Adam L Hartman

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Intermittent fasting: a "new" historical strategy for controlling seizures?
    Adam L Hartman
    Department of Neurology, Johns Hopkins Medicine, 600N Wolfe St, Meyer 2 147, Baltimore, MD 21287, United States
    Epilepsy Res 104:275-9. 2013
  2. pmc Harnessing the power of metabolism for seizure prevention: focus on dietary treatments
    Adam L Hartman
    Department of Neurology, Johns Hopkins Medicine, Baltimore, MD, USA
    Epilepsy Behav 26:266-72. 2013
  3. pmc The mTOR inhibitor rapamycin has limited acute anticonvulsant effects in mice
    Adam L Hartman
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 7:e45156. 2012
  4. pmc Neuroprotection in metabolism-based therapy
    Adam L Hartman
    Johns Hopkins University, Neurology, 600 N Wolfe St, Meyer 2 147, Baltimore, MD 21287, USA
    Epilepsy Res 100:286-94. 2012
  5. pmc Efficacy of the ketogenic diet in the 6-Hz seizure test
    Adam L Hartman
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Epilepsia 49:334-9. 2008
  6. pmc The ketogenic diet: uses in epilepsy and other neurologic illnesses
    Kristin W Barañano
    Adam L Hartman, MD John M Freeman Pediatric Epilepsy Center, Johns Hopkins Medical Institutions, 600 North Wolfe Street, Meyer 2 147, Baltimore, MD 21287, USA
    Curr Treat Options Neurol 10:410-9. 2008
  7. ncbi request reprint Update on epilepsy and cerebral localization
    Adam L Hartman
    Department of Neurology, Johns Hopkins Hospital, 600 N Wolfe Street, Meyer 2 147, Baltimore, MD 21287, USA
    Curr Neurol Neurosci Rep 7:498-507. 2007
  8. pmc The neuropharmacology of the ketogenic diet
    Adam L Hartman
    John M Freeman Pediatric Epilepsy Center, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Pediatr Neurol 36:281-92. 2007
  9. pmc Pediatric stroke: do clinical factors predict delays in presentation?
    Adam L Hartman
    Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    J Pediatr 154:727-32. 2009
  10. ncbi request reprint Clinical aspects of the ketogenic diet
    Adam L Hartman
    The John M Freeman Pediatric Epilepsy Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Epilepsia 48:31-42. 2007

