James G Herman

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Defining a chromatin pattern that characterizes DNA-hypermethylated genes in colon cancer cells
    Kelly M McGarvey
    Divisions of Cancer Biology, The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland 21231, USA
    Cancer Res 68:5753-9. 2008
  2. ncbi request reprint Gene silencing in cancer in association with promoter hypermethylation
    James G Herman
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins Medical Institutions, Baltimore, USA
    N Engl J Med 349:2042-54. 2003
  3. ncbi request reprint Methylation-specific polymerase chain reaction
    Oliver Galm
    Medizinische Klinik IV, Universitaetsklinikum Aachen, Aachen, Germany
    Methods Mol Med 113:279-91. 2005
  4. ncbi request reprint Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms
    Steven D Gore
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21287, USA
    Cancer Res 66:6361-9. 2006
  5. pmc CDX2 serves as a Wnt signaling inhibitor and is frequently methylated in lung cancer
    Xuefeng Liu
    Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, China
    Cancer Biol Ther 13:1152-7. 2012
  6. ncbi request reprint Circulating methylated DNA
    James G Herman
    Department of Oncology, Evelyn Grollman Glick Scholar, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Ann N Y Acad Sci 1022:33-9. 2004
  7. ncbi request reprint Prognostic importance of promoter hypermethylation of multiple genes in esophageal adenocarcinoma
    Malcolm V Brock
    Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Clin Cancer Res 9:2912-9. 2003
  8. ncbi request reprint Hypermethylation pathways to colorectal cancer. Implications for prevention and detection
    James G Herman
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins School of Medicine, Bunting Blaustein Cancer Research Building, 1650 Orleans, Room 543, Baltimore, MD 21231, USA
    Gastroenterol Clin North Am 31:945-58. 2002
  9. ncbi request reprint Hypermethylation of the GATA genes in lung cancer
    Mingzhou Guo
    Johns Hopkins Medical Institutions, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Clin Cancer Res 10:7917-24. 2004
  10. ncbi request reprint Epigenetic silencing of CDX2 is a feature of squamous esophageal cancer
    Mingzhou Guo
    Department of Oncology, Cancer Biology Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231 1000, USA
    Int J Cancer 121:1219-26. 2007

Collaborators

Detail Information

Publications103 found, 100 shown here

  1. pmc Defining a chromatin pattern that characterizes DNA-hypermethylated genes in colon cancer cells
    Kelly M McGarvey
    Divisions of Cancer Biology, The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland 21231, USA
    Cancer Res 68:5753-9. 2008
    ..Our data have great relevance for the increasing interest in reexpression of DNA-hypermethylated genes for the treatment of cancer...
  2. ncbi request reprint Gene silencing in cancer in association with promoter hypermethylation
    James G Herman
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins Medical Institutions, Baltimore, USA
    N Engl J Med 349:2042-54. 2003
  3. ncbi request reprint Methylation-specific polymerase chain reaction
    Oliver Galm
    Medizinische Klinik IV, Universitaetsklinikum Aachen, Aachen, Germany
    Methods Mol Med 113:279-91. 2005
    ..It is a rapid and cost-effective method that does not require radioactive reagents and can be used for the analysis of a large number of clinical samples...
  4. ncbi request reprint Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms
    Steven D Gore
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21287, USA
    Cancer Res 66:6361-9. 2006
    ..The promising percentage of major hematologic responses justifies the testing of such combinations in prospective randomized trials...
  5. pmc CDX2 serves as a Wnt signaling inhibitor and is frequently methylated in lung cancer
    Xuefeng Liu
    Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, China
    Cancer Biol Ther 13:1152-7. 2012
    ..CDX2 may serve as a tumor suppressor in lung cancer and inhibits lung cancer cell proliferation by suppressing Wnt signaling...
  6. ncbi request reprint Circulating methylated DNA
    James G Herman
    Department of Oncology, Evelyn Grollman Glick Scholar, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Ann N Y Acad Sci 1022:33-9. 2004
    ..These factors are presented and their impact on the detection of methylated DNA circulating in the bloodstream is demonstrated...
  7. ncbi request reprint Prognostic importance of promoter hypermethylation of multiple genes in esophageal adenocarcinoma
    Malcolm V Brock
    Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Clin Cancer Res 9:2912-9. 2003
    ..The association of clinicopathological and biomolecular risk factors to survival and recurrence was performed using the Log-rank test and Cox proportional hazards model for multivariate analysis...
  8. ncbi request reprint Hypermethylation pathways to colorectal cancer. Implications for prevention and detection
    James G Herman
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins School of Medicine, Bunting Blaustein Cancer Research Building, 1650 Orleans, Room 543, Baltimore, MD 21231, USA
    Gastroenterol Clin North Am 31:945-58. 2002
    ..These changes compliment and lead to genetic changes that are well established as central to colorectal cancer progression. They may also prove useful in molecular detection approaches...
