K J Helzlsouer

Summary

Affiliation: Johns Hopkins Bloomberg School of Public Health
Country: USA

Publications

  1. ncbi Single nucleotide polymorphisms in obesity-related genes and all-cause and cause-specific mortality: a prospective cohort study
    Lisa Gallicchio
    The Prevention and Research Center, The Weinberg Center for Women s Health and Medicine, Mercy Medical Center, Baltimore, Maryland 21202, USA
    BMC Med Genet 10:103. 2009
  2. ncbi Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population
    Han Yao Huang
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    BMC Genet 8:7. 2007
  3. ncbi Association between alpha-tocopherol, gamma-tocopherol, selenium, and subsequent prostate cancer
    K J Helzlsouer
    Department of Epidemiology, The Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205, USA
    J Natl Cancer Inst 92:2018-23. 2000
  4. ncbi Household exposure to passive cigarette smoking and serum micronutrient concentrations
    A J Alberg
    Department of Epidemiology, The Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205, USA
    Am J Clin Nutr 72:1576-82. 2000
  5. ncbi The risk of cervical cancer in relation to serum concentrations of folate, vitamin B12, and homocysteine
    A J Alberg
    Department of Epidemiology, Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    Cancer Epidemiol Biomarkers Prev 9:761-4. 2000
  6. ncbi The repeatability of serum carotenoid, retinoid, and tocopherol concentrations in specimens of blood collected 15 years apart
    G W Comstock
    Department of Epidemiology, Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205-2179, USA
    Cancer Epidemiol Biomarkers Prev 10:65-8. 2001
  7. ncbi COMT genotype, micronutrients in the folate metabolic pathway and breast cancer risk
    J E Goodman
    Department of Environmental Health Sciences, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Carcinogenesis 22:1661-5. 2001
  8. ncbi Association of common polymorphisms in IL10, and in other genes related to inflammatory response and obesity with colorectal cancer
    Konstantinos K Tsilidis
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA
    Cancer Causes Control 20:1739-51. 2009
  9. ncbi Genetic variation in the nucleotide excision repair pathway and colorectal cancer risk
    Sonja I Berndt
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 15:2263-9. 2006
  10. ncbi Prospective study of carotenoids, tocopherols, and retinoid concentrations and the risk of breast cancer
    Reiko Sato
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Cancer Epidemiol Biomarkers Prev 11:451-7. 2002

Research Grants

  1. CLUE STUDIES--EVALUATING BIOMARKERS OF CARCINOGENESIS
    Kathy Helzlsouer; Fiscal Year: 2004
  2. Androgens, Growth Factors, and Ovarian Cancer
    Kathy Helzlsouer; Fiscal Year: 2003

Detail Information

Publications77

  1. ncbi Single nucleotide polymorphisms in obesity-related genes and all-cause and cause-specific mortality: a prospective cohort study
    Lisa Gallicchio
    The Prevention and Research Center, The Weinberg Center for Women s Health and Medicine, Mercy Medical Center, Baltimore, Maryland 21202, USA
    BMC Med Genet 10:103. 2009
    ..We also examined the associations between the SNPs and body mass index (BMI) and change in BMI over time...
  2. ncbi Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population
    Han Yao Huang
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    BMC Genet 8:7. 2007
    ..The genes in which SNPs were analyzed include CCR2, CCR5, COX1, COX2, CRP, CSF1, CSF2, IFNG, IL1A, IL1B, IL2, IL4, IL6, IL8, IL10, IL13, IL18, LTA, MPO, NOS2A, NOS3, PPARD, PPARG, PPARGC1 and TNF...
  3. ncbi Association between alpha-tocopherol, gamma-tocopherol, selenium, and subsequent prostate cancer
    K J Helzlsouer
    Department of Epidemiology, The Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205, USA
    J Natl Cancer Inst 92:2018-23. 2000
    ..S. diet and the second most common tocopherol in human serum. A nested case-control study was conducted to examine the associations of alpha-tocopherol, gamma-tocopherol, and selenium with incident prostate cancer...
  4. ncbi Household exposure to passive cigarette smoking and serum micronutrient concentrations
    A J Alberg
    Department of Epidemiology, The Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205, USA
    Am J Clin Nutr 72:1576-82. 2000
    ..In part, this could be because the diets of passive smokers, like those of active smokers, differ from those of persons who are not exposed to cigarette smoke, especially with regard to antioxidants...
