Research Topics
Species | Joseph M HermanSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Randomized phase III multi-institutional study of TNFerade biologic with fluorouracil and radiotherapy for locally advanced pancreatic cancer: final resultsJoseph M Herman
Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, 401 N Broadway, Weinberg Suite 1440, Baltimore, MD 21231, USA
J Clin Oncol 31:886-94. 2013..We herein report final results of the largest randomized phase III trial performed to date among patients with locally advanced pancreatic cancer (LAPC) and the first to test gene transfer against this malignancy...
The quality-of-life effects of neoadjuvant chemoradiation in locally advanced rectal cancerJoseph M Herman
Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231 2410, USA
Int J Radiat Oncol Biol Phys 85:e15-9. 2013..Our goals were to prospectively explore acute changes in patient-reported QOL endpoints during and after treatment and to establish a distribution of scores that could be used for comparison as new treatment modalities emerge...- Radiotherapy using a water bath in the treatment of Bowen's disease of the digitJoseph M Herman
Department of Radiation Oncology, University of Michigan, Ann Arbor, USA
Radiother Oncol 88:398-402. 2008..Surgical treatment of BD of the digit can result in poor function and sometimes amputation. Here, we report our experience using a unique water bath technique to treat BD of the digit... - Analysis of fluorouracil-based adjuvant chemotherapy and radiation after pancreaticoduodenectomy for ductal adenocarcinoma of the pancreas: results of a large, prospectively collected database at the Johns Hopkins HospitalJoseph M Herman
Department of Radiation Oncology and Molecular Radiation Sciences, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Hospital, Baltimore, MD, USA
J Clin Oncol 26:3503-10. 2008..To examine the efficacy of adjuvant chemoradiotherapy after pancreaticoduodenectomy (PD) for pancreatic adenocarcinoma (PC) in patients undergoing resection at Johns Hopkins Hospital (JHH; Baltimore, MD)... - Adjuvant chemoradiotherapy after pancreatic resection for invasive carcinoma associated with intraductal papillary mucinous neoplasm of the pancreasMichael J Swartz
Department of Radiation Oncology and Molecular Radiation Sciences, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Hospital, Baltimore, MD 21231 2410, USA
Int J Radiat Oncol Biol Phys 76:839-44. 2010..Intraductal papillary mucinous neoplasms are mucin-producing cystic neoplasms of the pancreas. One-third are associated with invasive carcinoma. We examined the benefit of adjuvant chemoradiotherapy (CRT) for this cohort... - Adjuvant chemoradiation for pancreatic adenocarcinoma: the Johns Hopkins Hospital-Mayo Clinic collaborative studyCharles C Hsu
Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Hospital, Baltimore, MD, USA
Ann Surg Oncol 17:981-90. 2010..Our goal was to examine efficacy of adjuvant CRT in resected pancreatic adenocarcinoma compared with surgery alone... - Early mortality risk score: identification of poor outcomes following upfront surgery for resectable pancreatic cancerCharles C Hsu
The Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, 410 North Broadway Suite 1440, Baltimore, MD 21231 2410, USA
J Gastrointest Surg 16:753-61. 2012..This study examines the preoperative predictors of early mortality following PD and combines these variables into an early mortality risk score (EMRS)... - Adjuvant chemoradiation therapy after pancreaticoduodenectomy in elderly patients with pancreatic adenocarcinomaDavid P Horowitz
Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Int J Radiat Oncol Biol Phys 80:1391-7. 2011..To evaluate the efficacy of adjuvant chemoradiation therapy (CRT) for pancreatic adenocarcinoma patients ≥ 75 years of age... - Comparison of conventional and 3-dimensional computed tomography against histopathologic examination in determining pancreatic adenocarcinoma tumor size: implications for radiation therapy planningHaoming Qiu
Department of Radiation Oncology and Molecular Radiation Sciences, Sol Goldman Pancreatic Cancer Research Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Radiother Oncol 104:167-72. 2012.... - Patient readmission and mortality after surgery for hepato-pancreato-biliary malignanciesEric B Schneider
Center for Surgical Trials and Outcomes Research, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, MD
J Am Coll Surg 215:607-15. 2012..The objective of the current study was to compare readmission after pancreatic vs hepatobiliary surgical procedures, as well as to identify potential factors associated with higher readmission within 30 days of discharge... - Evaluation of adjuvant chemoradiation therapy for ampullary adenocarcinoma: the Johns Hopkins Hospital-Mayo Clinic collaborative studyAmol K Narang
Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Radiat Oncol 6:126. 2011..We combined the experience of two institutions to better delineate which patients may benefit from adjuvant chemoradiation... - Re-evaluating the impact of tumor size on survival following pancreaticoduodenectomy for pancreatic adenocarcinomaMechteld C de Jong
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Surg Oncol 103:656-62. 2011..We sought to examine the association of size with outcomes following resection of pancreatic adenocarcinoma... - Determining pattern of recurrence following pancreaticoduodenectomy and adjuvant 5-flurouracil-based chemoradiation therapy: effect of number of metastatic lymph nodes and lymph node ratioBolanle Asiyanbola
Department of Surgery, Johns Hopkins Hospital, 600 North Wolfe Street, Halsted 614, Baltimore, MD 22187 6681, USA
J Gastrointest Surg 13:752-9. 2009..There are limited data on patterns of recurrence and factors associated with local recurrence following pancreaticoduodenectomy for pancreatic adenocarcinoma and adjuvant 5-flurouracil-based chemoradiation therapy... - Conditional survival in patients with pancreatic ductal adenocarcinoma resected with curative intentSkye C Mayo
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Cancer 118:2674-81. 2012..Survival estimates, however, are dynamic and may change based on the time already survived. The authors sought to assess conditional survival among a large cohort of patients who underwent resection of PDAC... - Liver-directed therapy for hepatic metastases in patients undergoing pancreaticoduodenectomy: a dual-center analysisMechteld C de Jong
Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Ann Surg 252:142-8. 2010..To analyze the perioperative and long-term outcomes of patients undergoing liver-directed therapy after pancreaticoduodenectomy in a large dual-center cohort of patients... - Adjuvant chemoradiation therapy for adenocarcinoma of the distal pancreasKristin J Redmond
Department of Radiation Oncology and Molecular Radiation Sciences, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Ann Surg Oncol 17:3112-9. 2010..This study was designed to examine the effect of adjuvant 5-FU-based chemoradiation therapy (CRT) after distal pancreatectomy for adenocarcinoma of the distal pancreas... - Resected pancreatic adenosquamous carcinoma: clinicopathologic review and evaluation of adjuvant chemotherapy and radiation in 38 patientsK Ranh Voong
Department of Radiation Oncology and Molecular Radiation Sciences, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Hospital, Baltimore, MD 21231 6681, USA
Hum Pathol 41:113-22. 2010..Treatment with adjuvant chemoradiation therapy is associated with improved survival. The proportion of squamous differentiation in resected pancreatic adenosquamous carcinoma specimens does not appear to impact overall survival... - Outcomes of adjuvant chemoradiation after pancreaticoduodenectomy with mesenterico-portal vein resection for adenocarcinoma of the pancreasBoris Hristov
Department of Radiation Oncology and Molecular Radiation Sciences, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, MD, USA
Int J Radiat Oncol Biol Phys 76:176-80. 2010..The purpose of this study was to compare outcomes between pancreaticoduodenectomy (PD) with and without mesenterico-portal vein resection (VR) in patients receiving adjuvant CRT for pancreatic adenocarcinoma... - Treating patients with colon cancer liver metastasis: a nationwide analysis of therapeutic decision makingHari Nathan
Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Ann Surg Oncol 19:3668-76. 2012..Criteria for resectability of colon cancer liver metastases (CLM) are evolving, yet little is known about how physicians choose a therapeutic strategy for potentially resectable CLM... - Incidence and management of chyle leaks following pancreatic resection: a high volume single-center institutional experienceLia Assumpcao
Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Gastrointest Surg 12:1915-23. 2008..We sought to identify possible risk factors associated with chyle leaks following pancreatic resection, as well as determine the natural history of this rare complication... - Duodenal adenocarcinoma: clinicopathologic analysis and implications for treatmentGeorge A Poultsides
Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Ann Surg Oncol 19:1928-35. 2012..Duodenal adenocarcinoma is a rare cancer usually studied as a group with periampullary or small bowel adenocarcinoma; therefore, its natural history is poorly understood... - Palliative surgical management of patients with unresectable pancreatic adenocarcinoma: trends and lessons learned from a large, single institution experiencePeter J Kneuertz
Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Gastrointest Surg 15:1917-27. 2011..We examined trends in the relative use of palliative bypass over time with an emphasis on identifying changes in surgical indications, type of bypass performed, as well as perioperative outcomes associated with surgical palliation... - Impact of obesity on perioperative outcomes and survival following pancreaticoduodenectomy for pancreatic cancer: a large single-institution studySusan Tsai
Department of Surgery, Johns Hopkins Medical Institutions, 600N Wolfe Street, Baltimore, MD 21287, USA
J Gastrointest Surg 14:1143-50. 2010..To examine the effect of body mass index (BMI) on clinicopathologic factors and long-term survival in patients undergoing pancreaticoduodenectomy for pancreatic adenocarcinoma... - Predictors of survival after resection of retroperitoneal sarcoma: a population-based analysis and critical appraisal of the AJCC staging systemHari Nathan
Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Ann Surg 250:970-6. 2009..To identify predictors of survival after resection of retroperitoneal sarcoma (RPS) and to evaluate the performance of the American Joint Committee on Cancer (AJCC) staging system for RPS... - Management of patients with pancreatic adenocarcinoma: national trends in patient selection, operative management, and use of adjuvant therapySkye C Mayo
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Am Coll Surg 214:33-45. 2012..Advances in surgical technique and perioperative care have reduced perioperative mortality; however, temporal trends in perioperative morbidity and the use of adjuvant therapy on a population basis remain ill-defined... - Clinicopathologic analysis of ampullary neoplasms in 450 patients: implications for surgical strategy and long-term prognosisJordan M Winter
Department of Surgery, Johns Hopkins Medical Institutions, Halsted 610, 600 N Wolfe Street, Baltimore, MD 21287, USA
J Gastrointest Surg 14:379-87. 2010..We sought to examine the outcome of patients undergoing pancreaticoduodenectomy versus ampullectomy, as well as to identify factors predictive of lymph node metastasis in patients with ampullary neoplasms... - Analysis of local control in patients receiving IMRT for resected pancreatic cancersSusannah Yovino
Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Int J Radiat Oncol Biol Phys 83:916-20. 2012..A concern regarding this technique is the potential for geographic miss and decreased local control. We analyzed patterns of first failure among patients treated with IMRT for resected pancreatic cancer... - Vascular invasion in infiltrating ductal adenocarcinoma of the pancreas can mimic pancreatic intraepithelial neoplasia: a histopathologic study of 209 casesSeung Mo Hong
Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231 2410, USA
Am J Surg Pathol 36:235-41. 2012..3 mo) had a significantly worse survival than did patients with carcinomas without vascular invasion (25.1 mo; P=0.01, log-rank test). Microscopic vascular invasion is a poor prognostic indicator and can histologically mimic PanIN... - Pulmonary resection for isolated pancreatic adenocarcinoma metastasis: an analysis of outcomes and survivalGeorge J Arnaoutakis
Division of Thoracic Surgery, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
J Gastrointest Surg 15:1611-7. 2011..This study was conducted to determine if pulmonary metastasectomy (PM) for isolated pancreatic cancer metastases is safe and effective... - Sclerosing mesenteritis involving the pancreas: a mimicker of pancreatic cancerJennifer R Scudiere
Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
Am J Surg Pathol 34:447-53. 2010..Distinguishing SM from pancreatic carcinoma is crucial to appropriate management, as patients with SM may benefit from immunosuppressive therapy... - Presence of pancreatic intraepithelial neoplasia in the pancreatic transection margin does not influence outcome in patients with R0 resected pancreatic cancerHanno Matthaei
The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University, Baltimore, MD, USA
Ann Surg Oncol 18:3493-9. 2011..Margin status is one of the strongest prognosticators after resection of pancreatic ductal adenocarcinoma (PDAC). The clinical significance of pancreatic intraepithelial neoplasia (PanIN) at a surgical margin has not been established... - Peri-operative mortality and long-term survival after total pancreatectomy for pancreatic adenocarcinoma: a population-based perspectiveHari Nathan
Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Surg Oncol 99:87-92. 2009..We sought to analyze peri-operative mortality and long-term survival following TP versus PP for pancreatic adenocarcinoma... - Safety and efficacy of curative intent surgery for peri-ampullary liver metastasisMechteld C de Jong
Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Surg Oncol 102:256-63. 2010..The management of patients with peri-ampullary liver metastasis remains controversial. We sought to assess the safety and efficacy of curative intent surgery for peri-ampullary liver metastasis... - Pancreatic resection of isolated metastases from nonpancreatic primary cancersSushanth Reddy
