Joseph M Herman

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc ACR appropriateness criteria®  resectable rectal cancer
    William E Jones
    UT Health Science Center San Antonio, San Antonio, Texas, USA
    Radiat Oncol 7:161. 2012
  2. doi request reprint Phase 2 study of erlotinib combined with adjuvant chemoradiation and chemotherapy in patients with resectable pancreatic cancer
    Joseph M Herman
    Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland 21231, USA
    Int J Radiat Oncol Biol Phys 86:678-85. 2013
  3. doi request reprint Randomized phase III multi-institutional study of TNFerade biologic with fluorouracil and radiotherapy for locally advanced pancreatic cancer: final results
    Joseph M Herman
    Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, 401 N Broadway, Weinberg Suite 1440, Baltimore, MD 21231, USA
    J Clin Oncol 31:886-94. 2013
  4. pmc The quality-of-life effects of neoadjuvant chemoradiation in locally advanced rectal cancer
    Joseph M Herman
    Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231 2410, USA
    Int J Radiat Oncol Biol Phys 85:e15-9. 2013
  5. pmc Analysis of fluorouracil-based adjuvant chemotherapy and radiation after pancreaticoduodenectomy for ductal adenocarcinoma of the pancreas: results of a large, prospectively collected database at the Johns Hopkins Hospital
    Joseph M Herman
    Department of Radiation Oncology and Molecular Radiation Sciences, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Hospital, Baltimore, MD, USA
    J Clin Oncol 26:3503-10. 2008
  6. doi request reprint Radiotherapy using a water bath in the treatment of Bowen's disease of the digit
    Joseph M Herman
    Department of Radiation Oncology, University of Michigan, Ann Arbor, USA
    Radiother Oncol 88:398-402. 2008
  7. doi request reprint Influence of patient, physician, and hospital factors on 30-day readmission following pancreatoduodenectomy in the United States
    Omar Hyder
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland
    JAMA Surg 148:1095-102. 2013
  8. pmc Adjuvant chemoradiotherapy after pancreatic resection for invasive carcinoma associated with intraductal papillary mucinous neoplasm of the pancreas
    Michael J Swartz
    Department of Radiation Oncology and Molecular Radiation Sciences, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Hospital, Baltimore, MD 21231 2410, USA
    Int J Radiat Oncol Biol Phys 76:839-44. 2010
  9. pmc Adjuvant chemoradiation for pancreatic adenocarcinoma: the Johns Hopkins Hospital-Mayo Clinic collaborative study
    Charles C Hsu
    Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Hospital, Baltimore, MD, USA
    Ann Surg Oncol 17:981-90. 2010
  10. pmc Early mortality risk score: identification of poor outcomes following upfront surgery for resectable pancreatic cancer
    Charles C Hsu
    The Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, 410 North Broadway Suite 1440, Baltimore, MD 21231 2410, USA
    J Gastrointest Surg 16:753-61. 2012

Detail Information

Publications90

  1. pmc ACR appropriateness criteria®  resectable rectal cancer
    William E Jones
    UT Health Science Center San Antonio, San Antonio, Texas, USA
    Radiat Oncol 7:161. 2012
    ..In those instances where evidence is lacking or not definitive, expert opinion may be used to recommend imaging or treatment...
  2. doi request reprint Phase 2 study of erlotinib combined with adjuvant chemoradiation and chemotherapy in patients with resectable pancreatic cancer
    Joseph M Herman
    Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland 21231, USA
    Int J Radiat Oncol Biol Phys 86:678-85. 2013
    ..Gemcitabine-erlotinib therapy has demonstrated a survival benefit for patients with metastatic PDAC. Here we report the first phase 2 study of erlotinib in combination with adjuvant chemoradiation and chemotherapy for resected PDAC...
  3. doi request reprint Randomized phase III multi-institutional study of TNFerade biologic with fluorouracil and radiotherapy for locally advanced pancreatic cancer: final results
    Joseph M Herman
    Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, 401 N Broadway, Weinberg Suite 1440, Baltimore, MD 21231, USA
    J Clin Oncol 31:886-94. 2013
    ..We herein report final results of the largest randomized phase III trial performed to date among patients with locally advanced pancreatic cancer (LAPC) and the first to test gene transfer against this malignancy...
  4. pmc The quality-of-life effects of neoadjuvant chemoradiation in locally advanced rectal cancer
    Joseph M Herman
    Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231 2410, USA
    Int J Radiat Oncol Biol Phys 85:e15-9. 2013
    ..Our goals were to prospectively explore acute changes in patient-reported QOL endpoints during and after treatment and to establish a distribution of scores that could be used for comparison as new treatment modalities emerge...