  9. ncbi request reprint Hypermethylation of the GATA genes in lung cancer
    Mingzhou Guo
    Johns Hopkins Medical Institutions, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Clin Cancer Res 10:7917-24. 2004
    ..In lung cancer, DNA hypermethylation is known to be a common event...
  10. ncbi request reprint Epigenetic silencing of CDX2 is a feature of squamous esophageal cancer
    Mingzhou Guo
    Department of Oncology, Cancer Biology Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231 1000, USA
    Int J Cancer 121:1219-26. 2007
    ..Our results suggest that the inactivation of CDX2 in esophageal cancer associated with DNA methylation may be an important determinant of the squamous or non-adenomatous phenotype...
  11. pmc Aberrant silencing of cancer-related genes by CpG hypermethylation occurs independently of their spatial organization in the nucleus
    Hariharan P Easwaran
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Cancer Res 70:8015-24. 2010
    ..These findings have important implications for understanding relationships between nuclear organization and gene expression patterns in cancer...
  12. ncbi request reprint Promoter methylation of HIN-1 in the progression to esophageal squamous cancer
    Mingzhou Guo
    Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA
    Epigenetics 3:336-41. 2008
    ..These studies demonstrate HIN-1 silencing is associated with dense promoter region hypermethylation in esophageal cancer and suggest that methylation of HIN-1 is an early event in dysplastic transformation...
  13. pmc PcG proteins, DNA methylation, and gene repression by chromatin looping
    Vijay K Tiwari
    Cancer Biology Division, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University Medical Institutions, Baltimore, Maryland, USA
    PLoS Biol 6:2911-27. 2008
    ..The loops associate with a poised, low transcription state in EC cells and, with the addition of DNA methylation, completely repressed transcription in adult cancer cells...
  14. ncbi request reprint Accumulation of promoter methylation suggests epigenetic progression in squamous cell carcinoma of the esophagus
    Mingzhou Guo
    Cancer Biology Program, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Clin Cancer Res 12:4515-22. 2006
    ..We examined the changes in promoter region methylation occurring during neoplastic progression...
  15. pmc Epigenetic alteration of Wnt pathway antagonists in progressive glandular neoplasia of the lung
    Julien D F Licchesi
    Cancer Biology Program, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Carcinogenesis 29:895-904. 2008
    ....
  16. pmc Progressive chromatin repression and promoter methylation of CTNNA1 associated with advanced myeloid malignancies
    Ying Ye
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 69:8482-90. 2009
    ....
  17. pmc Epigenetic inactivation of the canonical Wnt antagonist SRY-box containing gene 17 in colorectal cancer
    Wei Zhang
    Division of Cancer Biology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, Baltimore, MD 21231, USA
    Cancer Res 68:2764-72. 2008
    ....
  18. doi request reprint DNA methylation markers and early recurrence in stage I lung cancer
    Malcolm V Brock
    Johns Hopkins Hospital, Baltimore, USA
    N Engl J Med 358:1118-28. 2008
    ..Despite optimal and early surgical treatment of non-small-cell lung cancer (NSCLC), many patients die of recurrent NSCLC. We investigated the association between gene methylation and recurrence of the tumor...
  19. pmc Epigenetic regulation of DACT2, a key component of the Wnt signalling pathway in human lung cancer
    Yan Jia
    Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, China
    J Pathol 230:194-204. 2013
    ..In conclusion, DACT2 methylation is a potential lung cancer detection marker. DACT2 is regulated by promoter region hypermethylation. DACT2 inhibits lung cancer proliferation by suppressing the Wnt signalling pathway in lung cancer...
  20. ncbi request reprint Hypermethylation of the GATA gene family in esophageal cancer
    Mingzhou Guo
    Cancer Biology Program, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231 1000, USA
    Int J Cancer 119:2078-83. 2006
    ..Our studies demonstrate frequent silencing of GATA-4 and GATA-5, but not GATA-6, in human esophageal neoplasia associated with gene promoter hypermethylation...
  21. pmc DNA promoter hypermethylation of p16 and APC predicts neoplastic progression in Barrett's esophagus
    Jean S Wang
    Department of Medicine Gastroenterology, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Am J Gastroenterol 104:2153-60. 2009
    ..We determined whether DNA promoter hypermethylation of genes frequently methylated in esophageal adenocarcinoma (p16 and APC) could be used as predictors of progression in BE...
