Research Topics
Species | Peter HollandSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Role of amygdala central nucleus in feature negative discriminationsPeter C Holland
Department of Psychological and Brain Sciences, Johns Hopkins University, USA
Behav Neurosci 126:670-80. 2012..The results are consistent with modern reformulations of both cue and reward processing theories that assign roles for both individual and aggregate error terms in associative learning...- Formation of excitatory and inhibitory associations between absent eventsPeter C Holland
Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
J Exp Psychol Anim Behav Process 34:324-35. 2008..The results indicated that the nature of representation-mediated learning is influenced by some of the same variables as more standard associative learning... 
Effects of hippocampal lesions in overshadowing and blocking proceduresPeter C Holland
Department of Psychological and Brain Sciences, Duke University, USA
Behav Neurosci 117:650-6. 2003....- Variations in unconditioned stimulus processing in unblockingPeter C Holland
Department of Psychological and Brain Sciences, Duke University, Durham, NC, USA
J Exp Psychol Anim Behav Process 31:155-71. 2005..The roles of reinforcement error signals in conditioning are discussed... - Enhanced conditioning produced by surprising increases in reinforcer value are unaffected by lesions of the amygdala central nucleusPeter C Holland
Johns Hopkins University, USA
Neurobiol Learn Mem 85:30-5. 2006..These results indicate that CN circuitry implicated in surprise-induced increases in event processing is preferentially engaged when expected events are omitted, and not when unexpected events are presented... - Amount of training and cue-evoked taste-reactivity responding in reinforcer devaluationPeter C Holland
Johns Hopkins University, Baltimore, MD 21218, USA
J Exp Psychol Anim Behav Process 34:119-32. 2008..Early in training, CSs may be capable of activating preevaluative processing of an absent food reinforcer that includes information about its palatability, but that capability is lost as training proceeds... - A neural systems analysis of the potentiation of feeding by conditioned stimuliPeter C Holland
Johns Hopkins University, 222 Ames Hall, 3400 North Charles St, Baltimore, MD 21218, USA
Physiol Behav 86:747-61. 2005.... - Amount of training effects in representation-mediated food aversion learning: no evidence of a role for associability changesPeter C Holland
Johns Hopkins University, Baltimore, Maryland 22128, USA
Learn Behav 33:464-78. 2005..These results suggest that the nature of associatively activated event representations changes over the course of training... - Different roles for amygdala central nucleus and substantia innominata in the surprise-induced enhancement of learningPeter C Holland
Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
J Neurosci 26:3791-7. 2006..Additional circuitry linking these brain regions may also be important in the maintenance of that information... - Limitations on representation-mediated potentiation of flavour or odour aversionsPeter C Holland
Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
Q J Exp Psychol (Hove) 59:233-50. 2006.... - Cognitive versus stimulus-response theories of learningPeter C Holland
Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
Learn Behav 36:227-41. 2008..In the course of describing Spence's views and my research, I hope to communicate some of the richness of Spence's S-R psychology and its currency within modern scientific analyses of behavior... - Disconnection of the amygdala central nucleus and the substantia innominata/nucleus basalis magnocellularis disrupts performance in a sustained attention taskPeter C Holland
Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
Behav Neurosci 121:80-9. 2007..The lesions impaired performance under conditions of increased attentional load, suggesting that a circuit that includes CeA and SI/nBM regulates these aspects of attention... - Amygdala-frontal interactions and reward expectancyPeter C Holland
Department of Psychological and Brain Sciences, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
Curr Opin Neurobiol 14:148-55. 2004.... - Relations between Pavlovian-instrumental transfer and reinforcer devaluationPeter C Holland
Department of Psychological and Brain Sciences, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
J Exp Psychol Anim Behav Process 30:104-17. 2004.... - The effects of amygdala lesions on conditioned stimulus-potentiated eating in ratsPeter C Holland
Department of Psychological and Brain Sciences, Duke University, Box 90086, Durham, NC 27708 0086, USA
Physiol Behav 76:117-29. 2002..These results are considered in the context of anatomical projections from these amygdalar areas to other brain regions involved in feeding, and the role of amygdala subregions in the acquisition of motivational value in conditioning... - Double dissociation of the effects of lesions of basolateral and central amygdala on conditioned stimulus-potentiated feeding and Pavlovian-instrumental transferPeter C Holland
Johns Hopkins University, 3400 North Charles St, 105 Ames Hall, Baltimore, MD 21218, USA
Eur J Neurosci 17:1680-94. 2003..Implications of the double dissociation of these two aspects of Pavlovian conditioned incentive motivation for amygdala function in associative learning are considered... - Operant and Pavlovian control of visual stimulus orienting and food-related behaviors in rats with lesions of the amygdala central nucleusPeter C Holland