  5. ncbi The risk of cervical cancer in relation to serum concentrations of folate, vitamin B12, and homocysteine
    A J Alberg
    Department of Epidemiology, Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    Cancer Epidemiol Biomarkers Prev 9:761-4. 2000
    ..None of the results of this study were statistically significant, but patterns of the associations are in accord with hypothesized mechanistic pathways concerning B vitamins and cervical cancer...
  6. ncbi The repeatability of serum carotenoid, retinoid, and tocopherol concentrations in specimens of blood collected 15 years apart
    G W Comstock
    Department of Epidemiology, Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205-2179, USA
    Cancer Epidemiol Biomarkers Prev 10:65-8. 2001
    ....
  7. ncbi COMT genotype, micronutrients in the folate metabolic pathway and breast cancer risk
    J E Goodman
    Department of Environmental Health Sciences, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Carcinogenesis 22:1661-5. 2001
    ..05) or above median levels of homocysteine (P(trend) = 0.02). These findings are consistent with a role for certain folate pathway micronutrients in mediating the association between COMT genotype and breast cancer risk...
  8. ncbi Association of common polymorphisms in IL10, and in other genes related to inflammatory response and obesity with colorectal cancer
    Konstantinos K Tsilidis
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA
    Cancer Causes Control 20:1739-51. 2009
    ..Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated using conditional logistic regression...
  9. ncbi Genetic variation in the nucleotide excision repair pathway and colorectal cancer risk
    Sonja I Berndt
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 15:2263-9. 2006
    ..00003). Our study suggests that genetic polymorphisms in the NER genes, ERCC6 and XPC, may be associated with an increased risk of colorectal cancer...
  10. ncbi Prospective study of carotenoids, tocopherols, and retinoid concentrations and the risk of breast cancer
    Reiko Sato
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Cancer Epidemiol Biomarkers Prev 11:451-7. 2002
    ..There was generally a protective association for other micronutrients in both cohorts, although none reached statistical significance. The results suggest that carotenoids may protect against the development of breast cancer...
  11. ncbi Single nucleotide polymorphisms in inflammation-related genes and mortality in a community-based cohort in Washington County, Maryland
    Lisa Gallicchio
    Prevention and Research Center, Weinberg Center for Women s Health and Medicine, Mercy Medical Center, Baltimore, MD 21202, USA
    Am J Epidemiol 167:807-13. 2008
    ..The authors' findings from this community-based prospective cohort study suggest that the selected SNPs are not associated with overall or cause-specific death, although CRP genotypes may be associated with systemic inflammation...
  12. ncbi Fruit, vegetable, and antioxidant intake and all-cause, cancer, and cardiovascular disease mortality in a community-dwelling population in Washington County, Maryland
    Jeanine M Genkinger
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Am J Epidemiol 160:1223-33. 2004
    ..These findings support the general health recommendation to consume multiple servings of fruits and vegetables (5-9/day)...
  13. ncbi Serum dehydroepiandrosterone and dehydroepiandrosterone sulfate and risk of melanoma or squamous cell carcinoma of the skin
    A J Alberg
    Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Anticancer Res 21:4051-4. 2001
    ..30). CONCLUSION: The results of this study do not support the hypothesis that physiological concentrations of DHEA or DHEAS protect against skin cancer in humans...
  14. ncbi The reliability of nipple aspirate and ductal lavage in women at increased risk for breast cancer--a potential tool for breast cancer risk assessment and biomarker evaluation
    K Visvanathan
    Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 16:950-5. 2007
    ..However, little is known about the reliability of the procedure...
  15. ncbi Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver cancer
    P A Egner
    Department of Environmental Health Sciences and Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 98:14601-6. 2001
    ....
  16. ncbi Association of IL10 and other immune response- and obesity-related genes with prostate cancer in CLUE II
    Ming Hsi Wang
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Prostate 69:874-85. 2009
    ..Chronic intra-prostatic inflammation and obesity are thought to influence prostate carcinogenesis. Thus, variants in genes in these pathways could be associated with prostate cancer risk...
  17. ncbi Body mass, polymorphisms in obesity-related genes, and the risk of developing breast cancer among women with benign breast disease
    Lisa Gallicchio
    Prevention and Research Center, The Weinberg Center for Women s Health and Medicine, Mercy Medical Center, 227 St Paul Place, Baltimore, MD 21202, USA
    Cancer Detect Prev 31:95-101. 2007
    ....
