MAUREEN RENEE HORTON

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Rheumatoid arthritis-associated interstitial lung disease: diagnostic dilemma
    Mark J Hamblin
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, 1830 East Monument Street, 5th Floor, Baltimore, MD 21205, USA
    Pulm Med 2011:872120. 2011
  2. pmc Pulmonary vaccination as a novel treatment for lung fibrosis
    Samuel L Collins
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 7:e31299. 2012
  3. pmc Pulmonary delivery of docosahexaenoic acid mitigates bleomycin-induced pulmonary fibrosis
    Hongyun Zhao
    Department of Medicine, Johns Hopkins University School of Medicine, 1830 East Monument Street, 5th Floor, Baltimore, MD, USA
    BMC Pulm Med 14:64. 2014
  4. pmc Hyaluronan fragments induce IFNβ via a novel TLR4-TRIF-TBK1-IRF3-dependent pathway
    Katharine E Black
    Department of Medicine, John Hopkins University School of Medicine, Baltimore, USA
    J Inflamm (Lond) 10:23. 2013
  5. doi request reprint Thalidomide for the treatment of cough in idiopathic pulmonary fibrosis: a randomized trial
    Maureen R Horton
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Intern Med 157:398-406. 2012
  6. doi request reprint Revisiting thalidomide: fighting with caution against idiopathic pulmonary fibrosis
    M R Horton
    Johns Hopkins University School of Medicine, Departmewnt of Medicine, Pulmonary and Critical Care Medicine, Baltimore, Maryland 21205, USA
    Drugs Today (Barc) 48:661-71. 2012
  7. ncbi request reprint Rheumatoid arthritis associated interstitial lung disease
    Maureen R Horton
    Johns Hopkins University School of Medicine, Division of Pulmonary and Critical Care Medicine, Baltimore, Maryland 21205, USA
    Crit Rev Comput Tomogr 45:429-40. 2004
  8. ncbi request reprint Primary pulmonary arterial hypertension presenting as diffuse micronodules on CT
    M R Horton
    Johns Hopkins University School of Medicine, Division of Pulmonary and Critical Care Medicine, Department of Pathology, Baltimore, Maryland 21205, USA
    Crit Rev Comput Tomogr 45:335-41. 2004
  9. ncbi request reprint Pulmonary alveolar proteinosis
    Maureen R Horton
    Johns Hopkins University School of Medicine, Division of Pulmonary and Critical Care Medicine, Baltimore, Maryland 21205, USA
    Crit Rev Comput Tomogr 44:321-45. 2003
  10. pmc Anti-oxidant inhibition of hyaluronan fragment-induced inflammatory gene expression
    Michael Eberlein
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Inflamm (Lond) 5:20. 2008

