Research Topics
| J T HolbrookSummaryAffiliation: Johns Hopkins Bloomberg School of Public Health Country: USA Publications
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Detail Information
Publications
Risk factors for advancement of cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome. Studies of Ocular Complications of AIDS Research GroupJ T Holbrook
Center for Clinical Trials, Department of Epidemiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Arch Ophthalmol 118:1196-204. 2000..To identify ocular and systemic factors that predict advancement of cytomegalovirus (CMV) retinitis during treatment...
Evaluation of the United States public health service guidelines for discontinuation of anticytomegalovirus therapy after immune recovery in patients with cytomegalovirus retinitisJanet T Holbrook
Center for Clinical Trials, Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21232, USA
Am J Ophthalmol 152:628-637.e1. 2011....
Challenges in the design and implementation of the Multicenter Uveitis Steroid Treatment (MUST) Trial--lessons for comparative effectiveness trialsJanet T Holbrook
Center for Clinical Trials, Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
Clin Trials 8:736-43. 2011..Randomized clinical trials (RCTs) are an important component of comparative effectiveness (CE) research because they are the optimal design for head-to-head comparisons of different treatment options...- Visual loss in patients with cytomegalovirus retinitis and acquired immunodeficiency syndrome before widespread availability of highly active antiretroviral therapyJanet T Holbrook
Center for Clinical Trials, Johns Hopkins University, 615 N Wolfe St, Room W5010, Baltimore, MD 21205, USA
Arch Ophthalmol 121:99-107. 2003..To evaluate rates and causes of visual loss among patients with acquired immunodeficiency syndrome (AIDS) and cytomegalovirus (CMV) retinitis before widespread availability of highly active antiretroviral therapy (HAART)... - Photographic measures of cytomegalovirus retinitis as surrogates for visual outcomes in treated patientsJ T Holbrook
Center for Clinical Trials, Johns Hopkins University, 615 N Wolfe St, Room 5010, Baltimore, MD 21205
Arch Ophthalmol 119:554-63. 2001..To evaluate photographic measures of cytomegalovirus (CMV) retinitis as surrogate outcomes for changes in vision in patients with CMV retinitis related to the acquired immunodeficiency syndrome... - Drug distribution for a large crossover trial of the safety of inactivated influenza vaccine in asthmaticsJanet T Holbrook
Center for Clinical Trials, Bloomberg School of Hygiene and Public Health, The Johns Hopkins University, 615 N Wolfe Street, Baltimore, MD 21205, USA
Control Clin Trials 23:87-92. 2002..Utilizing individual syringe kits, using the same identification for patient, kit, and drug assignment, and dispensing drug from a central facility helped to successfully meet these challenges... - Data and safety monitoring board deliberations resulting in the early termination of the Monoclonal Antibody Cytomegalovirus Retinitis TrialAdele M Kaplan Gilpin
Center for Clinical Trials, The Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
Control Clin Trials 24:92-8. 2003.... - Excess mortality in patients with AIDS in the era of highly active antiretroviral therapy: temporal changes and risk factorsMilo A Puhan
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Clin Infect Dis 51:947-56. 2010..We assessed temporal changes in excess mortality and elucidated risk factors for excess mortality in patients with AIDS diagnosed in the era of highly active antiretroviral therapy (HAART)... - Longitudinal study of the ocular complications of AIDS: 1. Ocular diagnoses at enrollmentDouglas A Jabs
Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Ophthalmology 114:780-6. 2007..To report the prevalence of ocular complications of AIDS in the era of highly active antiretroviral therapy (HAART)... - Longitudinal study of the ocular complications of AIDS: 2. Ocular examination results at enrollmentDouglas A Jabs
Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Ophthalmology 114:787-93. 2007..To report the clinical features on eye examination of patients with AIDS in the era of highly active antiretroviral therapy (HAART)... - Influence of filgrastim (granulocyte colony-stimulating factor) on human immunodeficiency virus type 1 RNA in patients with cytomegalovirus retinitisMichael Davidson
Center for Clinical Trials, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
J Infect Dis 186:1013-8. 2002..87 (P=.12) and respective log mean rates of change per month of -0.08 versus -0.21 (P=.08). This latter difference has borderline statistical significance, which suggests that filgrastim may reduce the decline of HIV-1 RNA loads... - Causes of visual acuity loss among patients with AIDS and cytomegalovirus retinitis in the era of highly active antiretroviral therapyJennifer E Thorne
Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Ophthalmology 113:1441-5. 2006..To quantitate the frequencies of the common causes of visual acuity loss for patients with AIDS and cytomegalovirus (CMV) retinitis in the era of highly active antiretroviral therapy (HAART)... - Incidence of and risk factors for visual acuity loss among patients with AIDS and cytomegalovirus retinitis in the era of highly active antiretroviral therapyJennifer E Thorne
Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Ophthalmology 113:1432-40. 2006..To describe the incidence of and risk factors for visual acuity loss among patients with AIDS and cytomegalovirus (CMV) retinitis in the era of highly active antiretroviral therapy (HAART)... - Risk factors for mortality in patients with AIDS in the era of highly active antiretroviral therapyDouglas A Jabs
Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Ophthalmology 112:771-9. 2005..To evaluate risk factors for mortality among patients with AIDS in the era of highly active antiretroviral therapy (HAART), particularly the effect of cytomegalovirus (CMV)... - Use of filgrastim as adjuvant therapy in patients with AIDS-related cytomegalovirus retinitisMichael Davidson
Center for Clinical Trials, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA
AIDS 16:757-65. 2002..Although a reduction in crude risk of some bacterial infections with filgrastim use was detected, after adjustment for potentially confounding factors these risks were smaller and no longer statistically significant... - Effect of cytomegalovirus retinitis on the risk of visual acuity loss among patients with AIDSJennifer E Thorne
Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Ophthalmology 114:591-8. 2007.... - Solid malignancies among patients in the Wegener's Granulomatosis Etanercept TrialJohn H Stone
Johns Hopkins University, Baltimore, Maryland, USA
Arthritis Rheum 54:1608-18. 2006..This study was undertaken to further explore the potential association between anti-TNF therapy and the development of malignancy in these patients... - Randomized trial of the effect of drug presentation on asthma outcomes: the American Lung Association Asthma Clinical Research CentersRobert A Wise
Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
J Allergy Clin Immunol 124:436-44, 444e1-8. 2009..Although asthma symptoms often improve with placebo, it is not known whether the response to placebo or active treatment can be augmented by increasing expectation of benefit... - Allergic rhinitis and sinusitis in asthma: differential effects on symptoms and pulmonary functionAnne E Dixon
Pulmonary and Critical Care Medicine, University of Vermont, Burlington, 05401, USA
Chest 130:429-35. 2006..The purpose of this study was to determine the impact of self-reported allergic rhinitis and sinusitis on lower airway disease in a large cohort of participants with well-characterized asthma... - Clinician versus reading center assessment of cytomegalovirus retinitis lesion sizeDavid V Weinberg
Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
Ophthalmology 112:559-66. 2005..Clinician assessment of retinitis area correlates negatively with VF, a clinically meaningful visual outcome in patients with CMV retinitis... - Immune response to influenza vaccination in children and adults with asthma: effect of corticosteroid therapyNicola A Hanania
Pulmonary and Critical Care Medicine, Baylor College of Medicine, 1504 Taub Loop, Houston, TX 77030, USA
J Allergy Clin Immunol 113:717-24. 2004..However, the effect of maintenance corticosteroid therapy on the immune response to influenza vaccine has received limited evaluation... - Randomized comparison of strategies for reducing treatment in mild persistent asthmaStephen P Peters
Wake Forest University, Winston Salem, NC, USA
N Engl J Med 356:2027-39. 2007.... - Dietary intake of soy genistein is associated with lung function in patients with asthmaLewis J Smith
Feinberg School of Medicine, Northwestern University, Evanston, Illinois, USA
J Asthma 41:833-43. 2004..Thus, increasing consumption of genistein is associated with better lung function in patients with asthma. Further studies are needed to determine whether dietary supplementation with genistein can reduce asthma severity... - Effect of obesity on clinical presentation and response to treatment in asthmaAnne E Dixon
University of Vermont, Burlington, VT 05401, USA
J Asthma 43:553-8. 2006..Obese and non-obese asthmatics have similar lung function abnormalities, but comorbidities and altered responses to medications may significantly affect asthma control in obese people... - The C523A beta2 adrenergic receptor polymorphism associates with markers of asthma severity in African AmericansJohn J Lima
The American Lung Association Asthma Clinical Research Centers, Jacksonville, Florida, USA
J Asthma 43:185-91. 2006..018). Symptom scores, pulmonary function, and rescue inhaler use paralleled exacerbation prevalence. We conclude the 523 A allele modifies asthma severity in African Americans...