J T Holbrook

Summary

Affiliation: Johns Hopkins Bloomberg School of Public Health
Country: USA

Publications

  1. ncbi request reprint Risk factors for advancement of cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome. Studies of Ocular Complications of AIDS Research Group
    J T Holbrook
    Center for Clinical Trials, Department of Epidemiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Arch Ophthalmol 118:1196-204. 2000
  2. pmc Evaluation of the United States public health service guidelines for discontinuation of anticytomegalovirus therapy after immune recovery in patients with cytomegalovirus retinitis
    Janet T Holbrook
    Center for Clinical Trials, Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21232, USA
    Am J Ophthalmol 152:628-637.e1. 2011
  3. pmc Challenges in the design and implementation of the Multicenter Uveitis Steroid Treatment (MUST) Trial--lessons for comparative effectiveness trials
    Janet T Holbrook
    Center for Clinical Trials, Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
    Clin Trials 8:736-43. 2011
  4. ncbi request reprint Visual loss in patients with cytomegalovirus retinitis and acquired immunodeficiency syndrome before widespread availability of highly active antiretroviral therapy
    Janet T Holbrook
    Center for Clinical Trials, Johns Hopkins University, 615 N Wolfe St, Room W5010, Baltimore, MD 21205, USA
    Arch Ophthalmol 121:99-107. 2003
  5. ncbi request reprint Photographic measures of cytomegalovirus retinitis as surrogates for visual outcomes in treated patients
    J T Holbrook
    Center for Clinical Trials, Johns Hopkins University, 615 N Wolfe St, Room 5010, Baltimore, MD 21205
    Arch Ophthalmol 119:554-63. 2001
  6. ncbi request reprint Drug distribution for a large crossover trial of the safety of inactivated influenza vaccine in asthmatics
    Janet T Holbrook
    Center for Clinical Trials, Bloomberg School of Hygiene and Public Health, The Johns Hopkins University, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Control Clin Trials 23:87-92. 2002
  7. ncbi request reprint Data and safety monitoring board deliberations resulting in the early termination of the Monoclonal Antibody Cytomegalovirus Retinitis Trial
    Adele M Kaplan Gilpin
    Center for Clinical Trials, The Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Control Clin Trials 24:92-8. 2003
  8. pmc Excess mortality in patients with AIDS in the era of highly active antiretroviral therapy: temporal changes and risk factors
    Milo A Puhan
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Clin Infect Dis 51:947-56. 2010
  9. ncbi request reprint Longitudinal study of the ocular complications of AIDS: 1. Ocular diagnoses at enrollment
    Douglas A Jabs
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 114:780-6. 2007
  10. ncbi request reprint Longitudinal study of the ocular complications of AIDS: 2. Ocular examination results at enrollment
    Douglas A Jabs
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 114:787-93. 2007

