Thomas Hartung

Summary

Affiliation: Johns Hopkins Bloomberg School of Public Health
Country: USA

Publications

  1. ncbi request reprint Comparative analysis of the revised Directive 2010/63/EU for the protection of laboratory animals with its predecessor 86/609/EEC - a t4 report
    Thomas Hartung
    Johns Hopkins University, CAAT, USA
    ALTEX 27:285-303. 2010
  2. pmc Look back in anger - what clinical studies tell us about preclinical work
    Thomas Hartung
    Johns Hopkins University, Bloomberg School of Public Health, CAAT, Baltimore, MD 21205, USA
    ALTEX 30:275-91. 2013
  3. pmc Inflammatory findings on species extrapolations: humans are definitely no 70-kg mice
    Marcel Leist
    Doerenkamp Zbinden Chair for in vitro Toxicology and Biomedicine, University of Konstanz, Constance, Germany
    Arch Toxicol 87:563-7. 2013
  4. ncbi request reprint Mechanistic validation
    Thomas Hartung
    Center for Alternatives to Animal Testing CAAT, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    ALTEX 30:119-30. 2013
  5. pmc Integrated testing strategies for safety assessments
    Thomas Hartung
    Johns Hopkins University, Bloomberg School of Public Health, CAAT, Baltimore, MD 21205, USA
    ALTEX 30:3-18. 2013
  6. ncbi request reprint Alternative approaches for medical countermeasures to biological and chemical terrorism and warfare
    Thomas Hartung
    Johns Hopkins University, Bloomberg School of Public Health, CAAT, Baltimore, MD 21205, USA
    ALTEX 29:251-60. 2012
  7. ncbi request reprint Systems toxicology
    Thomas Hartung
    Johns Hopkins University, Bloomberg School of Public Health, Center for Alternatives to Animal Testing CAAT, Baltimore, MD 21205, USA
    ALTEX 29:119-28. 2012
  8. ncbi request reprint Food for Thought ... on mapping the human toxome
    Thomas Hartung
    CAAT, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, USA
    ALTEX 28:83-93. 2011
  9. ncbi request reprint Evidence-based toxicology - the toolbox of validation for the 21st century?
    Thomas Hartung
    Johns Hopkins University, Dept Environmental Health Sciences, Center for Alternatives to Animal Testing, Baltimore, MD 21205, USA
    ALTEX 27:253-63. 2010
  10. doi request reprint From alternative methods to a new toxicology
    Thomas Hartung
    Dept Environmental Health Sciences, Johns Hopkins University, Baltimore, MD 21205, USA
    Eur J Pharm Biopharm 77:338-49. 2011

