Ahmet Hoke

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Treadmill exercise induced functional recovery after peripheral nerve repair is associated with increased levels of neurotrophic factors
    Jae Sung Park
    Departments of Neurology and Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 9:e90245. 2014
  2. doi request reprint Challenges in developing novel therapies for peripheral neuropathies: a summary of The Foundation for Peripheral Neuropathy Scientific Symposium 2012
    Ahmet Hoke
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Peripher Nerv Syst 18:1-6. 2013
  3. pmc Animal models of peripheral neuropathies
    Ahmet Hoke
    Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD 21205, USA
    Neurotherapeutics 9:262-9. 2012
  4. ncbi request reprint Neuroprotection in the peripheral nervous system: rationale for more effective therapies
    Ahmet Hoke
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Arch Neurol 63:1681-5. 2006
  5. ncbi request reprint Mechanisms of Disease: what factors limit the success of peripheral nerve regeneration in humans?
    Ahmet Hoke
    Neuromuscular Division, Department of Neurology at Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Nat Clin Pract Neurol 2:448-54. 2006
  6. ncbi request reprint In search of novel treatments for peripheral neuropathies and nerve regeneration
    Ahmet Hoke
    Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Discov Med 7:109-12. 2007
  7. ncbi request reprint Neuroprotection in the PNS: erythropoietin and immunophilin ligands
    Ahmet Hoke
    Department of Neurology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Path 509, Baltimore, Maryland 21287, USA
    Ann N Y Acad Sci 1053:491-501. 2005
  8. ncbi request reprint Proteoglycans in axonal regeneration
    Ahmet Hoke
    Department of Neurology, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Path 509, Baltimore, MD 21287, USA
    Exp Neurol 195:273-7. 2005
  9. pmc A (heat) shock to the system promotes peripheral nerve regeneration
    Ahmet Hoke
    Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    J Clin Invest 121:4231-4. 2011
  10. ncbi request reprint Glial cell line-derived neurotrophic factor alters axon schwann cell units and promotes myelination in unmyelinated nerve fibers
    Ahmet Hoke
    Johns Hopkins Hospital, Department of Neurology, Baltimore, Maryland 21205, and Amgen, Inc, Thousand Oaks, California 91320 1799, USA
    J Neurosci 23:561-7. 2003

Detail Information

Publications56

  1. pmc Treadmill exercise induced functional recovery after peripheral nerve repair is associated with increased levels of neurotrophic factors
    Jae Sung Park
    Departments of Neurology and Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 9:e90245. 2014
    ....
  2. doi request reprint Challenges in developing novel therapies for peripheral neuropathies: a summary of The Foundation for Peripheral Neuropathy Scientific Symposium 2012
    Ahmet Hoke
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Peripher Nerv Syst 18:1-6. 2013
    ....
  3. pmc Animal models of peripheral neuropathies
    Ahmet Hoke
    Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD 21205, USA
    Neurotherapeutics 9:262-9. 2012
    ..Future clinical trials will be needed to validate the translational usefulness of this outcome measure and validation against accepted outcome measures that rely on clinical symptoms or examination findings in patients...
  4. ncbi request reprint Neuroprotection in the peripheral nervous system: rationale for more effective therapies
    Ahmet Hoke
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Arch Neurol 63:1681-5. 2006
    ..Mechanistic studies that examine the axon-glia interaction and axonal biology are likely to yield novel therapeutic targets for peripheral neuropathies...
  5. ncbi request reprint Mechanisms of Disease: what factors limit the success of peripheral nerve regeneration in humans?
    Ahmet Hoke
    Neuromuscular Division, Department of Neurology at Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Nat Clin Pract Neurol 2:448-54. 2006
    ....
  6. ncbi request reprint In search of novel treatments for peripheral neuropathies and nerve regeneration
    Ahmet Hoke
    Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Discov Med 7:109-12. 2007
    ..Drug development programs should be aimed at understanding mechanisms of distal axonal degeneration and take into account the critical role Schwann cells play in axonal maintenance and nerve regeneration...