Detail Information

Publications25

  1. ncbi request reprint Risk factors for advancement of cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome. Studies of Ocular Complications of AIDS Research Group
    J T Holbrook
    Center for Clinical Trials, Department of Epidemiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Arch Ophthalmol 118:1196-204. 2000
    ..To identify ocular and systemic factors that predict advancement of cytomegalovirus (CMV) retinitis during treatment...
  2. pmc Evaluation of the United States public health service guidelines for discontinuation of anticytomegalovirus therapy after immune recovery in patients with cytomegalovirus retinitis
    Janet T Holbrook
    Center for Clinical Trials, Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21232, USA
    Am J Ophthalmol 152:628-637.e1. 2011
    ....
  3. pmc Challenges in the design and implementation of the Multicenter Uveitis Steroid Treatment (MUST) Trial--lessons for comparative effectiveness trials
    Janet T Holbrook
    Center for Clinical Trials, Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
    Clin Trials 8:736-43. 2011
    ..Randomized clinical trials (RCTs) are an important component of comparative effectiveness (CE) research because they are the optimal design for head-to-head comparisons of different treatment options...
  4. ncbi request reprint Visual loss in patients with cytomegalovirus retinitis and acquired immunodeficiency syndrome before widespread availability of highly active antiretroviral therapy
    Janet T Holbrook
    Center for Clinical Trials, Johns Hopkins University, 615 N Wolfe St, Room W5010, Baltimore, MD 21205, USA
    Arch Ophthalmol 121:99-107. 2003
    ..To evaluate rates and causes of visual loss among patients with acquired immunodeficiency syndrome (AIDS) and cytomegalovirus (CMV) retinitis before widespread availability of highly active antiretroviral therapy (HAART)...
  5. ncbi request reprint Photographic measures of cytomegalovirus retinitis as surrogates for visual outcomes in treated patients
    J T Holbrook
    Center for Clinical Trials, Johns Hopkins University, 615 N Wolfe St, Room 5010, Baltimore, MD 21205
    Arch Ophthalmol 119:554-63. 2001
    ..To evaluate photographic measures of cytomegalovirus (CMV) retinitis as surrogate outcomes for changes in vision in patients with CMV retinitis related to the acquired immunodeficiency syndrome...
  6. ncbi request reprint Drug distribution for a large crossover trial of the safety of inactivated influenza vaccine in asthmatics
    Janet T Holbrook
    Center for Clinical Trials, Bloomberg School of Hygiene and Public Health, The Johns Hopkins University, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Control Clin Trials 23:87-92. 2002
    ..Utilizing individual syringe kits, using the same identification for patient, kit, and drug assignment, and dispensing drug from a central facility helped to successfully meet these challenges...
  7. ncbi request reprint Data and safety monitoring board deliberations resulting in the early termination of the Monoclonal Antibody Cytomegalovirus Retinitis Trial
    Adele M Kaplan Gilpin
    Center for Clinical Trials, The Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Control Clin Trials 24:92-8. 2003
    ....
  8. pmc Excess mortality in patients with AIDS in the era of highly active antiretroviral therapy: temporal changes and risk factors
    Milo A Puhan
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Clin Infect Dis 51:947-56. 2010
    ..We assessed temporal changes in excess mortality and elucidated risk factors for excess mortality in patients with AIDS diagnosed in the era of highly active antiretroviral therapy (HAART)...
  9. ncbi request reprint Longitudinal study of the ocular complications of AIDS: 1. Ocular diagnoses at enrollment
    Douglas A Jabs
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 114:780-6. 2007
    ..To report the prevalence of ocular complications of AIDS in the era of highly active antiretroviral therapy (HAART)...
  10. ncbi request reprint Longitudinal study of the ocular complications of AIDS: 2. Ocular examination results at enrollment
    Douglas A Jabs
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 114:787-93. 2007
    ..To report the clinical features on eye examination of patients with AIDS in the era of highly active antiretroviral therapy (HAART)...
  11. ncbi request reprint Influence of filgrastim (granulocyte colony-stimulating factor) on human immunodeficiency virus type 1 RNA in patients with cytomegalovirus retinitis
    Michael Davidson
    Center for Clinical Trials, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    J Infect Dis 186:1013-8. 2002
    ..87 (P=.12) and respective log mean rates of change per month of -0.08 versus -0.21 (P=.08). This latter difference has borderline statistical significance, which suggests that filgrastim may reduce the decline of HIV-1 RNA loads...
  12. ncbi request reprint Causes of visual acuity loss among patients with AIDS and cytomegalovirus retinitis in the era of highly active antiretroviral therapy
    Jennifer E Thorne
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 113:1441-5. 2006