Collaborators

Detail Information

Publications20

  1. pmc Rheumatoid arthritis-associated interstitial lung disease: diagnostic dilemma
    Mark J Hamblin
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, 1830 East Monument Street, 5th Floor, Baltimore, MD 21205, USA
    Pulm Med 2011:872120. 2011
    ..Finally, we will explore the known and experimental treatment options that may have some benefit in the treatment of RA-ILD...
  2. pmc Pulmonary vaccination as a novel treatment for lung fibrosis
    Samuel L Collins
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 7:e31299. 2012
    ..Our findings clearly demonstrate the role of T cells in regulating pulmonary fibrosis as well as suggest that vaccinia-induced immunotherapy in the lung may prove to be a novel treatment approach to this otherwise fatal disease...
  3. pmc Pulmonary delivery of docosahexaenoic acid mitigates bleomycin-induced pulmonary fibrosis
    Hongyun Zhao
    Department of Medicine, Johns Hopkins University School of Medicine, 1830 East Monument Street, 5th Floor, Baltimore, MD, USA
    BMC Pulm Med 14:64. 2014
    ..Since n-3 polyunsaturated fatty acids (n-3 PUFAs) may beneficially modulate immune responses in a variety of inflammatory disorders, we investigated the therapeutic role of docosahexaenoic acid (DHA), a single n-3 PUFA, in lung fibrosis...
  4. pmc Hyaluronan fragments induce IFNβ via a novel TLR4-TRIF-TBK1-IRF3-dependent pathway
    Katharine E Black
    Department of Medicine, John Hopkins University School of Medicine, Baltimore, USA
    J Inflamm (Lond) 10:23. 2013
    ..HA fragments are known to induce inflammatory gene expression via TLR-MyD88-dependent pathways...
  5. doi request reprint Thalidomide for the treatment of cough in idiopathic pulmonary fibrosis: a randomized trial
    Maureen R Horton
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Intern Med 157:398-406. 2012
    ..Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disorder of unknown cause with no effective treatment. Cough affects up to 80% of patients with IPF, is frequently disabling, and lacks effective therapy...
  6. doi request reprint Revisiting thalidomide: fighting with caution against idiopathic pulmonary fibrosis
    M R Horton
    Johns Hopkins University School of Medicine, Departmewnt of Medicine, Pulmonary and Critical Care Medicine, Baltimore, Maryland 21205, USA
    Drugs Today (Barc) 48:661-71. 2012
    ..It remains to be seen whether the immunomodulatory and antiangiogenic properties of thalidomide will also make it a potential therapy against the clinical progression of IPF...
  7. ncbi request reprint Rheumatoid arthritis associated interstitial lung disease
    Maureen R Horton
    Johns Hopkins University School of Medicine, Division of Pulmonary and Critical Care Medicine, Baltimore, Maryland 21205, USA
    Crit Rev Comput Tomogr 45:429-40. 2004
    ..This article aims to clarify the current clinical, radiographic and pathologic status of RA-ILD...
  8. ncbi request reprint Primary pulmonary arterial hypertension presenting as diffuse micronodules on CT
    M R Horton
    Johns Hopkins University School of Medicine, Division of Pulmonary and Critical Care Medicine, Department of Pathology, Baltimore, Maryland 21205, USA
    Crit Rev Comput Tomogr 45:335-41. 2004
    ....
  9. ncbi request reprint Pulmonary alveolar proteinosis
    Maureen R Horton
    Johns Hopkins University School of Medicine, Division of Pulmonary and Critical Care Medicine, Baltimore, Maryland 21205, USA
    Crit Rev Comput Tomogr 44:321-45. 2003
  10. pmc Anti-oxidant inhibition of hyaluronan fragment-induced inflammatory gene expression
    Michael Eberlein
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Inflamm (Lond) 5:20. 2008
    ..HA fragments, via a TLR and NF-kappaB pathway, induce inflammatory gene expression in macrophages and epithelial cells. NAC and DMSO are potent anti-oxidants which may help balance excess ROS states...
  11. ncbi request reprint Threat matrix: low-molecular-weight hyaluronan (HA) as a danger signal
    Jonathan D Powell
    Bunting Blaustein Cancer Research Building, Johns Hopkins University School of Medicine, 1650 Orleans Street, Baltimore, MD 21231, USA
    Immunol Res 31:207-18. 2005
    ..In this review we hypothesize that low-molecular-weight species of the extracellular matrix polymer hyaluronan also performs this function by acting as an endogenous danger signal...
  12. ncbi request reprint NF-kappa B activation mediates the cross-talk between extracellular matrix and interferon-gamma (IFN-gamma) leading to enhanced monokine induced by IFN-gamma (MIG) expression in macrophages
    Maureen R Horton
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Biol Chem 277:43757-62. 2002
    ..These data emphasize the ability of "degraded self" to activate/modify immune responses through the NF-kappaB pathway...
  13. pmc Hyaluronan fragments promote inflammation by down-regulating the anti-inflammatory A2a receptor
    Samuel L Collins
    Department of Medicine, Division of Pulmonary and Critical Care, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Am J Respir Cell Mol Biol 45:675-83. 2011
    ..By defining the pro- and anti-inflammatory properties of extracellular matrix components, we will be better able to identify specific pharmacologic targets as potential therapies...
  14. ncbi request reprint Advanced visualization of airways with 64-MDCT: 3D mapping and virtual bronchoscopy
    Karen M Horton
    Department of Radiology, Johns Hopkins Medical Institutions, 601 N Caroline St, JHOC 3253, Baltimore, MD 21287, USA
    AJR Am J Roentgenol 189:1387-96. 2007
    ..Interest in virtual bronchoscopy is increasing as a result of improvements in computer hardware and software and advances in MDCT that allow acquisition of isotropic data...
  15. ncbi request reprint A clinician's guide to the diagnosis and treatment of interstitial lung diseases
    Sonye K Danoff
    Department of Medicine, Johns Hopkins University School of Medicine, 1830 East Monument Street, 5th Floor, Baltimore, MD 21205, USA
    South Med J 100:579-87. 2007
    ..This review will assist internists in the recognition and management of ILD, provide a benchmark for pulmonary referrals, and offer guidance in advising patients with this life-threatening disorder...
  16. ncbi request reprint Hyaluronan fragments act as an endogenous danger signal by engaging TLR2
    Kara A Scheibner
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, 1830 East Monument Street, Baltimore, MD 21205, USA
    J Immunol 177:1272-81. 2006
    ..Furthermore, we show that intact high m.w. HA can inhibit TLR-2 signaling. Finally, we demonstrate that LMW HA can act as an adjuvant promoting Ag-specific T cell responses in vivo in wild-type but not TLR-2(null) mice...
  17. ncbi request reprint Differential regulation of hyaluronan-induced IL-8 and IP-10 in airway epithelial cells
    Sada Boodoo
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Am J Physiol Lung Cell Mol Physiol 291:L479-86. 2006
    ..Furthermore, hyaluronan, by inducing IL-8 and IP-10 by distinct pathways, provides a unique target for differential regulation of key inflammatory chemokines...
  18. ncbi request reprint Egr-2 and Egr-3 are negative regulators of T cell activation
    Meredith Safford
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Immunol 6:472-80. 2005
    ..These data support the idea that Egr-2 and Egr-3 are involved in promoting a T cell receptor-induced negative regulatory genetic program...
  19. pmc The adenosine a2a receptor inhibits matrix-induced inflammation in a novel fashion
    Kara A Scheibner
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Respir Cell Mol Biol 40:251-9. 2009
    ....