  18. ncbi Influence of geographic location in modeling blood pesticide levels in a community surrounding a U.S. Environmental protection agency superfund site
    Shannon H Gaffney
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Environ Health Perspect 113:1712-6. 2005
    ..Spatial information may enable researchers to detect a potential exposure pattern that may not be revealed with only nonspatial variables...
  19. ncbi Active cigarette smoking, household passive smoke exposure, and the risk of developing pancreatic cancer
    Lisa Gallicchio
    Department of Epidemiology, Room E6132, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205, USA
    Prev Med 42:200-5. 2006
    ..Our results also indicate that household passive smoke exposure is not associated with pancreatic cancer risk, although our risk estimates lacked precision...
  20. ncbi C-reactive protein levels and subsequent cancer outcomes: results from a prospective cohort study
    Kathy J Helzlsouer
    Prevention and Research Center, Mercy Medical Center, 6th Floor, 227 St Paul Place, Baltimore, MD 21202, USA
    Eur J Cancer 42:704-7. 2006
    ..However, the potential benefits of anti-inflammatory chemopreventive agents must be weighed against their adverse effects before widespread use is recommended...
  21. ncbi Flame-broiled food, NAT2 acetylator phenotype, and breast cancer risk among women with benign breast disease
    Lisa Gallicchio
    Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21202, USA
    Breast Cancer Res Treat 99:229-33. 2006
    ..The variation of the association by acetylation phenotype, as determined by the genotypes of selected N-acetyltransferase 2 (NAT2) enzymes, was also examined...
  22. ncbi The importance of cytologic intrarater and interrater reproducibility: the case of ductal lavage
    Kala Visvanathan
    Department of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 15:2553-6. 2006
    ..27 +/- 0.09. Fair to moderate intrarater and interrater agreement of DL cytology was observed. Low intrarater and interrater cytologic consistency may compromise the interpretation of clinical studies of DL...
  23. ncbi Alcohol dehydrogenase genetic polymorphisms, low-to-moderate alcohol consumption, and risk of breast cancer
    Kala Visvanathan
    Department of Epidemiology, The Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Alcohol Clin Exp Res 31:467-76. 2007
    ..Because alcohol is a known risk factor for breast cancer, we evaluated the joint association of genetic variants in ADH and alcohol consumption in relation to breast cancer...
  24. ncbi N-acetyltransferase 2 (NAT2) genotypes, cigarette smoking, and the risk of breast cancer
    Anthony J Alberg
    Department of Epidemiology, Room E6132B, The Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Cancer Detect Prev 28:187-93. 2004
    ..The results for smoking were consistent with an inactivation role for NAT2 in breast cancer...
  25. ncbi Nicotine replacement therapy use among a cohort of smokers
    Anthony J Alberg
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Addict Dis 24:101-13. 2005
    ..Nicotine replacement therapy (NRT) has been shown to assist smokers to stop smoking in randomized trials, but little is known about its use in the general population...
  26. ncbi No association between pre-diagnostic plasma C-reactive protein concentration and subsequent prostate cancer
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Prostate 59:393-400. 2004
    ..We evaluated the association of pre-diagnostic plasma concentration of C-reactive protein, a sensitive, but non-specific indicator of inflammation, with subsequent risk of prostate cancer...
  27. ncbi Prediagnostic circulating follicle stimulating hormone concentrations and ovarian cancer risk
    Meghan A McSorley
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Int J Cancer 125:674-9. 2009
    ..These findings contradict the hypothesized role of FSH as a risk factor in ovarian carcinogenesis...
  28. ncbi Prediagnostic toenail cadmium and zinc and subsequent prostate cancer risk
    Elizabeth A Platz
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Prostate 52:288-96. 2002
    ..We evaluated the association between prediagnostic toenail cadmium and zinc concentrations and risk of prostate cancer in a cohort in which the primary route of exposure to cadmium and zinc is the diet...
  29. ncbi Prospective study of antioxidant micronutrients in the blood and the risk of developing prostate cancer
    Han Yao Huang
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205 2223, USA
    Am J Epidemiol 157:335-44. 2003
    ..Findings do not replicate previous reports of a protective association between lycopene and prostate cancer, but they suggest potential chemopreventive effects of gamma-tocopherol on prostate cancer...