Collaborators

Detail Information

Publications31

  1. pmc Intermittent fasting: a "new" historical strategy for controlling seizures?
    Adam L Hartman
    Department of Neurology, Johns Hopkins Medicine, 600N Wolfe St, Meyer 2 147, Baltimore, MD 21287, United States
    Epilepsy Res 104:275-9. 2013
    ..Three patients adhered to the combined intermittent fasting/KD regimen for 2 months and four had transient improvement in seizure control, albeit with some hunger-related adverse reactions...
  2. pmc Harnessing the power of metabolism for seizure prevention: focus on dietary treatments
    Adam L Hartman
    Department of Neurology, Johns Hopkins Medicine, Baltimore, MD, USA
    Epilepsy Behav 26:266-72. 2013
    ..Approaches discussed in this review offer a wide diversity of therapeutic targets that might be exploited by investigators in the search for safer and more effective epilepsy treatments...
  3. pmc The mTOR inhibitor rapamycin has limited acute anticonvulsant effects in mice
    Adam L Hartman
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 7:e45156. 2012
    ..To gain insights into how rapamycin suppresses seizures, we investigated the anticonvulsant activity of rapamycin using acute seizure tests in mice...
  4. pmc Neuroprotection in metabolism-based therapy
    Adam L Hartman
    Johns Hopkins University, Neurology, 600 N Wolfe St, Meyer 2 147, Baltimore, MD 21287, USA
    Epilepsy Res 100:286-94. 2012
    ..Additional insights may be obtained by considering the role of metabolism-based therapy in cell disability and death (specifically apoptosis, excitotoxicity, and autophagy)...
  5. pmc Efficacy of the ketogenic diet in the 6-Hz seizure test
    Adam L Hartman
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Epilepsia 49:334-9. 2008
    ....
  6. pmc The ketogenic diet: uses in epilepsy and other neurologic illnesses
    Kristin W Barañano
    Adam L Hartman, MD John M Freeman Pediatric Epilepsy Center, Johns Hopkins Medical Institutions, 600 North Wolfe Street, Meyer 2 147, Baltimore, MD 21287, USA
    Curr Treat Options Neurol 10:410-9. 2008
    ..The ketogenic diet also may have a role in improving outcomes in trauma and hypoxic injuries...
  7. ncbi request reprint Update on epilepsy and cerebral localization
    Adam L Hartman
    Department of Neurology, Johns Hopkins Hospital, 600 N Wolfe Street, Meyer 2 147, Baltimore, MD 21287, USA
    Curr Neurol Neurosci Rep 7:498-507. 2007
    ..The ability to predict preoperatively the effect of removal of specific tissues would benefit surgical planning for all patients who undergo cortical resections, including those with epilepsy...
  8. pmc The neuropharmacology of the ketogenic diet
    Adam L Hartman
    John M Freeman Pediatric Epilepsy Center, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Pediatr Neurol 36:281-92. 2007
    ....
  9. pmc Pediatric stroke: do clinical factors predict delays in presentation?
    Adam L Hartman
    Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    J Pediatr 154:727-32. 2009
    ..To explore associations between age, clinical presentation, or predisposing conditions and delayed diagnosis of arterial ischemic stroke...
  10. ncbi request reprint Clinical aspects of the ketogenic diet
    Adam L Hartman
    The John M Freeman Pediatric Epilepsy Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Epilepsia 48:31-42. 2007
    ..Ketogenic diets now are being used for diseases other than epilepsy. This critical analysis of the diet should provide the impetus for further clinical and basic research into the diet's application and mechanisms of action...
  11. pmc Does the effectiveness of the ketogenic diet in different epilepsies yield insights into its mechanisms?
    Adam L Hartman
    Pediatric Epilepsy Center, Department of Neurology, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Epilepsia 49:53-6. 2008
    ..The diet's utility in epilepsy syndromes of various etiologies and in some neurodegenerative disorders suggests it may have multiple mechanisms of action...
  12. doi request reprint Anticonvulsant and proconvulsant actions of 2-deoxy-D-glucose
    Maciej Gasior
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Epilepsia 51:1385-94. 2010
    ..For comparison, we studied 3-methyl-glucose (3-MG), which like 2-DG accumulates in cells and reduces glucose uptake, but does not inhibit glycolysis...
  13. pmc Seizure tests distinguish intermittent fasting from the ketogenic diet
    Adam L Hartman
    Department of Neurology, Johns Hopkins Medicine, Baltimore, Maryland 21205, USA
    Epilepsia 51:1395-402. 2010
    ..We challenged this assumption by profiling the effects of these dietary regimens in mice subjected to a battery of acute seizure tests...
  14. ncbi request reprint The anticonvulsant activity of acetone, the major ketone body in the ketogenic diet, is not dependent on its metabolites acetol, 1,2-propanediol, methylglyoxal, or pyruvic acid
    Maciej Gasior
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 3702, USA
    Epilepsia 48:793-800. 2007
    ..The anticonvulsant mechanism of acetone is unknown, but it is metabolized to several bioactive substances that could play a role...
  15. pmc Neuroprotective and disease-modifying effects of the ketogenic diet
    Maciej Gasior
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 3702, USA
    Behav Pharmacol 17:431-9. 2006
    ....
  16. doi request reprint Ketogenic diet for adults in super-refractory status epilepticus
    Kiran T Thakur
    From the Departments of Neurology K T T, J C P, E H K, R G G, A L H, A V, M C C and Pediatrics E H K, A L H, Johns Hopkins Hospital, Baltimore, MD Department of Neurology S E H, Mayo Clinic, Rochester, MN Department of Food and Nutrition Services K R, Rush University Medical Center, Chicago, IL Institute for Clinical and Translational Research B H, Johns Hopkins University, Baltimore Department of Neurology P W K, Johns Hopkins Bayview Medical Center, Baltimore and Departments of Anesthesiology Critical Care Medicine, Neurosurgery, and Medicine R G G, Johns Hopkins University School of Medicine, Baltimore, MD
