epidermal Growth Factor Receptor (EGFR) signaling in paired colorectal cancer and normal colon tissue samples using computer-aided immunohistochemical analysisWells Messersmith
Division of Medical Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University, Baltimore, Maryland 21231, USA
Cancer Biol Ther 4:1381-6. 2005..Colorectal tumors show higher staining of pEGFR and downstream effectors compared to matched normal colorectal tissues... - Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancersGeorg Feldmann
Department of Pathology, Johns Hopkins University School of Medicine, 1550 Orleans Street, Baltimore, MD 21231, USA
Cancer Res 67:2187-96. 2007.... - Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarrayAnirban Maitra
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Mod Pathol 16:902-12. 2003.... - Optimizing the development of targeted agents in pancreatic cancer: tumor fine-needle aspiration biopsy as a platform for novel prospective ex vivo drug sensitivity assaysBelen Rubio Viqueira
Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
Mol Cancer Ther 6:515-23. 2007..Ultimately, an approach of this nature may facilitate the further refinement of patient selection in favor of individuals with molecular profiles, predicting a greater likelihood of therapeutic benefit... - Telomere length abnormalities occur early in the initiation of epithelial carcinogenesisAlan K Meeker
Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Clin Cancer Res 10:3317-26. 2004..6%. The implications of these findings include the potential that telomere length assessment in situ may be a widely useful biomarker for monitoring disease prevention strategies and for improved early diagnosis... - Patterns of EphA2 protein expression in primary and metastatic pancreatic carcinoma and correlation with genetic statusShiyama V Mudali
Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Hospital, Baltimore, MD, USA
Clin Exp Metastasis 23:357-65. 2006..Our data confirms that EphA2 is overexpressed in pancreatic cancer, but suggests a relative loss of EphA2 in co-existent pancreatic cancer metastases as well as a role for EPHA2 in organ specific metastasis... - Exploring the host desmoplastic response to pancreatic carcinoma: gene expression of stromal and neoplastic cells at the site of primary invasionChristine A Iacobuzio-Donahue
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Am J Pathol 160:91-9. 2002..We have identified a highly organized structure of gene expression within the host stromal response to invasive pancreatic cancer that may reflect tumor-host communication and serve as a target for therapeutic intervention... - SMAD4 gene mutations are associated with poor prognosis in pancreatic cancerAmanda Blackford
Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
Clin Cancer Res 15:4674-9. 2009..Recently, the majority of protein coding genes were sequenced in a collection of pancreatic cancers, providing an unprecedented opportunity to identify genetic markers of prognosis for patients with adenocarcinoma of the pancreas... - Pathologically and biologically distinct types of epithelium in intraductal papillary mucinous neoplasms: delineation of an "intestinal" pathway of carcinogenesis in the pancreasN Volkan Adsay
Departments of Pathology, Karmanos Cancer Institute and Wayne State University, Detroit, MI 48201, USA
Am J Surg Pathol 28:839-48. 2004.... - A new branch on the tree: next-generation sequencing in the study of cancer evolutionJacqueline A Brosnan
Graduate Program in Pathobiology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Semin Cell Dev Biol 23:237-42. 2012.... - When should one subtract background fluorescence in 2-color microarrays?Robert B Scharpf
Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Biostatistics 8:695-707. 2007..Using these results, we develop recommendations for diagnostic visualizations that can help decisions about background subtraction... - Homozygous deletion of the MTAP gene in invasive adenocarcinoma of the pancreas and in periampullary cancer: a potential new target for therapySteven R Hustinx
Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
Cancer Biol Ther 4:83-6. 2005..Thus, pancreatic cancer is a promising cancer type in which to explore novel chemotherapeutic strategies to exploit the selective loss of MTAP function... - HMGA2 protein expression correlates with lymph node metastasis and increased tumor grade in pancreatic ductal adenocarcinomaAlexandra C Hristov
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Mod Pathol 22:43-9. 2009..Our results support a role for HMGA2 in the progression of pancreatic ductal adenocarcinoma and suggest that it could be a useful biomarker and rational therapeutic target in more advanced disease... - Risk of colorectal cancer in juvenile polyposisLodewijk A A Brosens
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Gut 56:965-7. 2007..However, the relative and absolute risk of colorectal malignancy in these patients is not known... - Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patientsTian Li Wang
The Howard Hughes Medical Institute, Sidney Kimmel Comprehensive Cancer Center and Department of Surgery, The Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA
Proc Natl Acad Sci U S A 101:3089-94. 2004..01). These data suggest that genetic amplification of TYMS is a major mechanism of 5-FU resistance in vivo and have important implications for the management of colorectal cancer patients with recurrent disease... - Prognostic significance of tumorigenic cells with mesenchymal features in pancreatic adenocarcinomaZeshaan A Rasheed
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Natl Cancer Inst 102:340-51. 2010..Aldehyde dehydrogenase (ALDH) activity can identify tumor-initiating cells and normal stem cells from several human tissues. We examined the prognostic significance and functional features of ALDH expression in pancreatic adenocarcinoma... - Methylation of TFPI2 in stool DNA: a potential novel biomarker for the detection of colorectal cancerSabine C Glöckner
Departments of Surgery, Oncology, and Pathology, Johns Hopkins University, Baltimore, Maryland 21287, USA
Cancer Res 69:4691-9. 2009..Detection of TFPI2 methylation in stool DNA may act as a useful adjunct to the noninvasive strategies for screening of CRCs in the future... - Coordinated epidermal growth factor receptor pathway gene overexpression predicts epidermal growth factor receptor inhibitor sensitivity in pancreatic cancerAntonio Jimeno