    ..To quantitate the frequencies of the common causes of visual acuity loss for patients with AIDS and cytomegalovirus (CMV) retinitis in the era of highly active antiretroviral therapy (HAART)...
  13. ncbi request reprint Incidence of and risk factors for visual acuity loss among patients with AIDS and cytomegalovirus retinitis in the era of highly active antiretroviral therapy
    Jennifer E Thorne
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 113:1432-40. 2006
    ..To describe the incidence of and risk factors for visual acuity loss among patients with AIDS and cytomegalovirus (CMV) retinitis in the era of highly active antiretroviral therapy (HAART)...
  14. ncbi request reprint Risk factors for mortality in patients with AIDS in the era of highly active antiretroviral therapy
    Douglas A Jabs
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 112:771-9. 2005
    ..To evaluate risk factors for mortality among patients with AIDS in the era of highly active antiretroviral therapy (HAART), particularly the effect of cytomegalovirus (CMV)...
  15. ncbi request reprint Use of filgrastim as adjuvant therapy in patients with AIDS-related cytomegalovirus retinitis
    Michael Davidson
    Center for Clinical Trials, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA
    AIDS 16:757-65. 2002
    ..Neutropenia in AIDS predisposes to bacterial infection. Granulocyte colony-stimulating factor (filgrastim) can reverse neutropenia...
  16. ncbi request reprint Effect of cytomegalovirus retinitis on the risk of visual acuity loss among patients with AIDS
    Jennifer E Thorne
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ophthalmology 114:591-8. 2007
    ....
  17. ncbi request reprint Solid malignancies among patients in the Wegener's Granulomatosis Etanercept Trial
    John H Stone
    Johns Hopkins University, Baltimore, Maryland, USA
    Arthritis Rheum 54:1608-18. 2006
    ..This study was undertaken to further explore the potential association between anti-TNF therapy and the development of malignancy in these patients...
  18. pmc Randomized trial of the effect of drug presentation on asthma outcomes: the American Lung Association Asthma Clinical Research Centers
    Robert A Wise
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 124:436-44, 444e1-8. 2009
    ..Although asthma symptoms often improve with placebo, it is not known whether the response to placebo or active treatment can be augmented by increasing expectation of benefit...
  19. ncbi request reprint Allergic rhinitis and sinusitis in asthma: differential effects on symptoms and pulmonary function
    Anne E Dixon
    Pulmonary and Critical Care Medicine, University of Vermont, Burlington, 05401, USA
    Chest 130:429-35. 2006
    ..The purpose of this study was to determine the impact of self-reported allergic rhinitis and sinusitis on lower airway disease in a large cohort of participants with well-characterized asthma...
  20. ncbi request reprint Clinician versus reading center assessment of cytomegalovirus retinitis lesion size
    David V Weinberg
    Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Ophthalmology 112:559-66. 2005
    ....
  21. ncbi request reprint Immune response to influenza vaccination in children and adults with asthma: effect of corticosteroid therapy
    Nicola A Hanania
    Pulmonary and Critical Care Medicine, Baylor College of Medicine, 1504 Taub Loop, Houston, TX 77030, USA
    J Allergy Clin Immunol 113:717-24. 2004
    ..However, the effect of maintenance corticosteroid therapy on the immune response to influenza vaccine has received limited evaluation...
  22. ncbi request reprint Randomized comparison of strategies for reducing treatment in mild persistent asthma
    Stephen P Peters
    Wake Forest University, Winston Salem, NC, USA
    N Engl J Med 356:2027-39. 2007
    ....
  23. ncbi request reprint Dietary intake of soy genistein is associated with lung function in patients with asthma
    Lewis J Smith
    Feinberg School of Medicine, Northwestern University, Evanston, Illinois, USA
    J Asthma 41:833-43. 2004
    ..Thus, increasing consumption of genistein is associated with better lung function in patients with asthma. Further studies are needed to determine whether dietary supplementation with genistein can reduce asthma severity...
  24. ncbi request reprint Effect of obesity on clinical presentation and response to treatment in asthma
    Anne E Dixon
    University of Vermont, Burlington, VT 05401, USA
    J Asthma 43:553-8. 2006
    ..Obese and non-obese asthmatics have similar lung function abnormalities, but comorbidities and altered responses to medications may significantly affect asthma control in obese people...
  25. ncbi request reprint The C523A beta2 adrenergic receptor polymorphism associates with markers of asthma severity in African Americans
    John J Lima
    The American Lung Association Asthma Clinical Research Centers, Jacksonville, Florida, USA
    J Asthma 43:185-91. 2006
    ..018). Symptom scores, pulmonary function, and rescue inhaler use paralleled exacerbation prevalence. We conclude the 523 A allele modifies asthma severity in African Americans...