  5. pmc Analysis of fluorouracil-based adjuvant chemotherapy and radiation after pancreaticoduodenectomy for ductal adenocarcinoma of the pancreas: results of a large, prospectively collected database at the Johns Hopkins Hospital
    Joseph M Herman
    Department of Radiation Oncology and Molecular Radiation Sciences, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Hospital, Baltimore, MD, USA
    J Clin Oncol 26:3503-10. 2008
    ..To examine the efficacy of adjuvant chemoradiotherapy after pancreaticoduodenectomy (PD) for pancreatic adenocarcinoma (PC) in patients undergoing resection at Johns Hopkins Hospital (JHH; Baltimore, MD)...
  6. doi request reprint Radiotherapy using a water bath in the treatment of Bowen's disease of the digit
    Joseph M Herman
    Department of Radiation Oncology, University of Michigan, Ann Arbor, USA
    Radiother Oncol 88:398-402. 2008
    ..Surgical treatment of BD of the digit can result in poor function and sometimes amputation. Here, we report our experience using a unique water bath technique to treat BD of the digit...
  7. doi request reprint Influence of patient, physician, and hospital factors on 30-day readmission following pancreatoduodenectomy in the United States
    Omar Hyder
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland
    JAMA Surg 148:1095-102. 2013
    ..IMPORTANCE It is not known whether hospital and surgeon volumes have an association with readmission among patients undergoing pancreatoduodenectomy...
  8. pmc Adjuvant chemoradiotherapy after pancreatic resection for invasive carcinoma associated with intraductal papillary mucinous neoplasm of the pancreas
    Michael J Swartz
    Department of Radiation Oncology and Molecular Radiation Sciences, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Hospital, Baltimore, MD 21231 2410, USA
    Int J Radiat Oncol Biol Phys 76:839-44. 2010
    ..Intraductal papillary mucinous neoplasms are mucin-producing cystic neoplasms of the pancreas. One-third are associated with invasive carcinoma. We examined the benefit of adjuvant chemoradiotherapy (CRT) for this cohort...
  9. pmc Adjuvant chemoradiation for pancreatic adenocarcinoma: the Johns Hopkins Hospital-Mayo Clinic collaborative study
    Charles C Hsu
    Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Hospital, Baltimore, MD, USA
    Ann Surg Oncol 17:981-90. 2010
    ..Our goal was to examine efficacy of adjuvant CRT in resected pancreatic adenocarcinoma compared with surgery alone...
  10. pmc Early mortality risk score: identification of poor outcomes following upfront surgery for resectable pancreatic cancer
    Charles C Hsu
    The Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, 410 North Broadway Suite 1440, Baltimore, MD 21231 2410, USA
    J Gastrointest Surg 16:753-61. 2012
    ..This study examines the preoperative predictors of early mortality following PD and combines these variables into an early mortality risk score (EMRS)...
  11. pmc Concurrent versus sequential sorafenib therapy in combination with radiation for hepatocellular carcinoma
    Aaron T Wild
    Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 8:e65726. 2013
    ..In conclusion, sequential RT-SOR demonstrates greater efficacy against HCC than concurrent RT-SOR both in vitro and in vivo. These results may have implications for clinical decision-making and prospective trial design...
  12. doi request reprint Adjuvant chemoradiation therapy after pancreaticoduodenectomy in elderly patients with pancreatic adenocarcinoma
    David P Horowitz
    Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Int J Radiat Oncol Biol Phys 80:1391-7. 2011
    ..To evaluate the efficacy of adjuvant chemoradiation therapy (CRT) for pancreatic adenocarcinoma patients ≥ 75 years of age...
  13. doi request reprint Comparison of conventional and 3-dimensional computed tomography against histopathologic examination in determining pancreatic adenocarcinoma tumor size: implications for radiation therapy planning
    Haoming Qiu
    Department of Radiation Oncology and Molecular Radiation Sciences, Sol Goldman Pancreatic Cancer Research Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Radiother Oncol 104:167-72. 2012
    ....
  14. doi request reprint Patient readmission and mortality after surgery for hepato-pancreato-biliary malignancies
    Eric B Schneider
    Center for Surgical Trials and Outcomes Research, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    J Am Coll Surg 215:607-15. 2012
    ..The objective of the current study was to compare readmission after pancreatic vs hepatobiliary surgical procedures, as well as to identify potential factors associated with higher readmission within 30 days of discharge...
  15. pmc Evaluation of adjuvant chemoradiation therapy for ampullary adenocarcinoma: the Johns Hopkins Hospital-Mayo Clinic collaborative study
    Amol K Narang
    Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Radiat Oncol 6:126. 2011
    ..We combined the experience of two institutions to better delineate which patients may benefit from adjuvant chemoradiation...
  16. pmc Re-evaluating the impact of tumor size on survival following pancreaticoduodenectomy for pancreatic adenocarcinoma
    Mechteld C de Jong
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Surg Oncol 103:656-62. 2011
    ..We sought to examine the association of size with outcomes following resection of pancreatic adenocarcinoma...
