Richard L Huganir


Affiliation: Johns Hopkins University
Country: USA


  1. Diering G, Huganir R. The AMPA Receptor Code of Synaptic Plasticity. Neuron. 2018;100:314-329 pubmed publisher
  2. Mehta S, Zhang Y, Roth R, Zhang J, Mo A, Tenner B, et al. Single-fluorophore biosensors for sensitive and multiplexed detection of signalling activities. Nat Cell Biol. 2018;20:1215-1225 pubmed publisher
  3. Widagdo J, Chai Y, Ridder M, Chau Y, Johnson R, Sah P, et al. Activity-Dependent Ubiquitination of GluA1 and GluA2 Regulates AMPA Receptor Intracellular Sorting and Degradation. Cell Rep. 2015;: pubmed publisher
    ..These data indicate that ubiquitination is an important regulatory signal for controlling AMPAR function, which may be crucial for synaptic plasticity. ..
  4. Heo S, Diering G, Na C, Nirujogi R, Bachman J, Pandey A, et al. Identification of long-lived synaptic proteins by proteomic analysis of synaptosome protein turnover. Proc Natl Acad Sci U S A. 2018;115:E3827-E3836 pubmed publisher
    ..We show that synapses contain LLPs that may underlie stabile long-lasting changes in synaptic structure and function. ..
  5. Araki Y, Zeng M, Zhang M, Huganir R. Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP. Neuron. 2015;85:173-89 pubmed publisher
  6. Sharma K, Choi S, Zhang Y, Nieland T, Long S, Li M, et al. High-throughput genetic screen for synaptogenic factors: identification of LRP6 as critical for excitatory synapse development. Cell Rep. 2013;5:1330-41 pubmed publisher
  7. Lagerlöf O, Hart G, Huganir R. O-GlcNAc transferase regulates excitatory synapse maturity. Proc Natl Acad Sci U S A. 2017;114:1684-1689 pubmed publisher
    ..There were also fewer and less mature dendritic spines on OGT knockout neurons. These data identify OGT as a molecular mechanism that regulates synapse maturity. ..
  8. Diering G, Heo S, Hussain N, Liu B, Huganir R. Extensive phosphorylation of AMPA receptors in neurons. Proc Natl Acad Sci U S A. 2016;113:E4920-7 pubmed publisher
    ..Furthermore, a large fraction of synapses are positive for phospho-GluA1-containing AMPARs. Our results support the large body of research indicating a prominent role of GluA1 phosphorylation in synaptic plasticity. ..
  9. Tan H, Queenan B, Huganir R. GRIP1 is required for homeostatic regulation of AMPAR trafficking. Proc Natl Acad Sci U S A. 2015;112:10026-31 pubmed publisher
    ..Collectively, our data point to an essential role of GRIP1-mediated AMPAR trafficking during inactivity-induced synaptic scaling. ..