  30. ncbi Association among an ornithine decarboxylase polymorphism, androgen receptor gene (CAG) repeat length and prostate cancer risk
    Kala Visvanathan
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Urol 171:652-5. 2004
    ..A nested case-control study was done to examine the association between this ODC genotype and prostate cancer risk, and whether it varies by AR gene CAG repeat length and smoking...
  31. ncbi A comparison between real-time polymerase chain reaction and hybrid capture 2 for human papillomavirus DNA quantitation
    Patti E Gravitt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 12:477-84. 2003
    ..The nonrandom distribution of multiple infections by case-control status and the apparent differential effect of viral load by genotype warrant caution when using HC 2 measurements to infer viral load associations with SIL and cancer...
  32. ncbi Circulating 25-hydroxyvitamin D and the risk of rarer cancers: Design and methods of the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers
    Lisa Gallicchio
    Mercy Medical Center, Baltimore, Maryland 21202, USA
    Am J Epidemiol 172:10-20. 2010
    ..This consortium approach permits estimation of the association between 25(OH)D and several rarer cancers with high accuracy and precision across a wide range of 25(OH)D concentrations...
  33. ncbi Mismatch repair polymorphisms and the risk of colorectal cancer
    Sonja I Berndt
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Int J Cancer 120:1548-54. 2007
    ..No association was observed with the MSH6 and MLH1 polymorphisms overall. This study suggests that common polymorphisms in the mismatch repair gene, MSH3, may increase the risk of colorectal cancer, especially proximal colon cancer...
  34. ncbi C-reactive protein concentrations and subsequent ovarian cancer risk
    Meghan A McSorley
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21202, USA, and Academic Oncology Unit, Guy s Hospital, London, United Kingdom
    Obstet Gynecol 109:933-41. 2007
    ..To estimate the association between prediagnostic levels of C-reactive protein (CRP), a marker of chronic systemic inflammation, and subsequent development of ovarian cancer...
  35. ncbi Association of markers of insulin and glucose control with subsequent colorectal cancer risk
    Sharon H Saydah
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Cancer Epidemiol Biomarkers Prev 12:412-8. 2003
    ....
  36. ncbi C-reactive protein and colorectal cancer risk: a systematic review of prospective studies
    Konstantinos K Tsilidis
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Int J Cancer 123:1133-40. 2008
    ..More work is needed to understand the extent to which circulating high-sensitivity C-reactive protein or other blood inflammatory markers are related to colonic inflammation...
  37. ncbi A prospective cohort study of bladder cancer risk in relation to active cigarette smoking and household exposure to secondhand cigarette smoke
    Anthony J Alberg
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Am J Epidemiol 165:660-6. 2007
    ..9, 95% CL: 0.4, 2.3). This study further solidifies the evidence that active smoking is causally associated with bladder cancer. Additional studies are needed to determine whether passive smoking is a risk factor for bladder cancer...
  38. ncbi Catechol-O-methyltransferase polymorphism is not associated with ovarian cancer risk
    J E Goodman
    Department of Environmental Health Sciences, The Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 9:1373-6. 2000
    ....
  39. ncbi Overview of the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers
    Kathy J Helzlsouer
    Mercy Medical Center, Baltimore, MD 21202, USA
    Am J Epidemiol 172:4-9. 2010
    ..The results of this study have application for the planning and conduct of intervention trials, especially in determining potential risks...
  40. ncbi Non-cancer adverse health conditions and perceived health and function among cancer survivors participating in a community-based cohort study in Washington County, Maryland
    Lisa Gallicchio
    Prevention and Research Center, Weinberg Center for Women s Health and Medicine, Mercy Medical Center, 227 St Paul Place, Baltimore, MD 21202, USA
    J Cancer Surviv 2:12-9. 2008
    ....
  41. ncbi Active and passive cigarette smoking and the risk of cervical neoplasia
    Cornelia L Trimble
    Department of Obstetrics and Gynecology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Obstet Gynecol 105:174-81. 2005
    ..The results of this long-term, prospective cohort study corroborate the association between active cigarette smoking and cervical neoplasia and provide evidence that passive smoking is a risk factor for cervical neoplasia...
  42. ncbi Polymorphisms in estrogen-metabolizing and estrogen receptor genes and the risk of developing breast cancer among a cohort of women with benign breast disease
    Lisa Gallicchio
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    BMC Cancer 6:173. 2006
    ....