  22. pmc GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer
    Yoshimitsu Akiyama
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Mol Cell Biol 23:8429-39. 2003
    ..Selection for silencing of both upstream transcription factors and their target genes in GI cancers could indicate that epigenetic silencing of the involved genes provides a summated contribution to tumor progression...
  23. pmc Acute myeloid leukemia is characterized by Wnt pathway inhibitor promoter hypermethylation
    Elizabeth A Griffiths
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Leuk Lymphoma 51:1711-9. 2010
    ....
  24. ncbi request reprint hTERT is expressed in cancer cell lines despite promoter DNA methylation by preservation of unmethylated DNA and active chromatin around the transcription start site
    Rebekah L Zinn
    Sidney Kimmel Comprehensive Cancer Center and Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Cancer Res 67:194-201. 2007
    ....
  25. doi request reprint An inactivating mutation in HDAC2 leads to dysregulation of apoptosis mediated by APAF1
    Christin L Hanigan
    Sidney Kimmel Comprehensive Cancer Center and Graduate Program in Cellular and Molecular Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Gastroenterology 135:1654-1664.e2. 2008
    ..Histone deacetylases (HDACs) are important regulators of chromatin involved in silencing tumor suppressor genes. We examined mutation of HDAC2 and examined consequences of HDAC2 loss...
  26. pmc Methylation of TFPI2 in stool DNA: a potential novel biomarker for the detection of colorectal cancer
    Sabine C Glöckner
    Departments of Surgery, Oncology, and Pathology, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Cancer Res 69:4691-9. 2009
    ..Detection of TFPI2 methylation in stool DNA may act as a useful adjunct to the noninvasive strategies for screening of CRCs in the future...
  27. pmc Epigenetic differences in cytogenetically normal versus abnormal acute myeloid leukemia
    Elizabeth A Griffiths
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
    Epigenetics 5:590-600. 2010
    ..Methylation of tumor suppression genes (TSGs) is common in myeloid malignancies. However, application of this as a molecular marker for risk stratification in patients with AML is limited...
  28. ncbi request reprint Epigenetic regulation of protein phosphatase 2A (PP2A), lymphotactin (XCL1) and estrogen receptor alpha (ER) expression in human breast cancer cells
    Judith C Keen
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Cancer Biol Ther 3:1304-12. 2004
    ..These gene products may be novel targets to be further explored in the development of new therapeutics for ER negative breast cancer...
  29. pmc Epigenetic silencing of CXCL14 induced colorectal cancer migration and invasion
    Baoping Cao
    Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing 100853, China and College of Medicine, Nankai University, Tianjin 300071, China
    Discov Med 16:137-47. 2013
    ..Restoration of CXCL14 expression suppressed colorectal cancer proliferation. CXCL14 inhibits colorectal cancer migration, invasion, and epithelial-to-mesenchymal transition (EMT) by suppressing NF-κB signaling. ..
  30. ncbi request reprint Dependence of histone modifications and gene expression on DNA hypermethylation in cancer
    Jill A Fahrner
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, Maryland 21231 1000, USA
    Cancer Res 62:7213-8. 2002
    ..Our findings suggest a new paradigm-DNA methylation may directly, or indirectly by inhibiting transcription, maintain key repressive elements of the histone code at a hypermethylated gene promoter in cancer...
  31. ncbi request reprint Hypermethylation of ASC/TMS1 is a sputum marker for late-stage lung cancer
    Emi Ota Machida
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Cancer Res 66:6210-8. 2006
    ..Thus, hypermethylation of ASC/TMS1 is a marker for late-stage lung cancer and, in sputum, could predict prognosis in patients resected for early-stage disease...
  32. ncbi request reprint Can we improve the cytologic examination of malignant pleural effusions using molecular analysis?
    Malcolm V Brock
    Division of Thoracic Surgery, Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Ann Thorac Surg 80:1241-7. 2005
    ..Deoxyribonucleic acid (DNA) methylation is a robust strategy for detecting cancer early in tissue. We hypothesized that DNA methylation would be more sensitive in diagnosing patients with malignant pleural effusions than cytology...
  33. pmc Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation
    Kevin Pruitt
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States of America
    PLoS Genet 2:e40. 2006
    ....
  34. pmc Promoter hypermethylation in sentinel lymph nodes as a marker for breast cancer recurrence
    Hetty E Carraway
    Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Breast Cancer Res Treat 114:315-25. 2009
    ..This study evaluates the methylation frequency and pattern in HNSN to determine if detection of hypermethylation of one or more genes is associated with an increased recurrence risk in node negative breast cancer...
  35. pmc Methylation of TFPI-2 is an early event of esophageal carcinogenesis
    Yan Jia
    Department of Gastroenterology and Hepatology, Chinese People s Liberation Army General Hospital, 28 Fuxing Road, Beijing 100853, China
    Epigenomics 4:135-46. 2012
    ..To explore the epigenetic changes and the function of TFPI-2 in esophageal cancer...