  17. doi request reprint Determining pattern of recurrence following pancreaticoduodenectomy and adjuvant 5-flurouracil-based chemoradiation therapy: effect of number of metastatic lymph nodes and lymph node ratio
    Bolanle Asiyanbola
    Department of Surgery, Johns Hopkins Hospital, 600 North Wolfe Street, Halsted 614, Baltimore, MD 22187 6681, USA
    J Gastrointest Surg 13:752-9. 2009
    ..There are limited data on patterns of recurrence and factors associated with local recurrence following pancreaticoduodenectomy for pancreatic adenocarcinoma and adjuvant 5-flurouracil-based chemoradiation therapy...
  18. doi request reprint Mapping patterns of local recurrence after pancreaticoduodenectomy for pancreatic adenocarcinoma: a new approach to adjuvant radiation field design
    Avani S Dholakia
    Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland
    Int J Radiat Oncol Biol Phys 87:1007-15. 2013
    ....
  19. pmc Conditional survival in patients with pancreatic ductal adenocarcinoma resected with curative intent
    Skye C Mayo
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Cancer 118:2674-81. 2012
    ..Survival estimates, however, are dynamic and may change based on the time already survived. The authors sought to assess conditional survival among a large cohort of patients who underwent resection of PDAC...
  20. doi request reprint Outcomes of adjuvant chemoradiation after pancreaticoduodenectomy with mesenterico-portal vein resection for adenocarcinoma of the pancreas
    Boris Hristov
    Department of Radiation Oncology and Molecular Radiation Sciences, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, MD, USA
    Int J Radiat Oncol Biol Phys 76:176-80. 2010
    ..The purpose of this study was to compare outcomes between pancreaticoduodenectomy (PD) with and without mesenterico-portal vein resection (VR) in patients receiving adjuvant CRT for pancreatic adenocarcinoma...
  21. doi request reprint Liver-directed therapy for hepatic metastases in patients undergoing pancreaticoduodenectomy: a dual-center analysis
    Mechteld C de Jong
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Surg 252:142-8. 2010
    ..To analyze the perioperative and long-term outcomes of patients undergoing liver-directed therapy after pancreaticoduodenectomy in a large dual-center cohort of patients...
  22. pmc Adjuvant chemoradiation therapy for adenocarcinoma of the distal pancreas
    Kristin J Redmond
    Department of Radiation Oncology and Molecular Radiation Sciences, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Surg Oncol 17:3112-9. 2010
    ..This study was designed to examine the effect of adjuvant 5-FU-based chemoradiation therapy (CRT) after distal pancreatectomy for adenocarcinoma of the distal pancreas...
  23. pmc Resected pancreatic adenosquamous carcinoma: clinicopathologic review and evaluation of adjuvant chemotherapy and radiation in 38 patients
    K Ranh Voong
    Department of Radiation Oncology and Molecular Radiation Sciences, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Hospital, Baltimore, MD 21231 6681, USA
    Hum Pathol 41:113-22. 2010
    ..Treatment with adjuvant chemoradiation therapy is associated with improved survival. The proportion of squamous differentiation in resected pancreatic adenosquamous carcinoma specimens does not appear to impact overall survival...
  24. pmc Treating patients with colon cancer liver metastasis: a nationwide analysis of therapeutic decision making
    Hari Nathan
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Surg Oncol 19:3668-76. 2012
    ..Criteria for resectability of colon cancer liver metastases (CLM) are evolving, yet little is known about how physicians choose a therapeutic strategy for potentially resectable CLM...
  25. doi request reprint Incidence and management of chyle leaks following pancreatic resection: a high volume single-center institutional experience
    Lia Assumpcao
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Gastrointest Surg 12:1915-23. 2008
    ..We sought to identify possible risk factors associated with chyle leaks following pancreatic resection, as well as determine the natural history of this rare complication...
  26. pmc Duodenal adenocarcinoma: clinicopathologic analysis and implications for treatment
    George A Poultsides
    Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Ann Surg Oncol 19:1928-35. 2012
    ..Duodenal adenocarcinoma is a rare cancer usually studied as a group with periampullary or small bowel adenocarcinoma; therefore, its natural history is poorly understood...
  27. pmc Palliative surgical management of patients with unresectable pancreatic adenocarcinoma: trends and lessons learned from a large, single institution experience
    Peter J Kneuertz
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Gastrointest Surg 15:1917-27. 2011
    ..We examined trends in the relative use of palliative bypass over time with an emphasis on identifying changes in surgical indications, type of bypass performed, as well as perioperative outcomes associated with surgical palliation...
  28. pmc Predictors of survival after resection of retroperitoneal sarcoma: a population-based analysis and critical appraisal of the AJCC staging system
    Hari Nathan
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Surg 250:970-6. 2009
    ..To identify predictors of survival after resection of retroperitoneal sarcoma (RPS) and to evaluate the performance of the American Joint Committee on Cancer (AJCC) staging system for RPS...