  43. ncbi Circulating 25-hydroxyvitamin D and risk of kidney cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers
    Lisa Gallicchio
    Mercy Medical Center, Baltimore, Maryland 21202, USA
    Am J Epidemiol 172:47-57. 2010
    ..The findings from this consortium-based study do not support the hypothesis that vitamin D is inversely associated with the risk of kidney cancer overall or with renal cell carcinoma specifically...
  44. ncbi Association of vasectomy and prostate cancer among men in a Maryland cohort
    Sabine Rohrmann
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, 615 N. Wolfe St, Room E6138, Baltimore, MD 21205, USA
    Cancer Causes Control 16:1189-94. 2005
    ..63; 95% CI 1.40-4.94) than in men who were younger at vasectomy. CONCLUSIONS: The results from this prospective study suggest a positive association between vasectomy and prostate cancer, especially low-grade disease...
  45. ncbi Nonsteroidal antiinflammatory drugs, cyclooxygenase polymorphisms, and the risk of developing breast carcinoma among women with benign breast disease
    Lisa Gallicchio
    Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21202, USA
    Cancer 106:1443-52. 2006
    ....
  46. ncbi Association between plasma total cholesterol concentration and incident prostate cancer in the CLUE II cohort
    Alison M Mondul
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Cancer Causes Control 21:61-8. 2010
    ..Our study supports two prior ones suggesting that cholesterol influences risk of high-grade prostate cancer, and indirectly supports the hypothesis that cholesterol-lowering is a mechanism by which statins are protective...
  47. ncbi WBC count and the risk of cancer mortality in a national sample of U.S. adults: results from the Second National Health and Nutrition Examination Survey mortality study
    Thomas P Erlinger
    Department of Medicine, Johns Hopkins Medical University School of Medicine, Baltimore, MD 21201, USA
    Cancer Epidemiol Biomarkers Prev 13:1052-6. 2004
    ..Additional studies are needed to determine whether circulating levels of inflammatory markers are associated with increased risk of incident cancer...
  48. ncbi C-reactive protein and the risk of incident colorectal cancer
    Thomas P Erlinger
    Department of Medicine, Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    JAMA 291:585-90. 2004
    ..Inflammation may play a role in the pathogenesis of colorectal cancer; however, epidemiological evidence supporting this hypothesis in average-risk persons is sparse...
  49. ncbi Nonsteroidal anti-inflammatory drugs and the risk of developing breast cancer in a population-based prospective cohort study in Washington County, MD
    Lisa Gallicchio
    Prevention and Research Center, Weinberg Center for Women s Health and Medicine, Mercy Medical Center, Baltimore, MD 21202, USA
    Int J Cancer 121:211-15. 2007
    ..Overall, findings from this study indicate that NSAID use is associated with a decrease in breast cancer risk and that the reduction in risk is similar for ER-positive and ER-negative tumors...
  50. ncbi Menopausal-type symptoms among breast cancer patients on aromatase inhibitor therapy
    L Gallicchio
    The Prevention and Research Center, Weinberg Center for Women s Health and Medicine, Mercy Medical Center, 227 St Paul Place, Baltimore, MD 21202, USA
    Climacteric 15:339-49. 2012
    ....
  51. ncbi Oltipraz chemoprevention trial in Qidong, People's Republic of China: modulation of serum aflatoxin albumin adduct biomarkers
    T W Kensler
    Department of Environmental Health Sciences, Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    Cancer Epidemiol Biomarkers Prev 7:127-34. 1998
    ..A follow-up Phase IIb trial with a longer intervention period will be necessary to determine the full extent to which aflatoxin biomarker burden can be reduced and whether diminution of biomarkers can be sustained over the long term...
  52. ncbi Decision-making about breast cancer susceptibility testing: how similar are the attitudes of physicians, nurse practitioners, and at-risk women?
    G Geller
    Department of Pediatrics, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    J Clin Oncol 16:2868-76. 1998
    ..To determine what consumers and providers would want to discuss about breast cancer susceptibility testing (BCST) and their preferred role in testing decisions...
  53. ncbi Epidemiology, prevention, and early detection of breast cancer
    A J Alberg
    Department of Epidemiology, The Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    Curr Opin Oncol 12:515-20. 2000
    ..The role of both environmental and endogenous exposures in breast carcinogenesis will be more clearly elucidated by studies that account for genetic polymorphisms, some of which may lead to differential susceptibility to harmful agents...
