Affiliation: Johns Hopkins University
- Potential biomarker of metformin actionLing He
Division of MetabolismDivision of EndocrinologyDepartments of Pediatrics, Physiology and Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USAKennedy Krieger InstituteBaltimore, Maryland 21287, USA
J Endocrinol 221:363-9. 2014..These data suggests that CBP phosphorylation in WBCs may be used as a biomarker of metformin action in the liver. ..
- Control of Foxo1 Gene Expression by Co-activator P300Anne R Wondisford
From the Division of Metabolism, Department of Pediatrics and
J Biol Chem 289:4326-33. 2014..By characterization of Foxo1 gene promoter, P300 regulates the Foxo1 gene expression through the binding to tandem cAMP-response element sites in the proximal promoter region of Foxo1 gene. ..
- Activation of basal gluconeogenesis by coactivator p300 maintains hepatic glycogen storageLing He
Division of Metabolism, Departments of Pediatrics, Physiology and Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Mol Endocrinol 27:1322-32. 2013..Our study demonstrates the important and unique role of p300 in glycogen synthesis through maintaining basal gluconeogenesis. ..
- Transcriptional co-activator p300 maintains basal hepatic gluconeogenesisLing He
Division of Metabolism, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Biol Chem 287:32069-77. 2012..p300(G422S) and hepatic-deleted p300 mice exhibited significant lower blood glucose levels in the fasted and post-prandial states, indicating a role for p300 in maintaining basal HGP...
- Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding proteinLing He
Division of Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Cell 137:635-46. 2009..Our findings point to CBP phosphorylation at Ser436 by metformin as critical for its therapeutic effect, and as a potential target for pharmaceutical intervention...
- CREB binding protein (CBP) activation is required for luteinizing hormone beta expression and normal fertility in miceRyan S Miller
Division of Pediatric Endocrinology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Mol Cell Biol 32:2349-58. 2012..As CBP can be phosphorylated by other factors, such as insulin, our studies suggest that CBP may act as a key regulator of Lhb expression in the gonadotroph by integrating homeostatic information with GNRH signaling...
- Insulin-like growth factor 1 mediates negative feedback to somatotroph GH expression via POU1F1/CREB binding protein interactionsChristopher J Romero
Division of Pediatric Endocrinology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Mol Cell Biol 32:4258-69. 2012..Our data confirm the inhibitory effects of IGF-1 on GH expression at the level of the promoter and provide evidence of CBP's role as a target of IGF-1R signaling...