Norman J Haughey

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Calcium dysregulation and neuronal apoptosis by the HIV-1 proteins Tat and gp120
    Norman J Haughey
    Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, Baltimore, Maryland 21224, USA
    J Acquir Immune Defic Syndr 31:S55-61. 2002
  2. ncbi request reprint Perturbation of sphingolipid metabolism and ceramide production in HIV-dementia
    Norman J Haughey
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Ann Neurol 55:257-67. 2004
  3. pmc A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis
    David Wheeler
    Department of Neurology, Richard T Johnson Division of Neuroimmunology and Neurological Infections, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Brain 131:3092-102. 2008
  4. pmc A biological perspective of CSF lipids as surrogate markers for cognitive status in HIV
    Norman J Haughey
    Department of Neurology, Division of Neuroimmunology and Neurological Infections, The Johns Hopkins University School of Medicine, Pathology 517, 600 North Wolfe Street, Baltimore, MD, 21287, USA
    J Neuroimmune Pharmacol 8:1136-46. 2013
  5. pmc Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis
    Norman J Haughey
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Biochim Biophys Acta 1801:878-86. 2010
  6. pmc Converging roles for sphingolipids and cell stress in the progression of neuro-AIDS
    Norman J Haughey
    Department of Neurology, Richard T Johnson Division of Neuroimmunology and Neurological Infections, The Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Front Biosci 13:5120-30. 2008
  7. pmc Sphingolipids in neurodegeneration
    Norman J Haughey
    Department of Neurology, Richard T Johnson Division of Neuroimmunology and Neurological Infections, The Johns Hopkins University School of Medicine, Meyer 6 109, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Neuromolecular Med 12:301-5. 2010
  8. pmc Roles for biological membranes in regulating human immunodeficiency virus replication and progress in the development of HIV therapeutics that target lipid metabolism
    Norman J Haughey
    Department of Neurology, Richard T Johnson Division of Neuroimmunology and Neurological Infections, The Johns Hopkins University School of Medicine, Meyer 6 109, 600N Wolfe Street, Baltimore, MD 21287, USA
    J Neuroimmune Pharmacol 6:284-95. 2011
  9. pmc Disturbance in cerebral spinal fluid sphingolipid content is associated with memory impairment in subjects infected with the human immunodeficiency virus
    Michelle M Mielke
    Department of Psychiatry, Richard T Johnson Division of Neuroimmunology and Neurological Infections, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Neurovirol 16:445-56. 2010
  10. pmc Inhibition of neutral sphingomyelinase-2 perturbs brain sphingolipid balance and spatial memory in mice
    Nino Tabatadze
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Neurosci Res 88:2940-51. 2010

Research Grants

  1. HIV Associated CNS Dysfunction with Aging
    Norman Haughey; Fiscal Year: 2003
  2. Interaction of Alcohol with HIV-Protein
    Norman J Haughey; Fiscal Year: 2010
  3. Dysfunctions of Sphingolipid and Sterol Metabolism in HIV-Dementia
    Norman J Haughey; Fiscal Year: 2010
  4. Interaction of Alcohol with HIV-Protein
    Norman Haughey; Fiscal Year: 2009
  5. Dysfunctions of Sphingolipid and Sterol Metabolism in HIV-Dementia
    Norman Haughey; Fiscal Year: 2009
  6. Interaction of Alcohol with HIV-Protein
    Norman Haughey; Fiscal Year: 2007
  7. Dysfunctions of Sphingolipid and Sterol Metabolism in HIV-Dementia
    Norman Haughey; Fiscal Year: 2007
  8. HIV Associated CNS Dysfunction with Aging
    Norman Haughey; Fiscal Year: 2007
  9. HIV Associated CNS Dysfunction with Aging
    Norman Haughey; Fiscal Year: 2006
  10. HIV Mediated Dysfunction of Neural Progenitor Cells
    Norman Haughey; Fiscal Year: 2006

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Calcium dysregulation and neuronal apoptosis by the HIV-1 proteins Tat and gp120
    Norman J Haughey
    Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, Baltimore, Maryland 21224, USA
    J Acquir Immune Defic Syndr 31:S55-61. 2002
    ..A better understanding of how gp120 and Tat disrupt neuronal calcium homeostasis may lead to the development of novel treatments for AIDS patients...