  54. ncbi A cross-sectional study of vitamin C and cognitive function in older adults: the differential effects of gender
    R Sato
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Nutr Health Aging 10:37-44. 2006
    ..These mixed results do not provide strong evidence of an association between vitamin C concentrations or intake and cognitive function...
  55. ncbi C-reactive protein and colorectal adenoma in the CLUE II cohort
    Konstantinos K Tsilidis
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Cancer Causes Control 19:559-67. 2008
    ..Thus, we evaluated the association between plasma C-reactive protein concentration and development of colorectal adenoma in a nested case-control study...
  56. ncbi Metabolic syndrome components and colorectal adenoma in the CLUE II cohort
    Konstantinos K Tsilidis
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Cancer Causes Control 21:1-10. 2010
    ..Thus, we evaluated the association between markers of the metabolic syndrome with colorectal adenoma development in a nested case-control study...
  57. ncbi A community-based study of cigarette smoking behavior in relation to variation in three genes involved in dopamine metabolism: Catechol-O-methyltransferase (COMT), dopamine beta-hydroxylase (DBH) and monoamine oxidase-A (MAO-A)
    Meredith S Shiels
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
    Prev Med 47:116-22. 2008
    ..The association between common polymorphisms of these genes and smoking behavior was assessed among 10,059 Caucasian volunteers in Washington County, MD in 1989...
  58. ncbi Serum antibodies to JC virus, BK virus, simian virus 40, and the risk of incident adult astrocytic brain tumors
    Dana E M Rollison
    Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Cancer Epidemiol Biomarkers Prev 12:460-3. 2003
    ..00 for SV40 (95% CI, 0.30-3.32). Given the high prevalence of JCV and BKV infections and the millions who were potentially exposed to SV40 through contaminated polio vaccines, future studies should attempt to replicate these findings...
  59. ncbi A new model ELISA, based on two monoclonal antibodies, for quantification of fatty acid synthase
    Young Y Wang
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    J Immunoassay Immunochem 23:279-92. 2002
    ..In summary, this monoclonal-monoclonal FAS-ELISA is sensitive, accurate, and precise in quantification of fatty acid synthase and has potential as a complementary tool in testing clinical samples...
  60. ncbi Utilization of BRCA1/2 genetic testing in the clinical setting: report from a single institution
    Soo Chin Lee
    Department of Oncology, Johns Hopkins Medical Institution, Baltimore, MD 21205, USA
    Cancer 94:1876-85. 2002
    ..Clinical testing for BRCA1/2 has been available since 1996. Interest in testing in the research and hypothetical situations has been consistently high, but there have been limited reports on its clinical utilization...
  61. ncbi Smoking and risk of fatal prostate cancer in a prospective U.S. study
    Sabine Rohrmann
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Urology 69:721-5. 2007
    ..To examine the association of cigarette smoking with subsequent fatal prostate cancer...
  62. ncbi Meat and dairy consumption and subsequent risk of prostate cancer in a US cohort study
    Sabine Rohrmann
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Rm E 6138, Baltimore, MD 21205, USA
    Cancer Causes Control 18:41-50. 2007
    ..To evaluate the association of meat and dairy food consumption with subsequent risk of prostate cancer...
  63. ncbi The relationship between gender, social support, and health-related quality of life in a community-based study in Washington County, Maryland
    Lisa Gallicchio
    Prevention and Research Center, Weinberg Center for Women s Health and Medicine Mercy Medical Center, Baltimore, MD 21202, USA
    Qual Life Res 16:777-86. 2007
    ..The purpose of this study was to determine the factors associated with HRQOL, especially levels of social support, and variation by gender...
  64. ncbi Investigation of human brain tumors for the presence of polyomavirus genome sequences by two independent laboratories
    Dana E M Rollison
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Int J Cancer 113:769-74. 2005
    ..Results for masked quality control tissues were concordant between laboratories. Nucleotide sequences for JCV, BKV and SV40 are rarely present in a large series of adult and pediatric brain tumors...
  65. ncbi Premenopausal levels of circulating insulin-like growth factor I and the risk of postmenopausal breast cancer
    Dana E Rollison
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Room E 6142, Baltimore, MD 21205, USA
    Int J Cancer 118:1279-84. 2006
    ..Age-stratification should be undertaken in larger investigations of IGF-I levels as predictors of postmenopausal breast cancer...