  36. ncbi request reprint Hypermethylation-associated Inactivation of the Cellular Retinol-Binding-Protein 1 Gene in Human Cancer
    Manel Esteller
    The Johns Hopkins Oncology Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Cancer Res 62:5902-5. 2002
    ..Epigenetic disruption of CRBP1 is a common event in human cancer that may have important implications for cancer prevention and treatment using retinoids...
  37. pmc Alcohol consumption and the risk of nasopharyngeal carcinoma: a systematic review
    Liwei Chen
    Center for Human Nutrition, Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA
    Nutr Cancer 61:1-15. 2009
    ..Considered in total, the quantitative summaries of the case-control evidence suggest that heavy alcohol consumption is associated with an increased risk of NPC...
  38. ncbi request reprint Carotenoids and the risk of developing lung cancer: a systematic review
    Lisa Gallicchio
    The Prevention and Research Center, Mercy Medical Center, Baltimore, MD, USA
    Am J Clin Nutr 88:372-83. 2008
    ..Carotenoids are thought to have anti-cancer properties, but findings from population-based research have been inconsistent...
  39. pmc Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer
    Rosalyn A Juergens
    Department of Oncology, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Cancer Discov 1:598-607. 2011
    ....
  40. doi request reprint Biomarkers for detection and prognosis of breast cancer identified by a functional hypermethylome screen
    Jana Jeschke
    Department of Surgery, Johns Hopkins University, Baltimore, MD, USA
    Epigenetics 7:701-9. 2012
    ..92) and validation cohort (HR = 2.87). Our study demonstrates an efficient method to utilize functional methylation changes in BC for the development of effective biomarkers for detection and prognosis prediction of BC...
  41. ncbi request reprint Prognostic value of hMLH1 methylation and microsatellite instability in pancreatic endocrine neoplasms
    Michael G House
    Department of Surgery, The Johns Hopkins Medical Institutions, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Surgery 134:902-8; discussion 909. 2003
    ..The aberrant promoter methylation of the mismatch repair gene, hMLH1, is associated with microsatellite instability (MSI) in cancer cells and often is associated with a favorable prognosis...
  42. pmc MS-qFRET: a quantum dot-based method for analysis of DNA methylation
    Vasudev J Bailey
    Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Genome Res 19:1455-61. 2009
    ..The direct application of MS-qFRET on clinical samples offers great promise for its translational use in early cancer diagnosis, prognostic assessment of tumor behavior, as well as monitoring response to therapeutic agents...
  43. ncbi request reprint Hypermethylation of a small CpGuanine-rich region correlates with loss of activator protein-2alpha expression during progression of breast cancer
    Donna B Douglas
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Cancer Res 64:1611-20. 2004
    ....
  44. ncbi request reprint CHFR promoter hypermethylation in colon cancer correlates with the microsatellite instability phenotype
    Johann C Brandes
    Cancer Biology Program, Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Carcinogenesis 26:1152-6. 2005
    ....
  45. pmc Epigenetic regulation of WNT signaling pathway genes in inflammatory bowel disease (IBD) associated neoplasia
    Mashaal Dhir
    Department of Surgery, Johns Hopkins University, Baltimore, MD 21231, USA
    J Gastrointest Surg 12:1745-53. 2008
    ..This study examined the role of epigenetic silencing of WNT signaling pathway genes in the pathogenesis of IBD-associated neoplasia...
  46. pmc DNA methylation analysis on a droplet-in-oil PCR array
    Yi Zhang
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
    Lab Chip 9:1059-64. 2009
    ..These results were consistent with standard MSP protocols, yet the simplicity of the droplet-in-oil microfluidic PCR platform provides an easy and efficient tool for DNA methylation analysis in a large-scale arrayed manner...
  47. doi request reprint Inhibition of SOX17 by microRNA 141 and methylation activates the WNT signaling pathway in esophageal cancer
    Yan Jia
    Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, China
    J Mol Diagn 14:577-85. 2012
    ..SOX17 is frequently methylated in esophageal cancer and in a progression tendency during esophageal carcinogenesis. Loss of SOX17 removes the normal inhibition of WNT signaling and promotes esophageal tumorigenesis...
  48. ncbi request reprint Evaluation of GATA-4 and GATA-5 methylation profiles in human pancreatic cancers indicate promoter methylation patterns distinct from other human tumor types
    Baojin Fu
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Cancer Biol Ther 6:1546-52. 2007
    ..While hypermethylation of GATA-5 seems to be a universal feature among human tumors, infrequent methylation of GATA-4, and its corresponding overexpression, appears unique to pancreatic cancer from other tumor types reported thus far...