Department of Surgery, The Johns Hopkins University, 600 North Wolfe Street, Carnegie 681, Baltimore, Maryland 21287, USA
Ann Surg Oncol 15:3199-206. 2008..The goal of this study is to report the safety and efficacy of pancreatic resection for isolated metastatic cancers from nonpancreatic primary disease... - Effect of metabolic syndrome on perioperative outcomes after liver surgery: A National Surgical Quality Improvement Program (NSQIP) analysisNeil H Bhayani
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Surgery 152:218-26. 2012..A subset of patients with obesity will have metabolic syndrome. We sought to examine the impact of metabolic syndrome on the risk of morbidity and mortality among a large cohort of patients who underwent hepatic resection... - Loss of E-cadherin expression and outcome among patients with resectable pancreatic adenocarcinomasSeung Mo Hong
Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
Mod Pathol 24:1237-47. 2011..02). Among patients undergoing pancreaticoduodenectomy for pancreatic ductal adenocarcinoma, partial loss of tumoral E-cadherin expression is an independent predictor of poor outcome... - Young patients undergoing resection of pancreatic cancer fare better than their older counterpartsJin He
Department of Surgery, Johns Hopkins University School of Medicine, 600 N Wolfe St, Osler 624, Baltimore, MD 21287, USA
J Gastrointest Surg 17:339-44. 2013..We investigated features of PDAC occurring in young patients (≤45 years) who underwent surgical resection in order to determine if any difference exists in comparison to elderly patients (≥70 years)... - Increased organ sparing using shape-based treatment plan optimization for intensity modulated radiation therapy of pancreatic adenocarcinomaSteven F Petit
Department of Computer Science, Johns Hopkins University, Baltimore, USA
Radiother Oncol 102:38-44. 2012..To develop a model to assess the quality of an IMRT treatment plan using data of prior patients with pancreatic adenocarcinoma... - Evaluating the impact of a single-day multidisciplinary clinic on the management of pancreatic cancerTimothy M Pawlik
Department of Surgery, The Sol Goldman Pancreatic Cancer Research Center, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, Baltimore, MD, USA
Ann Surg Oncol 15:2081-8. 2008..To evaluate the impact of a multidisciplinary clinic on the clinical care recommendations of patients with pancreatic cancer compared with the recommendations the patients received prior to review by the multidisciplinary tumor board... - Management of extremity soft tissue sarcomasMatthew T Hueman
Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Surg Clin North Am 88:539-57, vi. 2008..As is true for patients diagnosed with sarcoma at other anatomic sites, a multidisciplinary team approach streamlines care with attention to the complexities and intricacies of choosing and delivering optimal therapy... - Multidisciplinary management of recurrent hepatocellular carcinoma following liver transplantationPeter J Kneuertz
Department of Surgery, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Gastrointest Surg 16:874-81. 2012..While the majority of patients recur in the first two years after transplantation, late recurrence is not infrequent... - Management of retroperitoneal sarcomasMatthew T Hueman
The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Surg Clin North Am 88:583-97, vii. 2008..Optimizing disease control while minimizing the morbidity of therapy remains the primary goal of management. In this article, the authors describe the presentation, evaluation, and management of patients who have retroperitoneal sarcoma... - A tolerability and pharmacokinetic study of adjuvant erlotinib and capecitabine with concurrent radiation in resected pancreatic cancerWen Wee Ma
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA
Transl Oncol 3:373-9. 2010..The pharmacokinetic profile of this combination was also evaluated... - Phase 2 study of rituximab-ABVD in classical Hodgkin lymphomaYvette L Kasamon
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA
Blood 119:4129-32. 2012..Persistence of detectable circulating clonotypic B cells was associated with a greater relapse frequency (P < .05). Rituximab-ABVD and clonotypic B cells warrant additional study in classical Hodgkin lymphoma... - Clinicopathologic Comparison of High-Dose-Rate Endorectal Brachytherapy versus Conventional Chemoradiotherapy in the Neoadjuvant Setting for Resectable Stages II and III Low Rectal CancerJessica A Smith
Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2196, USA
Int J Surg Oncol 2012:406568. 2012..Conclusions. EBT offers several practical benefits over conventional radiotherapy techniques and appears to be at least as effective against low rectal cancer as measured by short-term outcomes... 
