Walter C Hubbard

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Detection and quantitation of fatty acid acyl conjugates of triamcinolone acetonide via gas chromatography-electron-capture negative-ion mass spectrometry
    Walter C Hubbard
    Division of Allergy and Clinical Immunology, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Anal Biochem 322:243-50. 2003
  2. ncbi request reprint Combined liquid chromatography-tandem mass spectrometry as an analytical method for high throughput screening for X-linked adrenoleukodystrophy and other peroxisomal disorders: preliminary findings
    Walter C Hubbard
    Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Osler 527, Baltimore, MD 21287, USA
    Mol Genet Metab 89:185-7. 2006
  3. doi request reprint Newborn screening for X-linked adrenoleukodystrophy (X-ALD): validation of a combined liquid chromatography-tandem mass spectrometric (LC-MS/MS) method
    Walter C Hubbard
    Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Osler 527, Baltimore, MD 21287, USA
    Mol Genet Metab 97:212-20. 2009
  4. doi request reprint Combined extraction of acyl carnitines and 26:0 lysophosphatidylcholine from dried blood spots: prospective newborn screening for X-linked adrenoleukodystrophy
    Yana Sandlers
    Department of Pediatrics at Johns Hopkins University, Baltimore, MD 21205, USA
    Mol Genet Metab 105:416-20. 2012
  5. ncbi request reprint Quantitative analysis of sphingoid base-1-phosphates as bisacetylated derivatives by liquid chromatography-tandem mass spectrometry
    Evgeny V Berdyshev
    Division of Pulmonary Critical Care Medicine, Johns Hopkins University, MFL Building, Center Tower, Room 683, 5200 Eastern Avenue, Baltimore, MD 21224, USA
    Anal Biochem 339:129-36. 2005
  6. pmc Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice
    Irina Petrache
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, JHAAC, 4B 65, Baltimore, Maryland 21224, USA
    Nat Med 11:491-8. 2005
  7. pmc A highly sensitive ultra performance liquid chromatography-tandem mass spectrometric (UPLC-MS/MS) technique for quantitation of protein free and bound efavirenz (EFV) in human seminal and blood plasma
    Lindsay B Avery
    Department of Pharmacology and Molecular Sciences, Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Osler 527, Baltimore, MD 21287, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 878:3217-24. 2010
  8. pmc Newborn screening for X-linked adrenoleukodystrophy: further evidence high throughput screening is feasible
    Christiane Theda
    Royal Women s Hospital, Neonatal Services, 20 Flemington Road, Parkville VIC 3052, Australia The University of Melbourne and the Murdoch Childrens Research Institute, Melbourne, Australia Frederick Memorial Hospital, 400 W 7th Street, Frederick, MD 21701, USA Department of Pediatrics, Johns Hopkins University School of Medicine, Johns Hopkins Children s Center, 1800 Orleans Street, Baltimore, MD 21287, USA Electronic address
    Mol Genet Metab 111:55-7. 2014
  9. pmc Apoptotic sphingolipid signaling by ceramides in lung endothelial cells
    Terry R Medler
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Respir Cell Mol Biol 38:639-46. 2008
  10. pmc Characterization and application of a disease-cell model for a neurodegenerative lysosomal disease
    Jameson J Ribbens
    McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Genet Metab 111:172-83. 2014