  7. ncbi request reprint Neuroprotection in the PNS: erythropoietin and immunophilin ligands
    Ahmet Hoke
    Department of Neurology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Path 509, Baltimore, Maryland 21287, USA
    Ann N Y Acad Sci 1053:491-501. 2005
    ..Both EPO and non-immunosuppressive immunophilin ligands are in early clinical development for the treatment of acquired peripheral neuropathies...
  8. ncbi request reprint Proteoglycans in axonal regeneration
    Ahmet Hoke
    Department of Neurology, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Path 509, Baltimore, MD 21287, USA
    Exp Neurol 195:273-7. 2005
  9. pmc A (heat) shock to the system promotes peripheral nerve regeneration
    Ahmet Hoke
    Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    J Clin Invest 121:4231-4. 2011
    ..In this issue of the JCI, Ma and colleagues show that this can be achieved in mice by overexpression of heat shock protein 27, providing hope for enhanced functional recovery in patients after peripheral nerve damage...
  10. ncbi request reprint Glial cell line-derived neurotrophic factor alters axon schwann cell units and promotes myelination in unmyelinated nerve fibers
    Ahmet Hoke
    Johns Hopkins Hospital, Department of Neurology, Baltimore, Maryland 21205, and Amgen, Inc, Thousand Oaks, California 91320 1799, USA
    J Neurosci 23:561-7. 2003
    ..This study demonstrates that the administration of high doses of a growth factor to adult rats can change the phenotype of nerve fibers from unmyelinated to myelinated...
  11. pmc Novel roles for osteopontin and clusterin in peripheral motor and sensory axon regeneration
    Megan C Wright
    Departments of Neurology, Neuroscience, and Orthopedics, The Johns Hopkins School of Medicine, Baltimore, Maryland 21287, and Departments of Neurology and Psychiatry, University of California, Los Angeles, Los Angeles, California 90095
    J Neurosci 34:1689-700. 2014
    ..Together, these studies suggest unique roles for SC-derived OPN and CLU in regeneration of peripheral motor and sensory axons. ..
  12. pmc Human Schwann cells retain essential phenotype characteristics after immortalization
    Helmar C Lehmann
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Stem Cells Dev 21:423-31. 2012
    ..These cells are particularly useful for drug screening and studies aimed at disease mechanisms involving SCs...
  13. ncbi request reprint Erythropoietin protects sensory axons against paclitaxel-induced distal degeneration
    Giorgia Melli
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Neurobiol Dis 24:525-30. 2006
    ..These findings suggest that recombinant human erythropoietin may be useful as a therapy to prevent paclitaxel-induced sensory polyneuropathy in patients undergoing chemotherapy...
  14. ncbi request reprint Immortalized neural stem cells differ from nonimmortalized cortical neurospheres and cerebellar granule cell progenitors
    Ruifa Mi
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA
    Exp Neurol 194:301-19. 2005
    ..2 transplants but not with other cells. We suggest that, while C17.2 cells can illustrate many fundamental aspects of neural biology and are useful in their own right, their unique properties cannot be generalized...
  15. ncbi request reprint Spatially distinct and functionally independent mechanisms of axonal degeneration in a model of HIV-associated sensory neuropathy
    Giorgia Melli
    Department of Neurology, Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Brain 129:1330-8. 2006
    ..Furthermore, chemokine receptor inhibitors, which are currently being developed as HIV entry inhibitor drugs, may also have a therapeutic role in HIV-associated peripheral neuropathies by preventing axonal degeneration...
  16. ncbi request reprint Transplanted neural stem cells promote axonal regeneration through chronically denervated peripheral nerves
    Walter Heine
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA
    Exp Neurol 189:231-40. 2004
    ..These findings suggest that improved regeneration in the PNS can be accomplished by combining neurotrophic factor support and removal of axon growth inhibitory components in the extracellular matrix...
  17. pmc An in vitro model of adult mammalian nerve repair
    Alka Vyas
    Department of Orthopaedic Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Exp Neurol 223:112-8. 2010
    ..The flexibility and control offered by this technique should thus make it a useful tool for the study of regeneration biology...