  29. doi request reprint Impact of obesity on perioperative outcomes and survival following pancreaticoduodenectomy for pancreatic cancer: a large single-institution study
    Susan Tsai
    Department of Surgery, Johns Hopkins Medical Institutions, 600N Wolfe Street, Baltimore, MD 21287, USA
    J Gastrointest Surg 14:1143-50. 2010
    ..To examine the effect of body mass index (BMI) on clinicopathologic factors and long-term survival in patients undergoing pancreaticoduodenectomy for pancreatic adenocarcinoma...
  30. doi request reprint Patterns of consultation and treatment of patients with hepatocellular carcinoma presenting to a large academic medical center in the US
    Sylvie Stacy
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Gastrointest Surg 17:1600-8. 2013
    ..This study sought to evaluate referral and treatment patterns among patients with HCC at a large academic medical center...
  31. doi request reprint Treatment and prognosis of patients with fibrolamellar hepatocellular carcinoma: a national perspective
    Skye C Mayo
    Department of Surgery, Johns Hopkins Hospital, Baltimore, MD
    J Am Coll Surg 218:196-205. 2014
    ..We sought to investigate the differences over time in surgically managed FLC compared with conventional HCC using population-based data...
  32. pmc Young patients undergoing resection of pancreatic cancer fare better than their older counterparts
    Jin He
    Department of Surgery, Johns Hopkins University School of Medicine, 600 N Wolfe St, Osler 624, Baltimore, MD 21287, USA
    J Gastrointest Surg 17:339-44. 2013
    ..We investigated features of PDAC occurring in young patients (≤45 years) who underwent surgical resection in order to determine if any difference exists in comparison to elderly patients (≥70 years)...
  33. pmc Management of patients with pancreatic adenocarcinoma: national trends in patient selection, operative management, and use of adjuvant therapy
    Skye C Mayo
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Am Coll Surg 214:33-45. 2012
    ..Advances in surgical technique and perioperative care have reduced perioperative mortality; however, temporal trends in perioperative morbidity and the use of adjuvant therapy on a population basis remain ill-defined...
  34. doi request reprint Clinicopathologic analysis of ampullary neoplasms in 450 patients: implications for surgical strategy and long-term prognosis
    Jordan M Winter
    Department of Surgery, Johns Hopkins Medical Institutions, Halsted 610, 600 N Wolfe Street, Baltimore, MD 21287, USA
    J Gastrointest Surg 14:379-87. 2010
    ..We sought to examine the outcome of patients undergoing pancreaticoduodenectomy versus ampullectomy, as well as to identify factors predictive of lymph node metastasis in patients with ampullary neoplasms...
  35. doi request reprint Trends and patterns of utilization in post-treatment surveillance imaging among patients treated for hepatocellular carcinoma
    Omar Hyder
    Department of Surgery, Johns Hopkins University School of Medicine, Blalock 688 600N Wolfe Street, Baltimore, MD, 21287, USA
    J Gastrointest Surg 17:1774-83. 2013
    ..We sought to define population-based patterns of surveillance and investigate if intensity of surveillance impacted outcome following HCC treatment...
  36. doi request reprint Peri-operative mortality and long-term survival after total pancreatectomy for pancreatic adenocarcinoma: a population-based perspective
    Hari Nathan
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Surg Oncol 99:87-92. 2009
    ..We sought to analyze peri-operative mortality and long-term survival following TP versus PP for pancreatic adenocarcinoma...
  37. pmc Analysis of local control in patients receiving IMRT for resected pancreatic cancers
    Susannah Yovino
    Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Int J Radiat Oncol Biol Phys 83:916-20. 2012
    ..A concern regarding this technique is the potential for geographic miss and decreased local control. We analyzed patterns of first failure among patients treated with IMRT for resected pancreatic cancer...
  38. pmc Vascular invasion in infiltrating ductal adenocarcinoma of the pancreas can mimic pancreatic intraepithelial neoplasia: a histopathologic study of 209 cases
    Seung Mo Hong
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231 2410, USA
    Am J Surg Pathol 36:235-41. 2012
    ..3 mo) had a significantly worse survival than did patients with carcinomas without vascular invasion (25.1 mo; P=0.01, log-rank test). Microscopic vascular invasion is a poor prognostic indicator and can histologically mimic PanIN...
  39. pmc Pulmonary resection for isolated pancreatic adenocarcinoma metastasis: an analysis of outcomes and survival
    George J Arnaoutakis
    Division of Thoracic Surgery, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Gastrointest Surg 15:1611-7. 2011
    ..This study was conducted to determine if pulmonary metastasectomy (PM) for isolated pancreatic cancer metastases is safe and effective...
  40. pmc Sclerosing mesenteritis involving the pancreas: a mimicker of pancreatic cancer
    Jennifer R Scudiere
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Am J Surg Pathol 34:447-53. 2010
    ..Distinguishing SM from pancreatic carcinoma is crucial to appropriate management, as patients with SM may benefit from immunosuppressive therapy...