  2. ncbi request reprint Perturbation of sphingolipid metabolism and ceramide production in HIV-dementia
    Norman J Haughey
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Ann Neurol 55:257-67. 2004
    ..These results suggest that HIV-1 infection may promote a lipid imbalance in neural cells, resulting in an overproduction of ceramide and consequent cellular dysfunction and death...
  3. pmc A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis
    David Wheeler
    Department of Neurology, Richard T Johnson Division of Neuroimmunology and Neurological Infections, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Brain 131:3092-102. 2008
    ..Modelling the biophysical consequence of this change in lipid composition of NAWM indicated an increase in the repulsive force between opposing bilayers that could explain decompaction and disruption of myelin structure...
  4. pmc A biological perspective of CSF lipids as surrogate markers for cognitive status in HIV
    Norman J Haughey
    Department of Neurology, Division of Neuroimmunology and Neurological Infections, The Johns Hopkins University School of Medicine, Pathology 517, 600 North Wolfe Street, Baltimore, MD, 21287, USA
    J Neuroimmune Pharmacol 8:1136-46. 2013
    ....
  5. pmc Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis
    Norman J Haughey
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Biochim Biophys Acta 1801:878-86. 2010
    ..Dietary and pharmacological interventions that target sphingolipid metabolism should be pursued for the prevention and treatment of neurodegenerative disorders...
  6. pmc Converging roles for sphingolipids and cell stress in the progression of neuro-AIDS
    Norman J Haughey
    Department of Neurology, Richard T Johnson Division of Neuroimmunology and Neurological Infections, The Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Front Biosci 13:5120-30. 2008
    ....
  7. pmc Sphingolipids in neurodegeneration
    Norman J Haughey
    Department of Neurology, Richard T Johnson Division of Neuroimmunology and Neurological Infections, The Johns Hopkins University School of Medicine, Meyer 6 109, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Neuromolecular Med 12:301-5. 2010
    ....
  8. pmc Roles for biological membranes in regulating human immunodeficiency virus replication and progress in the development of HIV therapeutics that target lipid metabolism
    Norman J Haughey
    Department of Neurology, Richard T Johnson Division of Neuroimmunology and Neurological Infections, The Johns Hopkins University School of Medicine, Meyer 6 109, 600N Wolfe Street, Baltimore, MD 21287, USA
    J Neuroimmune Pharmacol 6:284-95. 2011
    ..In this review, we summarize the roles that membrane lipids play in HIV infection and discuss the current status of therapeutics that attempt to modify biological membranes to inhibit HIV...
  9. pmc Disturbance in cerebral spinal fluid sphingolipid content is associated with memory impairment in subjects infected with the human immunodeficiency virus
    Michelle M Mielke
    Department of Psychiatry, Richard T Johnson Division of Neuroimmunology and Neurological Infections, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Neurovirol 16:445-56. 2010
    ..These findings suggest that the sphingomyelin:ceramide ratio for C18:0 may be a reasonable surrogate marker for memory dysfunction in HIV-infected subjects...
  10. pmc Inhibition of neutral sphingomyelinase-2 perturbs brain sphingolipid balance and spatial memory in mice
    Nino Tabatadze
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Neurosci Res 88:2940-51. 2010
    ..Our study identifies nSMase2 as an important component for efficient memory formation and underscores the importance of ceramide in regulating synaptic events related to learning and memory...
  11. ncbi request reprint Disruption of neurogenesis by amyloid beta-peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease
    Norman J Haughey
    Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, Baltimore, Maryland 21224, USA
    J Neurochem 83:1509-24. 2002
    ..Adverse effects of Abeta on NPC may contribute to the depletion of neurons and cognitive impairment in AD...
