J M Hardwick

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Viral versus cellular BCL-2 proteins
    J M Hardwick
    Department of Molecular Microbiology and Immunology, Johns Hopkins University School of Public Health, Baltimore, Maryland 21205, USA
    Cell Death Differ 10:S68-76. 2003
  2. pmc Multipolar functions of BCL-2 proteins link energetics to apoptosis
    J Marie Hardwick
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Trends Cell Biol 22:318-28. 2012
  3. pmc Seizure tests distinguish intermittent fasting from the ketogenic diet
    Adam L Hartman
    Department of Neurology, Johns Hopkins Medicine, Baltimore, Maryland 21205, USA
    Epilepsia 51:1395-402. 2010
  4. ncbi request reprint Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1
    B N Chau
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University, Schools of Medicine and Public Health, Baltimore, Maryland 21205, USA
    Mol Cell 6:31-40. 2000
  5. ncbi request reprint c-IAP1 is cleaved by caspases to produce a proapoptotic C-terminal fragment
    R J Clem
    Department of Molecular Microbiology and Immunology, Johns Hopkins Schools of Public Health and Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 276:7602-8. 2001
  6. pmc Modulation of cell death by Bcl-XL through caspase interaction
    R J Clem
    Department of Molecular Microbiology and Immunology, Johns Hopkins University Schools of Public Health and Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 95:554-9. 1998
  7. pmc Survival motor neuron protein modulates neuron-specific apoptosis
    D A Kerr
    Departments of Neurology, Molecular Microbiology and Immunology, Anesthesiology and Critical Care Medicine, and Pharmacology and Molecular Sciences, The Johns Hopkins Schools of Medicine and Public Health, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 97:13312-7. 2000
  8. ncbi request reprint Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c
    D G Kirsch
    Oncology Center, Pharmacology and Molecular Sciences, and Neurology, Johns Hopkins Schools of Public Health and Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 274:21155-61. 1999
  9. ncbi request reprint Inhibition of virus-induced neuronal apoptosis by Bax
    J Lewis
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University Schools of Medicine and Public Health, Baltimore, Maryland 21205, USA
    Nat Med 5:832-5. 1999
  10. pmc Gene-dependent cell death in yeast
    X Teng
    Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Cell Death Dis 2:e188. 2011

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Viral versus cellular BCL-2 proteins
    J M Hardwick
    Department of Molecular Microbiology and Immunology, Johns Hopkins University School of Public Health, Baltimore, Maryland 21205, USA
    Cell Death Differ 10:S68-76. 2003
    ..Thus, exploring the biochemical and biological functions of the viral BCL-2 family proteins will increase our understanding of their role in virus infections and will undoubtedly teach us something about their cellular kin...
  2. pmc Multipolar functions of BCL-2 proteins link energetics to apoptosis
    J Marie Hardwick
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Trends Cell Biol 22:318-28. 2012
    ..Even their sub-mitochondrial localizations remain controversial. Here we attempt to integrate seemingly conflicting information with the prospect that BCL-2 proteins themselves may be the critical crosstalk between life and death...
  3. pmc Seizure tests distinguish intermittent fasting from the ketogenic diet
    Adam L Hartman
    Department of Neurology, Johns Hopkins Medicine, Baltimore, Maryland 21205, USA
    Epilepsia 51:1395-402. 2010
    ..We challenged this assumption by profiling the effects of these dietary regimens in mice subjected to a battery of acute seizure tests...
  4. ncbi request reprint Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1
    B N Chau
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University, Schools of Medicine and Public Health, Baltimore, Maryland 21205, USA
    Mol Cell 6:31-40. 2000
    ..Consistent with this idea, Aven inhibited the proteolytic activation of caspases in a cell-free extract and suppressed apoptosis induced by Apaf-1 plus caspase-9. Thus, Aven represents a new class of cell death regulator...
  5. ncbi request reprint c-IAP1 is cleaved by caspases to produce a proapoptotic C-terminal fragment
    R J Clem
    Department of Molecular Microbiology and Immunology, Johns Hopkins Schools of Public Health and Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 276:7602-8. 2001
    ..To the contrary, deletion of the caspase recruitment domain increased proapoptotic activity, apparently by stabilizing the C-terminal fragment...
  6. pmc Modulation of cell death by Bcl-XL through caspase interaction
    R J Clem
    Department of Molecular Microbiology and Immunology, Johns Hopkins University Schools of Public Health and Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 95:554-9. 1998
    ....
  7. pmc Survival motor neuron protein modulates neuron-specific apoptosis
    D A Kerr
    Departments of Neurology, Molecular Microbiology and Immunology, Anesthesiology and Critical Care Medicine, and Pharmacology and Molecular Sciences, The Johns Hopkins Schools of Medicine and Public Health, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 97:13312-7. 2000
    ..g., Y272C), produce a proapoptotic form of SMN that may contribute to neuronal death in SMA and perhaps other neurodegenerative disorders...
  8. ncbi request reprint Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c
    D G Kirsch
    Oncology Center, Pharmacology and Molecular Sciences, and Neurology, Johns Hopkins Schools of Public Health and Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 274:21155-61. 1999
    ..Therefore, caspase-3-dependent cleavage of Bcl-2 appears to promote further caspase activation as part of a positive feedback loop for executing the cell...