Department of Psychological and Brain Sciences, Duke University, USA
Behav Neurosci 116:577-87. 2002.... - Control of appetitive and aversive taste-reactivity responses by an auditory conditioned stimulus in a devaluation task: a FOS and behavioral analysisErin C Kerfoot
Johns Hopkins University, Baltimore, Maryland 21218, USA
Learn Mem 14:581-9. 2007..Thus, through associative learning, auditory cues for food gained access to neural processing in several brain regions importantly involved in the processing of taste memory information... - Amygdalo-hypothalamic circuit allows learned cues to override satiety and promote eatingGorica D Petrovich
Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
J Neurosci 22:8748-53. 2002.... - Dissociable effects of disconnecting amygdala central nucleus from the ventral tegmental area or substantia nigra on learned orienting and incentive motivationHeather El-Amamy
Johns Hopkins University, Department of Psychological and Brain Sciences, 3400 North Charles Street, Baltimore, MD 21218, USA
Eur J Neurosci 25:1557-67. 2007..Otherwise, unilateral lesions of either midbrain region impaired transfer. Implications of these results for circuit models of amygdalo-striatal interactions in associative learning are discussed... - Dissociation of attention in learning and action: effects of lesions of the amygdala central nucleus, medial prefrontal cortex, and posterior parietal cortexJean Marie Maddux
Department of Psychological and Brain Sciences, John Hopkins University, Baltimore, MD 21218, USA
Behav Neurosci 121:63-79. 2007..These results are consistent with the view that CEA affects these distinct aspects of attention by influencing the activity of separate, specialized cortical regions via modulation of SI/nBM... - Narp regulates long-term aversive effects of morphine withdrawalIrving M Reti
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland, USA
Behav Neurosci 122:760-8. 2008..Taken together, these studies suggest that Narp modulates both acquisition and extinction of aversive responses to morphine withdrawal and, therefore, may regulate plasticity processes underlying drug addiction... - Different roles for orbitofrontal cortex and basolateral amygdala in a reinforcer devaluation taskCharles L Pickens
Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
J Neurosci 23:11078-84. 2003..In contrast, the OFC seems essential for one or more of these latter processes... - Amygdala central nucleus function is necessary for learning but not expression of conditioned visual orientingMichael McDannald
Johns Hopkins University, 222 Ames Hall, 3400 North Charles St, Baltimore, MD 21218, USA
Eur J Neurosci 20:240-8. 2004..Specialized roles for components of a circuit for conditioned orienting, which includes the central nucleus, the substantia nigra, and dorsolateral striatum, are discussed... - Lesions of orbitofrontal cortex impair rats' differential outcome expectancy learning but not conditioned stimulus-potentiated feedingMichael A McDannald
Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
J Neurosci 25:4626-32. 2005.... - The basolateral amygdala mediates the effects of cues associated with meal interruption on feeding behaviorEzequiel M Galarce
Johns Hopkins University, USA
Brain Res 1350:112-22. 2010..These studies extend our knowledge of the psychological and neural processes underlying cue-induced feeding. Understanding these mechanisms may contribute our understanding of the etiology and treatment of binge eating disorders... - Rat orbitofrontal cortex separately encodes response and outcome information during performance of goal-directed behaviorTomoyuki Furuyashiki
Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
J Neurosci 28:5127-38. 2008..These data demonstrate a broader role of OFC information processing in goal-directed behavior, beyond its widely recognized role in outcome expectancy... - A role for alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid GluR1 phosphorylation in the modulatory effects of appetitive reward cues on goal-directed behaviorHans S Crombag
Department of Psychological and Brain Sciences, Neurogenetics and Behavior Center, The Johns Hopkins University, Baltimore, MD, USA
Eur J Neurosci 27:3284-91. 2008.... - Substantia nigra pars compacta is critical to both the acquisition and expression of learned orienting of ratsHeather El-Amamy
Johns Hopkins University, 222 Ames Hall, 3400 North Charles Street, Baltimore, MD 21218, USA
Eur J Neurosci 24:270-6. 2006..Together with our previous findings, these results suggest that the SNc is trained by the CeA during learning and maintains acquired information so that it may modulate DLS sensory-motor function at the time of action... - Learned contextual cue potentiates eating in ratsGorica D Petrovich
Department of Psychological and Brain Sciences, Johns Hopkins University, 3400 North Charles St, Baltimore, MD 21218, United States
Physiol Behav 90:362-7. 2007..Furthermore, the data suggest that CS-potentiation of eating does not induce a general motivation to eat, akin to hunger, but instead more likely produces a more specific motivational state, akin to craving... - Effects of cues associated with meal interruption on feeding behaviorEzequiel M Galarce
Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, United States