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Comparative analysis of the revised Directive 2010/63/EU for the protection of laboratory animals with its predecessor 86/609/EEC - a t4 report
    Thomas Hartung
    Johns Hopkins University, CAAT, USA
    ALTEX 27:285-303. 2010
    ..It also represents a formal implementation of the 3Rs principle (Replacement, Reduction and Refinement of animal tests) put forward by Russel and Burch 1959...
  2. pmc Look back in anger - what clinical studies tell us about preclinical work
    Thomas Hartung
    Johns Hopkins University, Bloomberg School of Public Health, CAAT, Baltimore, MD 21205, USA
    ALTEX 30:275-91. 2013
    ..This paper discusses factors contributing to the lack of reproducibility and relevance of pre-clinical research. The conclusion: Publish less but of better quality and do not rely on the face value of animal studies. ..
  3. pmc Inflammatory findings on species extrapolations: humans are definitely no 70-kg mice
    Marcel Leist
    Doerenkamp Zbinden Chair for in vitro Toxicology and Biomedicine, University of Konstanz, Constance, Germany
    Arch Toxicol 87:563-7. 2013
    ..The low predictivity of animal experiments in research areas allowing direct comparisons of mouse versus human data puts strong doubt on the usefulness of animal data as key technology to predict human safety...
  4. ncbi request reprint Mechanistic validation
    Thomas Hartung
    Center for Alternatives to Animal Testing CAAT, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    ALTEX 30:119-30. 2013
    ....
  5. pmc Integrated testing strategies for safety assessments
    Thomas Hartung
    Johns Hopkins University, Bloomberg School of Public Health, CAAT, Baltimore, MD 21205, USA
    ALTEX 30:3-18. 2013
    ..This paper describes the state of the art of ITS and makes suggestions as to the definition, systematic combination, and quality assurance of ITS...
  6. ncbi request reprint Alternative approaches for medical countermeasures to biological and chemical terrorism and warfare
    Thomas Hartung
    Johns Hopkins University, Bloomberg School of Public Health, CAAT, Baltimore, MD 21205, USA
    ALTEX 29:251-60. 2012
    ..The prospects of such approaches, their impact on the field of alternative approaches, and necessary complementary activities are discussed. The need to adapt quality assurance measures and experiences from validation is stressed...
  7. ncbi request reprint Systems toxicology
    Thomas Hartung
    Johns Hopkins University, Bloomberg School of Public Health, Center for Alternatives to Animal Testing CAAT, Baltimore, MD 21205, USA
    ALTEX 29:119-28. 2012
    ....
  8. ncbi request reprint Food for Thought ... on mapping the human toxome
    Thomas Hartung
    CAAT, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, USA
    ALTEX 28:83-93. 2011
    ..The concept is explained, and opportunities and obstacles are discussed, aiming to promote an initiative which will form the core of a Human Toxicology Project to implement Toxicology for the 21st Century...
  9. ncbi request reprint Evidence-based toxicology - the toolbox of validation for the 21st century?
    Thomas Hartung
    Johns Hopkins University, Dept Environmental Health Sciences, Center for Alternatives to Animal Testing, Baltimore, MD 21205, USA
    ALTEX 27:253-63. 2010
    ..e. the collection and evaluation of existing evidence from various sources, represents a step in this direction. Here, we will explore new toxicological approaches via evidence-based toxicology (EBT)...
  10. doi request reprint From alternative methods to a new toxicology
    Thomas Hartung
    Dept Environmental Health Sciences, Johns Hopkins University, Baltimore, MD 21205, USA
    Eur J Pharm Biopharm 77:338-49. 2011
    ..Similarly, a portal for high-quality reviews of toxicological approaches and tools for the quantitative meta-analyses of data promise to serve as door opener for a new regulatory toxicology...
  11. doi request reprint Lessons learned from alternative methods and their validation for a new toxicology in the 21st century
    Thomas Hartung
    Environmental Health Sciences, Center for Alternatives to Animal Testing, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Toxicol Environ Health B Crit Rev 13:277-90. 2010
    ..However, more importantly, if brought together they can result in a Human Toxicology Project and a real revolution in regulatory toxicology...
  12. ncbi request reprint First alternative method validated by a retrospective weight-of-evidence approach to replace the Draize eye test for the identification of non-irritant substances for a defined applicability domain
    Thomas Hartung
    Johns Hopkins University, Bloomberg School of Public Health, Center for Alternatives to Animal Testing CAAT, Baltimore, MD 21205, USA