  49. pmc Single-tube analysis of DNA methylation with silica superparamagnetic beads
    Vasudev J Bailey
    Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Clin Chem 56:1022-5. 2010
    ..This method includes many disconnected steps with associated losses of material, potentially reducing the analytical sensitivity required for analysis of challenging clinical samples...
  50. ncbi request reprint Promoter hypermethylation of resected bronchial margins: a field defect of changes?
    Mingzhou Guo
    Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Clin Cancer Res 10:5131-6. 2004
    ..We hypothesized that DNA promoter hypermethylation changes at bronchial margins could be detected in patients with no histological evidence of malignancy and that they would reflect epigenetic events in the primary tumor...
  51. ncbi request reprint Inactivation of the tissue inhibitor of metalloproteinases-2 gene by promoter hypermethylation in lymphoid malignancies
    Oliver Galm
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans St, Baltimore, MD 21231, USA
    Oncogene 24:4799-805. 2005
    ..We conclude that promoter hypermethylation of TIMP-2 is a novel epigenetic event in the pathogenesis of lymphoid malignancies and may contribute to a more aggressive NHL phenotype...
  52. ncbi request reprint Tumor suppressor gene hypermethylation as a predictor of gastric stromal tumor behavior
    Michael G House
    Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD 21231 1000, USA
    J Gastrointest Surg 7:1004-14; discussion 1014. 2003
    ..This study supports the methylation status of E-cadherin as a prognostic marker for early GIST recurrence and survival...
  53. pmc Frequent inactivation of cysteine dioxygenase type 1 contributes to survival of breast cancer cells and resistance to anthracyclines
    Jana Jeschke
    Department of Surgery, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Clin Cancer Res 19:3201-11. 2013
    ..Comprehensive functional analyses provide an understanding of the biologic significance of this vast amount of DNA methylation data that may allow the determination of key epigenetic events associated with tumorigenesis...
  54. ncbi request reprint Survival after community diagnosis of early-stage non-small cell lung cancer
    Norma F Kanarek
    Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Md Electronic address
    Am J Med 127:443-9. 2014
    ..Our objective was to assess the contribution of diagnosis to first surgery interval to survival among patients diagnosed in the community with early-stage non-small cell lung cancer...
  55. pmc Whole-exome sequencing of pancreatic neoplasms with acinar differentiation
    Yuchen Jiao
    Department of Oncology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, MD, USA
    J Pathol 232:428-35. 2014
    ..Copyright © 2013 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. ..
  56. ncbi request reprint Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors
    Wen Yong Chen
    Division of Tumor Biology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, 1650 Orleans Street, Baltimore, Maryland 21231, USA
    Nat Genet 33:197-202. 2003
    ..We conclude that HIC1 is a candidate tumor-suppressor gene for which loss of function in both mouse and human cancers is associated only with epigenetic modifications...
  57. ncbi request reprint Delayed diagnosis and elevated mortality in an urban population with HIV and lung cancer: implications for patient care
    Malcolm V Brock
    Johns Hopkins Hospital, and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21287, USA
    J Acquir Immune Defic Syndr 43:47-55. 2006
    ..Lung cancer is more common in HIV-infected patients than in the general population. We examined how effectively lung cancer was being diagnosed in our HIV-infected patients...
  58. ncbi request reprint Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer
    Hiromu Suzuki
    Division of Tumor Biology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, 1650 Orleans Street, Baltimore, Maryland 21231, USA
    Nat Genet 36:417-22. 2004
    ....
  59. ncbi request reprint Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene
    Kurtis E Bachman
    The Howard Hughes Medical Institute, The Sidney Kimmel Comprehensive Cancer Center, and Program in Cellular and Molecular Medicine, The Johns Hopkins University School of Medicine, 1650 Orleans Street, Baltimore, MD 21231, USA
    Cancer Cell 3:89-95. 2003
    ..These results have important implications for understanding the biochemical events underlying the silencing of tumor suppressor genes and the resultant growth suppression...
  60. pmc Cancer as a manifestation of aberrant chromatin structure
    Malcolm V Brock
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21205 2196, USA
    Cancer J 13:3-8. 2007
    ..A more complete understanding of these key, regulatory events is vital in approaching a more rational drug therapy to various malignancies...
  61. ncbi request reprint Surgical resection of limited disease small cell lung cancer in the new era of platinum chemotherapy: Its time has come
    Malcolm V Brock
    Division of Thoracic Surgery, Department of Surgery, The Johns Hopkinds Medical Institutions, Baltimore, MD, USA
    J Thorac Cardiovasc Surg 129:64-72. 2005
    ..Although resection is not the standard of care in treating small cell lung cancer, new platinum drugs and modern staging have allowed the role of surgery to be reevaluated...