  12. ncbi request reprint Impaired long-term depression in P2X3 deficient mice is not associated with a spatial learning deficit
    Yue Wang
    Laboratory of Neurosciences, National Institute on Aging, Baltimore, MD 21224, USA
    J Neurochem 99:1425-34. 2006
    ....
  13. pmc Tumor necrosis factor-alpha-induced neutral sphingomyelinase-2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors
    David Wheeler
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Neurochem 109:1237-49. 2009
    ....
  14. pmc Ketone bodies protection against HIV-1 Tat-induced neurotoxicity
    Liang Hui
    Department of Pharmacology, Physiology and Therapeutics, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota, USA
    J Neurochem 122:382-91. 2012
    ..Ketogenic strategies have been used clinically for treatment of neurological disorders and our current results suggest that similar strategies may also provide clinical benefits in the treatment of HAND...
  15. pmc The human immunodeficiency virus coat protein gp120 promotes forward trafficking and surface clustering of NMDA receptors in membrane microdomains
    Hangxiu Xu
    Department of Neurology, Richard T Johnson Division of Neuroimmunology and Neurological Infections, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Neurosci 31:17074-90. 2011
    ..These findings demonstrate that gp120 contributes to synaptic dysfunction in the setting of HIV infection by interfering with NMDA receptor trafficking...
  16. pmc Plasma ceramides are altered in mild cognitive impairment and predict cognitive decline and hippocampal volume loss
    Michelle M Mielke
    Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Alzheimers Dement 6:378-85. 2010
    ..The present objective was to examine whether plasma ceramides varied by AD severity in a well-characterized clinic sample and were associated with cognitive decline and hippocampal volume loss over 1 year...
  17. pmc Plasma sphingomyelins are associated with cognitive progression in Alzheimer's disease
    Michelle M Mielke
    Department of Psychiatry, Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Alzheimers Dis 27:259-69. 2011
    ..These results suggest that increased SM/ceramide and DHSM/DHCer ratios dose-dependently predict slower progression among AD patients and may be sensitive blood-based biomarkers for clinical progression...
  18. pmc ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimer's but not normal brain
    Veera Venkata Ratnam Bandaru
    Department of Neurology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Neurobiol Aging 30:591-9. 2009
    ....
  19. ncbi request reprint Neuroprotective and antiretroviral effects of the immunophilin ligand GPI 1046
    Joseph P Steiner
    Department of Neurology, The Johns Hopkins University School of Medicine Pathology 509, 600 North Wolfe Street, Baltimore, MD 21287, USA
    J Neuroimmune Pharmacol 2:49-57. 2007
    ..Furthermore, GPI 1046 showed inhibition of HIV replication and Tat-mediated long terminal repeat (LTR) activation suggesting that this class of compounds may be worthy of further exploration as a potential treatment for HIV dementia...
  20. ncbi request reprint Dual effects of ATP on rat hippocampal synaptic plasticity
    Yue Wang
    Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuroreport 15:633-6. 2004
    ..We conclude that ATP modulates synaptic plasticity via dual effects on pre- and post-synaptic mechanisms...
  21. ncbi request reprint The immunophilin ligand GPI1046 protects neurons from the lethal effects of the HIV-1 proteins gp120 and Tat by modulating endoplasmic reticulum calcium load
    Emily Caporello
    Department of Neurology, John Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Neurochem 98:146-55. 2006
    ..These findings suggest that non-immunosuppressive immunophilin ligands may be useful neuroprotective drugs in HIV dementia...
  22. pmc GPI-1046 protects dorsal root ganglia from gp120-induced axonal injury by modulating store-operated calcium entry
    Ahmet Hoke
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Peripher Nerv Syst 14:27-35. 2009
    ..Together, these results suggest that GPI-1046 protects DRG from gp120-induced axonal damage by decreasing the entry of calcium through SOC, thus reducing the total volume of ER calcium that is available to be released by gp120...