Research Grants

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Detection and quantitation of fatty acid acyl conjugates of triamcinolone acetonide via gas chromatography-electron-capture negative-ion mass spectrometry
    Walter C Hubbard
    Division of Allergy and Clinical Immunology, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Anal Biochem 322:243-50. 2003
    ....
  2. ncbi request reprint Combined liquid chromatography-tandem mass spectrometry as an analytical method for high throughput screening for X-linked adrenoleukodystrophy and other peroxisomal disorders: preliminary findings
    Walter C Hubbard
    Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Osler 527, Baltimore, MD 21287, USA
    Mol Genet Metab 89:185-7. 2006
    ..There was no overlap between normal subjects versus affected subjects...
  3. doi request reprint Newborn screening for X-linked adrenoleukodystrophy (X-ALD): validation of a combined liquid chromatography-tandem mass spectrometric (LC-MS/MS) method
    Walter C Hubbard
    Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Osler 527, Baltimore, MD 21287, USA
    Mol Genet Metab 97:212-20. 2009
    ..These studies clearly show that the method is highly sensitive and accurate in identifying individuals with a defect in peroxisomal beta-oxidation such as X-ALD...
  4. doi request reprint Combined extraction of acyl carnitines and 26:0 lysophosphatidylcholine from dried blood spots: prospective newborn screening for X-linked adrenoleukodystrophy
    Yana Sandlers
    Department of Pediatrics at Johns Hopkins University, Baltimore, MD 21205, USA
    Mol Genet Metab 105:416-20. 2012
    ..It successfully combines the existing method for acyl carnitine analysis and 26:0 lysophosphatidyl choline that can be applied for prospective X-ALD newborn screening...
  5. ncbi request reprint Quantitative analysis of sphingoid base-1-phosphates as bisacetylated derivatives by liquid chromatography-tandem mass spectrometry
    Evgeny V Berdyshev
    Division of Pulmonary Critical Care Medicine, Johns Hopkins University, MFL Building, Center Tower, Room 683, 5200 Eastern Avenue, Baltimore, MD 21224, USA
    Anal Biochem 339:129-36. 2005
    ..6+/-0.2 pmol/ml, respectively. The addition of sphingosine (1 microM) to human pulmonary artery endothelial cells in culture resulted in a more than 20-fold increase in the cellular level of S1P, whereas the level of DHS1P was unchanged...
  6. pmc Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice
    Irina Petrache
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, JHAAC, 4B 65, Baltimore, Maryland 21224, USA
    Nat Med 11:491-8. 2005
    ..Finally, increased lung ceramides in individuals with smoking-induced emphysema suggests that ceramide upregulation may be a crucial pathogenic element and a promising target in this disease that currently lacks effective therapies...
  7. pmc A highly sensitive ultra performance liquid chromatography-tandem mass spectrometric (UPLC-MS/MS) technique for quantitation of protein free and bound efavirenz (EFV) in human seminal and blood plasma
    Lindsay B Avery
    Department of Pharmacology and Molecular Sciences, Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Osler 527, Baltimore, MD 21287, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 878:3217-24. 2010
    ..0>244.1 and m/z 298.0>227.9. The time required for the analysis of each sample was 8.0min. The analytical technique is capable of a reliable detection limit of ∼15-20fmol of EFV injected on column...
  8. pmc Newborn screening for X-linked adrenoleukodystrophy: further evidence high throughput screening is feasible
    Christiane Theda
    Royal Women s Hospital, Neonatal Services, 20 Flemington Road, Parkville VIC 3052, Australia The University of Melbourne and the Murdoch Childrens Research Institute, Melbourne, Australia Frederick Memorial Hospital, 400 W 7th Street, Frederick, MD 21701, USA Department of Pediatrics, Johns Hopkins University School of Medicine, Johns Hopkins Children s Center, 1800 Orleans Street, Baltimore, MD 21287, USA Electronic address
    Mol Genet Metab 111:55-7. 2014
    ..We prospectively applied this method to 4689 newborn blood spot samples; no false positives were observed. We show that high throughput neonatal screening for ALD is methodologically feasible. ..
  9. pmc Apoptotic sphingolipid signaling by ceramides in lung endothelial cells
    Terry R Medler
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Respir Cell Mol Biol 38:639-46. 2008
    ..The serine palmitoyl synthase-regulated ceramides synthesis may contribute to the amplification of pulmonary vascular injury induced by excessive ceramides...
  10. pmc Characterization and application of a disease-cell model for a neurodegenerative lysosomal disease
    Jameson J Ribbens
    McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Genet Metab 111:172-83. 2014
    ....
  11. ncbi request reprint Intermittent hypoxia induces hyperlipidemia in lean mice
    Jianguo Li
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA
    Circ Res 97:698-706. 2005
    ....
  12. pmc Superoxide dismutase protects against apoptosis and alveolar enlargement induced by ceramide
    Irina Petrache
    Division of Pulmonary, Allergy, Critical Care, and Occupational Medicine, Indiana University, Indianapolis, Indiana 46202 5120, USA
    Am J Physiol Lung Cell Mol Physiol 295:L44-53. 2008
    ..This work implicates excessive lung ceramides as amplifiers of lung injury through redox-dependent mechanisms...

Research Grants1

  1. Micromass Quattro API TSQ For LC-MS/MS Quantitation
    Walter Hubbard; Fiscal Year: 2002
    ..abstract_text> ..