  62. pmc Short double-stranded RNA induces transcriptional gene silencing in human cancer cells in the absence of DNA methylation
    Angela H Ting
    Graduate Program in Cellular and Molecular Medicine, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Nat Genet 37:906-10. 2005
    ..Moreover, we could accomplish such silencing in a cancer cell line genetically modified to lack virtually any capacity to methylate DNA...
  63. pmc A phase I dose-finding study of 5-azacytidine in combination with sodium phenylbutyrate in patients with refractory solid tumors
    Jianqing Lin
    Chemical Therapeutics Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Clin Cancer Res 15:6241-9. 2009
    ..The pharmacokinetics, pharmacodynamics, and antineoplastic effects were also studied...
  64. doi request reprint Promoter hypermethylation of hallmark cancer genes in atypical adenomatous hyperplasia of the lung
    Julien D F Licchesi
    Cancer Biology Program at the Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Clin Cancer Res 14:2570-8. 2008
    ....
  65. doi request reprint Methylation-specific PCR
    Julien D F Licchesi
    Cancer Biology Program, Sidney Kimmel Comprehensive Cancer Center Johns Hopkins, Baltimore, MD, USA
    Methods Mol Biol 507:305-23. 2009
    ....
  66. ncbi request reprint Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma
    Manel Esteller
    Division of Cancer Biology, The Johns Hopkins Oncology Center, Baltimore, MD 21231, USA
    J Natl Cancer Inst 94:26-32. 2002
    ..MGMT promoter hypermethylation is a favorable prognostic marker in patients with brain tumors treated with alkylating agents...
  67. pmc Comparing the DNA hypermethylome with gene mutations in human colorectal cancer
    Kornel E Schuebel
    Cancer Biology Division, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA
    PLoS Genet 3:1709-23. 2007
    ....
  68. pmc Genomic and epigenomic integration identifies a prognostic signature in colon cancer
    Joo Mi Yi
    Department of Oncology, Johns Hopkins University, Baltimore, Maryland 20892 8110, USA
    Clin Cancer Res 17:1535-45. 2011
    ..The importance of genetic and epigenetic alterations maybe in their aggregate role in altering core pathways in tumorigenesis...
  69. ncbi request reprint Epigenetic silencing of multiple genes in primary CNS lymphoma
    Linda C Chu
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Int J Cancer 119:2487-91. 2006
    ..Our study provides insight into the epigenetic alterations in PCNSL and provides potential biomarkers of disease...
  70. ncbi request reprint Promoter methylation profiles of tumor suppressor genes in intrahepatic and extrahepatic cholangiocarcinoma
    Bin Yang
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Mod Pathol 18:412-20. 2005
    ..Taking advantage of the unique concurrent methylation profile of multiple genes in cholangiocarcinoma may facilitate the distinction of cholangiocarcinoma from benign biliary epithelium in clinical settings...
  71. ncbi request reprint Progression of gene hypermethylation in gallstone disease leading to gallbladder cancer
    Michael G House
    Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231 1000, USA
    Ann Surg Oncol 10:882-9. 2003
    ..Aberrant methylation of tumor-suppressor genes is associated with a loss of gene function that can afford selective growth advantages to sporadic neoplastic cells arising during gallbladder inflammation...
  72. ncbi request reprint SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma
    Oliver Galm
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Blood 101:2784-8. 2003
    ..Silencing of the SOCS-1 gene may impair negative regulation of the Jak/STAT pathway and therefore result in greater responsiveness to cytokines, thus supporting survival and expansion of MM cells...
  73. ncbi request reprint A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer
    Hiromu Suzuki
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, 1650 Orleans Street, Baltimore, Maryland 21231, USA
    Nat Genet 31:141-9. 2002
    ....
  74. pmc Enzymatic regional methylation assay: a novel method to quantify regional CpG methylation density
    Oliver Galm
    Oncology Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Genome Res 12:153-7. 2002
    ..We demonstrate a use of this technique in determining the methylation density of the promoter region of the tumor suppressor gene p15INK4B and changes that occur after treatment with demethylating agents...
  75. pmc Lung cancer in never smokers: molecular profiles and therapeutic implications
    Charles M Rudin
    Johns Hopkins University School of Medicine, David H Koch Cancer Research Building, Room 544, 1550 Orleans Street, Baltimore, MD 21231, USA
    Clin Cancer Res 15:5646-61. 2009
    ..Focused analysis of molecular carcinogenesis in lung cancers in never smokers is needed, and may provide additional biologic insight with therapeutic implications for lung cancers in both ever smokers and never smokers...
