Genomes and Genes
Mehboob A Hussain
Affiliation: Johns Hopkins University
- Brn-4 transcription factor expression targeted to the early developing mouse pancreas induces ectopic glucagon gene expression in insulin-producing beta cellsMehboob A Hussain
Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02114, USA
J Biol Chem 277:16028-32. 2002..The early developmental expression of Brn-4 appears to be a dominant regulator of the glucagon expressing alpha cell lineage, even in the context of the beta cell lineage...
- Increased pancreatic beta-cell proliferation mediated by CREB binding protein gene activationMehboob A Hussain
Metabolism Division, Department of Pediatrics and Medicine, Johns Hopkins University, 600 N Wolfe Street, CMSC 10 113, Baltimore, MD 21287, USA
Mol Cell Biol 26:7747-59. 2006..In these beta cells, however, glucose-stimulated insulin secretion was diminished, resulting from concomitant CREB-CBP-mediated pgc1a gene activation...
- Exendin-4 stimulation of cyclin A2 in beta-cell proliferationWoo Jin Song
Metabolism Division, Departments of Pediatrics and Medicine, Johns Hopkins University, Baltimore, Maryland, USA
Diabetes 57:2371-81. 2008..We have examined effects, in particular those mediated through intracellular cAMP signaling, of the incretin hormone analog exendin-4 on cell cycle regulation in beta-cells...
- Prkar1a in the regulation of insulin secretionM A Hussain
Department of Pediatrics, Medicine and Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Horm Metab Res 44:759-65. 2012....
- Snapin mediates incretin action and augments glucose-dependent insulin secretionWoo Jin Song
Department of Pediatrics, Metabolism Division, Johns Hopkins University, Baltimore, MD 21287, USA
Cell Metab 13:308-19. 2011..Thus, snapin is a critical node in GSIS regulation and provides a potential therapeutic target to improve β cell function in T2DM...
- Short telomeres compromise β-cell signaling and survivalNini Guo
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
PLoS ONE 6:e17858. 2011..They implicate telomere length as a determinant of β-cell function and diabetes pathogenesis...
- Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding proteinLing He
Division of Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Cell 137:635-46. 2009..Our findings point to CBP phosphorylation at Ser436 by metformin as critical for its therapeutic effect, and as a potential target for pharmaceutical intervention...
- The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cellsZhongyan Zhang
Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Mol Biol Cell 22:2235-45. 2011..Consequently, mice lacking Opa1 in beta cells develop hyperglycemia. The data suggest that the function of Opa1 in the maintenance of the electron transport chain is physiologically relevant in beta cells...
- Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body compositionKeertik Fulzele
Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Cell 142:309-19. 2010....
- Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitorBrad P Barnett
Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Science 330:1689-92. 2010..In addition to serving as a research tool for mapping ghrelin actions, GO-CoA-Tat may help pave the way for clinical targeting of GOAT in metabolic diseases...
- Pancreatic β-Cell Response to Increased Metabolic Demand and to Pharmacologic Secretagogues Requires EPAC2AWoo Jin Song
Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland
Diabetes 62:2796-807. 2013..Our findings advance the rationale for developing EPAC2A-selective pharmacologic activators for β-cell-targeted pharmacotherapy in type 2 diabetes. ..
- The use of animal models to study stem cell therapies for diabetes mellitusWoo Jin Song
Metabolism Division, Department of Pediatrics, Johns Hopkins University, Baltimore, MD 21287, USA
ILAR J 51:74-81. 2009..Although there has been much progress in this area, further research is needed to enhance understanding and improve therapeutic strategies for this widespread disease...
- Exendin-4 as a stimulator of rat insulin I gene promoter activity via bZIP/CRE interactions sensitive to serine/threonine protein kinase inhibitor Ro 31-8220Oleg G Chepurny
Department of Physiology, New York University School of Medicine, New York, New York 10016, USA
Endocrinology 143:2303-13. 2002..It is concluded that the bZIP and CRE-mediated stimulation of RIP1 by Ex-4 explains, at least in part, how this insulinotropic hormone facilitates transcriptional activity of the rat insulin I gene...
- Beta-cell ProliferationFredric E Wondisford; Fiscal Year: 2010..The studies proposed herein are significant because they may lead to therapeutic approaches for treating diabetes mellitus in humans. ..
- Endocrine pancreatic cell regeneration from bone marrowMehboob A Hussain; Fiscal Year: 2010..4) To identify the cell type within BM that contributes to the pancreatic endocrine cell population. The long-term goal of these studies is to evaluate transplantation of BM derived cells as a potential treatment for diabetes mellitus. ..