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Species | Adam L HartmanSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Intermittent fasting: A "new" historical strategy for controlling seizures?Adam L Hartman
Departments of Neurology and Pediatrics, Johns Hopkins Medicine, 600N Wolfe St, Meyer 2 147, Baltimore, MD 21287, United States Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, United States Electronic address
Epilepsy Res 104:275-9. 2013..Three patients adhered to the combined intermittent fasting/KD regimen for 2 months and four had transient improvement in seizure control, albeit with some hunger-related adverse reactions...
Harnessing the power of metabolism for seizure prevention: focus on dietary treatmentsAdam L Hartman
Department of Neurology, Johns Hopkins Medicine, Baltimore, MD, USA
Epilepsy Behav 26:266-72. 2013..Approaches discussed in this review offer a wide diversity of therapeutic targets that might be exploited by investigators in the search for safer and more effective epilepsy treatments...- The mTOR inhibitor rapamycin has limited acute anticonvulsant effects in miceAdam L Hartman
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
PLoS ONE 7:e45156. 2012..To gain insights into how rapamycin suppresses seizures, we investigated the anticonvulsant activity of rapamycin using acute seizure tests in mice... - Neuroprotection in metabolism-based therapyAdam L Hartman
Johns Hopkins University, Neurology, 600 N Wolfe St, Meyer 2 147, Baltimore, MD 21287, USA
Epilepsy Res 100:286-94. 2012..Additional insights may be obtained by considering the role of metabolism-based therapy in cell disability and death (specifically apoptosis, excitotoxicity, and autophagy)... - Pediatric stroke: do clinical factors predict delays in presentation?Adam L Hartman
Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
J Pediatr 154:727-32. 2009..To explore associations between age, clinical presentation, or predisposing conditions and delayed diagnosis of arterial ischemic stroke... - Does the effectiveness of the ketogenic diet in different epilepsies yield insights into its mechanisms?Adam L Hartman
Pediatric Epilepsy Center, Department of Neurology, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
Epilepsia 49:53-6. 2008..The diet's utility in epilepsy syndromes of various etiologies and in some neurodegenerative disorders suggests it may have multiple mechanisms of action... - The ketogenic diet: uses in epilepsy and other neurologic illnessesKristin W Barañano
Adam L Hartman, MD John M Freeman Pediatric Epilepsy Center, Johns Hopkins Medical Institutions, 600 North Wolfe Street, Meyer 2 147, Baltimore, MD 21287, USA
Curr Treat Options Neurol 10:410-9. 2008..The ketogenic diet also may have a role in improving outcomes in trauma and hypoxic injuries... - Efficacy of the ketogenic diet in the 6-Hz seizure testAdam L Hartman
Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
Epilepsia 49:334-9. 2008.... 
Update on epilepsy and cerebral localizationAdam L Hartman
Department of Neurology, Johns Hopkins Hospital, 600 N Wolfe Street, Meyer 2 147, Baltimore, MD 21287, USA
Curr Neurol Neurosci Rep 7:498-507. 2007..The ability to predict preoperatively the effect of removal of specific tissues would benefit surgical planning for all patients who undergo cortical resections, including those with epilepsy...- The neuropharmacology of the ketogenic dietAdam L Hartman
John M Freeman Pediatric Epilepsy Center, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
Pediatr Neurol 36:281-92. 2007.... - Clinical aspects of the ketogenic dietAdam L Hartman
The John M Freeman Pediatric Epilepsy Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Epilepsia 48:31-42. 2007..Ketogenic diets now are being used for diseases other than epilepsy. This critical analysis of the diet should provide the impetus for further clinical and basic research into the diet's application and mechanisms of action... - Anticonvulsant and proconvulsant actions of 2-deoxy-D-glucoseMaciej Gasior
Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
Epilepsia 51:1385-94. 2010..For comparison, we studied 3-methyl-glucose (3-MG), which like 2-DG accumulates in cells and reduces glucose uptake, but does not inhibit glycolysis... - Seizure tests distinguish intermittent fasting from the ketogenic dietAdam L Hartman
Department of Neurology, Johns Hopkins Medicine, Baltimore, Maryland 21205, USA
Epilepsia 51:1395-402. 2010..We challenged this assumption by profiling the effects of these dietary regimens in mice subjected to a battery of acute seizure tests... - The anticonvulsant activity of acetone, the major ketone body in the ketogenic diet, is not dependent on its metabolites acetol, 1,2-propanediol, methylglyoxal, or pyruvic acidMaciej Gasior
Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 3702, USA
Epilepsia 48:793-800. 2007..The anticonvulsant mechanism of acetone is unknown, but it is metabolized to several bioactive substances that could play a role... - Neuroprotective and disease-modifying effects of the ketogenic dietMaciej Gasior
Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 3702, USA
Behav Pharmacol 17:431-9. 2006.... - The ketogenic diet: one decade laterJohn M Freeman
John M Freeman Pediatric Epilepsy Center, Johns Hopkins Medical Institutions, Baltimore, MD 21287 7247, USA
Pediatrics 119:535-43. 2007..Finally, this review looks toward possible future uses of the ketogenic diet for conditions other than epilepsy... - Comorbidity of migraine in children presenting with epilepsy to a tertiary care centerSarah A Kelley
Johns Hopkins University, Baltimore, MD, USA
Neurology 79:468-73. 2012..We also examined how often migraine is addressed and treated in a pediatric epilepsy cohort... - Ketogenic diets: new advances for metabolism-based therapiesEric H Kossoff
Departments of Neurology and Pediatrics, The John M Freeman Pediatric Epilepsy Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Curr Opin Neurol 25:173-8. 2012..Many of these patients will now turn to dietary therapies such as the ketogenic diet, medium-chain triglyceride diet, modified Atkins diet, and low glycemic index treatment... - High-dose oral prednisolone for infantile spasms: an effective and less expensive alternative to ACTHEric H Kossoff
Department of Neurology, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
Epilepsy Behav 14:674-6. 2009..16. Oral prednisolone had fewer adverse effects (53% vs 80%, P=0.10) and was less expensive ($200 vs approximately $70,000) than ACTH. We now routinely recommend oral prednisolone to all families of children with infantile spasms... - The ketogenic diet for medically and surgically refractory status epilepticus in the neurocritical care unitMackenzie C Cervenka
Department of Neurology, Johns Hopkins University School of Medicine, 600 N Wolfe St, Meyer 2 147, Baltimore, MD 21287 7247, USA
Neurocrit Care 15:519-24. 2011..Dietary therapies have been used for almost a century in children for controlling medically refractory seizures and status epilepticus and recent studies suggest efficacy and safety in adults as well... - Ketone bodies in epilepsyMelanie A McNally
Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Neurochem 121:28-35. 2012..Understanding how ketone bodies exert their effects will help optimize their use in treating epilepsy and other neurological disorders... - Metabolic treatments for intractable epilepsySarah A Kelley
Johns Hopkins Hospital, Baltimore, MD 21287, USA
Semin Pediatr Neurol 18:179-85. 2011..These therapies should be considered earlier in the treatment of intractable epilepsy because they offer a different approach to treatment that has proven efficacious, tolerable, and cost-effective... - The influence of concurrent anticonvulsants on the efficacy of the ketogenic dietPeter F Morrison
The Johns Hopkins Hospital, Baltimore, MD 21287 1000, USA
Epilepsia 50:1999-2001. 2009..04). These results provide practical information to clinicians who are treating children receiving both the KD and anticonvulsants... - The N-terminal helix of Bcl-xL targets mitochondriaMelanie A McNally
W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
Mitochondrion 13:119-24. 2013..Although positive charges and helical propensity are required for targeting, similar to import sequences the N-terminus is not sufficient for efficient mitochondrial import... - Pediatric epilepsy syndromesDeivasumathy Muthugovindan
Division of Pediatric Neurology, John M Freeman Pediatric Epilepsy Center, Johns Hopkins Medicine, Baltimore, MD 21287, USA
Neurologist 16:223-37. 2010..Early recognition and identification of epilepsy syndromes is essential to provide valuable information on management and prognosis... - Epilepsy surgery for the neurocutaneous disordersAdam L Hartman
Johns Hopkins Medical Institutions, Baltimore, MD 21287-1000, USA
Semin Pediatr Neurol 13:63-7. 2006..Options for surgical resection range from focal resections (in those with localized disease) to hemispherectomies (in those with hemispheric involvement)... - Behavior outbursts, orofacial dyskinesias, and CSF pleocytosis in a healthy childPranita D Tamma
Department of Pediatric Infectious Diseases, Johns Hopkins Medical Institution, 200 N Wolfe St, Suite 3150, Baltimore, MD 21287, USA
Pediatrics 128:e242-5. 2011..We report here the case of a previously healthy 7-year-old boy with new-onset aggressive behavior, seizure activity, and orofacial dyskinesias with cerebrospinal fluid and serum that tested positive for anti-NMDA receptors... - A systematic review of the role of intrapartum hypoxia-ischemia in the causation of neonatal encephalopathyErnest M Graham
Division of Maternal Fetal Medicine, Department of Gynecology Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Am J Obstet Gynecol 199:587-95. 2008..5 of 1000 live births. The proportion of cerebral palsy associated with intrapartum hypoxia-ischemia is 14.5%. The vast majority of cases of cerebral palsy in nonanomalous term infants are not associated with intrapartum hypoxia-ischemia... - The anticonvulsant activity of acetone does not depend upon its metabolitesMaciej Gasior
Epilepsia 49:936-7. 2008