  76. ncbi request reprint Epigenetics in lung cancer: focus on progression and early lesions
    James G Herman
    Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University, Baltimore, MD 21231, USA
    Chest 125:119S-22S. 2004
  77. ncbi request reprint Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung
    Montserrat Sanchez-Cespedes
    Department of Otolaryngology Head and Neck Surgery, Head and Neck Cancer Research Division, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2196, USA
    Cancer Res 62:3659-62. 2002
    ..Thus, our findings demonstrate for the first time that LKB1/STK11 inactivation is a very common event and may be integrally involved in the development of sporadic lung adenocarcinoma...
  78. ncbi request reprint Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours
    Manel Esteller
    Tumor Biology, The Johns Hopkins Oncology Center, Baltimore, MD 21231, USA
    J Pathol 196:1-7. 2002
    ..and apoptosis (DAPK, APAF-1, ...). The aberrant CpG island methylation can also be used as a biomarker of malignant cells and as a predictor of their behaviour, and may constitute a good target for future therapies...
  79. ncbi request reprint Molecular progression of promoter methylation in intraductal papillary mucinous neoplasms (IPMN) of the pancreas
    Michael G House
    Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Carcinogenesis 24:193-8. 2003
    ..Detection of methylation within selected genes may afford an accurate diagnostic molecular marker and predictor of neoplastic behavior...
  80. pmc Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies
    Tamer E Fandy
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD, USA
    Blood 114:2764-73. 2009
    ..In conclusion, methylation reversal of candidate TSGs during cycle 1 of therapy was not predictive of clinical response to combination "epigenetic" therapy. This trial is registered with http://www.clinicaltrials.gov under NCT00101179...
  81. ncbi request reprint K-ras mutations and RASSF1A promoter methylation in colorectal cancer
    Manon van Engeland
    Department of Pathology, University Maastricht, P O Box 616 6200 MD Maastricht, The Netherlands
    Oncogene 21:3792-5. 2002
    ..These data show that the majority of the studied CRCs with K-ras mutations lack RASSF1A promoter methylation, an event which occurs predominantly in K-ras wild-type CRCs (P=0.023, Chi-square test)...
  82. ncbi request reprint Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort
    Steven A Belinsky
    Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
    Cancer Res 66:3338-44. 2006
    ....
  83. ncbi request reprint Methylated tumor-specific DNA as a plasma biomarker in patients with glioma
    Kyle D Weaver
    Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Cancer Invest 24:35-40. 2006
    ..Patients with systemic malignancies have substantial quantities of tumor-specific DNA in their plasma which may serve as a potential biomarker for tumor burden. This approach has not been studied in gliomas...
  84. ncbi request reprint Epigenetic and genetic alterations of APC and CDH1 genes in lobular breast cancer: relationships with abnormal E-cadherin and catenin expression and microsatellite instability
    David Sarrio
    Laboratory of Breast and Gynecological Cancer, Molecular Pathology Program, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Int J Cancer 106:208-15. 2003
    ..The same tumors also show genetic and epigenetic alterations of APC gene. However, altered CDH1 and APC genes do not promote beta-catenin accumulation in this tumor type...
  85. ncbi request reprint The fundamental role of epigenetics in hematopoietic malignancies
    Oliver Galm
    Medizinische Klinik IV, Universitaetsklinikum Aachen, 52074 Aachen, Germany
    Blood Rev 20:1-13. 2006
    ..The ongoing exploration of basic events involved in altered gene transcription patterns and continued clinical investigative studies are helping to develop novel strategies for the diagnosis, prevention, and treatment of human cancer...
  86. ncbi request reprint Clinical implications of aberrant DNA methylation patterns in acute myelogenous leukemia
    Oliver Galm
    Medizinische Klinik IV, Universitatsklinikum Aachen, Rheinisch Westfälische Technische Hochschule Aachen, Aachen, Germany
    Ann Hematol 84:39-46. 2005
    ..The growing knowledge of the role of epigenetics in the aberrant silencing of cancer-related genes provides a rationale and molecular basis for targeted therapeutic approaches with demethylating agents in AML...
  87. ncbi request reprint Semiautomatic detection of DNA methylation at CpG islands
    Kyeong Man Hong
    National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biotechniques 38:354, 356, 358. 2005
  88. ncbi request reprint Standardized approach for microsatellite instability detection in gastric carcinomas
    Eva Musulen
    Servei de Patologia, UDIAT CD, Corporacio Sanitaria Parc Tauli, Sabadell, Spain
    Hum Pathol 35:335-42. 2004
    ..We have developed a simple, sensitive, and specific approach to assess the presence of MSI in gastric cancer that may have clinical applications...