  23. pmc Serum sphingomyelins and ceramides are early predictors of memory impairment
    Michelle M Mielke
    Department of Psychiatry, Division of Geriatric Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 550 North Broadway, Suite 308, Baltimore, MD 21205, USA
    Neurobiol Aging 31:17-24. 2010
    ..Results suggest serum SM and ceramides vary according to the timing of the onset of memory impairment and may be good pre-clinical predictors, or biomarkers, of memory impairment: a deficit observed early in AD pathogenesis...
  24. pmc Adenosine triphosphate released from HIV-infected macrophages regulates glutamatergic tone and dendritic spine density on neurons
    Luis B Tovar-y-Romo
    Department of Neurology, Richard T Johnson Division of Neuroimmunology and Neurological Infections, Johns Hopkins University School of Medicine, Pathology 517, 600 North Wolfe Street, Baltimore, MD 21287, USA
    J Neuroimmune Pharmacol 8:998-1009. 2013
    ..These data suggest that neuronal function may be depressed in HIV infected individuals by mechanisms that involve macrophage release of ATP that triggers secondary effects on glutamate handling. ..
  25. pmc Dendritic spine injury induced by the 8-hydroxy metabolite of efavirenz
    Luis B Tovar-y-Romo
    Department of Neurology, Richard T Johnson Division of Neuroimmunology and Neurological Infections, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Pharmacol Exp Ther 343:696-703. 2012
    ..These findings demonstrate that the 8-OH metabolite of EFV is a potent neurotoxin and highlight the importance of directly determining the effects of antiretroviral drugs and drug metabolites on neurons and other brain cells...
  26. ncbi request reprint Alzheimer's amyloid beta-peptide enhances ATP/gap junction-mediated calcium-wave propagation in astrocytes
    Norman J Haughey
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuromolecular Med 3:173-80. 2003
    ..These findings reveal a novel action of Abeta on the propagation of intercellular calcium signals in astrocytes, and also suggests a role for altered astrocyte calcium-signaling in the pathogenesis of AD...
  27. pmc Use of a glycolipid inhibitor to ameliorate renal cancer in a mouse model
    Subroto Chatterjee
    Department of Pediatrics, Division of Pediatric Cardiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    PLoS ONE 8:e63726. 2013
    ..By linking glycosphingolipid synthesis with tumor growth, renal cancer progression and regression can be evaluated. Thus inhibiting glycosphingolipid synthesis can be a bonafide target to prevent the progression of other types of cancer...
  28. pmc A failure to normalize biochemical and metabolic insults during morphine withdrawal disrupts synaptic repair in mice transgenic for HIV-gp120
    Veera Venkata Ratnam Bandaru
    Department of Neurology, Division of Neuroimmunology, Johns Hopkins University School of Medicine, Meyer 6 109, 600 North Wolfe Street, Baltimore, MD 21287, USA
    J Neuroimmune Pharmacol 6:640-9. 2011
    ....
  29. ncbi request reprint Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4
    TracyAnn Perry
    Section of Drug Design and Development, Laboratory of Neuroscience, Gerontology Research Center, National Institute on Aging NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 302:881-8. 2002
    ....
  30. pmc Selected statins produce rapid spinal motor neuron loss in vitro
    Beth B Murinson
    Department of Neurology, Johns Hopkins School of Medicine, Baltimore, USA
    BMC Musculoskelet Disord 13:100. 2012
    ..Although some have postulated class-effects, prior studies of hepatocytes and myocytes indicate that the statins may exhibit differential effects. Studies of neuronal cells have been limited...
  31. ncbi request reprint Disruption of neurogenesis in the subventricular zone of adult mice, and in human cortical neuronal precursor cells in culture, by amyloid beta-peptide: implications for the pathogenesis of Alzheimer's disease
    Norman J Haughey
    Laboratory of Neurosciences, National Institute on Aging, Gerontology Research Center, Baltimore, MD 21224, USA
    Neuromolecular Med 1:125-35. 2002
    ..Our data show that Abeta can impair cortical neurogenesis, and suggest that this adverse effect of Abeta contributes to the depletion of neurons and the resulting olfactory and cognitive deficits in AD...

