Christopher M Heaphy

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi request reprint The potential utility of telomere-related markers for cancer diagnosis
    Christopher M Heaphy
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    J Cell Mol Med 15:1227-38. 2011
  2. pmc Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors
    Roeland F de Wilde
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Mod Pathol 25:1033-9. 2012
  3. pmc Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas
    Yuchen Jiao
    Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, The Johns Hopkins Kimmel Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Oncotarget 3:709-22. 2012
  4. doi request reprint Shorter telomeres in luminal B, HER-2 and triple-negative breast cancer subtypes
    Christopher M Heaphy
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Mod Pathol 24:194-200. 2011
  5. doi request reprint Molecular and morphologic correlates of the alternative lengthening of telomeres phenotype in high-grade astrocytomas
    Doreen N Nguyen
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Brain Pathol 23:237-43. 2013
  6. pmc Altered telomeres in tumors with ATRX and DAXX mutations
    Christopher M Heaphy
    Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Science 333:425. 2011
  7. doi request reprint Mammary field cancerization: molecular evidence and clinical importance
    Christopher M Heaphy
    Department of Pathology, The Johns Hopkins Medical Institutions, 411 N Caroline St, Baltimore, MD 21231, USA
    Breast Cancer Res Treat 118:229-39. 2009
  8. pmc Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes
    Christopher M Heaphy
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Am J Pathol 179:1608-15. 2011
  9. pmc Telomeres are shortened in acinar-to-ductal metaplasia lesions associated with pancreatic intraepithelial neoplasia but not in isolated acinar-to-ductal metaplasias
    Seung Mo Hong
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Mod Pathol 24:256-66. 2011
  10. doi request reprint The alternative lengthening of telomeres phenotype in breast carcinoma is associated with HER-2 overexpression
    Andrea Proctor Subhawong
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA
    Mod Pathol 22:1423-31. 2009

Collaborators

Detail Information

Publications11

  1. doi request reprint The potential utility of telomere-related markers for cancer diagnosis
    Christopher M Heaphy
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    J Cell Mol Med 15:1227-38. 2011
    ..Future directions focusing on the direct detection of dysfunctional telomeres are explored. New markers for telomere dysfunction may eventually prove clinically useful...
  2. pmc Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors
    Roeland F de Wilde
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Mod Pathol 25:1033-9. 2012
    ....
  3. pmc Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas
    Yuchen Jiao
    Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, The Johns Hopkins Kimmel Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Oncotarget 3:709-22. 2012
    ....
  4. doi request reprint Shorter telomeres in luminal B, HER-2 and triple-negative breast cancer subtypes
    Christopher M Heaphy
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Mod Pathol 24:194-200. 2011
    ..Telomere length was shorter in more aggressive subtypes, such as luminal B, HER-2-positive and triple-negative tumors, suggesting that tumor telomere length may have utility as a prognostic and/or risk marker for breast cancer...
  5. doi request reprint Molecular and morphologic correlates of the alternative lengthening of telomeres phenotype in high-grade astrocytomas
    Doreen N Nguyen
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Brain Pathol 23:237-43. 2013
    ..Future studies are required to clarify the clinical and biological significance of ALT in high-grade astrocytomas...
  6. pmc Altered telomeres in tumors with ATRX and DAXX mutations
    Christopher M Heaphy
    Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Science 333:425. 2011
    ..ATRX mutations also correlate with abnormal telomeres in tumors of the central nervous system. These data suggest that an alternative telomere maintenance function may operate in human tumors with alterations in the ATRX or DAXX genes...
  7. doi request reprint Mammary field cancerization: molecular evidence and clinical importance
    Christopher M Heaphy
    Department of Pathology, The Johns Hopkins Medical Institutions, 411 N Caroline St, Baltimore, MD 21231, USA
    Breast Cancer Res Treat 118:229-39. 2009
    ....
  8. pmc Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes
    Christopher M Heaphy
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Am J Pathol 179:1608-15. 2011
    ..These findings may have therapeutic consequences, because ALT-positive cancers are predicted to be resistant to anti-telomerase therapies...
  9. pmc Telomeres are shortened in acinar-to-ductal metaplasia lesions associated with pancreatic intraepithelial neoplasia but not in isolated acinar-to-ductal metaplasias
    Seung Mo Hong
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Mod Pathol 24:256-66. 2011
    ..These results indicate that isolated acinar-to-ductal metaplasias are not a precursor to PanIN, and support the hypothesis that PanIN-associated acinar-to-ductal metaplasias arise secondary to PanIN lesions...
  10. doi request reprint The alternative lengthening of telomeres phenotype in breast carcinoma is associated with HER-2 overexpression
    Andrea Proctor Subhawong
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA
    Mod Pathol 22:1423-31. 2009
    ..As cancers using the ALT pathway are predicted to be resistant to therapies based on telomerase inhibition, these results may have therapeutic consequences...
  11. pmc Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells
    Hiroyuki Konishi
    The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 108:17773-8. 2011
    ..Thus, BRCA1 haploinsufficiency may accelerate hereditary breast carcinogenesis by facilitating additional genetic alterations...