  41. doi request reprint Referral patterns and treatment choices for patients with hepatocellular carcinoma: a United States population-based study
    Omar Hyder
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD
    J Am Coll Surg 217:896-906. 2013
    ..Reasons underlying variations are poorly understood. One source of variation may be disparate referral rates to specialists, leading to differences in cancer-directed treatments...
  42. pmc Presence of pancreatic intraepithelial neoplasia in the pancreatic transection margin does not influence outcome in patients with R0 resected pancreatic cancer
    Hanno Matthaei
    The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University, Baltimore, MD, USA
    Ann Surg Oncol 18:3493-9. 2011
    ..Margin status is one of the strongest prognosticators after resection of pancreatic ductal adenocarcinoma (PDAC). The clinical significance of pancreatic intraepithelial neoplasia (PanIN) at a surgical margin has not been established...
  43. doi request reprint Pancreatic resection of isolated metastases from nonpancreatic primary cancers
    Sushanth Reddy
    Department of Surgery, The Johns Hopkins University, 600 North Wolfe Street, Carnegie 681, Baltimore, Maryland 21287, USA
    Ann Surg Oncol 15:3199-206. 2008
    ..The goal of this study is to report the safety and efficacy of pancreatic resection for isolated metastatic cancers from nonpancreatic primary disease...
  44. doi request reprint Safety and efficacy of curative intent surgery for peri-ampullary liver metastasis
    Mechteld C de Jong
    Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Surg Oncol 102:256-63. 2010
    ..The management of patients with peri-ampullary liver metastasis remains controversial. We sought to assess the safety and efficacy of curative intent surgery for peri-ampullary liver metastasis...
  45. doi request reprint Hedgehog pathway inhibition radiosensitizes non-small cell lung cancers
    Jing Zeng
    Department of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231 2410, USA
    Int J Radiat Oncol Biol Phys 86:143-9. 2013
    ..Whether Hedgehog inhibition can affect radiation efficacy in vivo has not been reported...
  46. doi request reprint Post-treatment surveillance of patients with colorectal cancer with surgically treated liver metastases
    Omar Hyder
    Department of Surgery at Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Surgery 154:256-65. 2013
    ..We sought to define current population-based patterns of surveillance and investigate whether intensity of surveillance impacted outcome...
  47. doi request reprint Provider versus patient factors impacting hospital length of stay after pancreaticoduodenectomy
    Eric B Schneider
    Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Surgery 154:152-61. 2013
    ..Understanding factors that impact hospital duration of stay may have cost-saving implications. We sought to examine variation in duration of stay after PD occurring at the patient, surgeon, and hospital levels...
  48. pmc Effect of metabolic syndrome on perioperative outcomes after liver surgery: A National Surgical Quality Improvement Program (NSQIP) analysis
    Neil H Bhayani
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Surgery 152:218-26. 2012
    ..A subset of patients with obesity will have metabolic syndrome. We sought to examine the impact of metabolic syndrome on the risk of morbidity and mortality among a large cohort of patients who underwent hepatic resection...
  49. pmc Loss of E-cadherin expression and outcome among patients with resectable pancreatic adenocarcinomas
    Seung Mo Hong
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Mod Pathol 24:1237-47. 2011
    ..02). Among patients undergoing pancreaticoduodenectomy for pancreatic ductal adenocarcinoma, partial loss of tumoral E-cadherin expression is an independent predictor of poor outcome...
  50. doi request reprint Impact of adjuvant external beam radiotherapy on survival in surgically resected gallbladder adenocarcinoma: A propensity score-matched Surveillance, Epidemiology, and End Results analysis
    Omar Hyder
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD
    Surgery 155:85-93. 2014
    ..We sought to define the utilization and effect of adjuvant external-beam radiotherapy (XRT) on patients having undergone curative-intent resection for gallbladder cancer (GBC)...
  51. ncbi request reprint Baseline hemoglobin-A1c impacts clinical outcomes in patients with pancreatic cancer
    Katherine Y Fan
    From the aDepartment of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland bDepartment of Statistics, Stanford University, Palo Alto, California cDepartment of Radiation Oncology, University of California San Francisco, San Francisco, California and dDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center, eDepartment of Pathology, The Sol Goldman Pancreatic Cancer Research Center, fRussell H Morgan Department of Radiology and Radiological Sciences, gDivision of Endocrinology and Metabolism, Department of Internal Medicine, and hDepartment of Surgery, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland
    J Natl Compr Canc Netw 12:50-7. 2014
    ..5% or greater influence OS of patients with PDA even when accounting for other known prognostic factors. HbA1c level at presentation is significantly higher in patients with PDA than patients with BPD and seems to affect survival. ..
  52. doi request reprint Impact of sarcopenia on outcomes following intra-arterial therapy of hepatic malignancies
    Rebecca M Dodson
    Department of Surgery, Johns Hopkins University School of Medicine, Blalock 688 600 N Wolfe Street, Baltimore, 21287, MD, USA
    J Gastrointest Surg 17:2123-32. 2013
    ..Assessment of patient performance status is often subjective. Sarcopenia--measurement of muscle wasting--may be a more objective means to assess performance status and therefore mortality risk following intra-arterial therapy (IAT)...