More Information


  1. Lagerlöf O, Slocomb J, Hong I, Aponte Y, Blackshaw S, Hart G, et al. The nutrient sensor OGT in PVN neurons regulates feeding. Science. 2016;351:1293-6 pubmed publisher
    ..These results identify O-GlcNAcylation in ?CaMKII neurons of the PVN as an important molecular mechanism that regulates feeding behavior. ..
  2. Gu Y, Chiu S, Liu B, Wu P, Delannoy M, Lin D, et al. Differential vesicular sorting of AMPA and GABAA receptors. Proc Natl Acad Sci U S A. 2016;113:E922-31 pubmed publisher
    ..Our studies reveal vesicular sorting mechanisms controlling the constitutive exocytosis of AMPA and GABAA receptors, which are critical for the regulation of excitatory and inhibitory responses in neurons. ..
  3. Roth R, Zhang Y, Huganir R. Dynamic imaging of AMPA receptor trafficking in vitro and in vivo. Curr Opin Neurobiol. 2017;45:51-58 pubmed publisher
    ..Here, we discuss key studies and approaches using dynamic imaging to visualize AMPA receptor trafficking in vitro as well as imaging synaptic proteins, including AMPA receptors, in vivo. ..
  4. Chiu S, Diering G, Ye B, Takamiya K, Chen C, Jiang Y, et al. GRASP1 Regulates Synaptic Plasticity and Learning through Endosomal Recycling of AMPA Receptors. Neuron. 2017;93:1405-1419.e8 pubmed publisher
  5. Diering G, Nirujogi R, Roth R, Worley P, Pandey A, Huganir R. Homer1a drives homeostatic scaling-down of excitatory synapses during sleep. Science. 2017;355:511-515 pubmed publisher
    ..Our data suggest that homeostatic scaling-down, a global form of synaptic plasticity, is active during sleep to remodel synapses and participates in the consolidation of contextual memory. ..
  6. Gu Y, Huganir R. Identification of the SNARE complex mediating the exocytosis of NMDA receptors. Proc Natl Acad Sci U S A. 2016;113:12280-12285 pubmed
    ..Our study uncovers the postsynaptic function of the SNAP25-VAMP1-syntaxin4 complex in mediating the constitutive exocytosis of NMDA receptors, suggesting that this SNARE complex is involved in excitatory synaptic transmission. ..
  7. Goldschmidt H, Tu Sekine B, Volk L, Anggono V, Huganir R, Raben D. DGKθ Catalytic Activity Is Required for Efficient Recycling of Presynaptic Vesicles at Excitatory Synapses. Cell Rep. 2016;14:200-7 pubmed publisher
    ..Our data establish a role for DGK catalytic activity at the presynaptic nerve terminal in SV recycling. Altogether, these data suggest that DGKθ supports synaptic transmission during periods of elevated neuronal activity. ..
  8. Hussain N, Thomas G, Luo J, Huganir R. Regulation of AMPA receptor subunit GluA1 surface expression by PAK3 phosphorylation. Proc Natl Acad Sci U S A. 2015;112:E5883-90 pubmed publisher
    ..Collectively, these data delineate a novel signal cascade regulating AMPAR trafficking that may contribute to the molecular mechanisms that govern learning and cognition. ..
  9. Toda A, Huganir R. Regulation of AMPA receptor phosphorylation by the neuropeptide PACAP38. Proc Natl Acad Sci U S A. 2015;112:6712-7 pubmed publisher
    ..These results demonstrate that the neuropeptide PACAP38 inversely regulates the phosphorylation of two distinct sites on GluA1 and may play an important role modulating AMPAR function and synaptic plasticity in the brain. ..
  10. Volk L, Chiu S, Sharma K, Huganir R. Glutamate synapses in human cognitive disorders. Annu Rev Neurosci. 2015;38:127-49 pubmed publisher
    ..We first present a brief overview of glutamatergic synapses and then explore the genetic and phenotypic evidence for altered glutamate signaling in ID, ASD, and SCZ. ..
  11. Diering G, Gustina A, Huganir R. PKA-GluA1 coupling via AKAP5 controls AMPA receptor phosphorylation and cell-surface targeting during bidirectional homeostatic plasticity. Neuron. 2014;84:790-805 pubmed publisher
    ..Finally, we show that AMPARs scale differentially based on their phosphorylation status at S845. These results show that rearrangement in PKA signaling controls AMPAR phosphorylation and surface targeting during homeostatic plasticity. ..
  12. Hussain N, Diering G, Sole J, Anggono V, Huganir R. Sorting Nexin 27 regulates basal and activity-dependent trafficking of AMPARs. Proc Natl Acad Sci U S A. 2014;111:11840-5 pubmed publisher
    ..Loss of SNX27 abolishes recruitment of surface AMPARs during chemical LTP. Collectively, our data suggest a role for SNX27 in modulating synaptic plasticity through regulated interaction with AMPARs. ..