James P Hamilton

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Abdominal venous thrombosis presenting in myeloproliferative neoplasm with JAK2 V617F mutation: a case report
    Naveen Pemmaraju
    MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    J Med Case Rep 6:102. 2012
  2. pmc Epigenetics: principles and practice
    James P Hamilton
    Division of Gastroenterology and Hepatology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dig Dis 29:130-5. 2011
  3. pmc The miR-106b-25 polycistron, activated by genomic amplification, functions as an oncogene by suppressing p21 and Bim
    Takatsugu Kan
    Division of Gastroenterology, Department of Medicine, The Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland 21287, USA
    Gastroenterology 136:1689-700. 2009
  4. pmc Pituitary tumor-transforming 1 increases cell motility and promotes lymph node metastasis in esophageal squamous cell carcinoma
    Tetsuo Ito
    Division of Gastroenterology, Department of Medicine, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Cancer Res 68:3214-24. 2008
  5. doi request reprint Promoter hypermethylation of CDH13 is a common, early event in human esophageal adenocarcinogenesis and correlates with clinical risk factors
    Zhe Jin
    Division of Gastroenterology, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    Int J Cancer 123:2331-6. 2008
  6. pmc MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3
    Florin M Selaru
    Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Hepatology 49:1595-601. 2009
  7. ncbi request reprint Hypermethylation of the somatostatin promoter is a common, early event in human esophageal carcinogenesis
    Zhe Jin
    Division of Gastroenterology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Cancer 112:43-9. 2008
  8. doi request reprint Successful liver transplantation for Budd-Chiari syndrome in a patient with paroxysmal nocturnal hemoglobinuria treated with the anti-complement antibody eculizumab
    Andrew L Singer
    Department of Surgery, Comprehensive Transplant Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Liver Transpl 15:540-3. 2009
  9. pmc Novel decapeptides that bind avidly and deliver radioisotope to colon cancer cells
    John M Abraham
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 2:e964. 2007
  10. ncbi request reprint A genome-wide search identifies epigenetic silencing of somatostatin, tachykinin-1, and 5 other genes in colon cancer
    Yuriko Mori
    Department of Medicine, Division of Gastroenterology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Gastroenterology 131:797-808. 2006