  18. ncbi request reprint Ethoxyquin prevents chemotherapy-induced neurotoxicity via Hsp90 modulation
    Jing Zhu
    Departments of Neurology and Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD
    Ann Neurol 74:893-904. 2013
    ....
  19. pmc Pleiotrophin is a neurotrophic factor for spinal motor neurons
    Ruifa Mi
    Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 104:4664-9. 2007
    ..Our findings suggest a neurotrophic role for PTN that may lead to previously unrecognized treatment options for motor neuron disease and motor axonal regeneration...
  20. pmc Axonal protective effects of the myelin-associated glycoprotein
    Thien Nguyen
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Neurosci 29:630-7. 2009
    ..Exploiting this pathway may lead to therapeutic strategies for neurological diseases characterized by axonal loss...
  21. ncbi request reprint Establishment of a rodent model of HIV-associated sensory neuropathy
    Sanjay C Keswani
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Neurosci 26:10299-304. 2006
    ..This model will be useful in examining mechanisms of distal axonal degeneration and testing potential neuroprotective compounds that may prevent development of the sensory neuropathy...
  22. ncbi request reprint FK506-binding protein localizations in human penile innervation
    Gwen Lagoda
    Department of Urology, The Johns Hopkins Medical Institutions, Baltimore, MD 21287 2411, USA
    BJU Int 101:604-9. 2008
    ....
  23. pmc Immortalization and characterization of a nociceptive dorsal root ganglion sensory neuronal line
    Weiran Chen
    Department of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    J Peripher Nerv Syst 12:121-30. 2007
    ..The immortalized DRG neuronal cell line 50B11 can be used for high-throughput drug screening for neuroprotective agents for axonal degeneration and antinociceptive drugs that block TRPV-1...
  24. ncbi request reprint Motor neuron disease occurring in a mutant dynactin mouse model is characterized by defects in vesicular trafficking
    Fiona M Laird
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 28:1997-2005. 2008
    ..This novel mouse model will be instrumental for not only clarifying disease mechanisms in ALS, but also for testing therapeutic strategies to ameliorate this devastating disease...
  25. pmc The lateral thoracic nerve and the cutaneous maximus muscle--a novel in vivo model system for nerve degeneration and regeneration studies
    Baohan Pan
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21205, USA
    Exp Neurol 236:6-18. 2012
    ..The presence of the LTN and the CMM in a variety of species and its easy accessibility suggests that this in vivo model system offers considerable promise for future nerve degeneration and regeneration research...
  26. pmc Mitochondrial dysfunction in distal axons contributes to human immunodeficiency virus sensory neuropathy
    Helmar C Lehmann
    Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
    Ann Neurol 69:100-10. 2011
    ....
  27. ncbi request reprint Erythropoietin is neuroprotective in models of HIV sensory neuropathy
    Sanjay C Keswani
    Department of Neurology, The Johns Hopkins Hospital, 600 North Wolfe Street, Pathology 627A, Baltimore, MD 21287, USA
    Neurosci Lett 371:102-5. 2004
    ..Our results suggest that EPO may be useful in the treatment of HIV-SN...
  28. pmc Neuroimmunophilin ligands protect cavernous nerves after crush injury in the rat: new experimental paradigms
    Heather Valentine
    Department of Research, Guilford Pharmaceuticals Inc now MGI Pharma, Baltimore, Maryland 21287, United States
    Eur Urol 51:1724-31. 2007
    ....
  29. ncbi request reprint The use of GAP-43 mRNA quantification in high throughput screening of putative neuroprotective agents in dorsal root ganglion cultures
    Sanjay C Keswani
    Department of Neurology, Johns Hopkins University, 600 N Wolfe St, Path 509, Baltimore, MD 21287, USA
    J Neurosci Methods 136:193-5. 2004
    ..This was prevented, in a dose-dependent manner, by co-administration of FK506. This assay, performed in a 96-well format, can easily be scaled for high throughput screening (HTS) using robotic systems...