  53. doi request reprint Unnecessary tests and procedures in patients presenting with solid tumors of the pancreas
    Michol Cooper
    Department of Surgery, Johns Hopkins Hospital, Baltimore, MD, USA
    J Gastrointest Surg 17:1218-23. 2013
    ..A computed tomography (CT) scan is often the only study needed prior to surgery for resectable solid pancreas masses. However, many patients are evaluated with multiple studies and interventions that may be unnecessary...
  54. pmc Accuracy of marketing claims by providers of stereotactic radiation therapy
    Amol K Narang
    Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD 21231 2410, USA
    J Oncol Pract 9:57-62. 2013
    ..Given that this technology is also being heavily advertised on the Web sites of health care providers, the accuracy of providers' marketing claims should be rigorously evaluated...
  55. pmc Increased organ sparing using shape-based treatment plan optimization for intensity modulated radiation therapy of pancreatic adenocarcinoma
    Steven F Petit
    Department of Computer Science, Johns Hopkins University, Baltimore, USA
    Radiother Oncol 102:38-44. 2012
    ..To develop a model to assess the quality of an IMRT treatment plan using data of prior patients with pancreatic adenocarcinoma...
  56. pmc The twist box domain is required for Twist1-induced prostate cancer metastasis
    Rajendra P Gajula
    Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, 1550 Orleans Street, CRB2 Rm 406, Baltimore, MD 21231
    Mol Cancer Res 11:1387-400. 2013
    ..Implications: Targeting the Twist box domain of Twist1 may effectively limit prostate cancer metastatic potential...
  57. pmc Recent progress in pancreatic cancer
    Christopher L Wolfgang
    Associate Professor, Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD Associate Professor, Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD Associate Professor, Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD
    CA Cancer J Clin 63:318-48. 2013
    ..It is clear that multidisciplinary care that provides comprehensive and coordinated evaluation and treatment is the most effective way to manage patients with pancreatic cancer...
  58. doi request reprint A multi-institutional phase 2 study of neoadjuvant gemcitabine and oxaliplatin with radiation therapy in patients with pancreatic cancer
    Edward J Kim
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Cancer 119:2692-700. 2013
    ..The purpose of this study was to evaluate preoperative treatment with full-dose gemcitabine, oxaliplatin, and radiation therapy (RT) in patients with localized pancreatic cancer...
  59. doi request reprint Cadmium exposure and liver disease among US adults
    Omar Hyder
    Department of Surgery, Division of Surgical Oncology, Johns Hopkins University School of Medicine, Blalock 688 600 N Wolfe Street, Baltimore, MD 21287, USA
    J Gastrointest Surg 17:1265-73. 2013
    ....
  60. doi request reprint Multidisciplinary management of pancreatic cancer
    Rachit Kumar
    Department of Radiation Oncology and Molecular Radiation Sciences, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Surg Oncol Clin N Am 22:265-87. 2013
    ..In this review, the importance of multidisciplinary management of pancreatic cancer based on disease stage is discussed...
  61. pmc Clinical significance of the genetic landscape of pancreatic cancer and implications for identification of potential long-term survivors
    Shinichi Yachida
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Clin Cancer Res 18:6339-47. 2012
    ..Genetic alterations of KRAS, CDKN2A, TP53, and SMAD4 are the most frequent events in pancreatic cancer. We determined the extent to which these 4 alterations are coexistent in the same carcinoma, and their impact on patient outcome...
  62. pmc Evaluating the impact of a single-day multidisciplinary clinic on the management of pancreatic cancer
    Timothy M Pawlik
    Department of Surgery, The Sol Goldman Pancreatic Cancer Research Center, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, Baltimore, MD, USA
    Ann Surg Oncol 15:2081-8. 2008
    ..To evaluate the impact of a multidisciplinary clinic on the clinical care recommendations of patients with pancreatic cancer compared with the recommendations the patients received prior to review by the multidisciplinary tumor board...
  63. doi request reprint Management of extremity soft tissue sarcomas
    Matthew T Hueman
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Surg Clin North Am 88:539-57, vi. 2008
    ..As is true for patients diagnosed with sarcoma at other anatomic sites, a multidisciplinary team approach streamlines care with attention to the complexities and intricacies of choosing and delivering optimal therapy...
  64. pmc Multidisciplinary management of recurrent hepatocellular carcinoma following liver transplantation
    Peter J Kneuertz
    Department of Surgery, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Gastrointest Surg 16:874-81. 2012
    ..While the majority of patients recur in the first two years after transplantation, late recurrence is not infrequent...
  65. doi request reprint Management of retroperitoneal sarcomas
    Matthew T Hueman
    The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Surg Clin North Am 88:583-97, vii. 2008
    ..Optimizing disease control while minimizing the morbidity of therapy remains the primary goal of management. In this article, the authors describe the presentation, evaluation, and management of patients who have retroperitoneal sarcoma...