Collaborators

Detail Information

Publications23

  1. pmc Abdominal venous thrombosis presenting in myeloproliferative neoplasm with JAK2 V617F mutation: a case report
    Naveen Pemmaraju
    MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    J Med Case Rep 6:102. 2012
    ..abstract:..
  2. pmc Epigenetics: principles and practice
    James P Hamilton
    Division of Gastroenterology and Hepatology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dig Dis 29:130-5. 2011
    ..In the future, it is anticipated that innovative diagnostic tests, treatment regimens, and even lifestyle modifications will be based on epigenetic mechanisms and be incorporated into the practice of medicine...
  3. pmc The miR-106b-25 polycistron, activated by genomic amplification, functions as an oncogene by suppressing p21 and Bim
    Takatsugu Kan
    Division of Gastroenterology, Department of Medicine, The Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland 21287, USA
    Gastroenterology 136:1689-700. 2009
    ..Barrett's esophagus (BE) is a highly premalignant disease that predisposes to the development of esophageal adenocarcinoma (EAC); however, the involvement of microRNAs (miRs) in BE-EAC carcinogenic progression is not known...
  4. pmc Pituitary tumor-transforming 1 increases cell motility and promotes lymph node metastasis in esophageal squamous cell carcinoma
    Tetsuo Ito
    Division of Gastroenterology, Department of Medicine, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Cancer Res 68:3214-24. 2008
    ..Thus, PTTG1 constitutes a potential biomarker and therapeutic target in ESCCs with lymph node metastases...
  5. doi request reprint Promoter hypermethylation of CDH13 is a common, early event in human esophageal adenocarcinogenesis and correlates with clinical risk factors
    Zhe Jin
    Division of Gastroenterology, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    Int J Cancer 123:2331-6. 2008
    ..These findings suggest that hypermethylation of CDH13 is a common, tissue-specific event in human EAC, occurs early during BE-associated neoplastic progression, and correlates with known clinical neoplastic progression risk factors...
  6. pmc MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3
    Florin M Selaru
    Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Hepatology 49:1595-601. 2009
    ..Conclusions: MiR-21 is overexpressed in human CCAs. Furthermore, miR-21 may be oncogenic, at least in part, by inhibiting PDCD4 and TIMP3. Finally, these data suggest that TIMP3 is a candidate tumor suppressor gene in the biliary tree...
  7. ncbi request reprint Hypermethylation of the somatostatin promoter is a common, early event in human esophageal carcinogenesis
    Zhe Jin
    Division of Gastroenterology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Cancer 112:43-9. 2008
    ..The aim of the current study was to investigate whether and at what stage promoter hypermethylation of SST is involved in human esophageal carcinogenesis...
  8. doi request reprint Successful liver transplantation for Budd-Chiari syndrome in a patient with paroxysmal nocturnal hemoglobinuria treated with the anti-complement antibody eculizumab
    Andrew L Singer
    Department of Surgery, Comprehensive Transplant Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Liver Transpl 15:540-3. 2009
    ..Here we present the first report of a patient with PNH and BCS undergoing successful liver transplantation while receiving eculizumab, a humanized monoclonal antibody that blocks the activation of the terminal complement at C5...
  9. pmc Novel decapeptides that bind avidly and deliver radioisotope to colon cancer cells
    John M Abraham
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 2:e964. 2007
    ..The rapidly growing field of targeted tumor therapy often utilizes an antibody, sometimes tagged with a tumor-ablating material such as radioisotope, directed against a specific molecule...
  10. ncbi request reprint A genome-wide search identifies epigenetic silencing of somatostatin, tachykinin-1, and 5 other genes in colon cancer
    Yuriko Mori
    Department of Medicine, Division of Gastroenterology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Gastroenterology 131:797-808. 2006
    ..Gene silencing via promoter hypermethylation is a central event in the pathogenesis of cancers. To identify novel methylation targets in colon cancer, we conducted a genome-wide, microarray-based, in silico, and epigenetic search...
  11. pmc Silencing of claudin-11 is associated with increased invasiveness of gastric cancer cells
    Rachana Agarwal
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 4:e8002. 2009
    ..In the present study, we report that claudin-11 (CLDN11) is silenced in gastric cancer via hypermethylation of its promoter region...
  12. pmc Generation of small 32P-labeled peptides as a potential approach to colorectal cancer therapy
    John M Abraham
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 3:e2508. 2008
    ..This report proposes the development and use of (32)P-labeled peptides as potential individualized peptide-binding therapies for the treatment of colon adenocarcinoma patients...
  13. ncbi request reprint Reprimo methylation is a potential biomarker of Barrett's-Associated esophageal neoplastic progression
    James P Hamilton
    Department of Medicine, Division of Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Clin Cancer Res 12:6637-42. 2006
    ..We also sought to determine whether Reprimo expression could be restored in vitro by the demethylating agent 5-aza-deoxycytidine (5AzaC)...
  14. ncbi request reprint Polo-like kinase and survivin are esophageal tumor-specific promoters
    Fumiaki Sato
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Biochem Biophys Res Commun 342:465-71. 2006
    ..9-fold and 28.5-fold higher, respectively, than in normal lung and renal cells. The promoters of PLK and survivin could be useful tools for developing EC-specific gene therapy vectors...
  15. ncbi request reprint Molecular phenotype of inflammatory bowel disease-associated neoplasms with microsatellite instability
    Karsten Schulmann
    Division of Gastroenterology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Gastroenterology 129:74-85. 2005
    ..We sought to determine the frequency of high-level microsatellite instability (MSI-H) and the mutational and methylation profile of MSI-H IBD-related neoplasms (IBDNs)...
  16. doi request reprint Hypermethylation of the AKAP12 promoter is a biomarker of Barrett's-associated esophageal neoplastic progression
    Zhe Jin
    Division of Gastroenterology, Department of Medicine, Johns Hopkins University School of Medicine, 1503 East Jefferson Street, Baltimore, MD 21231, USA
    Cancer Epidemiol Biomarkers Prev 17:111-7. 2008
    ....
  17. ncbi request reprint Hypermethylation of tachykinin-1 is a potential biomarker in human esophageal cancer
    Zhe Jin
    Division of Gastroenterology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Clin Cancer Res 13:6293-300. 2007
    ..Our aim was to investigate whether and at what stage hypermethylation of the tachykinin-1 (TAC1) gene is associated with human esophageal neoplastic transformation...
  18. ncbi request reprint Promoter methylation and response to chemotherapy and radiation in esophageal cancer
    James P Hamilton
    Division of Gastroenterology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Clin Gastroenterol Hepatol 4:701-8. 2006
    ..Accordingly, our aim was to find methylation markers that could be used to predict response to chemoradiation...
  19. ncbi request reprint A review of the genomics of gastric cancer
    James P Hamilton
    Division of Gastroenterology, Department of Pathology, Marlene and Stewart Greenebaum Cancer Center, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA
    Clin Gastroenterol Hepatol 4:416-25. 2006
    ..An improved understanding of the genomics of gastric cancer should lead to the rapid development of novel diagnostic techniques and molecular-based treatment strategies...
  20. ncbi request reprint Mutational and LOH analyses of the chromosome 4q region in esophageal adenocarcinoma
    Anca Sterian
    Division of Gastroenterology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Oncology 70:168-72. 2006
    ..Findings from loss of heterozygosity (LOH) studies have suggested that the long arm of chromosome 4 might harbor tumor suppressor genes relevant to esophageal adenocarcinoma...
  21. pmc A multicenter, double-blinded validation study of methylation biomarkers for progression prediction in Barrett's esophagus
    Zhe Jin
    Gastroenterology Division, Johns Hopkins University, Baltimore, MD 21287, USA
    Cancer Res 69:4112-5. 2009
    ..118, respectively) in all 3 models. A methylation biomarker-based panel to predict neoplastic progression in BE has potential clinical value in improving both the efficiency of surveillance endoscopy and the early detection of neoplasia...
  22. pmc Epigenetic events in gastrointestinal cancer
    Florin M Selaru
    Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Am J Gastroenterol 104:1910-2. 2009
    ..In the future, innovative diagnostic tests and treatment regimens will likely be based on epigenetic mechanisms and be incorporated into the gastroenterologist's practice...
  23. pmc Three-tiered risk stratification model to predict progression in Barrett's esophagus using epigenetic and clinical features
    Fumiaki Sato
    Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 3:e1890. 2008
    ..In this study, we developed a 3-tiered risk stratification strategy, based on systematically selected epigenetic and clinical parameters, to improve Barrett's esophagus surveillance efficiency...