  30. ncbi request reprint Schwann cell chemokine receptors mediate HIV-1 gp120 toxicity to sensory neurons
    Sanjay C Keswani
    Department of Neurology, The Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Ann Neurol 54:287-96. 2003
    ..This newly described Schwann cell-neuron interaction may be pathogenically relevant not only in HIV-SN but also in other peripheral neuropathies...
  31. pmc Peripheral hyperstimulation alters site of disease onset and course in SOD1 rats
    Angelo C Lepore
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neurobiol Dis 39:252-64. 2010
    ....
  32. doi request reprint Compartmentalized microfluidic culture platform to study mechanism of paclitaxel-induced axonal degeneration
    In Hong Yang
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA
    Exp Neurol 218:124-8. 2009
    ..This compartmentalized microfluidic culture system can be used for studies aimed at understanding axon degeneration, neuroprotection and development of the nervous system...
  33. pmc GPI-1046 protects dorsal root ganglia from gp120-induced axonal injury by modulating store-operated calcium entry
    Ahmet Hoke
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Peripher Nerv Syst 14:27-35. 2009
    ..Together, these results suggest that GPI-1046 protects DRG from gp120-induced axonal damage by decreasing the entry of calcium through SOC, thus reducing the total volume of ER calcium that is available to be released by gp120...
  34. ncbi request reprint Enhanced differentiation of human neural crest stem cells towards the Schwann cell lineage by aligned electrospun fiber matrix
    Yong Juan Ren
    Department of Materials Science and Engineering, Johns Hopkins University, 205 Maryland Hall, Baltimore, MD 21218, USA
    Acta Biomater 9:7727-36. 2013
    ....
  35. ncbi request reprint FK506 is neuroprotective in a model of antiretroviral toxic neuropathy
    Sanjay C Keswani
    Department of Neurology, The Johns Hopkins University, Baltimore, MD, USA
    Ann Neurol 53:57-64. 2003
    ....
  36. ncbi request reprint A novel endogenous erythropoietin mediated pathway prevents axonal degeneration
    Sanjay C Keswani
    Department of Neurology, The Johns Hopkins Hospital, Baltimore, MD, USA
    Ann Neurol 56:815-26. 2004
    ..Our in vivo and in vitro data suggest that EPO prevents axonal degeneration and therefore may be therapeutically useful in a wide variety of human neurological diseases characterized by axonopathy...
  37. pmc Nitric oxide prevents axonal degeneration by inducing HIF-1-dependent expression of erythropoietin
    Sanjay C Keswani
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 108:4986-90. 2011
    ..Our results indicate that NO→HIF-1→EPO signaling represents an adaptive mechanism that protects against axonal degeneration...
  38. ncbi request reprint Differences between human and mouse embryonic stem cells
    Irene Ginis
    Stem Cell Section, Laboratory of Neurosciences, National Institute on Aging, NIH, Baltimore, MD 21224, USA
    Dev Biol 269:360-80. 2004
    ..2) and to feeder-free subclones of H1, H7, and H9, indicating that the observed differences between human and mouse ES cells were species-specific rather than arising from differences in culture conditions...
  39. ncbi request reprint Erythropoietin promotes the recovery of erectile function following cavernous nerve injury
    Mohamad E Allaf
    The James Buchanan Brady Urological Institute, Baltimore, Maryland, USA
    J Urol 174:2060-4. 2005
    ..We investigated the effects of recombinant human (rh) erythropoietin (EPO) on erectile function recovery in a rat model of cavernous nerve (CN) injury...
  40. doi request reprint Peripheral nerve vasculitis presenting as complex regional pain syndrome
    Sindhu Ramchandren
    Department of Neurology, Wayne State University, Detroit Medical Center, University Health Center 8C20, Detroit, MI 48201, USA
    J Clin Neuromuscul Dis 10:61-4. 2008
    ..To report the clinical, electrodiagnostic, and pathologic findings in 3 patients who presented with complex regional pain syndrome as their primary manifestation of peripheral nerve vasculitis...