  66. doi request reprint Low total lymphocyte count is associated with poor survival in patients with resected pancreatic adenocarcinoma receiving a GM-CSF secreting pancreatic tumor vaccine
    Aaron J Schueneman
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Surg Oncol 20:S725-30. 2013
    ..Although immune-based therapies are under rapid development, it is not known whether baseline complete blood counts, particularly lymphocytes, are associated with the clinical outcomes of patients receiving immunotherapies...
  67. doi request reprint Stereotactic body radiation therapy planning with duodenal sparing using volumetric-modulated arc therapy vs intensity-modulated radiation therapy in locally advanced pancreatic cancer: a dosimetric analysis
    Rachit Kumar
    Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, 401 N Broadway, Baltimore, MD 21231, USA
    Med Dosim 38:243-50. 2013
    ..These findings suggest clinical situations where each technique may be most useful if DS constraints are to be employed. ..
  68. pmc A tolerability and pharmacokinetic study of adjuvant erlotinib and capecitabine with concurrent radiation in resected pancreatic cancer
    Wen Wee Ma
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA
    Transl Oncol 3:373-9. 2010
    ..The pharmacokinetic profile of this combination was also evaluated...
  69. pmc Phase 2 study of rituximab-ABVD in classical Hodgkin lymphoma
    Yvette L Kasamon
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA
    Blood 119:4129-32. 2012
    ..Persistence of detectable circulating clonotypic B cells was associated with a greater relapse frequency (P < .05). Rituximab-ABVD and clonotypic B cells warrant additional study in classical Hodgkin lymphoma...
  70. pmc Clinicopathologic Comparison of High-Dose-Rate Endorectal Brachytherapy versus Conventional Chemoradiotherapy in the Neoadjuvant Setting for Resectable Stages II and III Low Rectal Cancer
    Jessica A Smith
    Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2196, USA
    Int J Surg Oncol 2012:406568. 2012
    ..Conclusions. EBT offers several practical benefits over conventional radiotherapy techniques and appears to be at least as effective against low rectal cancer as measured by short-term outcomes...
  71. pmc Management and recurrence patterns of desmoids tumors: a multi-institutional analysis of 211 patients
    Peter D Peng
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Surg Oncol 19:4036-42. 2012
    ..Desmoid tumors are rare soft-tissue neoplasms with limited data on their management. We sought to determine the rates of recurrence following surgery for desmoid tumors and identify factors predictive of disease-free survival...
  72. ncbi request reprint Prospective quality-of-life assessment in patients receiving concurrent gemcitabine and radiotherapy as a bladder preservation strategy
    Joseph M Herman
    Department ofRadiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Urology 64:69-73. 2004
    ..To assess, in a Phase I study, whether bladder preservation with concurrent gemcitabine and radiotherapy (RT) influenced patient-reported quality of life (QOL) as determined by the Functional Assessment of Cancer Therapy-Bladder (FACT-BL)...
  73. pmc Resectable pancreatic small cell carcinoma
    Jordan M Winter
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD
    Rare Tumors 3:e5. 2011
    ..Cisplatin and etoposide appears to be the preferred chemotherapy regimen, although its efficacy remains uncertain, as does the role of combined modality treatment with radiation...
  74. pmc Management of perihilar cholangiocarcinoma in the era of multimodal therapy
    Vicente Valero
    Department of Surgery, Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Harvey 611, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Expert Rev Gastroenterol Hepatol 6:481-95. 2012
    ..Orthotopic liver transplantation offers complete resection of locally advanced tumors in select patient groups...
  75. pmc Adjuvant chemoradiation versus surgery alone for adenocarcinoma of the ampulla of Vater
    Jessica Zhou
    Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Hospital, 401 N Broadway, Baltimore, MD 21231, USA
    Radiother Oncol 92:244-8. 2009
    ..To examine the role of adjuvant chemoradiation (CRT) in patients with resected ampullary adenocarcinoma...
  76. doi request reprint Transitoriness in cancer patients: a cross-sectional survey of lung and gastrointestinal cancer patients
    Maya Shaha
    Johns Hopkins University School of Nursing, 525 North Wolfe Street, Baltimore, MD 21205, USA
    Support Care Cancer 19:271-9. 2010
    ..Transitoriness is defined as a person's confrontation with life's finitude due to a cancer diagnosis...
  77. pmc Comparative analysis of traditional and coiled fiducials implanted during EUS for pancreatic cancer patients receiving stereotactic body radiation therapy
    Mouen A Khashab
    Department of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore, Maryland 21205, USA
    Gastrointest Endosc 76:962-71. 2012
    ..EUS-guided fiducial placement facilitates image-guided radiation therapy (IGRT)...