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21231 1000, USA
Cancer Res 68:2841-9. 2008..These results suggest a phenomenon of pathway addiction and support the value of unbiased system biology approaches in drug development... - Genomic and epigenomic integration identifies a prognostic signature in colon cancerJoo Mi Yi
Department of Oncology, Johns Hopkins University, Baltimore, Maryland 20892 8110, USA
Clin Cancer Res 17:1535-45. 2011..The importance of genetic and epigenetic alterations maybe in their aggregate role in altering core pathways in tumorigenesis... - Reed-Sternberg-like cells in lymph node aspirates in the absence of Hodgkin's disease: pathologic significance and differential diagnosisChristine A Iacobuzio-Donahue
John K Frost Cytopathology Laboratory, Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21287-6940, USA
Diagn Cytopathol 27:335-9. 2002..The significance and differential diagnosis of Reed-Sternberg-like cells in lymph nodes in the absence of Hodgkin's disease is discussed... - Peritumoral fibroblast SPARC expression and patient outcome with resectable pancreatic adenocarcinomaJeffrey R Infante
Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
J Clin Oncol 25:319-25. 2007..We evaluated the prognostic significance of tumor and peritumoral SPARC expression in patients with pancreatic adenocarcinoma... - Cathepsin D protein levels in colorectal tumors: divergent expression patterns suggest complex regulation and functionChristine Iacobuzio-Donahue
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
Int J Oncol 24:473-85. 2004..Loss of cathepsin D protein may provide an advantage to colorectal tumors related to a loss of cathepsin D function in proapototic or antiangiogenic pathways while increased cathepsin D may promote cancer cell proliferation or invasion... - Patchy distribution of pathologic abnormalities in autoimmune pancreatitis: implications for preoperative diagnosisVishal S Chandan
Department of Pathology, Division of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905, USA
Am J Surg Pathol 32:1762-9. 2008..IgG4 immunostaining of apparently negative biopsies may be helpful, but only in a small minority of cases... - Core signaling pathways in human pancreatic cancers revealed by global genomic analysesSian Jones
Sol Goldman Pancreatic Cancer Research Center, Ludwig Center and Howard Hughes Medical Institute at the Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
Science 321:1801-6. 2008..Dysregulation of these core pathways and processes through mutation can explain the major features of pancreatic tumorigenesis... - Pancreaticobiliary cancers with deficient methylenetetrahydrofolate reductase genotypesHiroyuki Matsubayashi
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 2196, USA
Clin Gastroenterol Hepatol 3:752-60. 2005..Methyl group deficiency might promote carcinogenesis by inducing DNA breaks and DNA hypomethylation. We hypothesized that deficient methylenetetrahydrofolate reductase (MTHFR) genotypes could promote pancreatic cancer development... - Histologic variations in juvenile polyp phenotype correlate with genetic defect underlying juvenile polyposisWillem Arnout van Hattem
Department of Pathology, University Medical Centre Utrecht, Utrecht, The Netherlands
Am J Surg Pathol 35:530-6. 2011..This study compares the histologic phenotype of juvenile polyps with a SMAD4 or BMPR1A germline mutation and sporadic juvenile polyps... - Heteroplasmic mitochondrial DNA mutations in normal and tumour cellsYiping He
The Ludwig Center for Cancer Genetics and Therapeutics and The Howard Hughes Medical Institute at The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland 21231, USA
Nature 464:610-4. 2010..In particular, they demonstrate that individual humans are characterized by a complex mixture of related mitochondrial genotypes rather than a single genotype... - Integrin alpha2 mediates selective metastasis to the liverKiyoshi Yoshimura
Department of Surgery, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, 600 North Wolfe Street, Blalock 685, Baltimore, MD 21287, USA
Cancer Res 69:7320-8. 2009..These findings define integrin alpha2 as a molecule conferring selective potential for formation of hepatic metastasis, as well as a possible target to prevent their formation... - Occurrence of colorectal adenomas in younger adults: an epidemiologic necropsy studyCheryl J Pendergrass
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Clin Gastroenterol Hepatol 6:1011-5. 2008..The colorectal adenoma is the precursor lesion in virtually all colorectal cancers. Occurrence of colorectal adenomas has been studied in older adults but analysis in younger adults is lacking... - Stromal responses to carcinomas of the pancreas: juxtatumoral gene expression conforms to the infiltrating pattern and not the biologic subtypeFrancesca Ricci
Department of Pathology, University La Sapienza, Roma, Italy
Cancer Biol Ther 4:302-7. 2005.... - Immunohistochemical and genetic evaluation of deoxycytidine kinase in pancreatic cancer: relationship to molecular mechanisms of gemcitabine resistance and survivalValeria Sebastiani
Department of Pathology, University La Sapienza, Rome, Italy
Clin Cancer Res 12:2492-7. 2006..In summary, pretreatment levels of dCK protein are most correlated with overall survival following gemcitabine treatment and are stable even after resistance to gemcitabine is clinically documented... - Claudin-4, mitogen-activated protein kinase kinase 4, and stratifin are markers of gastric adenocarcinoma precursor lesionsSteven C Cunningham
Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore Maryland 21231, USA
Cancer Epidemiol Biomarkers Prev 15:281-7. 2006..These findings may prove useful in the diagnosis and therapeutic targeting of gastric adenocarcinoma precursor lesions...
Research Grants
- TARGETS OF METASTATIC PANCREATIC CANCERChristine Iacobuzio Donahue; Fiscal Year: 2007..abstract_text> ..
- TGF-beta Signaling in Pancreatic Cancer ProgressionChristine A Iacobuzio Donahue; Fiscal Year: 2010..In this proposal we will study one of the most common pathways that control growth and normal development, the TGF-b pathway, and the mechanisms by which it is altered to promote pancreatic cancer formation and spread. ..