Research Grants15

  1. HIV Associated CNS Dysfunction with Aging
    Norman Haughey; Fiscal Year: 2003
    ..In vivo, we will test the protective effects of cholesterol reduction, inhibition of ceramide synthesis and reduction of oxidative stress in models of HIV protein-induced toxicity. ..
  2. Interaction of Alcohol with HIV-Protein
    Norman J Haughey; Fiscal Year: 2010
    ..Determination of how alcohol interacts with viral products to damage brain cells is critical for the rational design of therapeutics designed to protect brain functions. ..
  3. Dysfunctions of Sphingolipid and Sterol Metabolism in HIV-Dementia
    Norman J Haughey; Fiscal Year: 2010
    ..These findings may lead to the rational design of pharmaceutical agents that are neuroprotective by mechanisms that stabilize sphingolipid metabolism and prevent the abnormal clustering of dysfunctional NMDA receptors. ..
  4. Interaction of Alcohol with HIV-Protein
    Norman Haughey; Fiscal Year: 2009
    ..Determination of how alcohol interacts with viral products to damage brain cells is critical for the rational design of therapeutics designed to protect brain functions. ..
  5. Dysfunctions of Sphingolipid and Sterol Metabolism in HIV-Dementia
    Norman Haughey; Fiscal Year: 2009
    ..These findings may lead to the rational design of pharmaceutical agents that are neuroprotective by mechanisms that stabilize sphingolipid metabolism and prevent the abnormal clustering of dysfunctional NMDA receptors. ..
  6. Interaction of Alcohol with HIV-Protein
    Norman Haughey; Fiscal Year: 2007
    ..Determination of how alcohol interacts with viral products to damage brain cells is critical for the rational design of therapeutics designed to protect brain functions. ..
  7. Dysfunctions of Sphingolipid and Sterol Metabolism in HIV-Dementia
    Norman Haughey; Fiscal Year: 2007
    ..These findings may lead to the rational design of pharmaceutical agents that are neuroprotective by mechanisms that stabilize sphingolipid metabolism and prevent the abnormal clustering of dysfunctional NMDA receptors. ..
  8. HIV Associated CNS Dysfunction with Aging
    Norman Haughey; Fiscal Year: 2007
    ..In vivo, we will test the protective effects of cholesterol reduction, inhibition of ceramide synthesis and reduction of oxidative stress in models of HIV protein-induced toxicity. ..
  9. HIV Associated CNS Dysfunction with Aging
    Norman Haughey; Fiscal Year: 2006
    ..In vivo, we will test the protective effects of cholesterol reduction, inhibition of ceramide synthesis and reduction of oxidative stress in models of HIV protein-induced toxicity. ..
  10. HIV Mediated Dysfunction of Neural Progenitor Cells
    Norman Haughey; Fiscal Year: 2006
    ..Findings from these studies could identify novel therapeutic targets for the treatment of HIV-related neurological disease. ..
  11. HIV Associated CNS Dysfunction with Aging
    Norman Haughey; Fiscal Year: 2005
    ..In vivo, we will test the protective effects of cholesterol reduction, inhibition of ceramide synthesis and reduction of oxidative stress in models of HIV protein-induced toxicity. ..
  12. HIV Associated CNS Dysfunction with Aging
    Norman Haughey; Fiscal Year: 2004
    ..In vivo, we will test the protective effects of cholesterol reduction, inhibition of ceramide synthesis and reduction of oxidative stress in models of HIV protein-induced toxicity. ..
  13. Interaction of Alcohol with HIV-Protein
    Norman J Haughey; Fiscal Year: 2010
    ..Determination of how alcohol interacts with viral products to damage brain cells is critical for the rational design of therapeutics designed to protect brain functions. ..