  9. ncbi request reprint Inhibition of virus-induced neuronal apoptosis by Bax
    J Lewis
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University Schools of Medicine and Public Health, Baltimore, Maryland 21205, USA
    Nat Med 5:832-5. 1999
    ..These findings indicate that cell-specific factors determine the anti-apoptotic versus pro-apoptotic function of Bax...
  10. pmc Gene-dependent cell death in yeast
    X Teng
    Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Cell Death Dis 2:e188. 2011
    ..Although these death mechanisms are yet uncharacterized, this study facilitates further exploration...
  11. pmc Pro-B-cell-specific transcription and proapoptotic function of protein kinase Ceta
    T A Morrow
    Graduate Program in Immunology, The Johns Hopkins University School of Public Health, Baltimore, Maryland 21205, USA
    Mol Cell Biol 19:5608-18. 1999
    ..These results suggest that the expression and proteolytic activation of PKCeta play an important role in the regulation of cell division and cell death during early B-cell development...
  12. pmc Bcl-2-mediated drug resistance: inhibition of apoptosis by blocking nuclear factor of activated T lymphocytes (NFAT)-induced Fas ligand transcription
    R K Srivastava
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224 6825, USA
    J Exp Med 190:253-65. 1999
    ..The effects of Bcl-2 can be overcome, at least partially, through phosphorylation of Bcl-2. Phosphorylated Bcl-2 cannot bind calcineurin, and NFAT activation, FasL expression, and apoptosis can occur after Bcl-2 phosphorylation...
  13. ncbi request reprint Perspective: virus infections and the death of neurons
    D E Griffin
    Dept of Molecular Microbiology and Immunology, Johns Hopkins University School of Hygiene and Public Health, 615 N Wolfe St, Baltimore, MD 21205
    Trends Microbiol 7:155-60. 1999
    ..Infected neurons develop cytoplasmic blebbing characteristic of apoptosis, but a paucity of apoptotic nuclear changes potentially indicates unique aspects of virus-induced neuronal apoptosis that remain to be discovered...
  14. ncbi request reprint Comparison of Bcl-2 to a Bcl-2 deletion mutant for mammalian cells exposed to culture insults
    B Figueroa
    Department of Chemical Engineering, The Johns Hopkins University, 3400 North Charles St, Baltimore, Maryland 21218, USA
    Biotechnol Bioeng 73:211-22. 2001
    ..These studies indicate that the cells regulate anti-apoptosis protein levels and these processing events can limit the effectiveness of cell death inhibition strategies in mammalian cell culture systems...
  15. pmc Fis1 deficiency selects for compensatory mutations responsible for cell death and growth control defects
    W C Cheng
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Cell Death Differ 15:1838-46. 2008
    ....
  16. ncbi request reprint Antibody-mediated clearance of alphavirus infection from neurons
    B Levine
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Science 254:856-60. 1991
    ..Thus, antibody can mediate clearance of alphavirus infection from neurons by restricting viral gene expression...
  17. ncbi request reprint Enhancement of suicidal DNA vaccine potency by delaying suicidal DNA-induced cell death
    T W Kim
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Gene Ther 11:336-42. 2004
    ..These results suggest that strategies to delay suicidal DNA-induced cell death using antiapoptotic proteins may greatly enhance the potency of suicidal DNA...
  18. ncbi request reprint Alternate functions of viral regulators of cell death
    Y B Chen
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell Death Differ 13:1318-24. 2006
  19. ncbi request reprint Mitochondrial factors with dual roles in death and survival
    W C Cheng
    Department of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, MD 21205, USA
    Oncogene 25:4697-705. 2006
    ..Here, we review some of the supporting evidence and stretch beyond the evidence to seek an understanding of the remaining questions...
  20. ncbi request reprint Conversion of Bcl-2 to a Bax-like death effector by caspases
    E H Cheng
    Department of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, MD 21205, USA
    Science 278:1966-8. 1997
    ..Cleavage-resistant mutants of Bcl-2 had increased protection from interleukin-3 withdrawal and Sindbis virus-induced apoptosis. Thus, cleavage of Bcl-2 by caspases may ensure the inevitability of cell death...
  21. ncbi request reprint Bax-independent inhibition of apoptosis by Bcl-XL
    E H Cheng
    Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland 21287 7681, USA
    Nature 379:554-6. 1996
    ..Specific mutations that disrupt the ability of Bcl-XL to interact with Bax or Bak still preserve 70-80% of the anti-death activity of wild-type Bcl-XL...
  22. ncbi request reprint Inhibition of drug-induced Fas ligand transcription and apoptosis by Bcl-XL
    R S Biswas
    Department of Pharmaceutical Sciences, University of Maryland, School of Pharmacy, Baltimore 21201, USA
    Mol Cell Biochem 225:7-20. 2001
    ..Thus, paclitaxel and other drugs that disturb microtubule function kill cells, at least in part, through the induction of FasL, and Bcl-XL-mediated resistance to these agents is related to failure to induce FasL expression...
  23. pmc A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors
    C S Duckett
    Howard Hughes Medical Institute, The University of Chicago, Chicago, IL 60637, USA
    EMBO J 15:2685-94. 1996
    ..Together these data suggest that iap and related cellular genes play an evolutionarily conserved role in the regulation of apoptosis...