  78. pmc DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer
    Christine A Iacobuzio-Donahue
    Department of Pathology, Surgery, and Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    J Clin Oncol 27:1806-13. 2009
    ..A comprehensive study of pancreatic cancers from patients who have succumbed to their disease has the potential to greatly expand our understanding of the most lethal stage of this disease and identify novel areas for intervention...
  79. ncbi request reprint Is resection of periampullary or pancreatic adenocarcinoma with synchronous hepatic metastasis justified?
    Ana Luiza Gleisner
    Department of Surgery, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, Maryland 22187 6681, USA
    Cancer 110:2484-92. 2007
    ..Specifically, the role of hepatic resection for metastatic periampullary or pancreatic adenocarcinoma remains controversial...
  80. doi request reprint Salvage therapy for liver-dominant colorectal metastatic adenocarcinoma: comparison between transcatheter arterial chemoembolization versus yttrium-90 radioembolization
    Kelvin Hong
    Division of Vascular and Interventional Radiology, Johns Hopkins Medical Institutions and Russell H Morgan, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    J Vasc Interv Radiol 20:360-7. 2009
    ..To compare transarterial chemoembolization (CE) versus yttrium-90 ((90)Y) radioembolization (RE) for liver-dominant metastatic colorectal adenocarcinoma as salvage therapy...
  81. doi request reprint Use of respiratory-correlated four-dimensional computed tomography to determine acceptable treatment margins for locally advanced pancreatic adenocarcinoma
    Seth D Goldstein
    Department of Surgery, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, MD 21231 2410, USA
    Int J Radiat Oncol Biol Phys 76:597-602. 2010
    ..Respiratory-induced excursions of locally advanced pancreatic adenocarcinoma could affect dose delivery. This study quantified tumor motion and evaluated standard treatment margins...
  82. ncbi request reprint The role of radiation in retroperitoneal sarcomas: a surgical perspective
    Timothy M Pawlik
    Department of Surgery, Division of Surgical Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 22187 6681, USA
    Curr Opin Oncol 19:359-66. 2007
    ..Radiation therapy for retroperitoneal sarcoma patients is complex because it requires decisions on not only the timing of administration, but also the technique of delivery...
  83. ncbi request reprint Local therapies for hepatic metastases
    Fabian M Johnston
    Department of Surgery, The Johns Hopkins University, Baltimore, MD 21287, USA
    J Natl Compr Canc Netw 11:153-60. 2013
    ..This article evaluates the available evidence on current regional strategies for managing patients with liver metastases, with an emphasis on CRLM and NELM, highlighting the clinical usefulness and limitations of each modality...
  84. ncbi request reprint Primary versus radiation-associated craniofacial osteosarcoma: Biologic and clinicopathologic comparisons
    Jonathan B McHugh
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109 0054, USA
    Cancer 107:554-62. 2006
    ..Although most are sporadic, some tumors occur in association with prior radiation therapy. The purpose of the current study was to compare clinicopathologic and prognostic features of primary and radiation-associated osteosarcoma...
  85. pmc SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer
    Amanda Blackford
    Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Clin Cancer Res 15:4674-9. 2009
    ..Recently, the majority of protein coding genes were sequenced in a collection of pancreatic cancers, providing an unprecedented opportunity to identify genetic markers of prognosis for patients with adenocarcinoma of the pancreas...
  86. doi request reprint The promise and pitfalls of positron emission tomography and single-photon emission computed tomography molecular imaging-guided radiation therapy
    Richard L Wahl
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Semin Radiat Oncol 21:88-100. 2011
    ..As MIGRT evolves, evidence must continue to be gathered to support improved clinical outcomes using MIGRT versus purely anatomic approaches...
  87. pmc Development of a novel preclinical pancreatic cancer research model: bioluminescence image-guided focal irradiation and tumor monitoring of orthotopic xenografts
    Richard Tuli
    Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Transl Oncol 5:77-84. 2012
    ....
  88. ncbi request reprint Phenylbutyrate sensitizes human glioblastoma cells lacking wild-type p53 function to ionizing radiation
    Carlos A Lopez
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 0010, USA
    Int J Radiat Oncol Biol Phys 69:214-20. 2007
    ..Because of its low cytotoxicity, cerebrospinal fluid penetration, and high oral bioavailability, we investigated PB as a potential radiation sensitizer in human glioblastoma cell lines...
  89. ncbi request reprint Gamma knife surgery for trigeminal neuralgia: outcome, imaging, and brainstem correlates
    Alice V Cheuk
    University of Maryland School of Medicine, Baltimore, MD, USA
    Int J Radiat Oncol Biol Phys 60:537-41. 2004
    ....
  90. ncbi request reprint Impact of total lymph node count and lymph node ratio on staging and survival after pancreatectomy for pancreatic adenocarcinoma: a large, population-based analysis
    Mark B Slidell
    Department of Surgery, Georgetown University Hospital, Washington, District of Columbia, USA
    Ann Surg Oncol 15:165-74. 2008
    ..LNR has never been investigated in a large population-based study of patients with pancreatic adenocarcinoma...