Appetite 52:693-702. 2009..These experiments may provide a novel animal model of binge-like behaviors in sated rats induced by external cues paired with meal interruption... - The brain-derived neurotrophic factor receptor TrkB is critical for the acquisition but not expression of conditioned incentive valueAlexander W Johnson
Department of Psychological and Brain Sciences, Neurogenetics and Behavior Center, Johns Hopkins University, Baltimore, MD 21218, USA
Eur J Neurosci 28:997-1002. 2008.... - The basolateral amygdala is critical to the expression of pavlovian and instrumental outcome-specific reinforcer devaluation effectsAlexander W Johnson
Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
J Neurosci 29:696-704. 2009..Thus, BLA apparently plays a critical role in maintaining or using sensory associations of reinforcer value when multiple outcomes must be coded but not under single-outcome conditions... - The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine neurons, encodes aversive stimuli and inhibits motor responsesThomas C Jhou
Behavioral Neuroscience Branch, National Institute on Drug Abuse, Baltimore, MD 21224, USA
Neuron 61:786-800. 2009..These findings suggest that aversive inputs from widespread brain regions and stimulus modalities converge onto the RMTg, which opposes reward and motor-activating functions of midbrain dopamine neurons... - Disconnection of the basolateral amygdala complex and nucleus accumbens impairs appetitive pavlovian second-order conditioned responsesBarry Setlow
Department of Psychology, Johns Hopkins University, Baltimore, Maryland 21218, USA
Behav Neurosci 116:267-75. 2002..The results suggest that the ABL and accumbens are part of a system critical for processing information about learned motivational value... - Assessing the role of the growth hormone secretagogue receptor in motivational learning and food intakeAlexander W Johnson
Neurogenetics and Behavior Center, Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD, 21218, USA
Behav Neurosci 123:1058-65. 2009..These results suggest dissociable functions of GHS-R in its influence over motivational learning and ingestive behavior... - Associatively learned representations of taste outcomes activate taste-encoding neural ensembles in gustatory cortexMichael P Saddoris
Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
J Neurosci 29:15386-96. 2009..Such representations may provide outcome-specific information for guiding goal-directed behavior... - The basolateral complex of the amygdala is necessary for acquisition but not expression of CS motivational value in appetitive Pavlovian second-order conditioningBarry Setlow
Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
Eur J Neurosci 15:1841-53. 2002.... - Orbitofrontal lesions impair use of cue-outcome associations in a devaluation taskCharles L Pickens
Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
Behav Neurosci 119:317-22. 2005..Gallagher, P. C. Holland, & G. Schoenbaum, 2003), these results indicate that the OFC is critical for the maintenance of information about the current incentive value of reinforcers or the use of that information to guide behavior... - Role of amygdalo-nigral circuitry in conditioning of a visual stimulus paired with foodHongjoo J Lee
Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
J Neurosci 25:3881-8. 2005..These experiments demonstrate a role for amygdalo-nigral circuitry in learned modulation of attention to signals for biologically significant events... - A selective role for neuronal activity regulated pentraxin in the processing of sensory-specific incentive valueAlexander W Johnson
Neurogenetics and Behavior Center, Johns Hopkins University, Baltimore, Maryland 21218, USA
J Neurosci 27:13430-5. 2007..These data suggest Narp has a selective role in processing sensory-specific information necessary for appropriate devaluation performance, but not in general motivational effects of reward-predictive cues on performance... - A necessary role for GluR1 serine 831 phosphorylation in appetitive incentive learningHans S Crombag
Department of Psychological and Brain Sciences, Neurogenetics and Behavior Center, Johns Hopkins University, Baltimore, MD 21218, USA
Behav Brain Res 191:178-83. 2008..Our findings provide novel evidence for a molecular mechanism in a form of appetitive incentive learning critical in regulating normal motivated behavior, as well as maladaptive forms such as addiction and eating disorders... - Excitatory and inhibitory learning with absent stimuliDaniel S Wheeler
Department of Psychological and Brain Sciences, John Hopkins University, Baltimore, MD 21218, USA
J Exp Psychol Anim Behav Process 34:247-55. 2008..The results show the dynamic influence of temporal contiguity on mediated learning... - Reinforcer-specificity of appetitive and consummatory behavior of rats after Pavlovian conditioning with food reinforcersEzequiel M Galarce
Department of Psychological and Brain Sciences, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, United States
Physiol Behav 91:95-105. 2007..The closer an action comes to ingestion, the more it is controlled by sensory properties conveyed by learned cues. These data are discussed in the context of allostatic regulation of food foraging and intake... - Medial prefrontal cortex is necessary for an appetitive contextual conditioned stimulus to promote eating in sated ratsGorica D Petrovich
Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
J Neurosci 27:6436-41. 2007..The current findings suggest a critical role for vmPFC in the brain network that mediates control of conditioned motivation to eat perhaps by a mechanism akin to appetite or craving... - Role of substantia nigra-amygdala connections in surprise-induced enhancement of attentionHongjoo J Lee
Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
J Neurosci 26:6077-81. 2006..These results show that SNc-CeA communication is critical to mechanisms by which the coding of prediction error by midbrain dopamine neurons is translated into enhancement of attention and learning modulated by the cholinergic system... - Amygdalar and prefrontal pathways to the lateral hypothalamus are activated by a learned cue that stimulates eatingGorica D Petrovich
Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
J Neurosci 25:8295-302. 2005..Our results indicate that a cue that has acquired the ability to promote eating in sated rats (CS+) strongly activates a functional network formed by direct pathways from the BL/BM and orbitomedial prefrontal cortex to the LHA... - Localized disruption of Narp in medial prefrontal cortex blocks reinforcer devaluation performanceAlexander W Johnson
Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland 21218, USA
Learn Mem 17:620-6. 2010..Thus, these results indicate that Narp released from mPFC neurons plays a key role in mediating synaptic changes underlying instrumental reinforcer devaluation... - Narp deletion blocks extinction of morphine place preference conditioningHans S Crombag
Department of Psychological and Brain Sciences, Neurogenetics and Behavior Center, The Johns Hopkins University, Baltimore, MD, USA
Neuropsychopharmacology 34:857-66. 2009..Thus, these findings indicate that Narp plays a selective role in extinction, possibly by its effects on AMPA receptor trafficking... - Lesions of basolateral amygdala impair extinction of CS motivational value, but not of explicit conditioned responses, in Pavlovian appetitive second-order conditioningJohn L Lindgren
Department of Psychological and Brain Sciences, Duke University, Durham, NC, USA
Eur J Neurosci 17:160-6. 2003.... - Conditioning and cognitionCharles L Pickens
Department of Psychological and Brain Sciences, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
Neurosci Biobehav Rev 28:651-61. 2004..The importance of identifying both cognitive process and brain system bases of performance in animal models is emphasized... - Amygdala central nucleus function is necessary for learning, but not expression, of conditioned auditory orientingFrank Groshek
Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
Behav Neurosci 119:202-12. 2005..Thus, although the central nucleus is critical to the acquisition of information required for conditioned orienting to auditory cues, it is not needed for maintaining this information for later use... 
Deficits in sensory-specific devaluation task performance following genetic deletions of cannabinoid (CB1) receptorHans S Crombag
Neurogenetics and Behavior Center, Department of Psychological and Brain Sciences, The Johns Hopkins University, Baltimore, Maryland 21218, USA
Learn Mem 17:18-22. 2010..These results identify a critical role for CB1 receptor in the ability of animals to represent, update, and/or use sensory-specific outcome representations to alter appetitive behaviors...- Learning processes affecting human decision making: An assessment of reinforcer-selective Pavlovian-to-instrumental transfer following reinforcer devaluationMelissa J Allman
Department of Behavioral Psychology, Kennedy Krieger Institute, Baltimore, MD, USA
J Exp Psychol Anim Behav Process 36:402-8. 2010..These results are discussed in terms of implications for understanding associative learning processes in humans and the ability of reward-paired cues to direct adaptive and maladaptive behavior... - Pavlovian influences on goal-directed behavior in mice: the role of cue-reinforcer relationsHans S Crombag
Department of Psychological and Brain Sciences, The Johns Hopkins University, Baltimore, Maryland 21218, USA
Learn Mem 15:299-303. 2008..Whereas 10-sec training conditions produced strong CRf (and no PIT), 2-min training conditions produced robust PIT (but no CRf)... - The influence of CS-US interval on several different indices of learning in appetitive conditioningAndrew R Delamater
Department of Psychology, Brooklyn College of the City University of New York, Brooklyn, New York 11210, USA
J Exp Psychol Anim Behav Process 34:202-22. 2008....
Research Grants
- Amygdala systems in associative learningPeter Holland; Fiscal Year: 2007..The proposed studies will clarify the CEA's roles in the modulation of basal forebrain cholinergic systems and midbrain-striatal dopamine systems in food-based associative learning. ..
- Associatively-activated event representationsPeter Holland; Fiscal Year: 2006..The proposed research provides a basis for the understanding of basic processing of imaginal events in associative learning. ..
- Role of amygdala systems in associative learningPeter Holland; Fiscal Year: 2005..abstract_text> ..
- AMYGDALA SYSTEMS AND ASSOCIATIVE LEARNINGPeter Holland; Fiscal Year: 1999..The proposed behavioral and neurobiological studies may provide new insights into cognitive functions of the amygdala, as well as relations between cognitive and motivational functions in associative learning. ..