  66. ncbi Active recruitment increased enrollment in a hereditary cancer registry
    Tara M Friebel
    Mid-Atlantic Cancer Genetics Network, Department of Pathology, Johns Hopkins University School of Medicine, Park SB202, 600 N. Wolfe St, Baltimore, MD 21287, USA
    J Clin Epidemiol 57:1172-6. 2004
    ..6% to 67.4%). CONCLUSION: Allocating research staff specifically for recruitment and personal contact with potential participants is effective in achieving increased enrollment into a national hereditary cancer research registry...
  67. ncbi Nonmelanoma skin cancer and risk for subsequent malignancy
    Jiping Chen
    Division of Cancer Prevention, National Cancer Institute, Rockville, MD, USA
    J Natl Cancer Inst 100:1215-22. 2008
    ..Individuals with a personal history of nonmelanoma skin cancer (NMSC) may have an increased risk of subsequent noncutaneous malignancies. To test this hypothesis, we carried out a community-based, prospective cohort study...
  68. ncbi Genetic variation in base excision repair genes and the prevalence of advanced colorectal adenoma
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Res 67:1395-404. 2007
    ..51; 95% CI, 0.33-0.78, P = 0.002 for PARP1 A284A). This study suggests that polymorphisms in APEX1, XRCC1, and PARP1 may be associated with advanced colorectal adenoma...
  69. ncbi C47T polymorphism in manganese superoxide dismutase (MnSOD), antioxidant intake and survival
    Jeanine M Genkinger
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Building 2, Boston, MA, United States
    Mech Ageing Dev 127:371-7. 2006
    ..A C47T transition in the MnSOD gene may affect the enzyme's distribution to the mitochondrion, a site of high oxidative stress. We examined the association between this polymorphism and survival...
  70. ncbi Prediagnostic circulating antibodies to JC and BK human polyomaviruses and risk of non-Hodgkin lymphoma
    Dana E Rollison
    H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Cancer Epidemiol Biomarkers Prev 15:543-50. 2006
    ....
  71. ncbi Markers of past infection with simian virus 40 (SV40) and risk of incident non-Hodgkin lymphoma in a Maryland cohort
    Dana E Rollison
    Division of Cancer Prevention and Control, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, Florida 33612, USA
    Cancer Epidemiol Biomarkers Prev 14:1448-52. 2005
    ..8% of cases and 1.6% of controls (OR, 1.51; 95% CI, 0.41-5.52). Our findings suggest that past infection with SV40 is not associated with an increased risk of developing NHL...
  72. ncbi Good news about oral contraceptives
    Nancy E Davidson
    N Engl J Med 346:2078-9. 2002
  73. ncbi Historical comparison of perfluorooctanesulfonate, perfluorooctanoate, and other fluorochemicals in human blood
    Geary W Olsen
    Medical Department, 3M Company, Mail Stop 220 6W 08, St Paul, MN 55144, USA
    Environ Health Perspect 113:539-45. 2005
    ..Comparison with other regional data collected in 2001 did not suggest a continued increase in concentrations since 1989...
  74. ncbi Contralateral prophylactic mastectomy: quantifying benefits and weighing the harms
    Kathy J Helzlsouer
    J Clin Oncol 23:4251-3. 2005
  75. ncbi Methods for identifying long-term adverse effects of treatment in patients with eye diseases: the Systemic Immunosuppressive Therapy for Eye Diseases (SITE) Cohort Study
    John H Kempen
    Center for Preventive Ophthalmology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Ophthalmic Epidemiol 15:47-55. 2008
    ....
  76. ncbi Processed meat consumption and adult gliomas in a Maryland cohort
    Dana E M Rollison
    Cancer Causes Control 15:99-100. 2004
  77. ncbi Personal hair dye use and cancer: a systematic literature review and evaluation of exposure assessment in studies published since 1992
    Dana E Rollison
    Division of Cancer Prevention and Control, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
    J Toxicol Environ Health B Crit Rev 9:413-39. 2006
    ..Replication of these findings is needed to determine whether the reported associations are real or spurious...

Research Grants2

  1. CLUE STUDIES--EVALUATING BIOMARKERS OF CARCINOGENESIS
    Kathy Helzlsouer; Fiscal Year: 2004
    ..abstract_text> ..
  2. Androgens, Growth Factors, and Ovarian Cancer
    Kathy Helzlsouer; Fiscal Year: 2003
    ..abstract_text> ..