    ALTEX 27:43-51. 2010
    ..Here, several of the people critically involved in this processes have summarized the important aspects of this history...
  13. ncbi request reprint Per aspirin ad astra
    Thomas Hartung
    CAAT, Johns Hopkins University, Baltimore, USA
    Altern Lab Anim 37:45-7. 2009
    ..The perspective lies in the Toxicology for the 21st Century initiatives, which aim to create a new approach from the scratch, by an evidence-based toxicology and a global "Human Toxicology Programme"...
  14. doi request reprint Are in vitro tests suitable for regulatory use?
    Thomas Hartung
    Johns Hopkins University, Bloomberg School of Public Health, Department of Environmental Health Sciences, Center for Alternatives to Animal Testing, Doerenkamp Zbinden Chair for Evidence based Toxicology, Baltimore, Maryland 21205, USA
    Toxicol Sci 111:233-7. 2009
    ..Here, we would like following Hegel a summary of thesis and antithesis, but also try to outline the synthesis...
  15. pmc A toxicology for the 21st century--mapping the road ahead
    Thomas Hartung
    Center for Alternatives to Animal Testing, Department for Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21231, USA
    Toxicol Sci 109:18-23. 2009
    ..This will require intense conceptual steering to have all pieces of the puzzle come together...
  16. ncbi request reprint An expert consortium review of the EC-commissioned report "alternative (Non-Animal) methods for cosmetics testing: current status and future prospects - 2010"
    Thomas Hartung
    Johns Hopkins University, Bloomberg School of Public Health, Center for Alternatives to Animal Testing, Baltimore, MD 21205, USA
    ALTEX 28:183-209. 2011
    ..Additional opportunities lie in more global collaborations and the inclusion of other industry sectors...
  17. ncbi request reprint Protecting more than animals
    Alan M Goldberg
    Johns Hopkins University, Center for Alternatives to Animal Testing, USA
    Sci Am 294:84-91. 2006
  18. ncbi request reprint t⁴ workshop report. Nanotoxicology: "the end of the beginning" - signs on the roadmap to a strategy for assuring the safe application and use of nanomaterials
    Ellen K Silbergeld
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    ALTEX 28:236-41. 2011
    ..Finally, the group recommended that a reliable, open, curated database be developed that interfaces with existing databases to enable sharing of information...
  19. ncbi request reprint Re-evaluation of animal numbers and costs for in vivo tests to accomplish REACH legislation requirements for chemicals - a report by the transatlantic think tank for toxicology (t(4))
    Costanza Rovida
    CAAT Center for Alternatives to Animals Testing, Johns Hopkins University, Bloomberg School of Public Health, Doerenkamp Zbinden Chair for Evidence based Toxicology, Baltimore, MD 21205, USA
    ALTEX 26:187-208. 2009
    ..The overall result suggests a demand of 54 million vertebrate animals and testing costs of 9.5 billion euro. This clearly challenges the feasibility of the program without a major investment into high-throughput methodologies...
  20. doi request reprint t4 workshop report: Pathways of Toxicity
    Andre Kleensang
    Johns Hopkins University, Bloomberg School of Public Health, Center for Alternatives to Animal Testing, Baltimore, MD, USA
    ALTEX 31:53-61. 2014
    ..Third, the workshop explored ways in which systems biology approaches could inform pathway annotation, and which resources are needed and available that can provide relevant PoT information to the diverse user communities. ..
  21. pmc Review: toxicometabolomics
    Mounir Bouhifd
    Johns Hopkins Bloomberg School of Public Health, Environmental Health Sciences, Chair for Evidence based Toxicology, Center for Alternatives to Animal Testing, 615 N Wolfe St, Baltimore, MD, 21205, USA
    J Appl Toxicol 33:1365-83. 2013
    ..In addition, this review lays out the prospects for further metabolomics application also in a regulatory context...
  22. ncbi request reprint Immunotoxicology: challenges in the 21st century and in vitro opportunities
    Thomas Hartung
    Johns Hopkins University, Bloomberg School of Public Health, CAAT, Baltimore, USA and University of Konstanz, CAAT Europe, Germany
    ALTEX 30:411-26. 2013
    ....
  23. ncbi request reprint Evidence-based toxicology for the 21st century: opportunities and challenges
    Martin L Stephens
    Johns Hopkins University, Baltimore, MD, USA
    ALTEX 30:74-103. 2013
    ..Priority activities include conducting pilot studies to demonstrate the value of evidence-based approaches to toxicology, as well as conducting educational outreach on these approaches...