Prospective quality-of-life assessment in patients receiving concurrent gemcitabine and radiotherapy as a bladder preservation strategyJoseph M Herman
Department ofRadiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
Urology 64:69-73. 2004..The results of this study suggest that concurrent gemcitabine with conformal RT is a tolerable treatment regimen for bladder preservation, as demonstrated by the excellent treatment compliance and similar FACT measurements...- Management of perihilar cholangiocarcinoma in the era of multimodal therapyVicente Valero
Department of Surgery, Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Harvey 611, 600 N Wolfe Street, Baltimore, MD 21287, USA
Expert Rev Gastroenterol Hepatol 6:481-95. 2012..Orthotopic liver transplantation offers complete resection of locally advanced tumors in select patient groups... - Resectable pancreatic small cell carcinomaJordan M Winter
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD
Rare Tumors 3:e5. 2011..Cisplatin and etoposide appears to be the preferred chemotherapy regimen, although its efficacy remains uncertain, as does the role of combined modality treatment with radiation... - Adjuvant chemoradiation versus surgery alone for adenocarcinoma of the ampulla of VaterJessica Zhou
Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Hospital, 401 N Broadway, Baltimore, MD 21231, USA
Radiother Oncol 92:244-8. 2009..To examine the role of adjuvant chemoradiation (CRT) in patients with resected ampullary adenocarcinoma... - Transitoriness in cancer patients: a cross-sectional survey of lung and gastrointestinal cancer patientsMaya Shaha
Johns Hopkins University School of Nursing, 525 North Wolfe Street, Baltimore, MD 21205, USA
Support Care Cancer 19:271-9. 2010..Transitoriness is defined as a person's confrontation with life's finitude due to a cancer diagnosis... - DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancerChristine A Iacobuzio-Donahue
Department of Pathology, Surgery, and Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
J Clin Oncol 27:1806-13. 2009..A comprehensive study of pancreatic cancers from patients who have succumbed to their disease has the potential to greatly expand our understanding of the most lethal stage of this disease and identify novel areas for intervention... - Multidisciplinary management of pancreatic cancerRachit Kumar
Department of Radiation Oncology and Molecular Radiation Sciences, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Surg Oncol Clin N Am 22:265-87. 2013..In this review, the importance of multidisciplinary management of pancreatic cancer based on disease stage is discussed... - Is resection of periampullary or pancreatic adenocarcinoma with synchronous hepatic metastasis justified?Ana Luiza Gleisner
Department of Surgery, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, Maryland 22187 6681, USA
Cancer 110:2484-92. 2007..Specifically, the role of hepatic resection for metastatic periampullary or pancreatic adenocarcinoma remains controversial... - Use of respiratory-correlated four-dimensional computed tomography to determine acceptable treatment margins for locally advanced pancreatic adenocarcinomaSeth D Goldstein
Department of Surgery, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, MD 21231 2410, USA
Int J Radiat Oncol Biol Phys 76:597-602. 2010..Respiratory-induced excursions of locally advanced pancreatic adenocarcinoma could affect dose delivery. This study quantified tumor motion and evaluated standard treatment margins... - Salvage therapy for liver-dominant colorectal metastatic adenocarcinoma: comparison between transcatheter arterial chemoembolization versus yttrium-90 radioembolizationKelvin Hong
Division of Vascular and Interventional Radiology, Johns Hopkins Medical Institutions and Russell H Morgan, Johns Hopkins Hospital, Baltimore, MD 21287, USA
J Vasc Interv Radiol 20:360-7. 2009..To compare transarterial chemoembolization (CE) versus yttrium-90 ((90)Y) radioembolization (RE) for liver-dominant metastatic colorectal adenocarcinoma as salvage therapy... - The role of radiation in retroperitoneal sarcomas: a surgical perspectiveTimothy M Pawlik
Department of Surgery, Division of Surgical Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 22187 6681, USA
Curr Opin Oncol 19:359-66. 2007..Although data suggest that the addition of intraoperative radiation therapy to external beam radiation therapy improves local control, intraoperative radiation therapy may be related to additional toxicity... - Hedgehog pathway inhibition radiosensitizes non-small cell lung cancersJing Zeng