  41. ncbi request reprint Peripheral neuropathies in human immunodeficiency virus infection
    Ahmet Hoke
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Suppl Clin Neurophysiol 57:195-210. 2004
  42. doi request reprint Signaling cue presentation and cell delivery to promote nerve regeneration
    Kellin Krick
    Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Curr Opin Biotechnol 22:741-6. 2011
    ..Recent advances in presenting directional guidance cues in nerve guidance conduits and improving the regenerative outcomes of cell delivery provide inspirations to engineering the next generation of nerve repair solutions...
  43. ncbi request reprint Sciatic nerve tumor and tumor-like lesions - uncommon pathologies
    Vibhor Wadhwa
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Skeletal Radiol 41:763-74. 2012
    ..In this article, the authors discuss normal anatomy of the sciatic nerve and MRI findings of the above-mentioned lesions...
  44. pmc Schwann cells as a therapeutic target for peripheral neuropathies
    Helmar C Lehmann
    Department of Neurology, Johns Hopkins Hospital, 600 N Wolfe St, 509 Pathology Building, Baltimore, MD 21287, USA
    CNS Neurol Disord Drug Targets 9:801-6. 2010
    ....
  45. pmc The effect of the alignment of electrospun fibrous scaffolds on Schwann cell maturation
    Sing Yian Chew
    Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
    Biomaterials 29:653-61. 2008
    ..However, up-regulation of the myelin-specific gene, P0, was observed only on aligned electrospun fibers, suggesting the propensity of aligned fibers in promoting Schwann cell maturation...
  46. pmc Denervation atrophy is independent from Akt and mTOR activation and is not rescued by myostatin inhibition
    Elizabeth M MacDonald
    McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dis Model Mech 7:471-81. 2014
    ..Thus, our studies show that denervation atrophy is not only independent from Akt, SGK and mTOR activation but also has a different underlying pathophysiological mechanism than disuse atrophy. ..
  47. doi request reprint The sympathetic innervation of the human foot
    A Lee Dellon
    Department of Plastic and Reconstructive Surgery, The Johns Hopkins University School of Medicine, Johns Hopkins Hospital Outpatient Center, 8th Floor, McElderry 8161, 601 North Caroline Street, Baltimore, MD 21287, USA
    Plast Reconstr Surg 129:905-9. 2012
    ..This research investigates the sympathetic innervation of the human foot using tyrosine hydroxylase immunohistochemistry...
  48. doi request reprint Skin biopsy-proven flecainide-induced neuropathy
    Ahmet Z Burakgazi
    Department of Neurology, George Washington University, Washington, DC, USA
    Muscle Nerve 45:144-6. 2012
    ....
  49. ncbi request reprint Recent advances in HIV neuropathy
    David R Cornblath
    School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Curr Opin Neurol 19:446-50. 2006
    ..To describe recent advances in HIV neuropathy...
  50. ncbi request reprint Recovery from paralysis in adult rats using embryonic stem cells
    Deepa M Deshpande
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 6965, USA
    Ann Neurol 60:32-44. 2006
    ..We explored the potential of embryonic stem cell-derived motor neurons to functionally replace those cells destroyed in paralyzed adult rats...
  51. doi request reprint Respiratory muscle weakness in peripheral neuropathies
    Ahmet Z Burakgazi
    Department of Neurology, George Washington University, Washington, DC, USA
    J Peripher Nerv Syst 15:307-13. 2010
    ..Criteria established for mechanical ventilation in GBS cases may be applied to other peripheral neuropathies with respiratory compromise as necessary...
  52. doi request reprint Clinical implications of peripheral myelin protein 22 for nerve compression and neural regeneration: a review
    Helen G Hui-Chou
    Division of Plastic and Reconstructive Surgery, Johns Hopkins University of Maryland Plastic Surgery Program, Baltimore, USA
    J Reconstr Microsurg 27:67-74. 2011
    ..A review of current literature elucidates clinical, microsurgical implications, and management of patients with PMP22-related neuropathy...
  53. doi request reprint A framework for diagnosing and classifying intensive care unit-acquired weakness
    Robert D Stevens
    Division of Neurosciences Critical Care, Department of Anesthesiology Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Crit Care Med 37:S299-308. 2009
    ..We propose a simple framework for diagnosing and classifying neuromuscular disorders acquired in critical illness...