Research Grants11

  1. REGULATION OF MATRIX-INDUCED GENES IN LUNG MACROPHAGES
    Maureen Horton; Fiscal Year: 2003
    ..These studies should allow the applicant to further enhance and develop her research skills and enable her to pursue the basic molecular mechanisms of pulmonary fibrosis that might lead to novel treatment approaches. ..
  2. Hyaluronan-induced signaling and gene regulation
    MAUREEN RENEE HORTON; Fiscal Year: 2010
    ..We believe that these studies will provide the pre-clinical basis for the use of specific agents in the treatment of inflammatory lung dis13ases such as idiopathic pulmonary fibrosis, chronic bronchitis and emphysema. ..
  3. The A2a adenosine receptor modulates hyaluronan mediated lung inflammation
    Maureen Horton; Fiscal Year: 2009
    ..We believe that these studies will provide the pre-clinical basis for the use of A2aR specific agonists in the treatment of inflammatory lung diseases such as idiopathic pulmonary fibrosis, chronic bronchitis and emphysema. ..
  4. Hyaluronan-induced signaling and gene regulation
    Maureen Horton; Fiscal Year: 2009
    ..We believe that these studies will provide the pre-clinical basis for the use of specific agents in the treatment of inflammatory lung dis13ases such as idiopathic pulmonary fibrosis, chronic bronchitis and emphysema. ..
  5. The A2a adenosine receptor modulates hyaluronan mediated lung inflammation
    Maureen Horton; Fiscal Year: 2007
    ..We believe that these studies will provide the pre-clinical basis for the use of A2aR specific agonists in the treatment of inflammatory lung diseases such as idiopathic pulmonary fibrosis, chronic bronchitis and emphysema. ..
  6. Hyaluronan-induced signaling and gene regulation
    Maureen Horton; Fiscal Year: 2006
    ..The elucidation of the role of ECM in inflammation may lead to a better understanding of the process of fibrosis as well as to new targets for novel treatment strategies. ..
  7. Hyaluronan-induced signaling and gene regulation
    Maureen Horton; Fiscal Year: 2005
    ..The elucidation of the role of ECM in inflammation may lead to a better understanding of the process of fibrosis as well as to new targets for novel treatment strategies. ..
  8. Hyaluronan-induced signaling and gene regulation
    Maureen Horton; Fiscal Year: 2004
    ..The elucidation of the role of ECM in inflammation may lead to a better understanding of the process of fibrosis as well as to new targets for novel treatment strategies. ..
  9. Hyaluronan-induced signaling and gene regulation
    Maureen Horton; Fiscal Year: 2003
    ..The elucidation of the role of ECM in inflammation may lead to a better understanding of the process of fibrosis as well as to new targets for novel treatment strategies. ..
  10. The A2a adenosine receptor modulates hyaluronan mediated lung inflammation
    MAUREEN RENEE HORTON; Fiscal Year: 2010
    ..We believe that these studies will provide the pre-clinical basis for the use of A2aR specific agonists in the treatment of inflammatory lung diseases such as idiopathic pulmonary fibrosis, chronic bronchitis and emphysema. ..