  89. ncbi request reprint Methylation-specific PCR unraveled
    Sarah Derks
    Research Institute GROW, Department of Pathology, University Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
    Cell Oncol 26:291-9. 2004
    ..This review discusses the critical parameters of MSP and presents an overview of the available MSP variants and the (clinical) applications...
  90. ncbi request reprint Hypermethylation in histologically distinct classes of breast cancer
    Young Kyung Bae
    Department of Pathology, Yeungnam University College of Medicine, Daegu, South Korea
    Clin Cancer Res 10:5998-6005. 2004
    ..We sought to determine whether the extent of hypermethylation or defined profiles of gene hypermethylation are associated with biological characteristics of breast cancers...
  91. pmc Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis
    Timothy A Chan
    Cancer Biology Program, The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, United States of America
    PLoS Med 5:e114. 2008
    ..We hypothesize that key tumor suppressor genes in cancer may be subject to mutation or hypermethylation...
  92. ncbi request reprint Specific inhibition of DNMT1 by antisense oligonucleotides induces re-expression of estrogen receptor-alpha (ER) in ER-negative human breast cancer cell lines
    Lan Yan
    Sidney Kimmel Comprehensive Cancer at Johns Hopkins University Medical School, Baltimore, Maryland USA
    Cancer Biol Ther 2:552-6. 2003
    ..Our results suggest that specific inhibition of DNMT1 expression alone is sufficient to re-express ERa in human breast cancer cell lines...
  93. pmc Aberrant hypermethylation of tumor suppressor genes in pancreatic endocrine neoplasms
    Michael G House
    Departments of Surgery
    Ann Surg 238:423-31; discussion 431-2. 2003
    ....
  94. ncbi request reprint A systematic profile of DNA methylation in human cancer cell lines
    Maria F Paz
    Cancer Epigenetics Laboratory, Molecular Pathology Program, Spanish National Cancer Center, Carlos III Institute of Health, 28029 Madrid, Spain
    Cancer Res 63:1114-21. 2003
    ..Our data provide a basis for a better use of human cancer cell lines in basic and translational research with respect to their DNA methylation environment...
  95. ncbi request reprint Alterations of the p16/Rb/cyclin-D1 pathway in vulvar carcinoma, vulvar intraepithelial neoplasia, and lichen sclerosus
    Enrique Lerma
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Hum Pathol 33:1120-5. 2002
    ....
  96. ncbi request reprint Effects of dietary folate and alcohol intake on promoter methylation in sporadic colorectal cancer: the Netherlands cohort study on diet and cancer
    Manon van Engeland
    The Research Institute GROW, Department of Pathology, University Maastricht, 6200 MD Maastricht, The Netherlands
    Cancer Res 63:3133-7. 2003
    ..085). Despite the size limitations of this study, these data suggest that folate and alcohol intake may be associated with changes in promoter hypermethylation in CRC...
  97. ncbi request reprint Identification of epigenetically silenced genes in tumor endothelial cells
    Debby M E I Hellebrekers
    Department of Pathology, Research Institute for Growth and Development, Maastricht University and University Hospital, Maastricht, The Netherlands
    Cancer Res 67:4138-48. 2007
    ....
  98. pmc A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing
    Joyce E Ohm
    Cancer Biology Division, The Sidney Kimmel Comprehensive Cancer Center
    Nat Genet 39:237-42. 2007
    ....
  99. ncbi request reprint Cancer epigenetics and methylation
    Manel Esteller
    Science 297:1807-8; discussion 1807-8. 2002
  100. ncbi request reprint Inhibition of DNA methylation and histone deacetylation prevents murine lung cancer
    Steven A Belinsky
    Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque, New Mexico 87108, USA
    Cancer Res 63:7089-93. 2003
    ..Thus, reduction in DNMT and histone deacetylase activities that likely block epigenetically mediated gene silencing might provide a novel clinical strategy to help prevent the leading cause of cancer death in the United States...
  101. ncbi request reprint DNA methylation mapping by tag-modified bisulfite genomic sequencing
    Weiguo Han
    Laboratory of Human Toxicology and Molecular Epidemiology, Wadsworth Center, NYS Department of Health, Albany, NY 12201, USA
    Anal Biochem 355:50-61. 2006
    ..7-fold difference in GSTP1 mRNA expression (p<0.01). The tBGS method simplifies detailed methylation scanning of kilobase-scale genomic DNA, facilitating more ambitious genomic methylation mapping studies...

Research Grants2

  1. CHFR Methylation for Predicting Taxane Sensitivity in Lung and Esophageal Cancer
    James Herman; Fiscal Year: 2007
    ..We will further develop a test for CHFR methylation and determine whether CHFR methylation can be used to predict which patients will respond to taxane based chemotherapies. ..