    Neurology 82:665-70. 2014
    ....
  17. ncbi request reprint The ketogenic diet: one decade later
    John M Freeman
    John M Freeman Pediatric Epilepsy Center, Johns Hopkins Medical Institutions, Baltimore, MD 21287 7247, USA
    Pediatrics 119:535-43. 2007
    ..Finally, this review looks toward possible future uses of the ketogenic diet for conditions other than epilepsy...
  18. doi request reprint Comorbidity of migraine in children presenting with epilepsy to a tertiary care center
    Sarah A Kelley
    Johns Hopkins University, Baltimore, MD, USA
    Neurology 79:468-73. 2012
    ..We also examined how often migraine is addressed and treated in a pediatric epilepsy cohort...
  19. doi request reprint Ketogenic diets: new advances for metabolism-based therapies
    Eric H Kossoff
    Departments of Neurology and Pediatrics, The John M Freeman Pediatric Epilepsy Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Curr Opin Neurol 25:173-8. 2012
    ..Many of these patients will now turn to dietary therapies such as the ketogenic diet, medium-chain triglyceride diet, modified Atkins diet, and low glycemic index treatment...
  20. pmc Posthemispherectomy hydrocephalus: results of a comprehensive, multiinstitutional review
    Sean M Lew
    Department of Neurosurgery, Children s Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Epilepsia 54:383-9. 2013
    ..Our goal was to better understand this phenomenon and to identify risk factors that may predispose patients to developing hydrocephalus after hemispherectomy surgery...
  21. doi request reprint High-dose oral prednisolone for infantile spasms: an effective and less expensive alternative to ACTH
    Eric H Kossoff
    Department of Neurology, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Epilepsy Behav 14:674-6. 2009
    ..16. Oral prednisolone had fewer adverse effects (53% vs 80%, P=0.10) and was less expensive ($200 vs approximately $70,000) than ACTH. We now routinely recommend oral prednisolone to all families of children with infantile spasms...
  22. doi request reprint The ketogenic diet for medically and surgically refractory status epilepticus in the neurocritical care unit
    Mackenzie C Cervenka
    Department of Neurology, Johns Hopkins University School of Medicine, 600 N Wolfe St, Meyer 2 147, Baltimore, MD 21287 7247, USA
    Neurocrit Care 15:519-24. 2011
    ..Dietary therapies have been used for almost a century in children for controlling medically refractory seizures and status epilepticus and recent studies suggest efficacy and safety in adults as well...
  23. doi request reprint Ketone bodies in epilepsy
    Melanie A McNally
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Neurochem 121:28-35. 2012
    ..Understanding how ketone bodies exert their effects will help optimize their use in treating epilepsy and other neurological disorders...
  24. doi request reprint Metabolic treatments for intractable epilepsy
    Sarah A Kelley
    Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Semin Pediatr Neurol 18:179-85. 2011
    ..These therapies should be considered earlier in the treatment of intractable epilepsy because they offer a different approach to treatment that has proven efficacious, tolerable, and cost-effective...
  25. doi request reprint The influence of concurrent anticonvulsants on the efficacy of the ketogenic diet
    Peter F Morrison
    The Johns Hopkins Hospital, Baltimore, MD 21287 1000, USA
    Epilepsia 50:1999-2001. 2009
    ..04). These results provide practical information to clinicians who are treating children receiving both the KD and anticonvulsants...
  26. pmc The N-terminal helix of Bcl-xL targets mitochondria
    Melanie A McNally
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Mitochondrion 13:119-24. 2013
    ..Although positive charges and helical propensity are required for targeting, similar to import sequences the N-terminus is not sufficient for efficient mitochondrial import...
  27. doi request reprint Pediatric epilepsy syndromes
    Deivasumathy Muthugovindan
    Division of Pediatric Neurology, John M Freeman Pediatric Epilepsy Center, Johns Hopkins Medicine, Baltimore, MD 21287, USA
    Neurologist 16:223-37. 2010
    ..Early recognition and identification of epilepsy syndromes is essential to provide valuable information on management and prognosis...
  28. ncbi request reprint Epilepsy surgery for the neurocutaneous disorders
    Adam L Hartman
    Johns Hopkins Medical Institutions, Baltimore, MD 21287 1000, USA
    Semin Pediatr Neurol 13:63-7. 2006
    ..Options for surgical resection range from focal resections (in those with localized disease) to hemispherectomies (in those with hemispheric involvement)...
  29. pmc Behavior outbursts, orofacial dyskinesias, and CSF pleocytosis in a healthy child
    Pranita D Tamma
    Department of Pediatric Infectious Diseases, Johns Hopkins Medical Institution, 200 N Wolfe St, Suite 3150, Baltimore, MD 21287, USA
    Pediatrics 128:e242-5. 2011
    ..We report here the case of a previously healthy 7-year-old boy with new-onset aggressive behavior, seizure activity, and orofacial dyskinesias with cerebrospinal fluid and serum that tested positive for anti-NMDA receptors...
  30. doi request reprint A systematic review of the role of intrapartum hypoxia-ischemia in the causation of neonatal encephalopathy
    Ernest M Graham
    Division of Maternal Fetal Medicine, Department of Gynecology Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Obstet Gynecol 199:587-95. 2008
    ..5 of 1000 live births. The proportion of cerebral palsy associated with intrapartum hypoxia-ischemia is 14.5%. The vast majority of cases of cerebral palsy in nonanomalous term infants are not associated with intrapartum hypoxia-ischemia...
  31. doi request reprint The anticonvulsant activity of acetone does not depend upon its metabolites
    Maciej Gasior
    Epilepsia 49:936-7. 2008