Department of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland
Int J Radiat Oncol Biol Phys 86:143-9. 2013..Whether Hedgehog inhibition can affect radiation efficacy in vivo has not been reported... - Clinical significance of the genetic landscape of pancreatic cancer and implications for identification of potential long-term survivorsShinichi Yachida
Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Clin Cancer Res 18:6339-47. 2012..Genetic alterations of KRAS, CDKN2A, TP53, and SMAD4 are the most frequent events in pancreatic cancer. We determined the extent to which these 4 alterations are coexistent in the same carcinoma, and their impact on patient outcome... - Local therapies for hepatic metastasesFabian M Johnston
Department of Surgery, The Johns Hopkins University, Baltimore, MD 21287, USA
J Natl Compr Canc Netw 11:153-60. 2013..This article evaluates the available evidence on current regional strategies for managing patients with liver metastases, with an emphasis on CRLM and NELM, highlighting the clinical usefulness and limitations of each modality... - Management and recurrence patterns of desmoids tumors: a multi-institutional analysis of 211 patientsPeter D Peng
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Ann Surg Oncol 19:4036-42. 2012..Desmoid tumors are rare soft-tissue neoplasms with limited data on their management. We sought to determine the rates of recurrence following surgery for desmoid tumors and identify factors predictive of disease-free survival... - Primary versus radiation-associated craniofacial osteosarcoma: Biologic and clinicopathologic comparisonsJonathan B McHugh
Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109-0054, USA
Cancer 107:554-62. 2006..In addition, they demonstrate higher expression rates of adverse prognostic indicators, further highlighting the distinction... - SMAD4 gene mutations are associated with poor prognosis in pancreatic cancerAmanda Blackford
Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
Clin Cancer Res 15:4674-9. 2009..Recently, the majority of protein coding genes were sequenced in a collection of pancreatic cancers, providing an unprecedented opportunity to identify genetic markers of prognosis for patients with adenocarcinoma of the pancreas... - The promise and pitfalls of positron emission tomography and single-photon emission computed tomography molecular imaging-guided radiation therapyRichard L Wahl
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Semin Radiat Oncol 21:88-100. 2011..As MIGRT evolves, evidence must continue to be gathered to support improved clinical outcomes using MIGRT versus purely anatomic approaches... - Comparative analysis of traditional and coiled fiducials implanted during EUS for pancreatic cancer patients receiving stereotactic body radiation therapyMouen A Khashab
Department of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore, Maryland 21205, USA
Gastrointest Endosc 76:962-71. 2012..EUS-guided fiducial placement facilitates image-guided radiation therapy (IGRT)... - Development of a novel preclinical pancreatic cancer research model: bioluminescence image-guided focal irradiation and tumor monitoring of orthotopic xenograftsRichard Tuli
Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Transl Oncol 5:77-84. 2012.... - Phenylbutyrate sensitizes human glioblastoma cells lacking wild-type p53 function to ionizing radiationCarlos A Lopez
Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 0010, USA
Int J Radiat Oncol Biol Phys 69:214-20. 2007..Because of its low cytotoxicity, cerebrospinal fluid penetration, and high oral bioavailability, we investigated PB as a potential radiation sensitizer in human glioblastoma cell lines... - Gamma knife surgery for trigeminal neuralgia: outcome, imaging, and brainstem correlatesAlice V Cheuk
University of Maryland School of Medicine, Baltimore, MD, USA
Int J Radiat Oncol Biol Phys 60:537-41. 2004..Treatment response and the development of facial numbness do not correlate with MRI imaging quality, presence of nerve compression, or radiation dose to the brainstem... - Impact of total lymph node count and lymph node ratio on staging and survival after pancreatectomy for pancreatic adenocarcinoma: a large, population-based analysisMark B Slidell
Department of Surgery, Georgetown University Hospital, Washington, District of Columbia, USA
Ann Surg Oncol 15:165-74. 2008..LNR has never been investigated in a large population-based study of patients with pancreatic adenocarcinoma...