  54. pmc High-dosage ascorbic acid treatment in Charcot-Marie-Tooth disease type 1A: results of a randomized, double-masked, controlled trial
    Richard A Lewis
    Department of Neurology, Wayne State University, Detroit, Michigan, USA
    JAMA Neurol 70:981-7. 2013
    ..A lower dosage (1.5 g/d) did not cause improvement in humans. It is unknown whether a higher dosage would prove more effective...
  55. pmc Expanding the spectrum of monoclonal light chain deposition disease in muscle
    Lyle W Ostrow
    Department of Neurology, Johns Hopkins School of Medicine, 733 N Broadway, Baltimore, Maryland 21205, USA
    Muscle Nerve 45:755-61. 2012
    ..The diagnosis of amyloid myopathy is delayed when monoclonal gammopathies are not detected on initial testing and muscle biopsies are nondiagnostic, and the EMG and symptoms can mimic an inflammatory myopathy...
  56. ncbi request reprint Designing, testing, and validating a focused stem cell microarray for characterization of neural stem cells and progenitor cells
    Yongquan Luo
    Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, USA
    Stem Cells 21:575-87. 2003
    ..Thus, this focused neural stem array provides a convenient and useful tool for detection and assessment of NSCs and progenitor cells and can reliably distinguish them from other cell populations...

Research Grants12

  1. An in vitro Model of Antiretroviral Toxic Neuropathy
    Ahmet Hoke; Fiscal Year: 2002
    ..Furthermore, this assay system may be useful in development of NRTIs without the neurotoxic side effects. ..
  2. HIV and antiretroviral toxic neuropathy
    Ahmet Hoke; Fiscal Year: 2010
    ..These goals are highly relevant to the patient population we serve in the clinic as there are no effective therapies for the painful sensory neuropathy associated with HIV infection and use of DDX drugs. ..
  3. HIV and antiretroviral toxic neuropathy
    Ahmet Hoke; Fiscal Year: 2009
    ..These goals are highly relevant to the patient population we serve in the clinic as there are no effective therapies for the painful sensory neuropathy associated with HIV infection and use of DDX drugs. ..
  4. HIV and antiretroviral toxic neuropathy
    Ahmet Hoke; Fiscal Year: 2007
    ..These goals are highly relevant to the patient population we serve in the clinic as there are no effective therapies for the painful sensory neuropathy associated with HIV infection and use of DDX drugs. ..
  5. Peripheral neurotoxicity by the HIV-1 coat protein gp120
    Ahmet Hoke; Fiscal Year: 2006
    ..A major strength of our proposal is our use of human tissues to study a disease that only affects humans. ..
  6. Peripheral neurotoxicity by the HIV-1 coat protein gp120
    Ahmet Hoke; Fiscal Year: 2007
    ..A major strength of our proposal is our use of human tissues to study a disease that only affects humans. ..
  7. Peripheral neurotoxicity by the HIV-1 coat protein gp120
    Ahmet Hoke; Fiscal Year: 2006
    ..A major strength of our proposal is our use of human tissues to study a disease that only affects humans. ..
  8. An in vitro Model of Antiretroviral Toxic Neuropathy
    Ahmet Hoke; Fiscal Year: 2005
    ..Furthermore, this assay system may be useful in development of NRTIs without the neurotoxic side effects. ..
  9. An in vitro Model of Antiretroviral Toxic Neuropathy
    Ahmet Hoke; Fiscal Year: 2004
    ..Furthermore, this assay system may be useful in development of NRTIs without the neurotoxic side effects. ..
  10. An in vitro Model of Antiretroviral Toxic Neuropathy
    Ahmet Hoke; Fiscal Year: 2003
    ..Furthermore, this assay system may be useful in development of NRTIs without the neurotoxic side effects. ..
  11. HIV and antiretroviral toxic neuropathy
    Ahmet Hoke; Fiscal Year: 2009
    ..These goals are highly relevant to the patient population we serve in the clinic as there are no effective therapies for the painful sensory neuropathy associated with HIV infection and use of DDX drugs. ..